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Carsten Sachse

@sachsegroup.bsky.social
532 followers 258 following 5 posts

The Sachse group @fz_juelich: #cryoEM #cryoET #CLEM #FIBSEM #autophagy.

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Carsten Sachse @sachsegroup.bsky.social · 23/12/2025
We are looking for a team leader to join the cryo-EM facility work at the new Ernst Ruska-Centre 2.0 at the Forschungszentrum Jülich. We have a series of microscopes used by (@irene-vercellino.bsky.social, Schröder, @sachsegroup.bsky.social) and external users. www.fz-juelich.de/de/karriere/...
fz-juelich.de
Team Leader – Life Science Cryo-Electron Microscopy (Cryo-EM) Facility
Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons (ER-C) at Forschungszentrum Jülich houses some of the world`s most advanced electron microscopes and tools for nanocharacterisation. U...
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Carsten Sachse @sachsegroup.bsky.social · 04/12/2025
Really happy to see the work (doi.org/10.1038/s414...) published. Here, we show the full-length helical cryo-EM structure of p62/SQSTM1 and first cryo-ET visual of p62 positive structures inside the cell.
doi.org
Structural organization of p62 filaments and the cellular ultrastructure of calcium-rich p62-enwrapped lipid droplet cargo - Nature Communications
The selective autophagy receptor p62/SQSTM1 is organized in a structured double helical filament in vitro, the cryo-electron tomographic images in ATG5 knockdown conditions reveal Ca-rich layers of p6...
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Reposted by Carsten Sachse
Irene Vercellino @irene-vercellino.bsky.social · 09/11/2025
Grateful to have received the Wilhelm und Else Heraeus-Stiftung Research Fellowship, to support my group’s work at the Ernst Ruska-Centre (ER-C) of Forschungszentrum Jülich #cryoem
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Reposted by Carsten Sachse
Tanmay Bharat @tbharat-lab.bsky.social · 23/04/2025
Finally in peer-reviewed form: Mapping the ultrastructural topology of the corynebacterial cell surface. @bupbuse.bsky.social @vikramalva.bsky.social Please also see concurrent beautiful work from @adriasogues.bsky.social and Han Remaut.
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Reposted by Carsten Sachse
Josh Dickerson @joshdcryoem.bsky.social · 23/04/2025
After years parked at a Polara, I’m excited to share that my PhD work is finally out! We figured out why imaging at liquid helium temperatures wasn’t working—and how to fix it. 🔗 www.pnas.org/doi/10.1073/...
pnas.org
Reducing the effects of radiation damage in cryo-EM using liquid helium temperatures | PNAS
The physical limit in determining the atomic structure of biological molecules is radiation damage. In electron cryomicroscopy, there have been num...
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Carsten Sachse @sachsegroup.bsky.social · 10/02/2025
Philipp's manuscript on our CryoVIA toolkit www.sciencedirect.com/science/arti... is out! For those interested in studying protein lipid interactions and high-throughput analysis of membrane structures (sizes, shapes, curvature etc.) - this could be your tool (github.com/philipp-scho...).
sciencedirect.com
CryoVIA: An image analysis toolkit for the quantification of membrane structures from cryo-EM micrographs
Imaging of lipid structures and associated protein complexes using cryoelectron microscopy (cryo-EM) is a common visualization and structure determina…
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Carsten Sachse @sachsegroup.bsky.social · 14/01/2025
Our first post on blue: grad student Philipp's software: for those interested in looking at membrane reconstitution by cryo-EM. Automated analysis of lipid fine structure and membrane shape classifications: biorxiv.org/cgi/content/...
biorxiv.org
CryoVIA - An image analysis toolkit for the quantification of membrane structures from cryo-EM micrographs
Imaging of lipid structures and associated protein complexes using electron cryo-microscopy (cryo-EM) is a common visualization and structure determination technique. The quantitative analysis of the ...
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Reposted by Carsten Sachse
Irene Vercellino @irene-vercellino.bsky.social · 18/12/2024
Excited to share that I have been elected as member of the "Junge Kolleg" of the Nordrhein-Westfalian Academy of Sciences and Arts. I am honoured to have this opportunity to serve the community! Here's the link to the announcement, unfortunately only in German www.awk.nrw/news/nachwuc...
awk.nrw
Nachwuchsförderung: Nordrhein-Westfälische Akademie nimmt neun neue Stipendiatinnen und Stipendiaten in ihr Junges Kolleg auf
Zum 1. Januar 2025 begrüßt die Nordrhein-Westfälische Akademie der Wissenschaften und der Künste neun weitere herausragende Talente in ihrem Jungen Kolleg. Sie haben die Jury in einem mehrstufigen Aus...
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