iiinova — where your digital self keeps evolving

Reposted by harry h behjat

Jonathan Rittmo @jorittmo.bsky.social · 01/10/2026

The first paper from my PhD is out in Nature Neuroscience! Aging and Alzheimer's disease reshape how the brain communicates. But not in the same way: aging vs AD related alterations follow two distinct axes of brain organization Paper → www.nature.com/articles/s41... #Alzheimers #Neuroimaging 🧵⬇️

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biofinder.bsky.social @biofinder.bsky.social · 07/04/2026

New publication out in Brain! 📢 We found that reference proteins Aβ40 and np-tau consistently helped already high-performing fluid biomarkers (e.g., MTBR-tau243 and p-tau variants) to more reliably represent brain Aβ and tau pathology measured by PET. 🔗 academic.oup.com/brain/advanc...

academic.oup.com

Validate User

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Toomas Erik Anijärv @teanijarv.bsky.social · 02/03/2026

I couldn't find a tool to plot different #neuroimaging data in one consistent style, so I made one! Meet yabplot (yet another brain plot) - a #Python package for (sub)cortex & tracts.🧠 - Simple API - Built-in atlases - Custom atlas support 🔗 github.com/teanijarv/ya... (drop a ⭐️!)

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Bratislav Misic @misicbata.bsky.social · 13/02/2026

Inter-individual variability of neurotransmitter receptor and transporter density in the human brain | doi.org/10.1007/s004... How do neuroreceptor distributions vary across people?

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Bratislav Misic @misicbata.bsky.social · 18/12/2025

netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1101/2025... Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging ⤵️

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Gabriel Weindel @gweindel.bsky.social · 04/11/2025

I uploaded the lecture I gave on hidden multivariate pattern methods in M/EEG at the #practicalMEEG2025 conference (wonderfully organized by @cuttingeeg.bsky.social). youtu.be/MgrqA7jMSBw It's just an introduction but maybe some will find it useful :)

youtu.be

HMP lecture #practicalMEEG2025

YouTube video by Gabriel Weindel

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Martin Hebart @martinhebart.bsky.social · 04/11/2025

Please repost! I am looking for a PhD candidate in the area of Computational Cognitive Neuroscience to start in early 2026. The position is funded as part of the Excellence Cluster "The Adaptive Mind" at @jlugiessen.bsky.social. Please apply here until Nov 25: www.uni-giessen.de/de/ueber-uns...

View from your office onto Giessen and surrounding villages.

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biofinder.bsky.social @biofinder.bsky.social · 29/10/2025

🚨Paper Out! Systematic Review & Meta-analysis of ALS Fluid Biomarkers 🧵Key findings: • NfL leads for both diagnosis (AUC 0.81–0.92) & prognosis (HR 2.8–4.3) • CSF chitinases, p-tau/t-tau: moderate values • Marked heterogeneity onlinelibrary.wiley.com/doi/10.1111/...

onlinelibrary.wiley.com

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Alain Goriely @alaingoriely.bsky.social · 21/10/2025

We just advertised the Hooke Fellowships for exceptional researchers (typically after their first post-doc). You are completely free to set up your own research agenda for three years. RT please my.corehr.com/pls/uoxrecru...

my.corehr.com

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Rick Betzel @richardfbetzel.bsky.social · 21/10/2025

Quantifying the compressibility of the human brain | arxiv.org/abs/2510.16327

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Alain Goriely @alaingoriely.bsky.social · 21/10/2025

The illusion of illusions One of the oldest myths in human history is that the Parthenon was cleverly built with curves so that it looks straight, to correct some visual illusions In this paper I demonstrate that there are NO optical corrections in the Parthenon arxiv.org/abs/2510.16831. [1/n]

arxiv.org

The illusion of illusions: There are no optical corrections in the Parthenon

One of the oldest and most enduring myths in human history is the belief that the Parthenon was cleverly designed with various curved structures and sizes in order to correct optical illusions, and th...

