iiinova — where your digital self keeps evolving

Reposted by Anthony Mathelier

EMBL-EBI @ebi.embl.org · 11/09/2026

Cancer research will shift from tracking how tumors grew to predicting how they will evolve in the future. Here is how our Research Group Leader @timcoorens.bsky.social sees the field evolving over the next 25 years. www.nature.com/articles/s41... #CancerResearch

041

Anthony Mathelier @amathelier.bsky.social · 17/08/2026

Exciting news! We've just moved into the brand new Livsvitenskapsbygningen (Life Science Building) in Oslo, with the whole @ncmbm.bsky.social! Incredible space, great views, and so many opportunities for collaboration ahead. 🧬🏢 @uio.no #LifeScience #Oslo #LVB

0141

Anthony Mathelier @amathelier.bsky.social · 06/08/2026

Thanks @flowerwhatelse.bsky.social . We processed the data as soon as we saw it a a preprint a long time ago 😄

020

Reposted by Anthony Mathelier

Evangelia Petsalaki @epetsalaki.bsky.social · 02/07/2026

Can GNNs really learn biology, or just graph topology? Our new preprint shows that GNNs predict gene essentiality better only when using real biological interaction networks. Biological network organization, not generic graph topology, drives prediction. www.biorxiv.org/content/10.6...

173

Reposted by Anthony Mathelier

EMBL @embl.org · 24/06/2026

For over 50 years, EMBL has led breakthroughs in European life sciences. Now, we are among those leading the AI revolution in biology. Powered by the passion of multidisciplinary experts, we integrate AI throughout our work and transform life’s complexity into new possibilities. #EMBL_AI

1182

Reposted by Anthony Mathelier

Michael Sars Centre @msarscentre.bsky.social · 04/06/2026

For our first #MSS2026 session after lunch, the focus was on digitizing gene regulation 💻 Three fantastic talks from Anthony Mathelier @amathelier.bsky.social @ncmbm.bsky.social, Boris Lenhard @borislenhard.bsky.social and Tom Michoel from @cbubergen.bsky.social 👏

061

Anthony Mathelier @amathelier.bsky.social · 04/06/2026

Glad to attend and speak at the Michael Sars Symposium 2026 #MSS2026 co-organized by @msarscentre.bsky.social and Computational Biology Unit, Bergen at University of Bergen. Looking forward to a great day of science. @ncmbm.bsky.social @embl.org @nordicembl.bsky.social

081

Anthony Mathelier @amathelier.bsky.social · 01/06/2026

🎉 The CBGR group turns 10! We just celebrated with collaborators, colleagues, friends & family. This milestone belongs to everyone involved; too many to name, but every single one of you made it happen. 🙏 Here's to the next 10 years! 🥂 @uio.no @nordicembl.bsky.social @ncmbm.bsky.social

052

Reposted by Anthony Mathelier

EACR - European Association for Cancer Research @helloeacr.bsky.social · 25/05/2026

Discover exciting new publications in the latest edition of Highlights in Cancer Research! Our Highlights in Cancer Research is a summary of the most interesting & impactful papers in cancer research, curated by the EACR Board. Read more in The Cancer Researcher: magazine.eacr.org/highlights-i...

053

Reposted by Anthony Mathelier

Mathieu Lupien @matlupien.bsky.social · 11/05/2026

Upcoming cancer epigenetics conference in Paris (Oct 13-16, 2026). Consider registering: www.atoutcom.com/cancer-epige...

atoutcom.com

Cancer Epigenetics

073

Reposted by Anthony Mathelier

Maxim Greenberg @maxvcg.bsky.social · 01/05/2026

This a very important, and extremely well-executed study from Ralph Grand’s group @uniheidelberg.bsky.social. Congrats to all the authors! www.biorxiv.org/content/10.6...

614643

Reposted by Anthony Mathelier

Rob Waterhouse @rmwaterhouse.bsky.social · 22/04/2026

ELIXIR - Europe's distributed research infrastructure for life science data - is recruiting a new Director elixir-europe.org/news/directo...

elixir-europe.org

ELIXIR Board initiates recruitment for new Director | ELIXIR

032

Reposted by Anthony Mathelier

Michael Sars Centre @msarscentre.bsky.social · 22/04/2026

Have you registered yet for #MSS2026? Join us to hear @amathelier.bsky.social from @ncmbm.bsky.social share his team’s latest work mapping transcription factor-DNA interactions across species, and much more 👏 We look forward to seeing you there! ➡️ tinyurl.com/JoinMSS2026 @cbubergen.bsky.social

063

Reposted by Anthony Mathelier

Nuria Lopez-Bigas @nlbigas.bsky.social · 15/04/2026

Tumor promotion through the lens of evolution This review grew out of many long conversations, shared ideas, and lively discussions It has been a real pleasure to think together with Allan, Paul, Eve, and Abel about how tumours develop and how carcinogens shape cancer risk rdcu.be/fdC2J

rdcu.be

Tumour promotion through the lens of evolution

Nature - This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable...

