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Kate Sears

@katesears.bsky.social
1.7K followers 867 following 516 posts

Hi I'm Kate, community lead for Open Medicine. We make expert medical knowledge easy to access so clinicians can offer the best treatment for their patients. myopenmedicine.com

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Kate Sears @katesears.bsky.social · 17h
Management of Platinum-Resistant and Later-Line Ovarian Cancer algorithm from @drkatymoore.bsky.social: myopenmedicine.com/algorithms/m...
myopenmedicine.com
Management of Platinum-Resistant and Later-Line Ovarian Cancer
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Kate Sears @katesears.bsky.social · 29/09/2026
Molecular Testing for Pancreatic Cancer algorithm from @mpishvaian.bsky.social: myopenmedicine.com/algorithms/m...
myopenmedicine.com
Molecular Testing for Pancreatic Cancer
Molecular testing for pancreatic cancer at first visit and within the first 2-4 weeks.
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Kate Sears @katesears.bsky.social · 28/09/2026
Post–EV + Pembrolizumab Treatment Advanced Urothelial Carcinoma algorithm from @drnataliagandur.bsky.social: myopenmedicine.com/algorithms/p...
myopenmedicine.com
Post–EV + Pembrolizumab Treatment Advanced Urothelial Carcinoma
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Kate Sears @katesears.bsky.social · 25/09/2026
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Kate Sears @katesears.bsky.social · 24/09/2026
Second relapse multiple myeloma from @vincentrk.bsky.social:
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Kate Sears @katesears.bsky.social · 23/09/2026
Treatment of Myeloma: First Relapse from @vincentrk.bsky.social:
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Kate Sears @katesears.bsky.social · 22/09/2026
Comprehensive thoracic solid tumor staging and treatment options algorithm from Prof. Andrea Bille at Guy's and St Thomas' NHS Trust: myopenmedicine.com/algorithms/c...
myopenmedicine.com
Comprehensive thoracic solid tumor staging and treatment options
Lung cancer management based on TNM staging, where early-stage (I–II) disease is primarily treated with surgical resection (with possible adjuvant therapy), while more advanced stages (III–IV) incorpo...
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Kate Sears @katesears.bsky.social · 21/09/2026
RET fusion–positive NSCLC: evolving adjuvant and metastatic targeted therapies from Dr. Gilberto Lopes at Sylvester Cancer Center: myopenmedicine.com/algorithms/r...
myopenmedicine.com
RET fusion–positive NSCLC: evolving adjuvant and metastatic targeted therapies
The metastatic portion is broadly aligned with current standards: comprehensive RET fusion testing at diagnosis and first-line selective RET inhibition (selpercatinib or pralsetinib) is guideline-conc...
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Kate Sears @katesears.bsky.social · 18/09/2026
Universal Germline Genetic Testing in Prostate Cancer algorithm from Dr. Neal Shore at Atlantic Urology Clinics: myopenmedicine.com/algorithms/u...
myopenmedicine.com
Universal Germline Genetic Testing in Prostate Cancer
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Kate Sears @katesears.bsky.social · 17/09/2026
Low Risk and Favorable Intermediate Risk for Prostate Cancer algorithm from @tylersbrt.bsky.social: myopenmedicine.com/algorithms/l...
myopenmedicine.com
Low Risk and Favorable Intermediate Risk for Prostate Cancer
Selection and follow-up for men with low-risk and select favorable intermediate-risk prostate cancer. Tyler Seibert, MD, PhD, Genitourinary Section Chief at UC San Diego Radiation Oncology outlines cr...
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Kate Sears @katesears.bsky.social · 16/09/2026
Surgery for thymic tumor algorithm from Prof. Andrea Bille at Guy's and St. Thomas' NHS Foundation Trust: myopenmedicine.com/algorithms/s...
myopenmedicine.com
Surgery for thymic tumour
Stage-based management of thymic tumors, emphasizing complete surgical resection (via VATS/RATS or open thymectomy) for early stages, with increasing need for en bloc resection of involved structures ...
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Kate Sears @katesears.bsky.social · 15/09/2026
IBCG Risk Stratification Model for Intermediate-Risk NMIBC algorithm from Dr. Ashish Kamat: myopenmedicine.com/algorithms/i...
myopenmedicine.com
IBCG Risk Stratification Model for Intermediate-Risk NMIBC
Intermediate-Risk Non–Muscle-Invasive Bladder Cancer (IR NMIBC) Risk Stratification Model by the International Bladder Cancer Group (IBCG).
