iiinova — where your digital self keeps evolving

bedzhov lab @bedzhovlab.bsky.social · 08/09/2026

2x Group leader/Professor positions at Uni Salzburg in: Developmental biology: www.plus.ac.at/personalwese... Endocrinology: www.plus.ac.at/personalwese...

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The Company of Biologists @biologists.bsky.social · 04/09/2026

Funded places are available for early-career researchers at our Workshop on Bridging Scales and Disciplines to Understand Robust Development, 18-21 April 2027, organised by Mauricio Rocha Martins and Giulia Paci @giuliapaci.bsky.social Find out more and apply at www.biologists.com/workshops/ap...

Workshop - Bridging Scales and Disciplines to Understand Robust Development, early-career researchers apply for funded places

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bedzhov lab @bedzhovlab.bsky.social · 27/08/2026

Group leader position at SFB 1748 'Reproduction.MS' position: www.medizin.uni-muenster.de/reproduction... SFB 1748: www.medizin.uni-muenster.de/reproduction...

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Mauricio Rocha @rocha-lab.bsky.social · 25/07/2026

Very happy that our workshop on developmental robustness is happening! Thank you to @biologists.bsky.social for making it possible and to all the speakers for accepting the invitation. Join us! Applications for funded positions are now open.

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bedzhov lab @bedzhovlab.bsky.social · 30/06/2026

“Decoding and Modelling the Programming of Life” Looking forward to an inspiring seminar with Véronique Azuara (Imperial College London) on July 2nd at 13:15, MiC. 🌟

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bedzhov lab @bedzhovlab.bsky.social · 15/06/2026

“Play, Pause, Rewind: protein metabolism and the control of developmental tempo” Looking forward to an exciting seminar with Teresa Rayon @trayon.bsky.social (Babraham Institute, Cambridge) on June 18th at 13:15, MiC. Everyone is welcome.

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bedzhov lab @bedzhovlab.bsky.social · 12/06/2026

Congrats to Shashank for successfully defending his PhD thesis! 👨‍🎓

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SFB 1348 @sfb1348.bsky.social · 14/01/2026

Cellular Interfaces reloaded: Join us for the @sfb1348.bsky.social International Meeting on „Mechanochemical signals at cellular interfaces" in Münster from May 27–29, 2026. Registration opens in February! Limited spots – first come, first serve! More info: tinyurl.com/ypyzd23w @uni-muenster.de

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bedzhov lab @bedzhovlab.bsky.social · 12/01/2026

Developmental regulation of Erk signaling by mitotic kinases doi.org/10.1126/scia...

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bedzhov lab @bedzhovlab.bsky.social · 12/01/2026

We found that in addition to Fgf/Mek, Erk is activated by Aurora kinase A to promote differentiation. During cell division, Erk localizes at the centrosomes, where its activation depends on Plk1. Congrats to Fei & the team! doi.org/10.1126/scia... 🐁 @sfb1348.bsky.social @mpi-muenster.bsky.social

doi.org

Developmental regulation of Erk signaling by mitotic kinases

The mitotic kinases aurora A and polo-like kinase 1 act as cell-intrinsic regulators of Erk signaling in pluripotent stem cells.

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bedzhov lab @bedzhovlab.bsky.social · 04/12/2025

This is our Tron-inspired candidate cover design for Dev Cell, illustrating the temporal sequence of epithelial morphogenesis during preimplantation development. Although the image was not selected for the cover, we enjoyed developing the concept. t.co/XQ43VeLSR0

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bedzhov lab @bedzhovlab.bsky.social · 02/12/2025

We found a new function of the core pluripotency transcription factors Oct4 and Sox2 in the early embryo! Check out our paper: doi.org/10.1016/j.de... Congratulations to Deepthi and the rest of the team! 🐁

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bedzhov lab @bedzhovlab.bsky.social · 27/11/2025

Thank you, Allison! ☺️♥️ This is very kind of you.

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Development @dev-journal.bsky.social · 26/11/2025

Pause and play: insights into mammalian embryonic diapause In this Spotlight, Rui Cehn and Ivan Bedzhov (@bedzhovlab.bsky.social) from @mpi-muenster.bsky.social discuss the emerging mechanisms that govern mammalian embryonic diapause. doi.org/10.1242/dev....

 Figure 2: Selected signalling, metabolic and morphogenetic responses in the diapausing mouse embryo. Nutrient deprivation, suppression of the mammalian target of rapamycin complex 1 (mTORC1) or Myc activity can trigger dormancy response in mouse embryos. Diapausing embryos activate the leukemia inhibitory factor/signal transducer and activator of transcription 3/transcription factor CP2-like protein 1 (LifR/STAT3/Tfcp2l1) pathway and increase their dependency on fatty acid oxidation. During the first 3 days of diapause between E4.5 and estimated day of gestation (EDG) 7.5, the number of cells gradually increases and canonical Wnt signalling is temporarily activated. After EDG7.5, Wnt activity is downregulated, the epiblast undergoes epithelialisation and Yap translocates to the nucleus, governing the survival and reactivation capacity of the pluripotent lineage. The three background colours indicate dormant (grey), quiet (light yellow) and active (dark yellow) metabolic states.

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bedzhov lab @bedzhovlab.bsky.social · 25/11/2025

Check out our Spotlight article, which outlines the metabolic states during early development, focusing on embryonic diapause. 🐁 doi.org/10.1242/dev....

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bedzhov lab @bedzhovlab.bsky.social · 11/11/2025

Congratulations to Deepthi for successfully defending her PhD thesis! 🎉

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bedzhov lab @bedzhovlab.bsky.social · 05/11/2025

“Implantation is the most difficult and unpredictable stage,” wrote IVF pioneer Sir Robert Edwards. In this review, we explore the cell shape and tissue dynamics in the early mouse embryo, focusing on the peri-implantation stages of development and embryonic dormancy.🐁 doi.org/10.1016/bs.c...

