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Peter Hall

@peterhall001.bsky.social
224 followers 160 following 17 posts

Breast Oncologist and Professor of Cancer Informatics, Edinburgh | Health Economics | Real World Evidence | cancer-data.ecrc.ed.ac.uk

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Reposted by Peter Hall
Peter Tennant @pwgtennant.bsky.social · 03/09/2025
The TARGET reporting guidelines for target trial emulation studies have arrived! #EpiSky #CausalSky jamanetwork.com/journals/jam...
jamanetwork.com
TARGET 2025 Statement
This Special Communication introduces the Transparent Reporting of Observational Studies Emulating a Target Trial (TARGET) 2025 guideline, a consensus-based guidance for reporting observational studie...
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Peter Hall @peterhall001.bsky.social · 29/08/2025
Adjuvant chemotherapy and hormonotherapy versus adjuvant hormonotherapy alone for women aged 70 years and older with high-risk breast cancer based on the genomic grade index (ASTER 70s): a randomised phase 3 trial - The Lancet www.thelancet.com/journals/lan...
thelancet.com
Adjuvant chemotherapy and hormonotherapy versus adjuvant hormonotherapy alone for women aged 70 years and older with high-risk breast cancer based on the genomic grade index (ASTER 70s): a randomised ...
The addition of adjuvant chemotherapy to hormonotherapy conferred no survival benefit in women aged 70 years and above with a GGI high-risk oestrogen receptor-positive HER2-negative breast cancer, and...
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Reposted by Peter Hall
The Health Foundation @healthfoundation.bsky.social · 29/08/2025
In this blog, Jack Elliott and Elaine Kelly examine trends in unpaid overtime among NHS staff since 2019 and consider the implications for future productivity. Read more ⬇️ bit.ly/4mILY3C
Bar chart of total unpaid hours worked across the NHS, expressed as full-time equivalent staff, 2019 to 2024 showing unpaid overtime in 2024 equivalent to workload of at least 33,000 full-time staff.
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Peter Hall @peterhall001.bsky.social · 21/08/2025
Preprint "The C-Index Multiverse" arxiv.org/abs/2508.14821
arxiv.org
The C-index Multiverse
Quantifying out-of-sample discrimination performance for time-to-event outcomes is a fundamental step for model evaluation and selection in the context of predictive modelling. The concordance index, ...
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Reposted by Peter Hall
Darren Dahly @statsepi.bsky.social · 12/08/2025
Target trial emulation is an important, useful idea, but we must remain careful to not allow novices to think it's a magical shortcut to causal inference. Nor can we lose sight of the *main* thing that separates randomized from non-randomized studies.
POTENTIAL RISKS OF TARGET TRIAL
TERMINOLOGY
There are risks that the term target trial emulation (TTE)
might mislead readers without methodological training. We
believe some readers may assume TTE represents a distinct
form of observational study design, rather than a framework
to help researchers identify and avoid self-inflicted errors in
observational studies. We are particularly concerned that
claims to have emulated an RCT will be mistaken for a claim
to have successfully emulated an RCT. The latter statement
implies that the inference is of a comparable standard to a
well-conducted RCT. To be certain, the TTE framework (2),
used correctly, will help investigators specify estimands,
and sidestep avoidable selection bias, but we are probably
more pessimistic than Schwarze et al. (1) about the ability
of ‘‘advanced methods’’ to address the threat of other
sources of bias. However, the difference in how
randomization accounts for confounding vs. ‘‘advanced
methods’’ like covariate adjustment, weighting, etc. is a
difference in kind, not in degree. This is because
randomization is guaranteed to eliminate confounding for
some key estimands, and to do so in a manner that
predominantly rests on our trust in a potentially verifiable
randomization process. In contrast, acting on the effect
estimate returned from an NRSI requires us to trust in the decisions and competence of the investigator, and even then,
no guarantee is possible, even in relatively simple sets of
relationships among a small set of potential covariates.
