Abstract. Microbial populations strongly shape their environment, which can re-route adaptation toward organism-generated fitness optima. However, the cond

An international team of researchers developed a new way to uncover hidden differences in how viruses infect and destroy individual microbial cells—solving a biological puzzle that has persisted for m...

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npj Viruses - Rage against the mean: a perspective on measuring fitness of individual phage particles

Abstract. Viruses are ubiquitous in all environments and impact host metabolism, evolution, and ecology, although our knowledge of their biodiversity is st

A frequent goal of phage biology is to quantify how well a phage kills a population of host bacteria. Unfortunately, traditional methods to quantif...

Mycobacteriophage Bxb1 is a well-characterized virus of Mycobacterium smegmatis with double-stranded DNA and a long, flexible tail. Mycobacteriophages…

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Phages, viruses of bacteria, play a pivotal role in Earth's biosphere and hold great promise as therapeutic and diagnostic tools in combating infectious diseases. Attachment of phages to bacterial cells is a crucial initial step of the interaction. The classic assay to quantify the dynamics of phage …

Many bacteria carry phage genome(s) in their chromosome (i.e., prophage), and this intertwines the fitness of the bacterium and the phage. Most Pseudomonas aeruginosa strains carry filamentous phages ...

A method developed by Yale scientists helps reveal how antibacterial agents interact with their host cells — a process that could boost a host of applications that benefit society.

The application of phage therapy for multidrug-resistant infections is mainly limited to personalized therapy due to the narrow host range of individual phages. Here, Kim et al. identify groups of pha...