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Lukas Goede

@lukasgoede.bsky.social
747 followers 404 following 45 posts

Neurology resident and Neuroscientist @ Charité - University Medicine Berlin| | Interested in deep brain stimulation, non-invasive brain stimulation and movement disorders

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Lukas Goede @lukasgoede.bsky.social · 14/06/2026
Tremor is highly heterogeneous. Our new study in @cp-cellreports.bsky.social shows that rest and action tremor map to different networks within the motor cortex. By refining DBS contact selection, we can engage these circuits to optimize treatment for both. www.cell.com/cell-reports...
cell.com
Action and rest tremor map to distinct networks within the primary motor cortex
Goede et al. show that different tremor types engage distinct regions of the motor cortex. Using deep brain stimulation network mapping, they find that optimal treatment of rest tremor involves effect...
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Lead-DBS @lead-dbs.org · 13/05/2026
With SPARK-DBS, @savirmadan.bsky.social adds a new tool to the ecosystem of Lead-DBS: The small-scale databasing tool can store, analyze and integrate stimulation parameters and scores in BIDS-compliant fashion. Toward standardized data analysis in DBS! www.sciencedirect.com/science/arti...
sciencedirect.com
SPARK-DBS: Toward standardized analysis of deep brain stimulation data
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Andreas Horn @andreashorn.org · 20/02/2026
A bit later, Leon Sobesky & @lukasgoede.bsky.social confirmed that the same is true for *pallidal* DBS. Here as well, electrodes that stimulate this exact PD response network would profit maximally from DBS. pubmed.ncbi.nlm.nih.gov/34453827/
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Andreas Horn @andreashorn.org · 20/02/2026
New @netstim.org publication alert: @bahnebahners.bsky.social in BRAIN out now: academic.oup.com/brain/advanc... A 🧵:
academic.oup.com
The deep brain stimulation response network in Parkinson’s disease operates in the high beta band
Bahners et al. identify a brain network linked to optimal therapeutic outcomes in patients with Parkinson’s disease receiving deep brain stimulation. This
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Lukas Goede @lukasgoede.bsky.social · 04/09/2025
What might the future of deep brain stimulation look like? Not just continuous stimulation, but decoding symptoms in real time and directing stimulation to the right brain circuits. Fascinating perspective article by @andreashorn.org & @julianneumann.bsky.social in @natrevneurol.nature.com:
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Michael Fox @foxmdphd.bsky.social · 24/05/2025
Is there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES
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Lukas Goede @lukasgoede.bsky.social · 22/05/2025
Tremor is a common symptom across many neurological disorders. But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis? We think: yes. Our study is out now in @natcomms.nature.com: 🔗 www.nature.com/articles/s41... 🧵 A thread.
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Lukas Goede @lukasgoede.bsky.social · 19/05/2025
Patient selection for Deep Brain Stimulation (DBS) is crucial. Are there ways to improve it? In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response - and serve as an additional marker for DBS outcomes. doi.org/10.1002/acn3... A thread. 🧵
doi.org
Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge?
Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 P...
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Andreas Horn @andreashorn.org · 12/05/2025
When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal: doi.org/10.1016/j.br...
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Lukas Goede @lukasgoede.bsky.social · 09/04/2025
Follow this interesting study led by @bahnebahners.bsky.social and @andreashorn.org using MEG‑LFP data to investigate cortico‑subthalamic coupling in Parkinson’s disease. The study showed that the optimal DBS response network defined by fMRI operates in the high‑beta band. Happy to be part of it!
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Frederic Schaper @fredschaper.bsky.social · 24/03/2025
Is generalized epilepsy a seizure of the whole brain or a specific brain network? In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome. Paper: nature.com/articles/s41... A 🧵 below:
nature.com
A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications
Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...