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Kate Sears @katesears.bsky.social · 14/09/2026
Newly Diagnosed Myeloma algorithm from @vincentrk.bsky.social: myopenmedicine.com/algorithms/n...
myopenmedicine.com
Newly Diagnosed Myeloma
Treatment algorithm for newly diagnosed myeloma patients.  Dr. Rajkumar is a contributing editor to the International Myeloma Foundation (https://www.myeloma.org/frontline-treatment-options).Watch Dr....
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Kate Sears @katesears.bsky.social · 11/09/2026
Gastric, Gastroesophageal Junction (GEJ) and Esophageal Adenocarcinoma algorithm from Dr. Yelena Janjigian at @mskcancercenter.bsky.social: myopenmedicine.com/algorithms/g...
myopenmedicine.com
Gastric, Gastroesophageal Junction (GEJ) and Esophageal Adenocarcinoma
Treatment algorithm for Gastric, Gastroesophageal Junction (GEJ) and Esophageal Adenocarcinoma by Yelena Y. Janjigian, MD, FASCO, Chief, Gastrointestinal Oncology Service at Memorial Sloan Kettering C...
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Kate Sears @katesears.bsky.social · 10/09/2026
Localized and metastatic primary malignant bone sarcoma algorithm from Dr. Michael Wagner at @mdanderson.bsky.social: myopenmedicine.com/algorithms/l...
myopenmedicine.com
Localized and metastatic primary malignant bone sarcoma
The algorithm is broadly aligned with contemporary management of primary malignant bone sarcomas: referral to a sarcoma center, histology-driven pathways, multimodality therapy for osteosarcoma and Ew...
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Kate Sears @katesears.bsky.social · 09/09/2026
Molecular Testing for Pancreatic Cancer algorithm freom @mpishvaian.bsky.social: myopenmedicine.com/algorithms/m...
myopenmedicine.com
Molecular Testing for Pancreatic Cancer
Molecular testing for pancreatic cancer at first visit and within the first 2-4 weeks.
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Reposted by Kate Sears
Open Medicine @openmedicine.bsky.social · 08/09/2026
Metastatic Triple-Negative Breast Cancer Treatment algorithm from Dr. Samantha El Warrak at Sylvester Cancer Center: myopenmedicine.com/algorithms/m...
myopenmedicine.com
Metastatic Triple-Negative Breast Cancer Treatment
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Kate Sears @katesears.bsky.social · 07/09/2026
Smoldering Myeloma algorithm from @vincentrk.bsky.social: myopenmedicine.com/algorithms/s...
myopenmedicine.com
Smoldering Myeloma
Dr. Rajkumar's video walk through. Treatment algorithm for smoldering myeloma. Incorporates the 2025 Daratumumab FDA approval for high risk smoldering myeloma. Active drugs in multiple myeloma referen...
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Kate Sears @katesears.bsky.social · 04/09/2026
Stage I Testicular Germ Cell Tumors After Orchiectomy: Surveillance, Adjuvant Therapy, and Risk-Adapted Follow-Up algorithm from @drnataliagandur.bsky.social: myopenmedicine.com/algorithms/s...
myopenmedicine.com
Stage I Testicular Germ Cell Tumors After Orchiectomy: Surveillance, Adjuvant Therapy, and Risk-Adapted Follow-Up
This algorithm is broadly aligned with contemporary stage I testicular GCT management: confirm true clinical stage I with appropriate post-orchiectomy marker kinetics and imaging, then select surveill...
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Kate Sears @katesears.bsky.social · 03/09/2026
Stage I–III Non-Small Cell Lung Cancer Treatment algorithm from @janichinmay.bsky.social and Dr. Gilberto Lopes: myopenmedicine.com/algorithms/s...
myopenmedicine.com
Stage I–III Non-Small Cell Lung Cancer Treatment
The algorithm is broadly aligned with current management of stage I–IIIB NSCLC: guideline-concordant diagnostic workup, surgery or SBRT for early-stage disease, biomarker-driven adjuvant targeted ther...
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Kate Sears @katesears.bsky.social · 02/09/2026
Management of Platinum-Sensitive Recurrent Ovarian Cancer algorithm from @drkatymoore.bsky.social: myopenmedicine.com/algorithms/m...
myopenmedicine.com
Management of Platinum-Sensitive Recurrent Ovarian Cancer
The algorithm is broadly aligned with contemporary management of platinum-sensitive recurrent epithelial ovarian cancer: use of platinum-based combinations, consideration of secondary cytoreductive su...
