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alexandrsember.bsky.social

@alexandrsember.bsky.social
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bioRxiv Genomics @biorxiv-genomic.bsky.social · 02/10/2026
X-Y divergence of house fly (Musca domestica) proto-sex chromosomes follows distinct evolutionary trajectories despite residing in the same genome www.biorxiv.org/content/10.64898/20…
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Judith Mank @judithmank.bsky.social · 23/09/2026
Building on Wouter's work on male colour pattern architecture (doi.org/10.1038/s415...), Yuying found that autosomal inversions capture male colour pattern loci far more often than chance, and that these inversions account for a disproportionate share of total pattern variation. 3/
doi.org
Deep learning reveals the complex genetic architecture of male guppy colouration - Nature Ecology & Evolution
Guppy colouration is a very diverse trait under natural and sexual selection. Using a combination of high-resolution phenotyping and genomic analysis, the authors reveal the genetic architecture of th...
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Judith Mank @judithmank.bsky.social · 23/09/2026
So very, very happy to see this out @plosbiology.org : Ancient inversion polymorphisms associate with sexually selected traits across natural guppy populations. Beautiful work by two very clever and talented coauthors, Yuying Lin and @vdbijl.bsky.social . journals.plos.org/plosbiology/... 1/
journals.plos.org
Ancient inversion polymorphisms associate with sexually selected traits across natural guppy populations
Genomic inversions spanning many genes can persist for millions of years. This study of Trinidadian guppy populations reveals how both ecological conditions and mate choice help maintain this hidden l...
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Zebrafish Rock! 🎃 @zebrafishrock.bsky.social · 18/09/2026
ICYMI... New #cichlid work from @astridboehne.bsky.social & team 🐠
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Genome Biology and Evolution @genomebiolevol.bsky.social · 18/09/2026
Smith, Musilova & @astridboehne@bsky.social find new sex chromosomes in a group of cichlids from Lake Tanganyika and show that while these involve the same chromosome pairs, the sex chromosomes evolved independently. 🔗 academic.oup.com/gbe/article/... #societyjournal #genome #evolution
GBE | Same Sex Chromosomes With Independent Origins in Haplochromine Cichlids

Known sex chromosomes, and sex-linked regions thereof, of African haplochromine cichlid fishes, relative to the genome of Astatotilapia calliptera (bottom-left illustration). While there is great diversity of sex chromosomes and regions of sex linkage across this clade, LG5 and LG7 frequently reappear as sex-linked, particularly within the Lake Tanganyika-specific tribe of haplochromines, the Tropheini. Sex-linked regions on LG5 and LG7 are shown, highlighted in blue for XY systems and orange for ZW systems. In species in which sex-linkage is not known, this is marked with ‘?’. Other known sex chromosomes are listed on the right. Species included in this study are marked in bold. Proposed origins of different sex determination systems or genes are shown with yellow arrows on tree branches, while losses are shown with black arrows.
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Evolution Letters @evolletters.bsky.social · 17/08/2026
How do bumblebees determine sex—and why does it matter for conservation? A new study identifies the B. terrestris sex-determination region, with major implications for managing genetic diversity. doi.org/10.1093/evle... Image credit: M. Almbauer
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Darrin T. Schultz @dts.bsky.social · 19/08/2026
Our new paper in Science Advances asks how animals' genomes have changed since their origin from a common ancestor over 600 million years ago, and what patterns in their DNA have arisen in the churn of speciation and extinction. www.science.org/doi/10.1126/...
Five-panel diagram explaining fusion-with-mixing in chromosome evolution. Red and blue represent two different ancestral chromosomes throughout.

A, Fusion-with-mixing: a red chromosome and a blue chromosome fuse into one half-red, half-blue bar. Down the page, successive rows show inversions, drawn as X-shaped crossings between rows, progressively interleaving the two colors until the bottom bar is finely striped. A widening gray wedge labeled Entropy runs alongside an arrow marked Time plus evolution, pointing down.