This distinction will be obvious to methodological experts,
but they only constitute a small proportion of researchers
and research-consumers
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Reposted by Peter Hall
Darren Dahly @statsepi.bsky.social · 16/07/2025
Do. Not. Give. This. To. The. Medics. PLEASE.
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Reposted by Peter Hall
medRxivpreprint @medrxivpreprint.bsky.social · 24/10/2024
Vaginal estrogen therapy initiation after breast cancer and oncological outcomes: a nationwide population-based target trial emulation. www.medrxiv.org/content/10.1101/202…
medrxiv.org
Vaginal estrogen therapy initiation after breast cancer and oncological outcomes: a nationwide population-based target trial emulation. https://www.medrxiv.org/content/10.1101/2024.10.23.24315966v1
Background: Genitourinary syndrome of menopause (GSM) frequently occurs after breast cancer (BC), le
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Peter Hall @peterhall001.bsky.social · 27/04/2025
www.nature.com/articles/s41...
nature.com
Less-frequent surveillance is noninferior to annual mammography - Nature Reviews Clinical Oncology
Nature Reviews Clinical Oncology - Less-frequent surveillance is noninferior to annual mammography
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Reposted by Peter Hall
Edinburgh Cancer Informatics @cancerdataedin.bsky.social · 07/03/2025
We're hiring! A vacancy has opened up in the team for the position of Post-Doctoral Research Fellow. 🔬 🧑🏼‍💻 If this sounds like something you'd be interested in, details can be found on our website below. 👇 cancer-data.ecrc.ed.ac.uk/2025/03/07/r...
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Reposted by Peter Hall
Cancer Research UK Scotland Institute @cruk-si.bsky.social · 27/02/2025
Haven't registered your place for the Beatson International Cancer Conference 2025 yet? Find out what delegates had to say about last year's event 📅Register by 21 March: beatsonconference.org #BICC2025
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Peter Hall @peterhall001.bsky.social · 21/02/2025
Today is the 4th Edinburgh Breast Cancer Special Symposium #EBCSS25 www.ebcss.org
ebcss.org
Home | EBCSS 2025 Edinburgh
EBCSS Edinburgh International Breast Cancer Conference
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Peter Hall @peterhall001.bsky.social · 16/02/2025
A pooled analysis evaluating prognostic significance of Residual Cancer Burden in invasive lobular breast cancer www.nature.com/articles/s41...
nature.com
A pooled analysis evaluating prognostic significance of Residual Cancer Burden in invasive lobular breast cancer - npj Breast Cancer
npj Breast Cancer - A pooled analysis evaluating prognostic significance of Residual Cancer Burden in invasive lobular breast cancer
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Reposted by Peter Hall
Elisabetta Bonzano MD, PhD @elisabettabonzano.bsky.social · 30/01/2025
📌 Adjuvant Atezolizumab for Early Triple-Negative Breast CancerThe ALEXANDRA/IMpassion030 Randomized Clinical Trial jamanetwork.com/journals/jama/… @oncoalert.bsky.social
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Peter Hall @peterhall001.bsky.social · 31/01/2025
Annual versus less frequent mammographic surveillance in people with breast cancer aged 50 years and older in the UK (Mammo-50): a multicentre, randomised, phase 3, non-inferiority trial - The Lancet www.thelancet.com/journals/lan...
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Reposted by Peter Hall
Cancer Research UK @cancerresearchuk.org · 22/01/2025
Together with the NIHR (National Institute for Health and Care Research), the EPSRC, Health Data Research UK (HDR UK) and ADR UK (Administrative Data Research UK), we’re announcing a £10m programme which will help identify individual cancer risk 🙌 Read more 👉 cruk.ink/42q0aaY
cruk.ink
£10m funding for new programme to help identify individual cancer risk - Cancer Research UK - Cancer News
Today, Cancer Research UK, the NIHR and the EPSRC are announcing £10 million to create the Cancer Data-Driven Detection programme
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Karin Purshouse @karinpurshouse.bsky.social · 06/01/2025
So happy to share the latest study from NOTCH led by Dr Karen Mactier from @NHS_Lothian @UofGlasgow, looking at UK-wide practice in managing a rare cancer, uterine sarcoma 👇👇👇 pubmed.ncbi.nlm.nih.gov/39725428/
pubmed.ncbi.nlm.nih.gov
TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK - PubMed
Our data highlight the diversity in patient management in uterine sarcoma and a marked survival advantage for patients diagnosed with stage I disease. These data highlight the importance of a multidis...