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Kate Sears @katesears.bsky.social · 01/09/2026
Belzutifan Practical Guidance in Advanced Clear-Cell RCC algorithm from @drchoueiri.bsky.social: myopenmedicine.com/algorithms/b...
myopenmedicine.com
Belzutifan Practical Guidance in Advanced Clear-Cell RCC
This belzutifan-focused pathway is broadly aligned with current evidence and labeling for advanced/metastatic ccRCC after prior PD-(L)1 inhibitor and VEGF-targeted therapy, centering on LITESPARK-005 ...
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Kate Sears @katesears.bsky.social · 31/08/2026
TALAPRO-2: Talazoparib + Enzalutamide in HRR-Altered First-Line mCRPC algorithm from @neerajagarwal.bsky.social: myopenmedicine.com/algorithms/t...
myopenmedicine.com
TALAPRO-2: Talazoparib + Enzalutamide in HRR-Altered First-Line mCRPC
The algorithm is broadly aligned with contemporary mCRPC management: maintain ADT, perform HRR (germline/somatic) testing early, and consider PARP inhibitor combinations for HRR-altered disease. Place...
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Kate Sears @katesears.bsky.social · 27/08/2026
Early and Advanced Triple Negative Breast Cancer (TNBC) from @ilanaschlam.bsky.social: myopenmedicine.com/algorithms/e...
myopenmedicine.com
Early and Advanced Triple Negative Breast Cancer (TNBC)
The algorithm is broadly aligned with contemporary TNBC practice: neoadjuvant pembrolizumab plus chemotherapy for high-risk early TNBC; adjuvant escalation strategies for residual disease including ca...
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Kate Sears @katesears.bsky.social · 26/08/2026
TALAPRO-3: Talazoparib + Enzalutamide + ADT in HRR-Altered mCSPC from @neerajagarwal.bsky.social: myopenmedicine.com/algorithms/t...
myopenmedicine.com
TALAPRO-3: Talazoparib + Enzalutamide + ADT in HRR-Altered mCSPC
The algorithm is broadly aligned with current mCSPC practice in emphasizing ADT as backbone therapy, recommending treatment intensification, and incorporating germline/somatic testing to guide therapy...
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Kate Sears @katesears.bsky.social · 25/08/2026
PSMA-Positive mHSPC: Integrating Lu-177 Vipivotide Tetraxetan With ADT + ARPI algorithm from Prof. Arun Azad: myopenmedicine.com/algorithms/p...
myopenmedicine.com
PSMA-Positive mHSPC: Integrating Lu-177 Vipivotide Tetraxetan With ADT + ARPI
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Kate Sears @katesears.bsky.social · 24/08/2026
Newly Diagnosed Myeloma from @vincentrk.bsky.social: myopenmedicine.com/algorithms/n...
myopenmedicine.com
Newly Diagnosed Myeloma
Treatment algorithm for newly diagnosed myeloma patients.  Dr. Rajkumar is a contributing editor to the International Myeloma Foundation (https://www.myeloma.org/frontline-treatment-options).
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Kate Sears @katesears.bsky.social · 29/07/2026
Primary Plasma Cell Leukemia algorithm from Dr. Samer Al Hadidi: myopenmedicine.com/algorithms/p...
myopenmedicine.com
Primary Plasma Cell Leukemia
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Kate Sears @katesears.bsky.social · 21/07/2026
Newly Diagnosed Philadelphia Chromosome–Positive ALL: Frontline TKI Selection, Early Blinatumomab, MRD, and Allo-HCT Decision-Making algorithm from @talhabadarmd.bsky.social: myopenmedicine.com/algorithms/n...
myopenmedicine.com
Newly Diagnosed Philadelphia Chromosome–Positive ALL:Frontline TKI Selection, Early Blinatumomab, MRD, and Allo-HCT Decision-Making
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Kate Sears @katesears.bsky.social · 17/07/2026
AMPLITUDE: Niraparib + Abiraterone/Prednisone + ADT in HRR-Altered mCSPC algorithm from @drnataliagandur.bsky.social: myopenmedicine.com/algorithms/a...
myopenmedicine.com
AMPLITUDE: Niraparib + Abiraterone/Prednisone + ADT in HRR-Altered mCSPC
The algorithm is broadly aligned with current mCSPC practice for diagnosis, early treatment intensification with AR pathway inhibitors, and routine consideration of germline/somatic testing. However, ...