B, Independent regulation: two separate chromosomes, one red and one blue. In each, a regulatory element, drawn as an oval, acts by an arrow on a gene within its own chromosome only.

C, FWM and novel regulation: on a fused, mixed chromosome, a red gene and a blue gene now sit next to each other across an inversion breakpoint. Red and blue arrows show regulatory elements reaching across it to act on the other chromosome's gene.

D, Regulatory entanglement: an extensively mixed chromosome, finely striped. Below it, a row of alternating red and blue genes is linked by a dense web of crossing curved arrows, so many overlapping regulatory connections that unmixing the chromosome would break them.

E, Emergence of entangled loci: a five-species phylogeny. A red and a blue chromosome fuse at an ancestral node, and helical icons on later branches mark continued mixing. Colored boxes mark four new red-blue regulatory interactions arising after inversions. Species A keeps its two chromosomes separate. In species B through E, the two earliest interactions, cyan boxes 1 and 2, are present in every descendant lineage, while later ones, yellow 3 and magenta 4, appear in fewer.
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Nature Reviews Genetics @natrevgenet.nature.com · 18/08/2026
ICYMI: New online! Genetics and genomics of hybridization
dlvr.it
Genetics and genomics of hybridization
Nature Reviews Genetics, Published online: 11 August 2026; doi:10.1038/s41576-026-00995-7Hybridization, the exchange of genes between divergent lineages, is now recognized as widespread across eukaryotes and essential to understanding genome evolution. In this Review, Schumer and Rieseberg overview methodological advances facilitating recent progress, reassess the frequency, causes and consequences of hybridization, and highlight key open questions.
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bioRxiv Genomics @biorxiv-genomic.bsky.social · 15/08/2026
Elevated isoform richness in males largely reflects transcriptional noise rather than proteomic complexity www.biorxiv.org/content/10.64898/20…
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Mark Hibbins, Great Lakes Swashbuckler @rejectresubmit.bsky.social · 14/08/2026
New review from me and @stepheniwright.bsky.social! We argue the time is ripe for a phylogenomic approach to the study of plant sex chromosomes: doi.org/10.32942/X2S...
doi.org
Plant sex chromosome evolution in the phylogenomic era
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Adam Phillippy @aphillippy.bsky.social · 06/08/2026
For the past 30 years, “whole-genome sequencing” has been a misnomer. Today the T2T Consortium publishes a dozen papers heralding a future of truly complete genomes for humans and nearly any vertebrate 👨‍🔬🐒🐦🐀🦒🐎🫏🐹🐟 (sorry, no salamanders): www.cell.com/consortium/t... 🧵[1/15]
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Molecular Cell @cp-molcell.bsky.social · 05/08/2026
Online Now: α-Satellite RNA maintains centromeric cohesion through R-loops Online now:
dlvr.it
α-Satellite RNA maintains centromeric cohesion through R-loops
Yang et al. show that α-satellite RNA, derived from human centromeric satellite repeats, forms R-loops at human centromeres to ensure faithful chromosome segregation by recruiting Shugoshin 1. This mechanism is essential for preserving chromosomal stability.
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Gokcumen Lab @gokcumenlab.bsky.social · 30/07/2026
Typeset version of new paper out in @genomebiolevol.bsky.social. Link: academic.oup.com/gbe/article/... We identified segmental duplications in genomes from 117 vertebrate species (thanks to @vertebrategenomes.bsky.social ). We describe the properties and evolution of segmental duplications.
academic.oup.com
Genomes From 117 Vertebrate Species Reveal Rapidly Evolving Segmental-Duplication Landscapes
Abstract. Segmental duplications are major drivers of evolutionary innovation; yet, their dynamics across vertebrates remain poorly understood. Here, we id
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KamilSJaron.bsky.social @kamilsjaron.bsky.social · 23/07/2026
New preprint: 338 coleopteran genomes reveal exceptional rearrangement variation compared to other insect orders. Big congrats to @arf-mln.bsky.social, for getting this giant piece together. Big collaboration of @joanameier.bsky.social's and my groups. 🧵👇 doi.org/10.64898/202...