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Andreas Horn @andreashorn.org · 21/03/2025
Interested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder? Take a look at our summary of this exciting field and how things could be brought together out now in BPS: www.biologicalpsychiatryjournal.com/article/S000... A brief 🧵
biologicalpsychiatryjournal.com
Deep Brain Stimulation response circuits in Obsessive Compulsive Disorder
In the field of deep brain stimulation (DBS), two major themes are currently making significant progress. First, the framework of connectomic DBS, in which circuits that are associated with improvemen...
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Lukas Goede @lukasgoede.bsky.social · 01/03/2025
Want to learn DBS electrode localization with @lead-dbs.org while being able to verify your results? This new tool from the @netstim.org lab lets you compare your performance against experts. Spearheaded by Savir Madan & @laurenahart.bsky.social
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Lukas Goede @lukasgoede.bsky.social · 15/02/2025
A fantastic resource for science communication: Openly available icons illustrating different Parkinson’s disease symptoms, created by @patriciazvarova.bsky.social with patient feedback. Explore them here: osf.io/ybcah/
osf.io
Illustrated Database of UPDRS-III Items: A Visual Guide for Parkinson’s Disease Motor Assessment
This database provides a set of illustrations representing each item of the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) Part III, facilitating a visual representatio...
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Andrew Pines @andrewpines.bsky.social · 12/02/2025
jamanetwork.com/journals/jam... Thread below👇
jamanetwork.com
Mapping Lesions That Cause Psychosis
This case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit
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Andreas Horn @andreashorn.org · 19/01/2025
Interested in modeling DBS induced white matter activations? Konstantin Butenko has a new preprint on all the options available within OSS-DBS / @lead-dbs.org including Electric Field Projections and probabilistic Pathway Activation Modeling: www.medrxiv.org/content/10.1...
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Andreas Horn @andreashorn.org · 08/01/2025
🚨Interested in Dystonia?🚨 @braincircuits.bsky.social GPi DBS for dystonia is effective. More recently, STN DBS has been investigated, as an alternative. In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks… www.pnas.org/doi/10.1073/...
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Lukas Goede @lukasgoede.bsky.social · 06/01/2025
We report an interesting case of late-onset Pelizaeus-Merzbacher-like disease 1, diagnosed via genetic testing in a patient with decades-long progressive spasticity and tremor. Explore it now in Movement Disorders Clinical Practice! movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com
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Nico Dosenbach @ndosenbach.bsky.social · 02/01/2025
The brain’s action-mode is created by a dedicated action-mode network (AMN) rdcu.be/d5odm. In the brain’s mode continuum, AMN sits opposite DMN’s default-mode, as yin-yang. AMN might be key in pain, apathy, Parkinson’s. New @natrevneurosci.bsky.social w/ Marc Raichle & @gordonneuro.bsky.social 🧵 ⬇️
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Andreas Horn @andreashorn.org · 27/12/2024
New landmark TMS trial dropped by Jonathan Downar's team, which will revolutionize care for depression even more than the SAINT trial did – extensive (10 hour!) sessions of TMS in a single day, enhanced by single dose of cycloserine. 90% response, 70% remission! www.researchgate.net/publication/...
researchgate.net
(PDF) Real-world effectiveness of a single-day regimen for transcranial magnetic stimulation using Optimized, Neuroplastogen-Enhanced techniques in Depression (ONE-D)
PDF | Background: Conventional transcranial magnetic stimulation (TMS) regimens are logistically burdensome, requiring days or weeks of clinic visits.... | Find, read and cite all the research you nee...
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Lukas Goede @lukasgoede.bsky.social · 19/12/2024
Today at noon ET - make sure not to miss these talks about evoked potentials in neuromodulation. Registration is free.
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Network Stimulation Institute @netstim.org · 13/12/2024
Today we say goodbye to @bahnebahners.bsky.social who spent the last year with us as a Thiemann visiting fellow – safe travels, don't be a stranger & thank you so much for bringing so much fun, joy and science into the lab & the @braincircuits.bsky.social!
