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Krista Freeman

@kfreeman.bsky.social
789 followers 1K following 22 posts

Big phan of physics & phages | cryo-EM, phage engineering, a little immunology | e-bike enthusiast CWRU Physics Assistant Professor Cleveland kid.

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Reposted by Krista Freeman
Miguel López Rivera @riveralopz.bsky.social · 29/05/2026
(1/6) Thrilled to share this story! In our preprint from my PhD in the @kranzuschlab.bsky.social, with help from the Hatfull lab and @soreklab.bsky.social, we discover RyDEP, a phage-encoded RyR-domain glycosidase that allows phages to evade Thoeris defense. Highlights below! doi.org/10.64898/202...
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Krista Freeman @kfreeman.bsky.social · 05/09/2025
Well, I just was denied the COVID vaccine in Cleveland, Ohio. I can’t begin to express the rage I feel at being barred from protecting my vulnerable loved ones. My “senators” just got voicemails - I will keep calling until access to these safe and effective vaccines is restored. My body, my choice.
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Reposted by Krista Freeman
Chrystal Starbird @drstarbird.bsky.social · 21/08/2025
Join me in donating to ABRCMS. For many of us early in our careers (and for many of us now), this is THE conference. Let’s make sure future generations get the same experience. I was told if each poster judge donated $25, their goal would be quickly met, but I think we can do better! 🙏🏾💪🏾
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Reposted by Krista Freeman
ASM @asm.org · 02/05/2025
Together with leading science organizations, ASM filed an amicus brief calling for immediate restoration of NIH grants supporting early-career scientists. Read the press release: asm.org/press-releas...
asm.org
Four Leading Science Organizations File Amicus Brief Supporting Funding Restoration
ASM joined leading life science organizations in an amicus brief filed in support of a suit calling for immediate funding restoration.
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Reposted by Krista Freeman
Cell - a Cell Press journal @cp-cell.bsky.social · 15/04/2025
Now online! Structure and infection dynamics of mycobacteriophage Bxb1
dlvr.it
Structure and infection dynamics of mycobacteriophage Bxb1
Cryo-EM and cryo-ET reveal the structural details and conformational dynamics of mycobacteriophage Bxb1 as it infects its Mycobacterium smegmatis host.
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Reposted by Krista Freeman
Vivek Mutalik @vivekmutalik.bsky.social · 17/04/2025
#phage #phagesky
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Reposted by Krista Freeman
Ben Engel @cellarchlab.com · 18/04/2025
Some eye-catching #TeamTomo work here. Congrats to @kfreeman.bsky.social and all the authors! 🧪🧶🧬🔬
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Reposted by Krista Freeman
ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 18/04/2025
Krista Freeman et al 𝘊𝘌𝘓𝘓 stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm can inform precise targeted phage therapies for TB and NTM infections www.cell.com/cell/fulltex...
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Sudipta Mondal @sudipta-cryoet.bsky.social · 17/04/2025
Host invasion by a mycobacteriophage—visualized in action! 🦠✨ Thrilled to have contributed to this exciting work! Great collaboration with the amazing Krista @kfreeman.bsky.social & Graham Hatfull lab. Huge thanks to the Park lab for this fantastic opportunity 🙌 #CryoEM #CryoET #phage #mycobacteria
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Reposted by Krista Freeman
Katie Wetzel @kswetzel1.bsky.social · 16/04/2025
Do you love phages? Other viruses? Cool science done by cool people? Check out this paper by my former bay mate @kfreeman.bsky.social and colleagues that sheds light on the cool molecular machines that are phage tails.
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Krista Freeman @kfreeman.bsky.social · 16/04/2025
Hurray, it is finally out! Meet bacteriophage Bxb1 - the subject of my first full-phage cryo-EM study. My structures are beautifully complemented by the Park Lab’s cryo-ET analysis, shedding light on mycobacteriophage structural changes during infection. www.sciencedirect.com/science/arti...
sciencedirect.com
Structure and infection dynamics of mycobacteriophage Bxb1
Mycobacteriophage Bxb1 is a well-characterized virus of Mycobacterium smegmatis with double-stranded DNA and a long, flexible tail. Mycobacteriophages…
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Reposted by Krista Freeman
Sasha Larsen Akins @akinssasha.bsky.social · 21/01/2025
Excited about progress we are making to build a system for preclinical interrogation of #phages for #Tb #TBSKY virologyj.biomedcentral.com/articles/10....
virologyj.biomedcentral.com
Evaluation of host immune responses to Mycobacteriophage Fionnbharth by route of delivery - Virology Journal