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Kate Sears @katesears.bsky.social · 14/07/2026
Adjuvant RCC After Nephrectomy: Risk, Surveillance, Pembrolizumab, and the Pembro/Belzutifan Decision from @drchoueiri.bsky.social: myopenmedicine.com/algorithms/a...
myopenmedicine.com
Adjuvant RCC After Nephrectomy: Risk, Surveillance, Pembrolizumab, and the Pembro/Belzutifan Decision
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Kate Sears @katesears.bsky.social · 10/07/2026
Stage I Testicular Germ Cell Tumors After Orchiectomy: Surveillance, Adjuvant Therapy, and Risk-Adapted Follow-Up algorithm from @drnataliagandur.bsky.social: myopenmedicine.com/algorithms/s...
myopenmedicine.com
Stage I Testicular Germ Cell Tumors After Orchiectomy: Surveillance, Adjuvant Therapy, and Risk-Adapted Follow-Up
This algorithm is broadly aligned with contemporary stage I testicular GCT management: confirm true clinical stage I with appropriate post-orchiectomy marker kinetics and imaging, then select surveill...
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Kate Sears @katesears.bsky.social · 09/07/2026
Newly Diagnosed Non-APL Acute Myeloid Leukemia: Initial Treatment Selection from @talhabadarmd.bsky.social: myopenmedicine.com/algorithms/n...
myopenmedicine.com
Newly Diagnosed Non-APL Acute Myeloid Leukemia: Initial Treatment Selection
This algorithm is broadly aligned with contemporary adult non-APL AML practice: urgent exclusion of APL and stabilization, early comprehensive cytogenetic/molecular profiling, fitness-based selection ...
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Kate Sears @katesears.bsky.social · 06/07/2026
TALAPRO-3: Talazoparib + Enzalutamide + ADT in HRR-Altered mCSPC from @neerajagarwal.bsky.social @drnataliagandur.bsky.social: myopenmedicine.com/algorithms/t...
myopenmedicine.com
TALAPRO-3: Talazoparib + Enzalutamide + ADT in HRR-Altered mCSPC
The algorithm is broadly aligned with current mCSPC practice in emphasizing ADT as backbone therapy, recommending treatment intensification, and incorporating germline/somatic testing to guide therapy...
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Reposted by Kate Sears
meducationai.bsky.social @meducationai.bsky.social · 01/07/2026
Nice use of the living algorithm format. The piece that trips people up in platinum sensitive relapse is maintenance selection after response, since prior PARP exposure in front line increasingly limits repeat PARP and pushes the BRCA and HRD conversation earlier.
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Reposted by Kate Sears
Dana-Farber Cancer Institute @danafarber.bsky.social · 25/06/2026
Yesterday, the @fda.gov approved the antibody-drug conjugate sacituzumab govitecan for first-line treatment of metastatic triple-negative breast cancer. This action is based on results from the ASCENT-03 & -04 global clinical trials, which @stolaney1.bsky.social helped to lead. ➡️ bit.ly/4uZoDP0
Sara Tolaney, MD, MPH
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Kate Sears @katesears.bsky.social · 25/06/2026
Management of Platinum-Sensitive Recurrent Ovarian Cancer from Dr. Kathleen Moore at @unmc.bsky.social: myopenmedicine.com/algorithms/m...
myopenmedicine.com
Management of Platinum-Sensitive Recurrent Ovarian Cancer
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Reposted by Kate Sears
meducationai.bsky.social @meducationai.bsky.social · 22/06/2026
Really clean framework. The hinge most trainees underweight is daratumumab-refractory versus not, since that one branch reroutes everything toward carfilzomib pairings or BCMA-directed therapy earlier. Good to see the len-refractory pathway called out too, since that is the real-world default now.
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Kate Sears @katesears.bsky.social · 24/06/2026
Systemic Therapy Selection for Metastatic Pheochromocytoma and Paraganglioma algorithm from Dr. Michael Glover at @mdanderson.bsky.social: myopenmedicine.com/algorithms/s...
myopenmedicine.com
Systemic Therapy Selection for Metastatic Pheochromocytoma and Paraganglioma
The algorithm is broadly aligned with contemporary management of metastatic PPGL by emphasizing symptom stabilization, careful selection between observation vs treatment, and use of functional imaging...
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Kate Sears @katesears.bsky.social · 17/06/2026
First-line Advanced/Metastatic Squamous NSCLC: HARMONi-6 based Treatment Selection from Drs. Ben Bleiberg and Charu Aggarwal at @pennmedicine.bsky.social: myopenmedicine.com/algorithms/f...
myopenmedicine.com
First-line Advanced/Metastatic Squamous NSCLC: HARMONi-6 based Treatment Selection
The algorithm is broadly aligned with current first-line management of advanced/metastatic squamous NSCLC: universal biomarker testing, PD-L1–informed selection, and chemoimmunotherapy as the dominant...
