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Antonis Antoniou

@antonis02.bsky.social
432 followers 313 following 18 posts

Professor of Cancer Risk Prediction Director, Cancer Data-Driven Detection University of Cambridge Genetic epidemiology, Data Science, Cancer prevention and early detection

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Antonis Antoniou @antonis02.bsky.social · 24/10/2025
New study from group, extends the BOADICEA/CanRisk breast cancer risk model to include continuous mammographic density (MD) from automated tools like Volpara & STRATUS Available via CanRisk (www.canrisk.org) 📄 Ficorella et al, JCO Precision Oncology: doi.org/10.1200/PO-2...
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Oscar M Rueda @ruedalab.bsky.social · 13/08/2025
Are you looking for a statistics/ML postdoc? Come to work with @antonis02.bsky.social and me in the NEMO study, an international collaboration aiming to detect ovarian cancer earlier through cutting-edge multi-omics, funded by the Alliance for Cancer Early Detection. www.cam.ac.uk/jobs/researc...
cam.ac.uk
Research Associate*/Research Assistant in Multi-omics Early Detection of Ovarian Cancer (Fixed Term)
An exciting opportunity has arisen for a highly motivated Research Associate to join the Centre for Cancer Genetic Epidemiology (CCGE) at the Department of Public Health & Primary Care, University of
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Kyriaki Michailidou @kmichailidou.bsky.social · 26/05/2025
1/🧬 Excited to share our latest paper in Nature Communications @natcomms.nature.com. We analyzed germline sequencing data from 400,000+ women to strengthen how we classify BRCA1 & BRCA2 variants. 🔗 www.nature.com/articles/s41... 🧵
nature.com
Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification - Nature Communications
BRCA1 and BRCA2 are well known breast cancer predisposition genes, however, many variants have not yet been classified for their pathogenicity. Here, the authors analyse a large combined cohort to pro...
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The Lancet Obstetrics, Gynaecology, & Women’s Health @lancetobgyn-wh.bsky.social · 22/05/2025
Just published in The Lancet, interim results from the BRAID randomised trial of supplemental breast imaging for women with dense breast tissue. Read the open access Article here 👉 www.thelancet.com/journals/lan... @thelancet.com
thelancet.com
Comparison of supplemental breast cancer imaging techniques—interim results from the BRAID randomised controlled trial
Abbreviated MRI and contrast-enhanced mammography detected three times as many invasive cancers compared with ABUS, with cancers being half the size. This study shows that supplemental imaging could l...
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Paul Pharoah @paulpharoah.bsky.social · 15/05/2025
This thread reminded me of the work of my late father as a medic and epidemiologist in Papua New Guinea in the 1960's. In the highlands of PNG endemic goitre was very common and in some remote valleys endemic cretinism was also common. The Jimi Valley was one such area. 1/n
Aerial view of the highland rain forest of the Jimi Valley, Papua new Guinea.
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Sam Lambert @iamslambert.bsky.social · 14/05/2025
Are you a new PhD interested in cardiovascular disease, big data, cohorts, or multi-omics? Join our Cardiovascular Epidemiology Unit at the University of Cambridge for a British Heart Foundation-funded postdoctoral position. Open to those not currently in the CVD field. 🔗: buff.ly/R7YJvfl
buff.ly
Research Assistant/Research Associate* in Cardiovascular Epidemiology (BHF Scholarship) (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant/Research Associate* in Cardiovascular Epidemiology (BHF Scholarship) (Fixed Term) in the Department of Public Health and Primary Care, Cardiovascular Epidemiology Unit at the…
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Cancer Research UK Cambridge Centre @crukcamcentre.bsky.social · 09/05/2025
This research, published in the @thelancet.bsky.social Oncology, was led by Hend Hassan, a PhD student at the Centre for @ccge-cambridge.bsky.social @dphpc.bsky.social. Read more: crukcambridgecentre.org.uk/news/removin...
