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And this specificity is remarkable, since we are talking about the cingulate cortex here – one of the most unspecific parts of the human brain (since super old – agranular PFC). E.g. see these many functions that the network is generally associated with (10.1101/2023.10.10.561772):

However, running this unthresholded map through the neurosynth decoder gives you 'pain', 'painful', 'noxious', 'nociceptive' as the most similar network terms from the body of the fMRI literature assembled by neurosynth.

The network looks pretty unspecific as shown – you may think – well, salience network, right? This supports the prominent criticism voiced by van den Heuvel et al., earlier this year (www.nature.com/articles/s41...)

New lesion network mapping paper from the Berlin group (Stegemann et al.) on post-stroke pain in @ohbmofficial.bsky.social can serve as a good example in the whole LNM validity discussion: They describe a network associated with new severe pain after stroke. pubmed.ncbi.nlm.nih.gov/42420807/

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Two different frequency bands each representing different things.

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Fantastic work on adaptive circuit targeting DBS decoding gait problems and switching to the optimal gait setting in such moments.

Next up is yet another legend of the „new wave“ of adaptive DBS: Eduardo Mourad.

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Volitional stimulation - super cool!

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Personal opinion here - I thoroughly believe that @littleneuro.bsky.social and @julianneumann.bsky.social are single-handedly leading the next wave of AI-decoding based adaptive DBS. Way ahead of the curve and so much great stuff in the pipeline. V nice to see them both speak in the same session!

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Next up is none less than Simon Little - one of the few people that may claim has fostered a new FDA approval in the field of DBS.

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What a great discussion! #optoDBS 2026

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Fantastic new work in the pipeline in both labs - exactly in the spirit of #optoDBS. So excited by this line of work and this fantastic shared keynote!

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The work challenges the dogma of GO vs NOGO pathways toward MOREOFTHIS vs STOPTHAT pathways started by Eric in the mouse and replicated by Julian in the human.

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The collaboration between @julianneumann.bsky.social and @yttrilab.bsky.social that led to this years keynote seems like a match made in heaven. But in fact, the two met at #optoDBS 2017!

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Andreas Horn @andreashorn.org · 30/05/2026

And were live! #optoDBS 2026 is oft to a great start here at Campus Biotech in Geneva. Christian Lüscher kicking off the conference - and since we are broadening the scope a lot: will we call it #optoMOD in the future?

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Tremor is highly heterogeneous, leading to a familiar clinical puzzle: with deep brain stimulation (DBS), we can sometimes suppress a patient's rest tremor almost completely, while action tremor remains bothersome. www.cell.com/cell-reports...

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Andreas Horn @andreashorn.org · 14/05/2026

Panierraupe und Matter Planier.

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Andreas Horn @andreashorn.org · 18/04/2026

Which way best defines the optimal deep brain stimulation target in #Parkinsons? x-y-z coordinates? sweet spots? fiber tracts? whole-brain networks? @patriciazvarova.bsky.social has just answered this question: All of them. New study out now in AoN: onlinelibrary.wiley.com/doi/epdf/10....

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Andreas Horn @andreashorn.org · 31/03/2026

Save the date – see you in Seville!

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Andreas Horn @andreashorn.org · 26/03/2026

I'm looking forward to speaking at the Orchard OCD Conference in London on 4-5 June. I will be joining the panel "Advances In Neuromodulation and Neurosurgical Strategies for OCD" with Ludvic Zrinzo, Rebecca Prices, and Elsa Fouragnan. …

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Andreas Horn @andreashorn.org · 20/03/2026

Dear neuromodulation enthusiasts! Please join us at OptoDBS 2026, which will take place at the Campus Biotech in Geneva, Switzerland, from June 10th to 12th: www.optodbs.ch Please Repost for reach – thank you!! 🙏🙏

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Andreas Horn @andreashorn.org · 08/03/2026

Happy to share results ASAP. Still working on the stats.

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Andreas Horn @andreashorn.org · 27/02/2026

A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method. See below 👇 for our response. www.biorxiv.org/content/10.6...

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Andreas Horn @andreashorn.org · 26/02/2026

I recently came into possession of a new item for my office, which will undoubtedly become a critical all-purpose fix for our scientific projects. If, in the future, folks at @netstim.org should ever require more data, they can just reach behind the sofa and get it!

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Andreas Horn @andreashorn.org · 23/02/2026

Fantastic talk by @barbarahollunder.bsky.social on weaving together findings across studies in the field of connectomic DBS at the Würzburg expert summit!

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That's all folks, thanks for the attention! Congratulations to @bahnebahners.bsky.social and team for leading this fantastic work! Paper: pubmed.ncbi.nlm.nih.gov/41645667/ Press: uni-koeln.de/en/universit...

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(That tremor is in fact different also when seen with the fMRI lens was recently mapped out across various modalities in detail by @lukasgoede.bsky.social in @natcomms.nature.com: www.nature.com/articles/s41...)

As in fMRI, these results seemed specific to hypokinetic motor improvements, not so much for improvements of tremor as a hyperkinetic symptom.

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While data for this was scarce, there were also hints that contrasting DBS ON vs. OFF during MEG scanning as well as DBS evoked potentials map to a similar network centered around this general SMA/pre-SMA/cingulomotor region.

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Findings were robust enough to calculate the network on data acquired in Düsseldorf on one MEG scanner – which was then used to explain variance in independent patients operated in Berlin and scanned using a different device.

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And in fact, when analyzing this data in the beta range, optimal improvements associate with coherence to a network that spatially resembles the PD response network described earlier.

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To characterize the PD response network, @bahnebahners.bsky.social used the same method in our present publication based on data acquired by the teams of Esther Florin and Andrea Kühn (🙏🙏🙏)

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What has been well studied across time is the signature of elevated beta synchrony (often expressed in form of long bursts) in the subthalamic nucleus. Well phenotyped by Peter Brown, Andrea Kühn, Helen Bronte-Stewart, @julianneumann.bsky.social etc. Review: pubmed.ncbi.nlm.nih.gov/37105806/

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Lukas went on to show that even the levodopa effects were stronger when 'priming' the network by tDCS – maybe / likely Levodopa also acts on the same network? pubmed.ncbi.nlm.nih.gov/40386963/