iiinova — where your digital self keeps evolving

Reposted by Brugues Lab

André Nadler @nadlerlab.bsky.social · 29/07/2026

Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...

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Reposted by Brugues Lab

TUD | Biotechnology Center (BIOTEC) @biotec-tud.bsky.social · 02/07/2026

Welcome Prof. Ágnes Tóth-Petróczy! New Professor of Systems Biology and Protein Evolution & joint group leader at BIOTEC @tudresden.bsky.social & CASUS. She focuses on disordered proteins - ones that lack a fixed 3D structure - yet play essential roles. Read more ➡️ tud.link/784yv9 #CMCBnews

tu-dresden.de

Sachsen bindet Spitzenforscherin im Bereich der Bioinformatik: Prof. Ágnes Tóth-Petróczy verstärkt das BIOTEC und CASUS

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Reposted by Brugues Lab

Physics of Life Dresden @poldresden.bsky.social · 24/06/2026

🏆 Introducing the inaugural Suzanne Eaton Awards for Physics of Life! We're thrilled to announce the 2026 recipients: L. Mahadevan @harvard.edu and Anna Erzberger @embl.org. 👨‍🔬Both scientists will give award lectures on 20. November, more info to follow ➡️Read our announcement here: tud.link/cjm8t2

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Brugues Lab @brugueslab.bsky.social · 18/06/2026

It was an honor to introduce @alisonkickuth.bsky.social during the Otto Hahn medal ceremony from the @maxplanck.de in recognition for her amazing PhD, where she discovered a new mechanism for unilateral cytokinesis (www.nature.com/articles/s41...)

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Brugues Lab @brugueslab.bsky.social · 11/06/2026

Congratulations Dr Uršič for the amazing defense!!

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Reposted by Brugues Lab

MwahahahahahadScientist @mads100tist.bsky.social · 14/05/2026

I deleted the previous post because it had a typo. If you could share, that would be great!

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Reposted by Brugues Lab

Physics of Life Dresden @poldresden.bsky.social · 12/05/2026

🚨One week left! Applications for our Postdoctoral Fellows Program will close on 20. May! We offer numerous benefits: ✅ 3-year funded position ✅ Core research funding to cover travel, publishing, and project costs ✅Mentorship from 2+ PoL PIs ..and much more! Apply now: tud.link/y3djda

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Institut Curie @institutcurie.bsky.social · 07/05/2026

Registration for the Cell Biology and Cancer course at Institut Curie is now open! Explore how biological forms emerge across scales, from intracellular organization to tissues. 📅 November 16th-20th, 2026 (Paris) ⏳ Deadline: September 10th, 2026 🔗 training.institut-curie.org/cours/biolog...

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Brugues Lab @brugueslab.bsky.social · 16/04/2026

Congratulations for this beautiful story!!

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Brugues Lab @brugueslab.bsky.social · 10/04/2026

Very proud of Joana Vidigueira from the lab, who won one of the DIGS-ILS Fellow Awards 2026! www.digs-ils.phd/news/2025/06...

digs-ils.phd

DIGS-ILS Fellow Awards 2026

Awards given to five DIGS-ILS PhD candidates

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Physics of Life Dresden @poldresden.bsky.social · 26/03/2026

🚀 Are you planning to secure funding to start your own research group? (e.g. ERC, Emmy Noether, etc). 👨‍🔬Physics of Life can host you, and offers numerous benefits! We are launching a new Program to host and support third-party funded junior groups. Check out the details here: tud.link/xayd8s

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Brugues Lab @brugueslab.bsky.social · 24/03/2026

Congratulations, this looks amazing!

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Reposted by Brugues Lab

Lisa Heinke @lisaheinke.bsky.social · 09/03/2026

Check out my newest Research highlight on work by @brugueslab.bsky.social on how the cytoplasm of early embryos retains its partitioning prior to cellularisation - and what workarounds different species have developed against an inherent cytoskeletal instability!

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Brugues Lab @brugueslab.bsky.social · 06/03/2026

Really nice highlight of our recent paper on cytoplasmic partitioning by physical instabilities!