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The Lancet Oncology @thelancetoncol.bsky.social · 08/05/2025
Online first: Long-term health outcomes of bilateral salpingo-oophorectomy in BRCA1 and BRCA2 pathogenic variant carriers with personal history of #breastcancer: a retrospective cohort study using linked electronic health records www.thelancet.com/journals/lan...
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Antonis Antoniou @antonis02.bsky.social · 08/05/2025
📢 New publication from the group in @thelancetoncol.bsky.social led by Hend Hasan for her PhD, we used linked EHR + genetic testing data to study 3,400+ BRCA1/2 carriers with history of breast cancer. What happens long-term after BSO? 📄 Paper: www.thelancet.com/journals/lan... 🧵
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Antonis Antoniou @antonis02.bsky.social · 16/04/2025
Only 10 days left to apply for these positions👇
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Andrea Ganna @andganna.bsky.social · 15/04/2025
After UK, Denmark announces a national gateway to access health data novonordiskfonden.dk/en/news/new-...
novonordiskfonden.dk
New national gateway to health data will drive health solutions of the future - Novo Nordisk Fonden
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Mike Inouye @mikeinouye.bsky.social · 09/04/2025
This study is a big deal. Is it going to be the one that kicks down the PRS door? Maybe. And that’s saying something. Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....
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Mike Inouye @mikeinouye.bsky.social · 08/04/2025
📣📣 New postdoc in biomedical data science available in our lab!! www.jobs.cam.ac.uk/job/50966/ Flexible funding - many research areas in scope + ideas welcome Check out our group www.inouyelab.org/home And the awesome Cambridge research environment! @vpd-hlri.bsky.social @uniofcam.bsky.social
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Cancer Research UK Policy @crukpolicy.bsky.social · 07/04/2025
[1/5] We welcome today’s Government announcement of the creation of a Health Data Research Service. This is a vital step towards enabling cancer researchers to access the right data at the right time, improving outcomes for patients ⏱️🔍 www.gov.uk/government/n...
gov.uk
Prime Minister turbocharges medical research
Better and faster access to NHS data for researchers with gold standard security and privacy measures.
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Cancer Research UK Policy @crukpolicy.bsky.social · 19/03/2025
[1/5] Getting the right data at the right time is essential for researchers looking to beat cancer sooner. Using advanced data modelling and AI, the CD3 programme is a £10m commitment to understanding who is likely to get cancer and when. 🔬 However to deliver on its promise Government must:
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Centre for Cancer Genetic Epidemiology @ccge-cambridge.bsky.social · 12/03/2025
CCGE researchers evaluate the contribution of gene variants to cancer risk for multiple cancer types. The results highlight several potential new susceptibility genes including the DNA repair gene NHEJ1. Follow the link below to find out more www.cell.com/ajhg/fulltex...
cell.com
The contribution of coding variants to the heritability of multiple cancer types using UK Biobank whole-exome sequencing data
We developed a method to estimate the contribution of rare coding variants to cancer heritability and applied it to 11 cancers in the UK Biobank. Our results provide insights into the contribution of ...
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Muin J. Khoury @muinjkhoury.bsky.social · 08/03/2025
“It’s been exhaustively studied.” www.nytimes.com/2025/03/07/h...
nytimes.com
C.D.C. Will Investigate Debunked Link Between Vaccines and Autism
Dozens of studies have failed to find evidence of a link. The decision to re-examine the question comes as a measles outbreak, driven by low vaccination rates, widens in Texas.
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Antonis Antoniou @antonis02.bsky.social · 05/03/2025
📣 Job Opportunities - Alongside our recently advertised Senior Research Programme Manager position, we now have 2 more exciting opportunities to join the Cancer Data-Driven Detection (CD3) programme 1️⃣ Research Programme Manager shorturl.at/Cs1kg 2️⃣ Research Community Coordinator shorturl.at/4w9Na
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The Polygenic Score Catalog @pgscatalog.bsky.social · 04/03/2025
📣 Excited to share our new tutorial with @training.ebi.embl.org ! The course covers the basics of polygenic scores and describes the PGS Catalog resources (buff.ly/L8e6a3J, including pgsc_calc), a great overview of the area. Access the course online at buff.ly/CEBWMio!
