STING signaling in the innate immune system is well known for its role in the antiviral type I interferon response. Tang et al. find that STING acts as an immune sensor of lysosomal activity. When the...

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SARS-CoV-2 breakthrough infections in previously vaccinated individuals are characterized by reduced activation of innate immune responses.

Background The immature lungs of very preterm infants are exposed to supraphysiologic oxygen, contributing to bronchopulmonary dysplasia (BPD), a chronic lung disease that is the most common morbidity...

This study provides one of the most comprehensive immune profiles of elderly individuals, uncovering high-resolution immune changes associated with aging. Our findings highlight clinically relevant im...

Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

RSV vaccination was effective in preventing RSV-related illness, including associated health-care use, in adults aged 60 years and older during the 2023–24 respiratory illness season, supporting curre...

The microbiome of Antarctic worms helps them cope with extremely cold conditions, providing insights into the role of the microbiome in host health and adaptation.

Robles-Vera et al. unveil the capacity of gut microbiota translocation, particularly Enterococcus faecalis, to mediate a Mincle-dependent induction of trained immunity in myeloid bone marrow progenito...

RELMβ mediates a gut immune–epithelial circuit regulating tolerance to food antigens, offering targetable candidates for the prevention and treatment of food allergies.

The gut protist Tritrichomonas musculis induces migration of innate lymphoid cells and eosinophils to shape immune responses in the lungs of mice and humans.

The genus Streptomyces are valuable producers of antibiotics and other pharmaceutically important bioactive compounds. Advances in molecular engineering tools, such as CRISPR, has provided some access...

Layering an organic material on top of 2D materials achieves stable, fast phosphorescent light emission without using expensive and hazardous heavy metals.

Researchers at The Jackson Laboratory and Trudeau Institute have identified the first mouse strain that is susceptible to severe COVID-19 without the need for genetic modification. This development, r...

In 2024, several human infections with highly pathogenic clade 2.3.4.4b bovine influenza H5N1 viruses in the United States raised concerns about their capability for bovine-to-human or even human-to-h...

NTMir is the only NTM patient advocacy organization leading the fight against NTM lung disease and Bronchiectasis by building a community, researching, improving treatments, advocating for increased r...

Lower airway enrichment with oral commensals has been previously associated with severe primary graft dysfunction (PGD) after lung transplantation (LT…

The American Thoracic Society is the world's leading medical society dedicated to accelerating the advancement of global respiratory health through…

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