Sign in

Christian Brueffer

@brueffer.io
1.7K followers 1.3K following 23 posts

Consultant in #bioinformatics and #cancer applications @insilico.consulting (all things #genomics, #liquidbiopsy, and #workflows) • 🇸🇪 🇩🇪 • 🧬🖥️ • brueffer.io ORCiD: 0000-0002-3826-0989

PostsRepliesMedia
Reposted by Christian Brueffer
Cancer Research UK National Biomarker Centre @cruknbc.bsky.social · 21/09/2026
📢 We are recruiting a Principal Bioinformatician (NBC/26/34) to join Vsevolod Makeev's Bioinformatics & Biostatistics team! An exciting opportunity for a skilled, highly motivated Computational Biologist in rare cancer research. 👉 Find out more & apply: cruknbc.org/vacancy-prin...
cruknbc.org
Vacancy: Principal Bioinformatician, Bioinformatics and Biostatistics Team - National Biomarker Centre
We are looking for a skilled and motivated Computational Biologist to join the Bioinformatics and Biostatistics Team.
025
Reposted by Christian Brueffer
Lambros Frantzeskakis @lambrosf.bsky.social · 21/09/2026
If you’re a graduate student and interested in fungi please apply, this a great opportunity to experience research in an industry setting jobs.bayer.com/job/Chesterf...
jobs.bayer.com
Fungal Discovery & Genomics Co-Op
Fungal Discovery & Genomics Co-Op
01421
Reposted by Christian Brueffer
medRxivpreprint @medrxivpreprint.bsky.social · 24/08/2026
Population-scale integration of tumor transcriptomics into breast cancer care: a decade of the SCAN-B initiative www.medrxiv.org/content/10.64898/20…
011
Reposted by Christian Brueffer
Anna Santure @annasanture.bsky.social · 24/08/2026
University of Auckland is looking for: Lead Technologist – Genomics - Te Kura Mātauranga Koiora | School of Biological Sciences in Auckland, New Zealand. jobs.smartrecruiters.com/TheUniversit...
jobs.smartrecruiters.com
Lead Technologist – Genomics - Te Kura Mātauranga Koiora | School of Biological Sciences
Company Description:  Waipapa Taumata Rau | The University of AucklandKo te whare Pūtaiao | The Faculty of Science at the University of Auckland is the largest and most highly...
0914
Reposted by Christian Brueffer
Keith Robison @omicsomics.bsky.social · 19/08/2026
HiFi's Not Very Pacific Waters omicsomics.blogspot.com/2026/08/hifi...
omicsomics.blogspot.com
HiFi's Not Very Pacific Waters
PacBio had a major shakeup early this month. First came a large round of layoffs, which caught several individuals who were very much the fa...
196
Reposted by Christian Brueffer
Adam Phillippy @aphillippy.bsky.social · 06/08/2026
For the past 30 years, “whole-genome sequencing” has been a misnomer. Today the T2T Consortium publishes a dozen papers heralding a future of truly complete genomes for humans and nearly any vertebrate 👨‍🔬🐒🐦🐀🦒🐎🫏🐹🐟 (sorry, no salamanders): www.cell.com/consortium/t... 🧵[1/15]
3201106
Reposted by Christian Brueffer
Sergey Nurk @sergeynurk.bsky.social · 07/07/2026
Senior Bioinformatics Software Developer opening in my team in ONT's Applications department! Hybrid with a few days a week in our Oxford headquarters. We can sponsor visas! www.linkedin.com/jobs/view/44...
linkedin.com
Oxford Nanopore Technologies hiring Senior Bioinformatics Software Engineer, Applications in Oxfordshire, England, United Kingdom | LinkedIn
Posted 3:04:10 PM. Job DescriptionOur goal is to bring the widest benefits to society through enabling the analysis of…See this and similar jobs on LinkedIn.
12218
Reposted by Christian Brueffer
Tim Fennell @tfenne.bsky.social · 22/06/2026
Realized that I released a couple of new tools last week and didn't announce anything. The first one is *dupblaster*. Samblaster inspired streaming queryname grouped duplicate marking for NGS reads: github.com/fulcrumgenom...
github.com
GitHub - fulcrumgenomics/dupblaster: Blazingly fast, streaming duplicate detection for NGS data
Blazingly fast, streaming duplicate detection for NGS data - fulcrumgenomics/dupblaster
1153
Reposted by Christian Brueffer
Rob Patro @robp.bsky.social · 14/06/2026
salmon 2.0 (the rust re-write) is now live! It's also the version you get if you install via bioconda. This is a from-scratch rewrite in rust, and the base for future development. I'll post a more detailed thread tomorrow, but you can read the docs here combine-lab.github.io/salmon/
combine-lab.github.io
salmon
Fast, accurate transcript quantification from RNA-seq reads.
