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Yttri Lab

@yttrilab.bsky.social
311 followers 356 following 18 posts

Interrogating the functional interactions of motor and decision circuits that lead to behavior labs.bio.cmu.edu/yttri

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Yttri Lab @yttrilab.bsky.social · 12/02/2026
A fun article about our work and the Olympics. There's some interesting relationships between skiing and basal ganglia function. Also see the front of @cmu.edu 's homepage! @cmuscience.bsky.social @cmu-neuroscience.bsky.social @ahmarilab.bsky.social theconversation.com/hesitation-i...
theconversation.com
Hesitation is costly in sports but essential to life – neuroscientists identified its brain circuitry
There are specific parts of the brain that trigger hesitation in times of uncertainty.
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Yttri Lab @yttrilab.bsky.social · 07/01/2026
Hot off the @nature.com press!! Our A-SOiD behavior library developed specifically for pain to quantify a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties @flybottleescape.bsky.social @cmu-neuroscience.bsky.social @cmu.edu www.nature.com/articles/s41...
nature.com
Mimicking opioid analgesia in cortical pain circuits - Nature
The anterior cingulate cortex encodes affective pain behaviours modulated by opioids; targeting opioid-sensitive neurons through a new chemogenetic gene therapy replicates the analgesic effects of mor...
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Yttri Lab @yttrilab.bsky.social · 17/12/2025
So proud of @mattgeramita.bsky.social and this stellar work on striatal dynamics, decisions, and impulsivity. Really pertinent for thinking about probabilistic vs deterministic frameworks too And yes the song by @ahmarilab.bsky.social is absolutely worth listening to!
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Yttri Lab @yttrilab.bsky.social · 14/11/2025
I hope this new-ish paper will challenge people to think about the interpretations of our models STRIATUM SUPPORTS REINFORCEMENT AND NOT ACTION SELECTION (!!!) tinyurl.com/HodgeAndYttri @cmuscience.bsky.social @cmu-neuroscience.bsky.social #neuroskyence
tinyurl.com
Striatal modulation supports context-specific reinforcement and not action selection
Hodge et al. used closed-loop optogenetic stimulation and naturalistic behaviors to determine that striatal activity does not select the action to perform but rather biases performance through reinfor...
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Yttri Lab @yttrilab.bsky.social · 12/02/2025
In an effort to bring #neuroskyence to @bsky.app I wanted to share our recent paper in Neuron tinyurl.com/LesionsOfM1 @markolas.bsky.social and I asked what forelimb M1 contributes to striatal and behavioral dynamics using joystick tasks and CFA lesions @cmuscience.bsky.social @the-cnbc.bsky.social
tinyurl.com
Motor cortex is responsible for motoric dynamics in striatum and the execution of both skilled and unskilled actions
Nicholas and Yttri find that in the absence of motor cortex, the stratum alone is not capable of producing goal-directed behavior. Lesions of motor cortex also produce a freezing of gait-like behavior...
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