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Reposted by Brugues Lab

Barriga Lab @eliasbarrigalab.bsky.social · 26/02/2026

We are #Hiring! Our lab is looking for a LabTech/Lab Manager! Take a look to our research here! physics-of-life.tu-dresden.de/team/pol-gro... Drop a line if you are interested to know more details! #labtech #labtechnician #biology #labtechnicians #labmanager #labwork #Xenopus #zebrafish #devbiol

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Reposted by Brugues Lab

FocalPlane @focalplane.bsky.social · 10/02/2026

Our latest ‘Imaging spotlight’ is from Jan Brugués @brugueslab.bsky.social & Alison Kickuth @alisonkickuth.bsky.social where they discuss the microscopy & microrheology techniques that they used in their research dissecting the mechanics of cytokinesis. focalplane.biologists.com/2026/02/10/i...

focalplane.biologists.com

Imaging spotlight - How to divide without a ring: a mechanical ratchet drives unilateral cytokinesis - FocalPlane

Imaging spotlight - How to divide without a ring: a mechanical ratchet drives unilateral cytokinesis - News

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Brugues Lab @brugueslab.bsky.social · 29/01/2026

It was great to work with you guys!

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Brugues Lab @brugueslab.bsky.social · 29/01/2026

interestingly zebrafish and Drosophila embryos have roughly the same size at the one cell stage, but use the different partition strategies (unstable and stable), so it is more about regulating nucleation and timing I think!

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Brugues Lab @brugueslab.bsky.social · 29/01/2026

Thank you! Yes, to the extend that organism size may regulate aster growth/size, but smaller organisms could potentially have the instability if autocatalytic growth dominates turnover. Temperature will certainly have an effect in both growth and cell cycle timing (which prevents instability).

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Brugues Lab @brugueslab.bsky.social · 28/01/2026

We thank @minclab.bsky.social, @buzzbaum.bsky.social, and an anonymous reviewer for their constructive feedback! This work has been a great collaboration between Melissa Rinaldin, @alisonkickuth.bsky.social, Adam Lamson, Benjamin Dalton, Yitong Xu, Pavel Mejstřík, and @ditalialab.bsky.social (9/9)

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Brugues Lab @brugueslab.bsky.social · 28/01/2026

Our results indicate that the temporal control of microtubule dynamics could have driven the evolutionary emergence of species-specific mechanisms for effective cytoplasmic organization, revealing a fundamental synergy between physical instabilities and biological clocks. (8/9)

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Brugues Lab @brugueslab.bsky.social · 28/01/2026

In zebrafish embryos, unstable microtubule waves fill the geometry of the entire embryo from the first division. In contrast, in Drosophila embryos, stable microtubule asters resulting from reduced microtubule nucleation gradually fill the cytoplasm throughout multiple divisions. (7/9)

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Brugues Lab @brugueslab.bsky.social · 28/01/2026

These regulatory mechanisms give rise to two possible strategies to fill the cytoplasm, which we experimentally demonstrate in zebrafish and Drosophila embryos (6/9)

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Brugues Lab @brugueslab.bsky.social · 28/01/2026

We found two distinct solutions: embryos can either • match cell cycle duration to the time needed for the instability to unfold, or • limit microtubule nucleation. (5/9)

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Brugues Lab @brugueslab.bsky.social · 28/01/2026

This instability arises from a competition between autocatalytic microtubule nucleation and microtubule turnover. How do embryos achieve robust cytoplasmic partitioning despite this instability? (4/9)

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Brugues Lab @brugueslab.bsky.social · 28/01/2026

Cytoplasmic organization is orchestrated by microtubule structures that traverse the embryo, partitioning it into physically distinct and stable compartments. Despite robustness of embryonic development, we uncover an intrinsic instability in this process driven by the microtubule cytoskeleton (3/9)

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Brugues Lab @brugueslab.bsky.social · 28/01/2026

This poses an intriguing question: how is cytoplasm robustly and accurately organized in absence of physical barriers, and how is cytoplasmic partitioning achieved within the constrained time window of rapid embryonic divisions? (2/9)

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Brugues Lab @brugueslab.bsky.social · 28/01/2026

Establishing physical boundaries is a fundamental process in biology. During early embryonic development, the cytoplasm must be rapidly partitioned into individualised cells—often before or in absence of membrane ingression. This was beautifully recapitulated in frog extracts (Cheng et al,2019)(1/9)

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Brugues Lab @brugueslab.bsky.social · 28/01/2026

Really excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de

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Brugues Lab @brugueslab.bsky.social · 08/01/2026

Thanks for the nice words André!!

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