25316
Reposted by Christian Brueffer
Dr. Sebastian Beier @sebastianbeier.bsky.social · 01/06/2026
Our paper on Trimmomatic v0.40 is officially published in Bioinformatics! A decade after the original, the ~50,000-times-cited NGS trimmer gets a major overhaul. Here's what's new 🧵 doi.org/10.1093/bioi... #Bioinformatics #NGS
doi.org
Trimmomatic: A decade of feature-rich, high-performance NGS read preprocessing
AbstractMotivation. Trimmomatic is a widely adopted tool for preprocessing high-throughput sequencing data, particularly from Illumina platforms. Since its
185
Christian Brueffer @brueffer.io · 29/05/2026
Fantastic to see this work published, congratulations to all co-authors! It further validates the value of structural variants (SVs) as biomarkers for cancer liquid biopsy, as implemented in SAGA Diagnostics' Pathlight MRD test. #ctDNA #MRD #LiquidBiopsy #PrecisionMedicine #BrCa #BreastCancer
022
Reposted by Christian Brueffer
Genome in a Bottle Consortium @genomeinabottle.bsky.social · 06/05/2026
Excited to announce we’ve constructed a complete, haplotype-resolved assembly of a human pancreatic cancer genome. By comparing tumor cell line and normal tissue assemblies directly, we developed phased somatic benchmarks. Thanks to many in GIAB! www.biorxiv.org/content/10.6...
biorxiv.org
085
Reposted by Christian Brueffer
Fena Ochs @fenaochs.bsky.social · 02/01/2026
We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...
nature.com
Postdocs at Center for Gene Expression in Department of Cellular and Molecular Medicine - Copenhagen, Hovedstaden (DK) job with University of Copenhagen | 12849488
We are looking for 2 or more highly motivated postdocs interested in ribosome biology, 3D chromatin organisation, or regulation of protein turnove...
02225
Reposted by Christian Brueffer
Matt Holt @holtjma.bsky.social · 12/12/2025
There's an opening in our CompBio group at #PacBio. Apply below if you're interested in method / tool development for long-read sequencing applications! #Bioinformatics pacbio.wd12.myworkdayjobs.com/PacBio-/job/...
0136
Reposted by Christian Brueffer
Gosia Trynka @gosiatrynka.bsky.social · 04/12/2025
Hiring Senior Computational Postdoc to lead large-scale scRNAseq analysis for Project JAGUAR, one of the world’s most comprehensive single-cell immune resources from Latin American ancestries. If big data, global partnerships, human diversity and immune regulation excite you, apply! bit.ly/3XyFWrW
sanger.wd103.myworkdayjobs.com
Senior Postdoctoral Fellow
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
078
Reposted by Christian Brueffer
Aaron Quinlan (he/him) @aaronquinlan.bsky.social · 02/12/2025
We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen. 1/n
quinlanlab.org
Intro to Bedder – The Quinlan Lab
5298151
Reposted by Christian Brueffer
Trevor Graham @trevorgraham.bsky.social · 13/11/2025
Calling cancer data scientists! 📊 💽 🧮 We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...
jobs.icr.ac.uk
Data Scientist in Sutton | The Institute of Cancer Research
View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 to £53,500 (Dependent on experience ) Reporting to: Professor Trevor Gra...
01313
Reposted by Christian Brueffer
Lars Gamfeldt @gamfeldt.bsky.social · 10/11/2025
Opportunity! Anybody knows of young marine ecologists (within 7 years from earned PhD) that would like to come to Gothenburg, Sweden, for a nationally funded Assistant Professorship? It is highly competitive but well funded. (1) of (3)
22546
Reposted by Christian Brueffer
conda @conda.org · 04/11/2025
Conda in the Packaging Spectrum: From pip to Docker to Nix If conda is a distribution, where does it fit alongside pip, Docker, and Nix? Part 2 of the 3-part series! 🚀 #conda #packaging #python conda.org/blog/conda-p...
conda.org
Conda in the Packaging Spectrum: From pip to Docker to Nix | conda.org
Part 2 of the 'Conda Is Not PyPI' series, placing conda among pip, Docker, and Nix and explaining its middle-path design.