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Reposted by Peter Hall
Katie Spencer @katiespencer.bsky.social · 06/01/2025
Are you a health economist, epidemiologist or data scientist with experience using routine healthcare data? Interested in equity in cancer care? Come and join this exciting @nihr.bsky.social funded project! Work with a range of stakeholders and build your skills. jobs.leeds.ac.uk/Vacancy.aspx...
jobs.leeds.ac.uk
Job Opportunity at University of Leeds: Research Fellow
Are you an ambitious researcher looking for your next challenge? Do you have a background in economics, econometrics, statistics, epidemiology or health data science? Are you interested in working wit...
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Richard Simcock @breastdocuk.bsky.social · 11/12/2024
4w Denosumab or 12w The efficacy results of the REDUSE study are not mature yet but the tox results are in Less drug - fewer tox events ONJ all grades 8.1 vs 5.2% #SABCS24
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Peter Hall @peterhall001.bsky.social · 10/12/2024
#SABCS24 FDA session highlighting need to consider Minimum Effictive Dose, not just Maximum Tolerated Dose. Reminds me of the GO2 trial in gastric ca last decade. Breast cancer drug development catching up? jamanetwork.com/journals/jam...
jamanetwork.com
Efficacy of Reduced-Intensity Chemotherapy Among Older and Frail Patients With Advanced Gastroesophageal Cancer
This randomized clinical trial assesses the efficacy of reduced-intensity chemotherapy for patient quality of life and cancer control in the treatment of older and/or frail patients.
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Peter Hall @peterhall001.bsky.social · 02/12/2024
The Sudlow Review on the challenges and opportunities for using UK linked healthcare data for research www.hdruk.ac.uk/helping-with...
hdruk.ac.uk
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Reposted by Peter Hall
Toni Choueiri, MD @drchoueiri.bsky.social · 30/11/2024
Our latest in @naturecomms.bsky.social from @danafarber.bsky.social / @mskcc.bsky.social collaboration: AI to extract cancer outcomes in EMR! www.nature.com/articles/s41...
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Peter Hall @peterhall001.bsky.social · 29/11/2024
Very good to see more de-escalation trials publishing in HER2 positive early breast cancer. Here the HELEN-006 trial. www.thelancet.com/journals/lan...
thelancet.com
De-escalated neoadjuvant weekly nab-paclitaxel with trastuzumab and pertuzumab versus docetaxel, carboplatin, trastuzumab, and pertuzumab in patients with HER2-positive early breast cancer (HELEN-006)...
These findings might suggest a potential advantage of nab-paclitaxel combined with trastuzumab and pertuzumab compared with the standard regimen in neoadjuvant therapy for patients with HER2-positive ...
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Reposted by Peter Hall
Kristoffer Stewart @journal-kristoffer.bsky.social · 28/11/2024
📣 Check out this recent study: UK national observational cohort study investigating Tolerance of Anti-cancer Systemic Therapy in the Elderly: the TOASTIE study From @drmarkbaxter.bsky.social and colleagues: bmjoncology.bmj.com/content/3/1/... #cancer #chemotherapy
bmjoncology.bmj.com
UK national observational cohort study investigating Tolerance of Anti-cancer Systemic Therapy in the Elderly: the TOASTIE study
Objective The Cancer and Aging Research Group (CARG) score was developed to predict severe chemotherapy-induced toxicity risk in older adults; validation study results have varied. The Tolerance of An...