Phylogeny of 338 species with tips painted by the chromosomal ancestry of their contemporary genomes (well separated colours indicate only few changes, while blending indicates rearrangements). Colouring of the branches is by the number of rearrangements. The ring between paints and phylogeny indicates wether the chromosomal rearrangement was fusion dominated (brown) or fission dominated (teal) process.  
Photo credits: Udo Schmidt, Lech Borowiec, JL Tachet, David Navrátil, Fred Chevaillot, Siga, Cosmin Manci, John Hallmén, Igor Souza-Gonçalves, Alex Hyde, H. Coiffait, David Ignace, Yves Bousquet.
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Robin Burns @robinburns.bsky.social · 25/07/2026
Delighted to share our paper on neo-chromosomes! We induced centromere fission using CRISPR in Arabidopsis and increased the chromosome count from n=5 to n=6. The broken chromosomes ends quickly “healed” by adding telomeres de novo and the new karyotype is stable through mitosis and meiosis! 1/3
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Nature @nature.com · 16/07/2026
Nature research paper: Highly fragmented European wetlands with uneven restoration needs go.nature.com/4538due
go.nature.com
Highly fragmented European wetlands with uneven restoration needs - Nature
Satellite imagery and machine learning used for the mapping of six seminatural open wetland types and land-use disturbance in European countries shows that wetlands are highly fragmented and have uneven restoration needs.
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Molecular Biology and Evolution @molbioevol.bsky.social · 13/07/2026
Foley & Murphy reveal that UCEs and BUSCO loci are not sampled randomly from the genome and are underrepresented in mammalian sex chromosomes and other low-recombining genomic regions. 🔗 doi.org/10.1093/molbev/msag155 #societyjournal #evobio #molbio
MBE | Phylogenomic blind spots: the limits of UCE and BUSCO loci in the presence of gene flow
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Charlie Underwood @charlieunderwood.bsky.social · 02/07/2026
In meiosis homologous chromosomes pair and exchange DNA non-randomly. How does reproductive gender and chromosome sequence shape recombination landscapes? To answer this we generated new wild tomato genomes and many reciprocal crosses with @usadellab.bsky.social www.nature.com/articles/s41...
nature.com
Wild tomato genome assemblies reveal structural variants and repeat content act as recombination barriers - Nature Communications
Introgression of genes from wild tomato species can enhance the robustness of modern tomatoes. Here van Rengs et al. describe the genomes of wild tomato species and show how reproductive gender and st...
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Rob Waterhouse @rmwaterhouse.bsky.social · 28/06/2026
“…advances in genetics and genomics have revealed that innovation arises and evolves through diverse mechanisms” -- timely for my presentation @official-smbe.bsky.social tomorrow! #SMBE2026
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Nature @nature.com · 16/06/2026
Nature research paper: SIRT7 regulates dosage compensation and safeguards the female X chromosome go.nature.com/4eCf8jz
go.nature.com
SIRT7 regulates dosage compensation and safeguards the female X chromosome - Nature
SIRT7 safeguards X-chromosome integrity and dosage balance with autosomes.
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Genome Biology and Evolution @genomebiolevol.bsky.social · 13/03/2026
Tomarovsky et al. resequenced sable, pine marten, and hybrids of these two mustelids, finding a broad spectrum of hybrid types with mosaic recombinant chromosomes that confirm hybrid fertility and indicate crossover is not suppressed. 🔗 doi.org/10.1093/gbe/evag018 #genome #evolution
GBE | Genomics of Sable (Martes zibellina) × Pine Marten (Martes martes) Hybridization
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Nature @nature.com · 11/03/2026
Nature research paper: Gene conversion empowers natural selection in a clonal fish species go.nature.com/4uDK6Ou
go.nature.com
Gene conversion empowers natural selection in a clonal fish species - Nature
Analysis of the asexually reproducing Amazon molly Poecilia formosa and its sexually reproducing progenitors Poecilia mexicana and Poecilia latipinna reveals that it maintains a divergent mutational landscape and has evaded functional mutational decay via gene conversion.