0127
Reposted by Christian Brueffer
Karl Schmid @kjschmid.bsky.social · 07/10/2025
The Cluster of Excellence @greenrobust.de is hiring: - Computer Scientist/Research data manager: shorturl.at/xSvvO - Data steward: shorturl.at/l6NCv - Scientific coordinator 'Plant Perturbation Atlas': shorturl.at/vBU6x Deadline: Friday, 7 November 2025 RT are welcome #plantjobs #plantscijobs
uni-hohenheim.de
Stellenangebote: Universität Hohenheim
Aktuelle Stellenangebote der Universität Hohenheim.
01825
Reposted by Christian Brueffer
James Bonfield @jbonfield.bsky.social · 15/09/2025
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change. Ie: it's not us (Samtools team)! Be warned
2145126
Reposted by Christian Brueffer
Tuuli Lappalainen @tuuliel.bsky.social · 19/08/2025
A postdoc position in genomics available at our infrastructure in Uppsala, Sweden! An interesting R&D role a bit outside the traditional academic environment, great colleagues, work at the forefront of (long-read) sequencing. www.uu.se/en/about-uu/...
uu.se
Postdoctoral position - Uppsala University
Postdoctoral position, Department of Immunology, Genetics and Pathology, Uppsala University
03738
Christian Brueffer @brueffer.io · 20/08/2025
Done!
010
Reposted by Christian Brueffer
Mike Inouye @mikeinouye.bsky.social · 25/07/2025
📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791... You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
11918
Reposted by Christian Brueffer
Peter Andersen @germline.bsky.social · 16/05/2025
📣 🥳 🧑‍💻 Our department is hiring: Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark Deadline June 1st Thanks for sharing! mbg.au.dk/en/news-and-...
mbg.au.dk
Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - BiRC - Bioinformatics Research Center, Aarhus University
07089
Reposted by Christian Brueffer
Heng Li @lh3lh3.bsky.social · 18/04/2025
Minimap2-2.29 released with the support of short RNA-seq read alignment. More explanation and results here: lh3.github.io/2025/04/18/s...
lh3.github.io
Short RNA-seq read alignment with minimap2
0307
Reposted by Christian Brueffer
acenglish.bsky.social @acenglish.bsky.social · 10/01/2025
🚀 Truvari v5.0 is here! 🎉 What’s new? 🔹 Enhanced symbolic variant support for <DEL>, <DUP>, <INV> 🔹 Robust BND comparison for cross-representation SV matching 🔹 Improved SV sequence similarity & HUGE SV support 🔹 Cleaner UI & Revamped API 👉 More: github.com/ACEnglish/tr... #Genomics #Bioinformatics
github.com
GitHub - ACEnglish/truvari: Structural variant toolkit for VCFs
Structural variant toolkit for VCFs. Contribute to ACEnglish/truvari development by creating an account on GitHub.
065
Reposted by Christian Brueffer
Matteo Bocci @matteobocci.bsky.social · 13/03/2025
#ICYMI our deep dive into ALK1 biology, at the intersection between angiogenesis and immunology with clear implication for the targeting of immunomodulatory cues & cancer therapy!
012
Reposted by Christian Brueffer
Sarah Moser @sarahmoser.bsky.social · 03/03/2025
BRCA1 turned 30 🎉 To celebrate, Jos Jonkers and I explored three decades of BRCA1 research - what we’ve learned about its biology, its role in tumorigenesis and future directions to improve the life of BRCA1 mutation carriers. Now out in Cancer Discovery ⬇️: aacrjournals.org/cancerdiscov...
aacrjournals.org
Thirty Years of BRCA1: Mechanistic Insights and Their Impact on Mutation Carriers
Abstract. Thirty years ago, the cloning of the first breast cancer susceptibility gene, BRCA1, marked a milestone in our understanding of hereditary breast and ovarian cancers. This discovery initiate...
16226
Reposted by Christian Brueffer
Genome in a Bottle Consortium @genomeinabottle.bsky.social · 20/12/2024
Our first curated draft somatic structural variant benchmark for the new GIAB PDAC tumor cell line HG008-T is at ftp-trace.ncbi.nlm.nih.gov/ReferenceSam..., based on extensive short+long read sequencing data described in doi.org/10.1101/2024.... Feedback to improve future versions is very welcome!
ftp-trace.ncbi.nlm.nih.gov
Index of /ReferenceSamples/giab/data_somatic/HG008/Liss_lab/analysis/NIST_HG008-T_somatic-stvar_DraftBenchmark_V0.1-20241219
0158
Reposted by Christian Brueffer
Paolo Tarantino, MD @ptarantinomd.bsky.social · 25/11/2024
Regular abstracts from #SABCS24 are out! 3407 pages of new breast cancer discoveries. Find them here: sabcs.org/Portals/0/Do...
sabcs.org
06215
Christian Brueffer @brueffer.io · 24/11/2024
Added!
