Reposted by Alex TonksRhys Morgan @rhysmorganlab.bsky.social · 30/09/2025Very grateful to have been awarded our first @bloodcanceruk.bsky.social research grant over the summer for our work targeting aberrant Wnt/β-catenin signalling in acute myeloid leukaemia (AML). Our new project headed by Dr Wagstaff begins Oct 1st developing new ways to target oncogenic β-catenin 👊 2112
Reposted by Alex TonksRhys Morgan @rhysmorganlab.bsky.social · 16/04/2025Couldn't recommend this PhD highly enough! Go join an exciting new young PI doing some super interesting/translational leukaemia research. 111
Reposted by Alex TonksAlan Parker @alanlparker.bsky.social · 27/01/2025Fantastic to see significant investment in health and social care research in Wales. Excited & proud to co-lead a new £3M Wales Applied Virology Unit with @richstanton.bsky.social and David Gillespie - impactful research ahead #Virology #Unit #Research healthandcareresearchwales.org/about/news/m...healthandcareresearchwales.orgHealth and Care Research Wales announces major £49m investment in research infrastructureHealth and Care Research Wales announces major £49m investment in research infrastructure 161
Reposted by Alex TonksProf Tom Cotter @proftomcotter.bsky.social · 15/01/2025Early-career researchers describe how they juggled workloads, emotions and finances after having children. Todays issue of Nature 🧪 082
Reposted by Alex TonksWilliam (Bill) Grey @billgrey.bsky.social · 14/01/2025Please share our new PhD position: We are looking for a data scientists to work on leukaemia models of #AML and cancer stem cells or #LSCs. This mixes wet and dry lab and aims to replace animals in research by developing new in vitro tools. tinyurl.com/6rfan796 tinyurl.com/fmys7caytinyurl.comMulti-omic analysis of human blood cancer stem cells to develop new predictive tools, and develop novel culture systems at University of York on FindAPhD.comPhD Project - Multi-omic analysis of human blood cancer stem cells to develop new predictive tools, and develop novel culture systems at University of York, listed on FindAPhD.com 174
Reposted by Alex TonksChristian Frezza @frezzalab.bsky.social · 06/01/2025Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation | EMBO reports www.embopress.org/doi/full/10....embopress.orgPro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation | EMBO reportsimageimageA reduction in oxidation phosphorylation is considered to be a hallmark of pro-inflammatory macrophage polarization. This study shows that respiratory inhibition is not required for macropha... 03313
Reposted by Alex TonksGuillaume Bossis @guillaumebo6.bsky.social · 07/01/2025We are hiring a post-doc to study SUMOylation in leukemias @igmm-montpel.bsky.social Apply here: emploi.cnrs.fr/Offres/CDD/U...emploi.cnrs.fr Portail Emploi CNRS - Offre d'emploi - Post-doctorant chimioresistance des leucémies aigues et SUMOylation (H/F) 074
Reposted by Alex TonksAlessandro Donada @alessandrodonada.bsky.social · 03/01/2025This is the most accessible explanation I have ever read on FDR. 👏👏 👏 121
Reposted by Alex TonksMing Tommy Tang @tommytang.bsky.social · 02/01/2025Chatomics! Testing 10,000 genes at once? 🧬 If you’re relying on p-values alone, you’re probably drowning in false positives. Let’s talk about FDR and q-values—the smarter way to analyze your results. 195
Reposted by Alex TonksWolfgang Huber @wkhuber.bsky.social · 03/01/2025How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3) doi.org/10.1038/s415...doi.orgAnalysis of multi-condition single-cell data with latent embedding multivariate regression - Nature GeneticsLatent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ... 724692
Reposted by Alex TonksAlan Parker @alanlparker.bsky.social · 02/01/2025Announcement 📣 REGISTRATION IS LIVE!! If you plan to join us in Cardiff for #IAMXVI then do register ASAP as places are limited! Do note the early bird deadline is 1 Feb! See you in #Cardiff in July #virology #adenovirus #meeting www.eventsforce.net/cbs/frontend...eventsforce.net 021
Reposted by Alex TonksMick Milsom @milsommick.bsky.social · 30/12/2024Check out our new review in @isehsociety.bsky.social journal Experimental Hematology, asking the question: to what degree is HSC dysfunction responsible for hematologic aging www.exphem.org/article/S030...exphem.orgDEFINE_ME 0217
Reposted by Alex TonksEuropean Cancer Stem Cell Research Institute @ecscri.bsky.social · 20/12/2024The strategy of the European Cancer Stem Cell Research Institute is to translate our cutting-edge research into novel therapies. We welcome the opportunity to host academic and clinical researchers whose interests align with the focus of ECSCRI. 031
Reposted by Alex TonksPOG Research @pogresearch.bsky.social · 11/12/2024We are hiring!! We are looking for a research assistant/ associate to get involved in an EPSRC Programme Grant that aims to engineer an in vitro bone marrow niche to control stem cell regulation, metastatic evolution and cancer dormancy eur03.safelinks.protection.outlook.com?url=https%3A...eur03.safelinks.protection.outlook.com' 142