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Nature @nature.com · 27/02/2026
Genomic analysis shows that interbreeding between female Neanderthals and human males was less common than the opposite combination go.nature.com/4qYL44M
go.nature.com
Neanderthal dad, human mum: study reveals ancient procreation pattern
Genomic analysis shows that interbreeding between female Neanderthals and human males was less common than the opposite combination.
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Ancient Aliens @ancientaliens.bsky.social · 17/02/2026
To date, no scientist has been able to solve the enigma of the origin of the mysterious blue stones. alienigenasdopassado.com.br/en/the-myste... #aliens #ancientaliens #ancientastronauts #ancienthistory #UFOs #ufosightings #UAPs #Ufology #ufolovers #extraterrestrials #mysteries
alienigenasdopassado.com.br
The Mysterious Blue Sky Stones - Ancient Aliens
To date, no scientist has been able to solve the enigma of the origin of the mysterious blue stones.
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Ekolist.cz @ekolist.bsky.social · 02/02/2026
ekolist.cz
František Lukl: Otevřený dopis ministru životního prostředí - Ekolist.cz
Vážený pane ministře, Svaz měst a obcí České republiky se musí velice hlasitě ozvat na obranu edukativních vzdělávacích programů pro děti a mládež, které nabízejí neziskové organizace zřizované mnohdy...
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Scientific American @sciam.bsky.social · 30/01/2026
An exoplanet called HD 137010 b might be the closest thing astronomers have ever seen to “Earth 2.0.” The trouble is that it’s only been seen once—and may never be glimpsed again
scientificamerican.com
Another Earth or a blip in the data? We may never find out
An exoplanet called HD 137010 b might be the closest thing astronomers have ever seen to “Earth 2.0.” The trouble is that it’s only been seen once—and may never be glimpsed again
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Nature Reviews Genetics @natrevgenet.nature.com · 28/01/2026
New online! Long non-coding RNAs as orchestrators of dosage compensation
dlvr.it
Long non-coding RNAs as orchestrators of dosage compensation
Nature Reviews Genetics, Published online: 27 January 2026; doi:10.1038/s41576-026-00934-6In this Journal Club, Hodkinson and Larschan recall a 2002 paper by Meller and Rattner that used the power of Drosophila genetics to demonstrate the integral role of long non-coding RNAs in dosage compensation.
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André Marques @amarques.bsky.social · 27/01/2026
A new extreme of meiotic evolution: ✔️ 𝗻𝗼 crossovers ✔️ 𝗻𝗼 gene conversion ✔️ 𝗻𝗼𝗿𝗺𝗮𝗹 meiosis & fertility Sex mimics clonality without becoming asexual, in the holocentric multicellular eukaryote 𝘙𝘩𝘺𝘯𝘤𝘩𝘰𝘴𝘱𝘰𝘳𝘢 𝘵𝘦𝘯𝘶𝘪𝘴. more about it: www.biorxiv.org/content/10.6...
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Molecular Cell @cp-molcell.bsky.social · 26/01/2026
Anchoring the acentric: How retention elements give ecDNA immortality
dlvr.it
Anchoring the acentric: How retention elements give ecDNA immortality
In a recent Nature article, Venkat Sankar et al. uncover ecDNA harboring specific DNA sequences called retention elements, contact regions of mitotic chromosomes that are bookmarked by transcription factors and chromatin proteins to promote coordinated inheritance. Retention elements are essential for ecDNA amplification, even in the absence of positive selection, and their silencing can lead to rapid ecDNA depletion.