13314

Anthony Mathelier @amathelier.bsky.social · 14/04/2026

Very happy to land in beautiful Bergen to attend the ELIXIR Norway annual All Hands Meeting @elixir-europe.org. Three exciting days ahead discussing ELIXIR Norway's contributions to support life science researchers with bioinformatics services, data management tools, and secure e-infrastructure.

070

Anthony Mathelier @amathelier.bsky.social · 19/03/2026

Proud to have taken a part of this great work!

100

Reposted by Anthony Mathelier

Chymkowitch lab @chymkowitchlab.bsky.social · 19/03/2026

Excited to share that our latest research has been published in @narjournal.bsky.social Read the article here: academic.oup.com/nar/article/... Congratulations to Patrizia Nothnagel and many thanks to all people involved including Nolwenn Briand, Bjørn Steen Skålhegg and @amathelier.bsky.social.

academic.oup.com

Validate User

351

Anthony Mathelier @amathelier.bsky.social · 03/03/2026

👇 Still a couple of days to apply to join our amazing team as a Research Scientist / Software Developer. Apply if you want to build and maintain reproducible pipelines for large-scale genomic analysis to support our study of breast cancer cis-regulatory signatures and JASPAR, among other things.

022

Anthony Mathelier @amathelier.bsky.social · 19/02/2026

The TFBS tracks for 8 species using JASPAR 2026 TF binding profiles are now available as native tracks on the UCSC genome browser @genomebrowser.bsky.social ! genome.ucsc.edu/goldenPath/n...

genome.ucsc.edu

UCSC Genome Browser: News Archives

020

Reposted by Anthony Mathelier

Alex Palazzo @ribonucleicacids.bsky.social · 13/02/2026

Ever notice that when one gene is disrupted, its orthologs get upregulated? This phenomenon, known as transcriptional adaptation, has been controversial and mysterious - glad to see that we are starting to learn how it works.

science.org

Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation

Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...

25117

Anthony Mathelier @amathelier.bsky.social · 12/02/2026

📢 Hiring! Our group @ncmbm.bsky.social seeks a Research Scientist contributing to: • Reproducible pipelines for large-scale genomics • cisreg signature analysis in breast cancer • Continued development of JASPAR • Cross-disciplinary collaboration Apply now 👉 www.jobbnorge.no/en/available...

078

Anthony Mathelier @amathelier.bsky.social · 10/02/2026

Looking forward to two days of talks and discussions around research and innovation in Life Science in Norway! @uio.no

030

Anthony Mathelier @amathelier.bsky.social · 07/02/2026

Let's get in touch then to see how/if it would work

100

Anthony Mathelier @amathelier.bsky.social · 07/02/2026

Let me know if you plan to come to Oslo/Norway.

100

Anthony Mathelier @amathelier.bsky.social · 02/02/2026

Looking forward to participating in this symposium! Thanks for the invitation.

010

Reposted by Anthony Mathelier

Aaron Quinlan (he/him) @aaronquinlan.bsky.social · 02/12/2025

We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen. 1/n

quinlanlab.org

Intro to Bedder – The Quinlan Lab

5298151

Reposted by Anthony Mathelier

Žiga Avsec @avsecz.bsky.social · 28/01/2026

AlphaGenome is out in @nature.com today along with model weights! 🧬 📄 Paper: www.nature.com/articles/s41... 💻 Weights: github.com/google-deepm... Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc

48740

Reposted by Anthony Mathelier

Sushmita Roy @sroyyors.bsky.social · 27/01/2026

Thanks to @ferhatay.bsky.social and Aly Khan, we’re excited to announce a new chapter for RECOMB-RSG 2026. After years with ISCB/DREAM, we are transitioning to an official RECOMB satellite meeting (May 25 in Thessaloniki). recomb-rsg.github.io

recomb-rsg.github.io

RECOMB-RSG 2026 | Regulatory Genomics Satellite

144

Anthony Mathelier @amathelier.bsky.social · 28/01/2026

RECOMB-RSG 2026 Deadline: Feb 15. Tracks for: Preprints, Highlights (Recent Papers), Lightning talks Details: recomb-rsg.github.io 3/3

recomb-rsg.github.io

RECOMB-RSG 2026 | Regulatory Genomics Satellite

000

Anthony Mathelier @amathelier.bsky.social · 28/01/2026

This move supports a "discussion-first" format. As the field moves toward complex genomics and system-level integration, the community needs a venue designed for deep technical exchange and diverse perspectives. 2/3