For much of the last decade, tuberculosis (TB) was the leading cause of mortality due to an infectious pathogen (Mycobacterium tuberculosis, M.tb). Approximately 1.3 million deaths in 2023 worldwide w...
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Reposted by Krista Freeman
Phage papers @phagepapers.bsky.social · 05/12/2024
Use of epigenetically modified bacteriophage and dual beta-lactams to treat a Mycobacterium abscessus sternal wound infection. DOI: 10.1038/s41467-024-54666-4 pubmed.ncbi.nlm.nih.gov/39609405
pubmed.ncbi.nlm.nih.gov
Use of epigenetically modified bacteriophage and dual beta-lactams to treat a Mycobacterium abscessus sternal wound infection - PubMed
Nontuberculous mycobacterium (NTM) infections are challenging to manage and are frequently non-responsive to aggressive but poorly-tolerated antibiotic therapies. Immunosuppressed lung transplant patients are susceptible to NTM infections and poor patient outcomes are common. Bacteriophages present …
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Reposted by Krista Freeman
Ben Monreal @benmonreal.bsky.social · 19/11/2024
Come join us at CWRU Physics! We're hiring in Condensed Matter Experiment at assistant professor level. 🧪⚛️ case.edu/academic-car...
case.edu
Assistant Professor (tenure-track) in Experimental Condensed Matter Physics - Department of Physics | Academic Careers | Case Western Reserve University
The Department of Physics at Case Western Reserve University invites applications for a tenure-track faculty position at the rank of Assistant Profes...
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Krista Freeman @kfreeman.bsky.social · 17/11/2024
Thanks for making this starter pack, Joscelyn! Awesome to see so many MOSAIC scholars assembling here in the bluer skies. So happy to connect!
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Krista Freeman @kfreeman.bsky.social · 30/10/2024
LOVING the NIH BioArt effort! BUT… where are the phages?? Hoping to see some in the official release! Anyone know if there’s a mechanism to request additions? #PhageSky
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Krista Freeman @kfreeman.bsky.social · 29/07/2024
I’m pleased to share that I’ll be joining Case Western Reserve University as an Assistant Professor of Physics, starting July 2025! Looking forward to returning to my Physics roots while continuing to investigate the wonderful world of phages. :)
A smiling woman (me!) wearing a Case Western Reserve University hat and pointing to the “Physics” sign above the door of the CWRU Physics department’s building.
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Krista Freeman @kfreeman.bsky.social · 01/05/2024
Whoops, meant to tag #phagesky
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Krista Freeman @kfreeman.bsky.social · 01/05/2024
Big congrats to Graham Hatfull on being elected a member of the National Academy of Sciences! I couldn’t ask for a better mentor. So glad to have had the opportunity to learn from him the last 7 (!) years!!
Graham Hatfull smiling and standing near balloons and a hand-drawn bacteriophage on a whiteboard. Photo credit Katie Wetzel.
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Krista Freeman @kfreeman.bsky.social · 19/11/2023
Home from my first ever ABRCMS and feeling, in a word, uplifted! I hope to come back year after year to cultivate friendships, learn from mentors, and connect with the amazing next generation of diverse scientists. Huge thanks to the ASM MOSAIC program for the warm welcome :)
Buddy Fuzzybum, our lab mascot (a bacteriophage made from pipe cleaners, a disposable dropper, foil, and googly eyes), posing with the ABRCMS sign.Me with the ABRCMS sign.Some of the ASM MOSAIC scholars, mentors, and advisory board members at an ABRCMS reception.
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Reposted by Krista Freeman
Ákos T Kovács @evolvedbiofilm.bsky.social · 04/10/2023
PhamClust: a phage genome clustering tool using proteomic equivalence @mSystemsJ Methods and Protocols from Graham Hatfull journals.asm.org/doi/10.1128/...
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Krista Freeman @kfreeman.bsky.social · 11/09/2023
Just test driving this new platform… apparently if I add a test tube my post will go to the ScienceSky feed? 🧪 And I suppose threads can be done with a string of comments on a post? So far so good… the waters do seem calmer here.
Photo of calm waters in the Aegean Sea off the rocky coast of Ikaria, a little Greek island I took my parents to this summer!
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Krista Freeman @kfreeman.bsky.social · 10/09/2023
Hi, my name is Krista… a recent transplant from Science Twitter. I’m a postdoc studying bacteriophages - viruses that infect bacteria. When I’m not reconstructing cool phage structures or working on my faculty applications, I love traveling and exploring the great outdoors.
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