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Mike Inouye @mikeinouye.bsky.social · 04/03/2025
📣 New from the lab: The contribution of genetic determinants of blood gene expression and splicing to molecular phenotypes and health outcomes www.nature.com/articles/s41... Check out the INTERVAL RNAseq portal www.intervalrna.org.uk Led by @alextokolyi.bsky.social & Elodie Persyn!
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Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · 01/03/2025
Calling all healthcare providers and researchers! Join us at #BRCA 2025, the 10th International Symposium on Hereditary Breast and Ovarian #Cancer, from May 6-9th 2025 ✅Inspiring speakers ✅In-depth sessions ✅Networking opportunities Visit www.brcasymposium.ca for more info!
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Antonis Antoniou @antonis02.bsky.social · 24/02/2025
📣CanRisk v.3 for breast and ovarian cancer risk prediction released today www.canrisk.org Includes 1️⃣ Adaptations to the U.K. ethnically diverse population: Pre-print: doi.org/10.1101/2025... 2️⃣ Continuous measures of mammographic density: Pre-print: doi.org/10.1101/2025...
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Mike Inouye @mikeinouye.bsky.social · 19/02/2025
Genetics, primary care records and lifestyle factors for short-term dynamic risk prediction of colorectal cancer bmjoncology.bmj.com/content/4/1/... Wonderful stuff from Samantha Ip, @antonis02.bsky.social , Angela Wood and co!
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Antonis Antoniou @antonis02.bsky.social · 19/02/2025
Read more about our recent collaborative work on multimodal dynamic risk modelling for colorectal cancer from the talented Sam Ip and Hannah Harrison. 👇
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PHG Foundation @phgfoundation.bsky.social · 18/02/2025
📣Vacancy alert!!! You'll need significant planning and organisational skills to coordinate and monitor across complex projects with multiple institutions (including us). 👉Cancer Data-Drive Detection (CD3) programme is a major new national research initiative. www.jobs.cam.ac.uk/job/50376/
jobs.cam.ac.uk
Senior Research Programme Manager (Fixed Term) - Job Opportunities - University of Cambridge
Senior Research Programme Manager (Fixed Term) in the Department of Public Health and Primary Care, Cancer Genetic Epidemiology at the University of Cambridge.
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Centre for Cancer Genetic Epidemiology @ccge-cambridge.bsky.social · 18/02/2025
Hello BlueSky colleagues – this is the new official account of the Centre for Cancer Genetic Epidemiology! Please follow us for updates and news related to our research.
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Antonis Antoniou @antonis02.bsky.social · 17/02/2025
📣 Exciting new opportunity to join the Cancer Data-Driven Detection (CD3) program as Senior Research Programme Manager based at @dphpc.bsky.social @cambridgeuni.bsky.social Closing date 16 March 2025 Please repost! More about CD3 below. 👇 www.jobs.cam.ac.uk/job/50376/
jobs.cam.ac.uk
Senior Research Programme Manager (Fixed Term) - Job Opportunities - University of Cambridge
Senior Research Programme Manager (Fixed Term) in the Department of Public Health and Primary Care, Cancer Genetic Epidemiology at the University of Cambridge.
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Robert S Miller MD @rsm2800.bsky.social · 21/01/2025
This interesting study linked germline testing and EHR/registry data from the UK NHS to characterize the risk of 2nd primary cancers for pts w/ pathogenic variants in BRCA1/BRCA2. 10-yr cumulative risk of contralateral BC was 16% in BRCA1+ and 12% in BRCA2+ ascopubs.org/doi/10.1200/...
ascopubs.org
Second Primary Cancer Risks After Breast Cancer in <i>BRCA1</i> and <i>BRCA2</i> Pathogenic Variant Carriers
PURPOSESecond primary cancer (SPC) risks after breast cancer (BC) in BRCA1/BRCA2 pathogenic variant (PV) carriers are uncertain. We estimated relative and absolute risks using a novel linkage of genet...
