Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

The mutation frequency decline (Mfd) enzyme mediates transcription-coupled repair in transcribed genes by directly interacting with RNA polymerase (RNAP) during transcription of coding sequences. Howe...

Abstract. Evolutionary “fitness” is operationalized in many different ways in models. Its role is to quantify that which is favored by natural selection. G

Abstract. The ability to sense DNA damage and activate DNA damage response pathways is critical for repairing DNA damage in all domains of life. The most w

Abstract. How gene order along chromosomes affects cellular homeostasis and genome evolution remains poorly understood. Bacterial chromosomes are organized

The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

Targeting two distinct steps of the transcription process yields synergistic antibiotics that kill non-replicating Mycobacterium tuberculosis and reduce drug resistance.

The Caribbean harbors diverse genetic resources, yet microbiome research in the region remains poorly characterized. Addressing infrastructure and training challenges through collaborations and capacity building is vital. This article reflects on the obstacles facing microbiome research in the region and proposes solutions to ensure equitable participation in the global microbial research ecosystem.

Explore how linguistic bias subtly reinforces privilege in science by constraining scientific dissemination.

Understanding core and conditional gene essentiality is crucial for decoding genotype-phenotype relationships in organisms. We present phage high-thro…

When the bacteria MRSA evolve to resist viral attacks, they regain their sensitivity to antibiotics.

In methicillin-resistant Staphylococcus aureus, evolution of bacteriophage resistance causes trade-offs that re-sensitize the bacteriato β-lactam antibiotics.

‘cuestiones caribeñas/caribbean matters’ confronts colonialism and highlights shared experiences across the archipelago MADISON, Wis. — Grapple with the Caribbean’s complex contradictions and engage i...