120
Reposted by Christian Brueffer
Stacey Tinianov, MPH @coffeemommy.bsky.social · 21/11/2024
WOOT! Just in time for #SABCS24 looks like @sabcs.bsky.social is officially on BlueSky! cc: @maryamlustberg.bsky.social @drsgraff.bsky.social @stage4kelly.bsky.social @amjohnston.bsky.social @amybeumer.bsky.social @raalbany.bsky.social @hoperugo.bsky.social
media.tenor.com
two women are standing next to each other and one of them is saying i 'm so glad that you are here
ALT: two women are standing next to each other and one of them is saying i 'm so glad that you are here
7185
Christian Brueffer @brueffer.io · 20/11/2024
Added!
010
Christian Brueffer @brueffer.io · 20/11/2024
Done!
120
Christian Brueffer @brueffer.io · 19/11/2024
Done! Sorry for the delay, notifications have been mad the last couple of days, so this one slipped through.
010
Christian Brueffer @brueffer.io · 19/11/2024
Done and welcome!
010
Christian Brueffer @brueffer.io · 17/11/2024
I dont care for either but my sambo has needs ;-)
110
Christian Brueffer @brueffer.io · 17/11/2024
Vegemite too by any chance?
110
Christian Brueffer @brueffer.io · 16/11/2024
Happy to join the bioinformatics + genomics starter. Thanks for the work!
000
Christian Brueffer @brueffer.io · 16/11/2024
Done!
000
Reposted by Christian Brueffer
The OncoAlert Network 🚨 @oncoalert.bsky.social · 16/11/2024
Dear Colleagues, For all of you in BlueSky, Greetings, We are Now Here!! We invite you to Join & Follow OncoAlert at @oncoalert.bsky.social Thank you for your support!
1157
Christian Brueffer @brueffer.io · 16/11/2024
For the #cancer / #oncology folks, OncoAlert is now on bsky: @oncoalert.bsky.social
040
Reposted by Christian Brueffer
Santiago Carmona 🧬 🖥️ 🧑🏾‍🔬 @carmonation.bsky.social · 15/11/2024
in case this is useful to someone in this massive platform migration: a starting pack for single-cell omics computational methods go.bsky.app/GmS1cH
go.bsky.app
single-cell computational methods
Join the conversation
159847
Reposted by Christian Brueffer
Johanna Joyce @johannajoyce.bsky.social · 14/11/2024
Inspired by the other amazing starter packs - here's one for cancer researchers! I tried to make this broad - from immunology to genomics to cell biology and so much more.. This list also includes organizations & institutes supporting cancer researchers 🧪🔬⚕️🩺 Hope its useful! go.bsky.app/FEoaJMc
99361127
Christian Brueffer @brueffer.io · 15/11/2024
Thanks Johanna, could you add me as well? @laosaal.bsky.social would be another good addition.
120
Christian Brueffer @brueffer.io · 15/11/2024
I've created a Breast Cancer Starter Pack covering clinical oncology and research. Please share, and let me know in case you'd like to be added. #brca #breastcancer go.bsky.app/6KXpPSy
9137
Reposted by Christian Brueffer
Keith Robison @omicsomics.bsky.social · 13/04/2024
We are actively recruiting for two open Computational Biology positions in our NGS group - both covered by this listing www.ginkgobioworks.com/job-listings...
067
Christian Brueffer @brueffer.io · 20/02/2024
Happy to have contributed a small part to this study. "Ultrahigh" #HER2 copy number by #dPCR or #RNAseq signals poor response to adjuvant #trastuzumab in breast cancer.
061
Reposted by Christian Brueffer
Bérénice Batut @bebatut.bsky.social · 19/02/2024
Online Hackathon to improve the annotation of @galaxyproject.bsky.social resources for microbial data analysis (and beyond): galaxyproject.org/events/2024-... 📆 Date: March 11th - 15th 📍 Location: Online via Zoom & chat. 2 daily stand-ups 👥 Participation: Free. Open to anyone, anywhere
galaxyproject.org
Hackathon - Improving the annotation of Galaxy resources for microbial
This hackathon aims to improve the annotation of Galaxy resources for microbial data analysis and beyond
055