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Inherited Cancer Registry (ICARE) @inheritedcancer.bsky.social · 28/01/2025
Through linking test results to electronic health records in England from 1995-2019, researchers estimated relative & absolute second primary #cancer risks for #BRCA carriers after #breastcancer. Read the full article to learn more: ascopubs.org/doi/10.1200/... @tpalmd.bsky.social
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Mike Inouye @mikeinouye.bsky.social · 13/02/2025
📣📣Genomic data sharing: you don’t know what you’ve got (till it’s gone) www.nature.com/articles/s41... A comment @natrevgenet.bsky.social from @katholt.bsky.social and me
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Department of Public Health and Primary Care @dphpc.bsky.social · 12/02/2025
Hello BlueSky community, and welcome to our official account! 🎉 Follow us for the latest updates, events, and news. Stay connected and engage with our community!
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Simon Cook @drsimoncook.bsky.social · 08/02/2025
This is a very sad day. It diminishes the USA; it will drive people into poverty and it will lead to many needless deaths
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Ananya Choudhury @achoud72.bsky.social · 01/02/2025
Happy PM day to all who celebrate! PubMed, that is. BMJ Oncology is proud to announce that all our content is now available on PubMed! 🎉 🍾 🥂 @journal-kristoffer.bsky.social @mazer.us @eabhalynn.bsky.social @oncoalert.bsky.social
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Loïc Lannelongue @loiclnlg.bsky.social · 27/01/2025
🚨🌱 Interested in making scientific computing greener? Here is a chance to do just that in Cambridge: 2 open research roles to work with me and the Green Algorithms project. More details about the roles below👇 and at www.lannelongue-group.org/join/ ⏳ Closing: Feb 4 for one, Feb 17 for the other
Photo of Cambridge River and view over King's College with a group of people punting.Photo of the Heart and Lungs Research Institute on Cambridge Biomedical Campus. The building is bronze-colour and in front of a pond.
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Raza Ali Lab @hrazaalilab.bsky.social · 24/01/2025
There is a full weekend ahead to look into our open Postdoc position. If you'd like to study breast cancer tissue architecture with cutting-edge imaging data and novel computational methods, please apply! The deadline to apply is next Wednesday, the 29th 😉
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Antonis Antoniou @antonis02.bsky.social · 22/01/2025
A huge thank you to our funders for making this possible! It’s been truly inspiring to work alongside an extraordinary community of co-investigators & patient and public partners, in developing the proposals. Deeply grateful for the constant support from the central CRUK team throughout the process.
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JAMA @jama.com · 17/01/2025
This Medical News article discusses the ongoing debate about whether the word #cancer should be dropped from the names of indolent tumors of the prostate and breast. #MedSky #OncSky
jamanetwork.com
Will Renaming Some Cancers as Noncancers Hurt or Help?
This Medical News article discusses the ongoing debate about whether the word cancer should be dropped from the names of indolent tumors of the prostate and breast.
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Mary Dixon-Woods @marydixonwoods.bsky.social · 11/01/2025
Many, many, many things have been tried in trying to improve access to general practice. @thisinstitute.bsky.social and @healthfoundation.bsky.social have curated those efforts: bjgpopen.org/content/earl...
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Cancer Research UK Cambridge Centre @crukcamcentre.bsky.social · 10/01/2025
Looking for a PhD studentship to commence October 2025?   The Early Cancer Institute invites applications from UK students for two 3.5 year fully funded non-clinical studentships.  Application deadline: 16 February 2025 Find out more ➡️ zurl.co/1HyFJ
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Sounak Sahu @sounaksahu.bsky.social · 09/01/2025
Excited to share our latest study in @nature.com We used a humanized-mouse ES cell model to explore the functional consequences of all possible BRCA2 missense variants. We've clinically classified >6,500 variants and >1,200 reported in ClinVar! www.nature.com/articles/s41...
nature.com
Saturation genome editing-based clinical classification of BRCA2 variants - Nature
CRISPR–Cas9-based saturation genome editing in a humanized mouse embryonic stem cell line was used for comprehensive functional characterization of single nucleotide variants in a region of BRCA2, and...