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Kate Sears @katesears.bsky.social · 16/06/2026
Management of 1st Relapse Multiple Myeloma from Dr. Rajshekhar Chakraborty at @cuimcmedicinedept.bsky.social: myopenmedicine.com/algorithms/m...
myopenmedicine.com
Management of 1st Relapse Multiple Myeloma
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Kate Sears @katesears.bsky.social · 09/06/2026
Newly Diagnosed Myeloma algorithm from @vincentrk.bsky.social: myopenmedicine.com/algorithms/n...
myopenmedicine.com
Newly Diagnosed Myeloma
Treatment algorithm for newly diagnosed myeloma patients.  Dr. Rajkumar is a contributing editor to the International Myeloma Foundation (https://www.myeloma.org/frontline-treatment-options).
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Kate Sears @katesears.bsky.social · 08/06/2026
STK11/KEAP1 Advanced/Metastatic Squamous NSCLC algorithm from Drs. Charu Aggarwal and Ben Bleiberg @pennmedicine.bsky.social: myopenmedicine.com/algorithms/s...
myopenmedicine.com
STK11/KEAP1 Advanced/Metastatic Squamous NSCLC
The algorithm is partially aligned with current metastatic squamous NSCLC practice in its emphasis on broad molecular testing and guideline-directed targeted therapy when actionable drivers are presen...
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Kate Sears @katesears.bsky.social · 05/06/2026
Second-line / Previously Treated Metastatic Pancreatic Cancer (mPDAC) from @mpishvaian.bsky.social: myopenmedicine.com/algorithms/s...
myopenmedicine.com
Second-line / Previously Treated Metastatic Pancreatic Cancer (mPDAC)
The algorithm is broadly aligned with current practice for previously treated metastatic PDAC in emphasizing performance status assessment, clinical trial enrollment, molecular profiling, and use of e...
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Kate Sears @katesears.bsky.social · 04/06/2026
Advanced Dedifferentiated Liposarcoma: Systemic Therapy from Dr. Michael Wagner at @danafarber.bsky.social: myopenmedicine.com/algorithms/a...
myopenmedicine.com
Advanced Dedifferentiated Liposarcoma: Systemic Therapy
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Kate Sears @katesears.bsky.social · 03/06/2026
First-Line Metastatic Urothelial Carcinoma: EV + Pembrolizumab vs Platinum-Based Therapy from @drnataliagandur.bsky.social: myopenmedicine.com/algorithms/f...
myopenmedicine.com
First-Line Metastatic Urothelial Carcinoma: EV + Pembrolizumab vs Platinum-Based Therapy
This algorithm (1L Metastatic Urothelial Carcinoma: EV/Pembro vs Platinum) should answer one practical question: In a patient with previously untreated unresectable or metastatic urothelial carcinoma,...
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Kate Sears @katesears.bsky.social · 02/06/2026
IBCG Risk Stratification Model for Intermediate-Risk NMIBC from @ashishkamatmd.bsky.social: myopenmedicine.com/algorithms/i...
myopenmedicine.com
IBCG Risk Stratification Model for Intermediate-Risk NMIBC
Intermediate-Risk Non–Muscle-Invasive Bladder Cancer (IR NMIBC) Risk Stratification Model by the International Bladder Cancer Group (IBCG).
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Reposted by Kate Sears
Tian Zhang, MD @tiansterzhangmd.bsky.social · 29/05/2026
@IyerGopa @MSKCancerCenter with phase 1 #NEXUS01 of nectin4 delivering topoisomerase inhibitor — ligand is still relevant for some EV-pembro refectory #bladdercancer w responses. @asco #ASCO26 @oncoalert @urotoday
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Kate Sears @katesears.bsky.social · 29/05/2026
First line Metastatic Castration-Resistant Prostate Cancer (mCRPC) from Dr. Fred Saad: myopenmedicine.com/algorithms/f...
myopenmedicine.com
First line Metastatic Castration-Resistant Prostate Cancer (mCRPC)
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Kate Sears @katesears.bsky.social · 28/05/2026
Early and Advanced Triple Negative Breast Cancer (TNBC) from @ilanaschlam.bsky.social: myopenmedicine.com/algorithms/e...
myopenmedicine.com
Early and Advanced Triple Negative Breast Cancer (TNBC)
Post ASCO, ESMO and SABCS 2025 TNBC algorithm. Radiation is indicated for some with early stage disease. Add Zometa for postmenopausal patients, q6 months for 2-3 years (Early stage).*Keynote522 studi...
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