Feasibility benchmark: can single-cell RNA-seq preprocessing (rapids-singlecell style) be GPU-accelerated on Apple Silicon/Metal? Measured on an M5 Pro. Spoiler: the Apple-GPU linalg gap blocks it....

The performance of single-cell foundation models is dependent on many factors. This study assesses the effect of the pretraining dataset’s size and diversity, revealing potential challenges in pursuin...

Nature Communications - Primary sclerosing cholangitis (PSC) is an autoimmune condition affecting the liver. Here, the authors generate an immunobiliary transcriptomic atlas and show that dendritic...

CellVoyager is an artificial intelligence agent capable of exploring new biological hypotheses by autonomously analyzing single-cell RNA sequencing datasets and accounting for background information a...

Discovering new therapies for complex age-related disease.

The direct contribution of aberrant epithelial cells to lung fibrosis is largely unknown. The authors use murine and human systems to identify how these cells activate fibroblasts, and how reciprocal signals cause them to enter a profibrotic state.