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bedzhov lab @bedzhovlab.bsky.social · 04/11/2025

Our lab turns 10! 🎂🎉 Huge thanks to everyone who’s been part of our journey! ♥️

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SFB 1348 @sfb1348.bsky.social · 28/08/2025

Looking forward to an exciting seminar with Leo Kurian @kurianlab.bsky.social @goetheuni.bsky.social on Sept 11. He will speak about #RNA regulatory principles of engineering fate in living systems More info: www.uni-muenster.de/SFB1348/en Everyone's welcome! @sfb1348.bsky.social @uni-muenster.de

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bedzhov lab @bedzhovlab.bsky.social · 20/06/2025

Cellular dynamics in the dormant embryo (highlights of Rui Chen's work on embryo dormancy) www.biospektrum.de/system/files...

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HetCCI (SPP 2493) @hetcci.bsky.social · 11/06/2025

Proud to kick-off #HetCCI, a DFG-funded research consortium in Germany (Priority Programme #SPP2493 on heterotypic cell-cell interactions in epithelia). Follow us if interested in how epithelial cells interact with non-epithelial tissues in different settings! Webpage will follow asap. #cellbiology

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German Stem Cell Network GSCN @gscnoffice.bsky.social · 02/06/2025

GSCN Stem Cell Club is on 5 July with I. Bedzhov and M. Kraushar at 16:15 - join the lectures & discussion at 16:15. Find link & info: gscn.org #stemcells #regeneration #developmentalbiology #stammzellen @mdc-berlin.bsky.social sky.social @dkfz.bsky.social @maxplanck.de @bihatcharite.bsky.social

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bedzhov lab @bedzhovlab.bsky.social · 28/05/2025

Protocol for 3D In Vitro Culture of Early Mouse Embryos and Trophoblast Tissue Explants link.springer.com/protocol/10.... Congratulations to Devila, Shashank and Nirai, and thanks to Adrian for his instrumental support @adrianranga.bsky.social @mpi-muenster.bsky.social @sfb1348.bsky.social

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bedzhov lab @bedzhovlab.bsky.social · 21/05/2025

the MPI band Heizzentrale, live, Friday 23rd 🤘🤘 @MPI Münster

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bedzhov lab @bedzhovlab.bsky.social · 06/05/2025

Step-by-step protocol for induction, maintenance, and exit from embryo dormancy in mice doi.org/10.1016/j.xp... Congrats to Rui Chen and Rui Fan!

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bedzhov lab @bedzhovlab.bsky.social · 31/03/2025

Ufuk Günesdogan (University of Göttingen) will speak about “Transcriptional and Epigenetic Programming of Human Primordial Germ Cells”. The seminar will take place in the MIC lecture hall (Röntgenstr. 16, Münster), on Thursday, 3rd of April at 5:15. @guenesdoganlab.bsky.social @sfb1348.bsky.social

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bedzhov lab @bedzhovlab.bsky.social · 27/03/2025

Congratulations, Stefan to you and your team! Fantastic work, beautifully illustrated!

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bedzhov lab @bedzhovlab.bsky.social · 17/03/2025

Congrats to Fei Chen for successfully defending her PhD thesis! 👩‍🎓

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Peter Fabian @fabianlab.bsky.social · 27/01/2025

There's an 🤩 impressive lineup of speakers for this event: 🇸🇪🇦🇹 @adameykolab.bsky.social 🇩🇪 @bedzhovlab.bsky.social 🇺🇸 @crumplab.bsky.social 🇩🇪 @anne-grapin.bsky.social 🇫🇷 @pasteur.fr 🇨🇭 @lanevol.bsky.social 🇪🇸 @jamesasharpe.bsky.social ❤️ home country discussing #science! JOIN US ✨!

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SFB 1348 @sfb1348.bsky.social · 17/01/2025

We have an exciting line-up of speakers for our @sfb1348.bsky.social meeting "Cellular Interfaces across Scales: from Molecules to Tissue Dynamics" from May 7 - 9, 2025. Registration will start on February 1, 2025. More information: crc1348-conference.ycode.site

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bedzhov lab @bedzhovlab.bsky.social · 15/01/2025

exhibition inVISIBLE at the foyer of the Multiscale Imaging Centre, Münster uni.ms/inVISIBLE

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SFB 1348 @sfb1348.bsky.social · 13/01/2025

Cantas Alev (Kyoto University) will give an exciting @sfb1348.bsky.social lecture about “Towards reconstituting human and primate early embryonic development in vitro” today at 5:15 pm. Everyone is welcome! More: www.uni-muenster.de/SFB1348/en/i...

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bedzhov lab @bedzhovlab.bsky.social · 20/12/2024

Wishing you a wonderful holiday season! ❄️

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bedzhov lab @bedzhovlab.bsky.social · 30/09/2024

Congrats to Rui Chen for successfully defending her PhD thesis! 👩‍🎓

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bedzhov lab @bedzhovlab.bsky.social · 07/09/2024

Cell Stem Cell cover image of our recent paper on embryo dormancy. Congrats to Rui Chen & the team! www.cell.com/cell-stem-ce...

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bedzhov lab @bedzhovlab.bsky.social · 25/07/2024

Just as sci-fi heroes enter stasis for space travel, embryos can pause their development in a state of dormancy. We present the single-cell atlas of embryo dormancy revealing its dynamics & the role of the microenvironment. Congrats to Rui Chen & the team! doi.org/10.1016/j.st...

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