iiinova — where your digital self keeps evolving

Reposted by Alexander Minges

Malte Gersch @maltegersch.bsky.social · 05/05/2025

Super happy to share that our work on the specific inhibition of USP30 - a clinical stage Parkinson's drug target - is now online at NSMB www.nature.com/articles/s41... Have a read if you fancy chimeric protein engineering or a framework for DUB ligandability. Huge congratulations to Nafizul & team!

nature.com

Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30 - Nature Structural & Molecular Biology

Kazi et al. report the crystal structure of the mitochondrial deubiquitinase USP, a clinical stage Parkinson’s disease drug target, in complex with a specific inhibitor. The authors delineate a framew...

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Alexander Minges @athemis.bsky.athemis.de · 18/03/2025

Grateful for the fantastic #Dataverse upload event of the @crc1430.bsky.social. Many inspiring discussions and a huge pile of datasets for me to work through the next days. Thanks to all participants!

Seminar room with group tables and wall screen reading "Dataverse".

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Reposted by Alexander Minges

CRC 1430 @crc1430.bsky.social · 10/03/2025

🚀 We’re proud to celebrate Gina Simon, a @crc1430.bsky.social PhD researcher in @hellerschmiedlab.bsky.social at @unidue-zmb.bsky.social, who received the Data Champion Award! Gina shares how eLabFTW streamlines research and boosts efficiency. #DataChampion #eLabFTW www.uni-due.de/rds/en/datac...

uni-due.de

Data Champion: Gina Simon

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Science Magazine @science.org · 25/02/2025

Tomatoes lose their bitterness and toxicity as they ripen thanks to DNA demethylation, the hormone ethylene, and key transcription factors, finds a new #ScienceAdvances study. scim.ag/4bfdr8u

scim.ag

Removal of toxic steroidal glycoalkaloids and bitterness in tomato is controlled by a complex epigenetic and genetic network

A complex regulatory network controls the removal of toxic steroidal glycoalkaloids during tomato ripening.

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Reposted by Alexander Minges

Structural Biology @actacrystd.iucr.org · 24/02/2025

Many crystal structure analyses that previously required experimental phase evaluation can now be solved by AlphaFold-guided MR. In effect, this and related MR approaches are de novo phasing methods. #MolecularReplacement #MachineLearning doi.org/10.1107/S205...

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Reposted by Alexander Minges

Protein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · 17/02/2025

Interested in developing a dataset for a Large Language Models (LLMs) project? Register for March 5: www.ebi.ac.uk/training/eve... Webinar by Melanie Vollmar (ARISE Fellow working with @pdbeurope.bsky.social team) From @training.ebi.embl.org's series on: LLM & Bioinformatics

ebi.ac.uk

Developing a dataset for LLM projects -

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Robert Koch-Institut @rki.de · 12/02/2025

🚀 Die Gesundheitsberichterstattung #GBE am #RKI stellt regelmäßig Daten zu nichtübertragbaren Krankheiten und ihren Einflussfaktoren auf #GitHub und #Zenodo bereit: maschinenlesbar, offen, frei verwendbar. 🔗 www.gbe.rki.de/DE/Startseit... #OpenData #Gesundheit #Transparenz #PublicHealth

Transparenz durch Open Data
RKI stellt Daten zur freien Nachnutzung bereit

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Reposted by Alexander Minges

Lander Lab @landerlab.bsky.social · 22/01/2025

Just because it's a homo-oligomer, don't assume it's symmetric! @benjabsnt.bsky.social & collaborators used cryo-EM to study the transthyretin (TTR) tetramer (55 kDa), shedding light on its misfolding pathways linked to amyloid disease. Now in peer-reviewed form: www.nature.com/articles/s41...

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Reposted by Alexander Minges

Beck Laboratory @becklab.bsky.social · 17/01/2025

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:

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Protein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · 17/01/2025

PDB-IHM (formerly PDB-Dev) is for integrative structures. Intergrative structures = from multiple experimental & computational methods. Since mid-2024 assigned PDB ids & DOIs. Access via wwPDB archive or PDB-IHM - pdb-ihm.org 👉 www.wwpdb.org/news/news?year=2025#6…

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Reposted by Alexander Minges

David De Sancho @daviddesancho.bsky.social · 16/01/2025

This is just out and already looks like textbook material #MustRead

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