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Aurora Ruiz-Herrera @aruizherrera.bsky.social · 25/01/2026
📣 Call for Abstracts! Working on sex chromosomes? Join us at SMBE 2026 in Copenhagen (28 June–2 July). All taxa, systems, and approaches welcome! ⏰ Deadline: 3 Feb 2026 👉 smbe2026.org/abstracts/
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Nature Reviews Genetics @natrevgenet.nature.com · 17/01/2026
ICYMI: New online! Whole-genome spatial transcriptomic imaging with RAEFISH
dlvr.it
Whole-genome spatial transcriptomic imaging with RAEFISH
Nature Reviews Genetics, Published online: 09 January 2026; doi:10.1038/s41576-025-00926-yIn this Tools of the Trade article, Yubao Cheng discusses the development of RAEFISH (reverse-padlock amplicon-encoding fluorescence in situ hybridization), a method that enables spatial transcriptomics with both single-molecule spatial resolution and genome-wide coverage.
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Cory Laran @corylaran.bsky.social · 13/01/2026
🤔 Think 🤔 about it.
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Ancient Aliens @ancientaliens.bsky.social · 10/01/2026
Researchers believe they could be representations of extraterrestrial beings that visited humanity in the past. alienigenasdopassado.com.br/en/the-myste... #aliens #ancientaliens #ancientastronauts #ancienthistory #UFOs #ufosightings #UAPs #Ufology #ufolovers #extraterrestrials #mysteries
alienigenasdopassado.com.br
The Mysterious 7,000 Year Old Vinca Figurines - Ancient Aliens
Researchers believe they could be representations of extraterrestrial beings that visited humanity in the past.
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Scientific American @sciam.bsky.social · 07/01/2026
NASA spent years and billions of dollars collecting Martian samples to bring home. But Congress's current proposed budget for the agency would leave them stranded. What's at stake? Take a deep dive with this recent feature:
scientificamerican.com
NASA Found Something on Mars. Now We Might Just Leave It There
NASA spent years and billions of dollars collecting Martian samples to bring home. Now they might be stranded
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Nature Reviews Genetics @natrevgenet.nature.com · 06/01/2026
New online! A genomic and epigenomic view of human centromeres
nature.com
A genomic and epigenomic view of human centromeres
Nature Reviews Genetics, Published online: 06 January 2026; doi:10.1038/s41576-025-00923-1The complex and repetitive nature of centromeres has historically posed challenges to their genomic assembly and functional understanding, which are now being overcome with long-read sequencing. This Review discusses recent genomic and epigenomic insights into human centromere biology that have positioned the field for future studies of centromere structure in chromosome biology and human disease.
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bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 02/01/2026
Non-canonical sex chromosome evolution revealed by extreme heterogeneity in homomorphic Y chromosome differentiation in the common frog www.biorxiv.org/content/10.64898/20…
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Aurora Ruiz-Herrera @aruizherrera.bsky.social · 17/12/2025
Excited to be part of the amazing team behind our upcoming symposium on Sex Evolution at #SMBE2026! 🔹 Daniel Jeffries 🔹 Paul Jay 🔹 @sphaeromeria.bsky.social 🔹 @astridboehne.bsky.social 🔹 @cbenvenuto.bsky.social Join us in Copenhagen for cutting-edge discussions on #sex #evolution
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Zhou Qi @zhouqi1982.bsky.social · 11/12/2025
microchromosome regions always tend to be mainly located in the nuclear interior, while macrochromosome derived region near the nuclear periphery. That is the chromosome rearrangements are constrained by their ancestral 3D locations in the nucleus
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Nature @nature.com · 29/11/2025
“There were some cells in there that were very messed up” In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man go.nature.com/4rvXH8Y
go.nature.com
We are all mosaics: vast genetic diversity found between cells in a single person
Nature - Technical advances allow researchers to trace the genetic changes that occur over time.
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Nicky Bay @nickybay.bsky.social · 29/11/2025
This is the Sunburst Candy Spider from Thailand. Not AI (sucks to have to declare this). Very real and had been on my wish list for a long time. The taxonomic placement is unclear, so we are leaving it at Cyrtarachninae.