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Peter Hall @peterhall001.bsky.social · 27/11/2024
This is how we should be doing Oncology trials - the Dutch SONIA trial looking at treatment sequencing of CDK 4/6 inhibitors in advanced breast cancer. A self funding efficiency trial! #oncsky www.nature.com/articles/s41...
nature.com
Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer - Nature
The phase 3 SONIA trial challenges the benefits of using cyclin-dependent kinase 4 and 6 inhibitors as a first-line compared with second-line treatment.
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Kate Absolom @drkateabsolom.bsky.social · 16/11/2024
Our latest mixed-methods paper in #bmjopen describes where cancer patients and staff found benefit in using an eHealth #proms based intervention as part of routine care during systemic/chemo treatment. bmjopen.bmj.com/content/bmjo...
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Peter Hall @peterhall001.bsky.social · 23/11/2024
Any good starter packs out there for folks using routine healthcare data for cancer research? #oncsky #cancerinformatics #causalinference
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Kimberly Curseen MD @curseen.bsky.social · 17/11/2024
Illness trajectories of incurable solid cancers We need to shift our approach to ambulatory palliative care education to managing patients over years and also define the boundaries and ways to collaborate between us and primary care for those living with cancer pubmed.ncbi.nlm.nih.gov/38428972/
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Reposted by Peter Hall
Owen Jackson @owenjackson.bsky.social · 21/11/2024
🧵 New research published today by the OECD: 💷 #Cancer adds £14.4bn to annual UK #health expenditure - even accounting for other health costs those who don't get cancer go on to require 📈Without action, per capita costs could increase by >50% by 2050 1/ news.cancerresearchuk.org/2024/11/21/t...
news.cancerresearchuk.org
The cost of cancer: what does it mean for the UK’s growth mission - Cancer Research UK - Cancer News
The OECD's report on the economic impact of cancer makes it clear the UK government needs to focus on tackling the disease.
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London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 21/11/2024
Patients with #cancer favour evidence of success over quick drug approvals. Ajay Aggarwal explains while offering patients new treatment options is crucial, survey suggests not all patients want faster cancer drug approvals without certainty they work. #PublicHealth www.lshtm.ac.uk/newsevents/n...
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Richard Simcock @breastdocuk.bsky.social · 20/11/2024
So here’s a starter pack of the UK Oncologists I’ve found so far - LMK who I have missed and I will follow and add.
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Rory Cellan-Jones @rorycj.bsky.social · 15/11/2024
open.substack.com/pub/rorycell... My latest healthtech Substack post is about those annoying letters that are addressed to your GP but should be written for the patient
open.substack.com
This charming gentleman has had enough of GP letters
Time for hospital doctors to write direct to patients
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Adam Raymakers @araymakers.bsky.social · 18/11/2024
I've created a #healtheconomics starter pack! There's a few other great packs out there but in this one I've tried to make it more international! 🌎 Let me know if you'd like to be added or if you have recommendations. And feel free to share! go.bsky.app/8Lj8FLB
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Altmetric @altmetric.com · 18/11/2024
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics
docs.bsky.app
Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
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Peter Hall @peterhall001.bsky.social · 18/11/2024
Looking for collaborators to work on federated Real World Evidence studies related to cancer. We are building our infrastructure and need high value demonstaror projects. #OHDSI #EHDEN #OMOP #RWE please get in touch
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Peter Hall @peterhall001.bsky.social · 18/11/2024
Hello Bluesky. I am an academic oncologist trying to improve use of routinely collected healthcare data for evidence based decision making. Background in Health Economics. Trying to keep up with data science. I treat patients with breast cancer at Edinburgh Cancer Centre. #oncology #rwe #healthecon
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Sciences @sciences.skyfleet.blue · 06/11/2024
Automated real-world data integration improves cancer outcome prediction
nature.com
Automated real-world data integration improves cancer outcome prediction - Nature
A study generates a clinicogenomics dataset resource, MSK-CHORD, that combines natural language processing-derived clinical annotations with patient medical data from various sources to improve models of cancer outcome.
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Peter Hall @peterhall001.bsky.social · 16/11/2024
How should we audit 'best supportive care' in poor prognosis cancers? What metric is measurable and objective? Any ideas?
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