100

Anthony Mathelier @amathelier.bsky.social · 28/01/2026

Excited to see the upcoming new chapter for RECOMB-RSG 2026. After years with ISCB/DREAM, it is transitioning to an official RECOMB satellite meeting (May 25 in Thessaloniki). recomb-rsg.github.io 1/3

recomb-rsg.github.io

RECOMB-RSG 2026 | Regulatory Genomics Satellite

111

Reposted by Anthony Mathelier

Ming Tommy Tang @tommytang.bsky.social · 24/01/2026

You swear at the code. You’re sure the computer’s being stupid. But it’s not the computer. It never was. 🧵

131

Reposted by Anthony Mathelier

Jason Moore @moorejh.bsky.social · 22/01/2026

Took this photo 12 years ago

1204

Anthony Mathelier @amathelier.bsky.social · 20/01/2026

inMOTIFin is a modular, user‑friendly Python toolkit for simulating and modifying regulatory DNA sequences. The code is open‑source via PyPI and Docker, with comprehensive docs. academic.oup.com/bioinformati...

academic.oup.com

inMOTIFin: a lightweight end-to-end simulation software for regulatory sequences

AbstractSummary. The accurate development, assessment, interpretation, and benchmarking of bioinformatics frameworks for analyzing transcriptional regulato

010

Anthony Mathelier @amathelier.bsky.social · 20/01/2026

inMOTIFin is now published in Bioinformatics! 🎉 It lets you generate random sequences and TF motifs, and insert motif instances with custom spacing, co‑occurrence and orientation. Use cases for de novo motif discovery, cooperative TF binding, and DL explainability. academic.oup.com/bioinformati...

academic.oup.com

inMOTIFin: a lightweight end-to-end simulation software for regulatory sequences

AbstractSummary. The accurate development, assessment, interpretation, and benchmarking of bioinformatics frameworks for analyzing transcriptional regulato

161

Reposted by Anthony Mathelier

David Suter @davidsuter.bsky.social · 14/01/2026

Start your independent as an ELISIR fellow right after your PhD, in one of the most terrific places in Europe !

01611

Anthony Mathelier @amathelier.bsky.social · 14/01/2026

Some interesting points raised here. I'm personally in favor of applications to be evaluated for soundness and feasibility, followed by lottery. Point of no returns: researchers are crossing a threshold in the fight for funding www.nature.com/articles/d41...

nature.com

Client Challenge

000

Anthony Mathelier @amathelier.bsky.social · 12/01/2026

Recognition as an @elixir-europe.org Core Data Resource reinforces JASPAR’s role as a trusted, FAIR reference for TF-based gene regulation research. Proud of this achieved milestone. A big thanks to all collaborators over the years and to the community.

060

Reposted by Anthony Mathelier

Jonathan Pritchard @jkpritch.bsky.social · 23/09/2024

Two new chapters from my free online book in human genetics out this weekend! These complete Part 3 of the book, on human population structure and history: 3.3: Human prehistory [separate thread] 3.4: Ancient DNA: a genetic time capsule [this thread] web.stanford.edu/group/pritch...

web.stanford.edu

An Owner's Guide to the Human Genome

514864

Reposted by Anthony Mathelier

Job Dekker @jobdekker.bsky.social · 17/12/2025

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...

nature.com

An integrated view of the structure and function of the human 4D nucleome - Nature

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...

211055

Reposted by Anthony Mathelier

European Conference on Computational Biology @eccb-europe.bsky.social · 03/11/2025

📣 The call for tutorials & workshops at #ECCB2026 is now open! Share your tools, methods or expertise with the community. 🗓️ Deadline: 5 January 2026 👉 Submit: tinyurl.com/tw-eccb26 💡 ECCB will take place on 31 Aug–4 Sept in Geneva, gathering 1,000+ scientists from academia, industry, & healthcare.

01915

Reposted by Anthony Mathelier

Damir Baranasic @da-bar.bsky.social · 03/12/2025

JASPAR 2026 is out 🎉 The new release massively expands the TF motif collections and adds a dedicated DeepLearning collection of motifs learned from deep learning models. Database: jaspar.elixir.no Paper (NAR): doi.org/10.1093/nar/... 🧵1/2

jaspar.elixir.no

JASPAR: An open-access database of transcription factor binding profiles

JASPAR is the largest open-access database of curated and non-redundant transcription factor (TF) binding profiles from six different taxonomic groups.

16328

Reposted by Anthony Mathelier

Damir Baranasic @da-bar.bsky.social · 03/12/2025

Glad to have contributed to this work, and big thanks to @amathelier.bsky.social, @damlaob.bsky.social, and @ievarau.bsky.social (and the whole JASPAR crew) for this great effort. #JASPAR #TFmotifs #DeepLearning #Genomics 🧵2/2

062