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Antonis Antoniou @antonis02.bsky.social · 16/12/2024
The latest publication from the group, led by talented early career researchers Carmen Petitjean and Xin Yang @xinyang6699.bsky.social on the performance of BOADICEA/CanRisk for breast cancer risk prediction in UKBiobank out now in JNCI. Paper: doi.org/10.1093/jnci... 🧵👇
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Antonis Antoniou @antonis02.bsky.social · 12/12/2024
Looking forward to speaking in this session today at #SABCS24 @sabcs.bsky.social on the latest work on CanRisk tools (www.canrisk.org) for breast cancer risk prediction, including adaptations to ethnically diverse populations. @crukcamcentre.bsky.social
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Maarten van Smeden @maartenvsmeden.bsky.social · 12/12/2024
NEW PAPER A scoping review of updating methods in AI/ML based prediction models doi.org/10.1016/j.jc... w/ @lottameijerink.bsky.social and others
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Dana-Farber’s Breast Oncology Center @dfcibreastonc.bsky.social · 11/12/2024
Dr. Judy Garber shared the OlympiA Phase 3 trial results in today's #SABCS24 General Session. #olaparib #BRCA1 #BRCA2 #BreastCancer
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bishara marzook @ghostpathogen.bsky.social · 06/12/2024
Have you ever wondered how knocking out every single gene in the human genome, one by one, might affect your intracellular pathogen of interest? We did, & boy was it a wild ride! Happy to share our preprint discovering the essential host genome for Cryptosporidium - www.biorxiv.org/content/10.1...
Schematic showing the experimental outline for a full genome arrayed CRISPR screen. 384-well plates containing cells with an arrayed crRNA library are infected with Cryptosporidium parasites, which undergo asexual rounds of replication intracellularly, followed by sexual development to male and female forms. Plates are then fixed and immunolabeled to detect all parasites, female parasites, host actin recruited to parasite vacuoles, and host nuclei. Three z-stacks were imaged by high content microscopy to detect apically located parasites as well as host cell actin and nuclei.
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Kimmo Aro @kihear.bsky.social · 04/12/2024
Long awaited peer review finally completed!! Our paper comparing quantitative metabolomics disease risk prediction with PGS is accepted in Nature Comms!! 🥳🥳 @nightingalehealth.com #riskprediction #metabolomics #nmr #genomics #polygenicscore www.nature.com/articles/s41...
nature.com
Metabolomic and genomic prediction of common diseases in 700,217 participants in three national biobanks - Nature Communications
Identifying individuals at high risk for chronic diseases can improve prevention. Here, the authors show that blood metabolomics scores effectively stratify disease risk and compare favorably to genet...
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Peter Hall @peterhall001.bsky.social · 18/11/2024
Looking for collaborators to work on federated Real World Evidence studies related to cancer. We are building our infrastructure and need high value demonstaror projects. #OHDSI #EHDEN #OMOP #RWE please get in touch
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Cancer Research UK Cambridge Institute @cruk-ci.bsky.social · 29/11/2024
@cambridgeuni.bsky.social
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The Polygenic Score Catalog @pgscatalog.bsky.social · 27/11/2024
If you're interested in the PGS Catalog Calculator we're hosting a free training webinar @ebi.embl.org on December 4th: www.ebi.ac.uk/training/eve... (registration required). Come along, or catch up with the recording after! cc @iamslambert.bsky.social
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Cancer Research UK Cambridge Centre @crukcamcentre.bsky.social · 27/11/2024
📢 Don’t miss our next Cancer Biology and Medicine talk tomorrow! DNA Repair Prof Steve Jackson @cruk-ci.bsky.social Thurs 28 Nov, 9:30-10:30 Theo Chalmers lecture theatre, School of Clinical Medicine All welcome! @cuhnhs.bsky.social @cambridgeuni.bsky.social
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