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Lead-DBS @lead-dbs.org · 10/12/2024
First paper to ever use a 12-year-old feature of Lead-DBS which is to visualize graph networks, implemented still during the PhD of @andreashorn.org and pretty obscure in a tool called lead groupconnectome. Achtzehn et al. on STN-DBS ➔ Cognitive Control: onlinelibrary.wiley.com/doi/10.1002/...
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Andreas Horn @andreashorn.org · 05/12/2024
Showed a glimpse of a new atlas that we're building in Paris yesterday. Pretty excited about it and implications for network modeling.
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Andreas Horn @andreashorn.org · 21/11/2024
Updated DBS starter pack including numerous new folks – @raynorproject.bsky.social @parkinsondotorg.bsky.social welcome to @bsky.app! go.bsky.app/B9A9Cho
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Abhimanyu Mahajan @amahajanmd.bsky.social · 21/11/2024
New to #BlueSky and interested in following people who treat and study movement disorders? #NeuroSky #MedSky #AcademicSky Link (not exhaustive): go.bsky.app/F4ZDiMh
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Lukas Goede @lukasgoede.bsky.social · 21/11/2024
Join us on stimulatingbrains.org! Looking forward to it!
stimulatingbrains.org
Stimulating Brains – A Podcast about Neuromodulation
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Benjamin Stecher @benjaminstecher.bsky.social · 20/11/2024
What an incredible episode of Stimulating Brains from Prof. @andreashorn.org with guests Prof. Susan Boehnke and astronomy CEO Mark McAuley. They covered a lot of important ground from Mark's Parkinson's diagnosis to the challenges he faced getting DBS to.. stimulatingbrains.org/63-mark-mcau...
stimulatingbrains.org
#63: Mark McAuley & Susan Boehnke – Patient-led Research, Patient-Centered Care and Neuroscience Education – Stimulating Brains
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Lukas Goede @lukasgoede.bsky.social · 14/11/2024
Make sure not to miss this session of @stimbrains.bsky.social next Thursday! Free registration link attached.
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Sara Larivière @saratheriver.bsky.social · 12/11/2024
We’re still looking for one more MSc or PhD student to join our lab @USherbrooke! 🇨🇦 Canadian students can start as early as January! We have many ongoing projects in neuroimaging of epilepsy and early brain development. More info here 👉🏼👉🏽👉🏾 slic-lab.github.io
slic-lab.github.io
Sherbrooke Laboratory for Integrative Connectomics | SLIC
Exploring cutting-edge research in neuroimaging, epilepsy, brain development, and so much more!
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Andreas Horn @andreashorn.org · 13/11/2024
Upon popular demand I created a started pack for people interested in Deep Brain Stimulation! Lmk if you'd like to be added! go.bsky.app/B9A9Cho
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Abhimanyu Mahajan @amahajanmd.bsky.social · 13/11/2024
Movement disorders starter pack. Hopefully not exhaustive. Please spread the word and expand this group. go.bsky.app/F4ZDiMh
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Bahne Bahners @bahnebahners.bsky.social · 11/11/2024
🚨🥁Preprint alert: #DBS Programming is currently a tedious trial and error process that involves testing many settings – each time asking the patient to perform motor tasks to see how things improve. Could we use DBS-#evokedpotentials to guide programming?doi.org/10.1101/2024.1…
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Andrew Pines @andrewpines.bsky.social · 12/11/2024
Super cool work, @lukasgoede.bsky.social and @bahnebahners.bsky.social ! Since tweetorial seems outdated, want to do a skydive into your paper?
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Lukas Goede @lukasgoede.bsky.social · 11/11/2024
Great to see more people joining BlueSky! I’ll be more active here too, starting off with our latest preprint on a novel approach using DBS-evoked potentials to streamline and enhance DBS programming. www.medrxiv.org/content/10.1...
medrxiv.org
Evoked response signatures explain deep brain stimulation outcomes
Deep brain stimulation (DBS) is an established treatment for Parkinson’s disease. Still, DBS parameter programming currently follows a tedious trial-and-error process. DBS-evoked cortical potentials (...
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