Reposted by Alex TonksDavid Kent @kentlab.bsky.social · 20/12/2024Two upcoming meetings for your 2025 diaries: EHA Research Conference (ReCon) - Malaga 17-20 March ehaweb.org/meetings/eha... @isehsociety.bsky.social ISEH Annual Meeting - Kumamoto 24-27 Sept www.iseh.org/page/iseh2025 and for HSC biologists in Europe...hold November 13-15th 2025 too.... !ehaweb.orgEHA Research Conference 2025Dates: March 17-20, 2025Location: Málaga, SpainChairs: Alba Maiques Diaz, Ruud Delwel, Panagiotis Ntziachristos, Marcus Buschbeck, Mark Dawson, Özgen Deniz, Kimberly Stegmaier, and Nina Cabezas Wallsc... 093
Alex Tonks @alextonks.bsky.social · 16/12/2024Great opportunity here 👇 if looking for a PhD project in great lab 010
Reposted by Alex TonksNewcastle University Centre for Cancer @nucancer.bsky.social · 20/11/2024We are one of just 7 UK cancer centres that are contributing to the CRUK Black Leaders in Cancer PhD Scholarship Programme. We have 10 exciting projects on offer to eligible candidates of Black heritage backgrounds. Read more about the scheme and what we have on offer www.ncl.ac.uk/cancer/train...ncl.ac.ukCRUK Black Leaders PhD Scholarship | Centre for Cancer | Newcastle University 0104
Alex Tonks @alextonks.bsky.social · 16/12/2024Introducing my Generation Z students to the save button in reality! You don’t want to know what they thought the 5.25 disk was 070
Reposted by Alex TonksProf Tom Cotter @proftomcotter.bsky.social · 14/12/2024A student of mine was very concerned by a news report saying the relative risk of a particular type of brain cancer had gone up by 50% When I looked at the absolute risk it went from 4 to 6 per 100,000. Told him not to worry. People have trouble dealing with absolute v relative risk!🧪 4355
Reposted by Alex TonksAndi Roy @roylab-oxford.bsky.social · 15/12/2024Registration and abstract submission is now open for this EMBO Childhood Leukaemia workshop that I am excited to help organise. See you in Kolkata!!meetings.embo.orgMolecular Basis and Mechanisms of Therapy Personalisation in Paediatric LeukaemiaOnly in the last decade have clinicians in India, with support from colleagues from the west, organized to develop multi-centre modern protocols for children with acute leukaemia. These protocols inc… 095
Reposted by Alex TonksKate Sears @katesears.bsky.social · 06/12/2024At #ASH24, sharing this terrific article on social media at medical conferences from @mtmdphd.bsky.social @rubenmesamd.bsky.social @bldcancerdoc.bsky.social #NaveenPemmaraju👇👇👇 pubmed.ncbi.nlm.nih.gov/29153078/pubmed.ncbi.nlm.nih.govThe use and impact of Twitter at medical conferences: Best practices and Twitter etiquette - PubMedThe use of social media, and in particular, Twitter, for professional use among healthcare providers is rapidly increasing across the world. One medical subspecialty that is leading the integration of... 1196
Alex Tonks @alextonks.bsky.social · 03/12/2024Tonks lab Christmas party! Shuffle board and ice free curling. Well done Rosie squared and for slaying the boys. Thanks to Owen Hughes for organising 141
Alex Tonks @alextonks.bsky.social · 02/12/2024Glorious sunny morning discussing leukaemia and new therapies for AML for students at Bath University. Thanks to Zoe Burke for the invite. #AML #inspiringnextgen 060
Reposted by Alex TonksMick Milsom @milsommick.bsky.social · 27/11/2024First post on BSky and I'm going to use it to promote the outstanding line up of faculty that we've managed to put together for #ISEH2025 in Kumamoto, Japan (with more to come). Save the date: lots of space reserved in the program for you to present your exciting science! Link below. 03618
Reposted by Alex TonksChristian Frezza @frezzalab.bsky.social · 26/11/2024Unraveling lipid metabolism for acute myeloid leukemia... : Current Opinion in Hematology 🧪 journals.lww.com/co-hematolog...journals.lww.comUnraveling lipid metabolism for acute myeloid leukemia... : Current Opinion in Hematologyman leukemia, particularly highlighting work in leukemic stem cells (LSCs), where lipids were assessed directly as a metabolite. Recent findings Lipid metabolism is essential to support LSC functio... 083
Reposted by Alex TonksRhys Morgan @rhysmorganlab.bsky.social · 25/11/2024Very excited to hosting Dr Sophie Kellaway from @uniofnottingham.bsky.social Medical School for the @sussexuni.bsky.social School of Life Sci Biochem & Biomed seminar this Fri 29th Nov. Her seminar will be on her research targeting transcriptional dysregulation in AML. GDSC seminar room 14-15.00. 021
Reposted by Alex TonksBrent Stockwell @brentstockwell.bsky.social · 22/11/2024Our perspective in Science Magazine on #Ferroptosis—#disease perils and #therapeutic promise www.science.org/doi/10.1126/... written for a general audience -- not too technical. Congrats to authors Ashley Brown and Tal Hirschhorn!science.orgFerroptosis—disease perils and therapeutic promiseMechanisms of iron-dependent cell death reveal potential new targets for disease treatment 39620
Reposted by Alex TonksProf Claire Hills @chillslincoln79.bsky.social · 23/11/2024Atlas of the plasma proteome in health and disease in 53,026 adults 👩🔬🥼👨🔬🧪. #proteomics #proteome #plasma #MedSky 👇👇 www.cell.com/cell/fulltex...cell.comAtlas of the plasma proteome in health and disease in 53,026 adultsA large-scale proteomics study involving 53,026 individuals maps 2,920 plasma proteins to 406 prevalent diseases, 660 incident diseases, and 986 health-related traits, identifying promising biomarkers... 1112756
Alex Tonks @alextonks.bsky.social · 23/11/2024Humbling to only have 1 follower! knew I could count on @rhysmorganlab.bsky.social. 141