An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.

The ability to quickly and affordably survey a patient’s entire genome is expected to accelerate research, diagnostics, and precision medicine.

A $2.9 million R01 research award from the National Institutes of Health will support the efforts of engineers at the UC Santa Cruz Genomics Institute to further develop and drive down the cost of com...

Nature Reviews Molecular Cell Biology - Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling...

The ability to quickly and affordably survey a patient's entire genome is expected to accelerate research, diagnostics, and precision medicine

Existing notions of pangenome coordinates rely on hard-to-compute multiple sequence alignments. On the other hand, pangenome-wide exact unique matches (multi-MUMs) can be computed efficiently, and represent conserved stretches of columns in the underlying MSA. We introduce Shredtools, which uses mul …

Single-molecule long-read sequencing of human sperm reveals variation in recombination across donors and that a substantial fraction of non-crossover gene conversions arises before meio...

Letter to the Editor

Newly developed methods enable construction of Icelandic haplotypes and mapping of population-scale short reads to a pangenome by reducing reference bias and improving discovery in low-mappability reg...

Abuelanin et al. combine PacBio HiFi with low-coverage CiFi proximity-ligation reads in a single library and sequencing run to generate contiguous, near-telomere-to-telomere, accurately phased diploid...

Background Plasmodium falciparum field isolates exhibit genomic variation, including copy number variation and sequence divergence. In contrast, the P. falciparum 3D7 reference genome (Pf3D7) was deri...

HPRC Data Release 2

Two decades after the Human Genome Project, we finally have the ability to read the complete genome of any human and (nearly) any species. These sequences provide the ideal foundation for training pre...

Bird genomes are the smallest among amniotes; however, they remain challenging to assemble due to their structural complexity. This study presents a f…

A milestone collection featuring near-perfect assembly of diploid human reference genomes, new T2T genomes across the vertebrate tree, and more.

Two decades after the Human Genome Project, we finally have the ability to read the complete genome of any human and (nearly) any species. These sequences provide the ideal foundation for training pre...

A pangenome reference overcomes the inherent limitation of any individual reference genome by integrating the variation present in a population. We present the Human Pangenome Reference Consortium’s (...