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Petr Nguyen @petrnguyen.bsky.social · 28/11/2025
Our whitepaper on #ProjectPsyche is online now in @cp-trendsecolevo.bsky.social! Psyche will generate reference genomes for all European butterflies. Just imagine what we’ll be able to learn from them. And if you can’t quite imagine it, have a look at the piece. :)
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Jana Helsen @helsenjana.bsky.social · 26/11/2025
How do new centromeres evolve while staying compatible with the division machinery? Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore. 👉 doi.org/10.1038/s41586-025-09779-1
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Dax Kellie @daxkellie.bsky.social · 26/11/2025
If you missed my talk but still want some tips for writing good code for scientists, my slides are here: daxkellie.quarto.pub/a-guide-to-w... All the links and references are there too in case you want to see more! 😀🧪🌏 #ESA2025 #rstats #quartopub
Title slide with text:
A guide to writing good code for the busy scientist

Black text over stripey pale brown-green background
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Dr. Wen-Juan Ma | 马文娟 @wenjuanma84.bsky.social · 22/11/2025
Excited that our new collaborative work on Amazonian frogs with giant meiotic chains of 8–12 😲 #SexChromosomes now is out in @commsbio.nature.com! 🐸🧬 Investigating the evolution of large meiotic rings of multiple X and Y chromosomes in two Leptodactylus species 🔗 www.nature.com/articles/s42...
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Ian Henderson @hendersi.bsky.social · 20/11/2025
CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis | Science www.science.org/doi/10.1126/... Very nice work from Holger Puchta & colleagues
science.org
CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis
The genome of Arabidopsis thaliana consists of 10 chromosomes. By inducing CRISPR-Cas–mediated breaks at subcentromeric and subtelomeric sequences, we fused entire chromosome arms, obtaining two eight...
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Genome Biology and Evolution @genomebiolevol.bsky.social · 19/11/2025
Grandchamp, @drdomain.bsky.social et al. publish a new Review on commonly used methods for de novo gene detection, address the limitations of nomenclature and detection methods, and establish a de novo gene annotation format to standardize reporting 🔗 doi.org/10.1093/gbe/evaf197 #genome #evolution
GBE | De Novo Gene Emergence: Summary, Classification, and Challenges of Current Methods
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Aurora Ruiz-Herrera @aruizherrera.bsky.social · 14/11/2025
🚨 New Paper Alert! Our latest perspective piece is out, and it’s one you won’t want to miss- 'The Genomic Kaleidoscope' academic.oup.com/gbe/article/... Co-lead by @mbrasovives.bsky.social @jrotwitguez.bsky.social & @diegoharta.bsky.social 📌 Check the full post here👇
academic.oup.com
Validate User
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Tony Gamble @tonygamble.eurosky.social · 27/10/2025
New Charlesworth & Charlesworth just dropped!!! 🧪🧬 HJ Muller and the relationship between sex chromosome degeneration and the evolution of dosage compensation url: academic.oup.com/gbe/article/...
academic.oup.com
HJ Muller and the relationship between sex chromosome degeneration and the evolution of dosage compensation
Abstract. A lack of recombination in the heterogametic sex between parts or all of newly evolving sex chromosomes results in the gradual accumulation of de
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Luca Soldini @lucasoldini.bsky.social · 27/10/2025
(1/9) Join us in Bern, Switzerland (8–11 Feb 2026) for our EMBO Workshop on Molecular Mechanisms of Selfish Elements and Strategies! Organized with Tanja Schwander, Laura Ross (@laurarossevo.bsky.social) and Axel Imhof. meetings.embo.org/event/26-sel... #EMBOselfishElements #EMBOevents
meetings.embo.org
Molecular mechanisms of selfish elements and strategies
Certain genes, chromosomes, organelles, or entire sets of chromosomes can bias their transmission to the next generation, propagating themselves at the expense of the rest of the genome. Referred to …
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Melissa Toups @meltoups.bsky.social · 25/10/2025
New preprint!
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