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Philippe Jawinski @pjawinski.bsky.social · 07/10/2025

🧠 Why do some brains age faster than others? 🧬 Our new Nature Aging study of over 56,000 participants explores the genetics of the “brain age gap” — the difference between your brain’s biological and chronological age. nature.com/articles/s43587-025-00962-7 Thread below 👇

nature.com

Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health - Nature Aging

This genomic study of magnetic resonance imaging-based brain age in 56,348 people identifies 59 genetic loci, links brain aging to mental and physical health, and suggests high blood pressure and type 2 diabetes as causal factors of brain aging.

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Nasia Metoki @nasiametoki.bsky.social · 07/10/2025

Is resting-state functional connectivity (rsFC), cortical thickness (CT), or cortical volume more effective at capturing sex and gender differences in the brains of preadolescents? Check out our new article (doi.org/10.1016/j.dc...) now out in Developmental Cognitive Neuroscience.

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Alex Fornito @alexfornito.bsky.social · 11/07/2025

1000s of studies have been published mapping neuroanatomical changes in psychiatric disorders. Can we ever converge on robust disease phenotypes? Our latest PP led by Trang Cao in a huge collab effort investigates this question... @nsb-lab.bsky.social

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Jake Chernicky @jakechernicky.bsky.social · 09/07/2025

Excited to share my first preprint investigating the feasibility and reliability of using precision RSFC in people with Parkinson’s disease! 🧠👇 📄: go.illinois.edu/PDfeasibility 🧵 Thread ⬇️ 1/12

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Benjamin Kay @benjaminkay.bsky.social · 30/09/2025

Ever wondered if your interesting brain-behavior correlation was over- or under-estimated due to head motion, but were afraid to ask? We’ve created a motion impact score for detecting spurious brain-behavior associations, now available in Nature Communications! doi.org/10.1038/s414...

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Alessandro Gozzi @gozziale.bsky.social · 10/09/2025

🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience ➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism? Check out what we found! 🧵1/n

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Julie Ottoy @ottoyjulie.bsky.social · 09/09/2025

🔥Recent advances in #neuroimaging of #Alzheimers disease 🧠✨ dx.doi.org/10.1002/alz.... ➡️ Valuable resource for both researchers & clinicians! ➡️ ATNIV biomarkers, staging, connectomics & more ➡️ Plus: how are sex & country represented in first/last authorship? @istaart.bsky.social Neuroimaging PIA

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harry h behjat @aitchbi.bsky.social · 07/10/2025

[🧵12] this work rests on the pivotal guidance of my advisory team @jwvogel.bsky.social Oskar Hansson @rikossenkoppele.bsky.social + decisive inputs from Ruben Smith & @dimitrivdv.bsky.social + plus the contributions of other brilliant minds at the @biofinder.bsky.social & demonlab.org labs 🙌

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harry h behjat @aitchbi.bsky.social · 07/10/2025

[🧵11] altogether, our findings provide strong evidence that individual functional brain architecture shapes tau propagation in humans, supporting the network-spread hypothesis by showing that variability in connectivity translates into heterogeneity in tau distribution 🧠

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harry h behjat @aitchbi.bsky.social · 07/10/2025

[🧵9] fourth, we asked, does FC also have prognostic value, that is, does individualised FC explain individual follow-up tau-PET patterns? it does.

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harry h behjat @aitchbi.bsky.social · 07/10/2025

[🧵8] third, we asked, is the superior explanatory power of FC over canonical PET patterns specific to tau and absent for e.g. B-amyloid pathology? it is.

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harry h behjat @aitchbi.bsky.social · 07/10/2025

[🧵7] second, as a largely overlooked dimension, we asked, does FC actually perform better in explaining individual tau-PET patterns than just using canonical patterns of tau-PET? it does.

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harry h behjat @aitchbi.bsky.social · 07/10/2025

[🧵6] first, we asked, does patient-specific FC help better to better explain the variance in individual tau-PET patterns than group-level FC does? it does.

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harry h behjat @aitchbi.bsky.social · 07/10/2025

[🧵5] in a large sample of deeply phenotyped patients across the AD continuum from @biofinder.bsky.social, we rigorously validated, at the individual level, the association between patterns of tau-PET and functional connectivity, on four fronts.

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harry h behjat @aitchbi.bsky.social · 07/10/2025

[🧵4] this is particularly important, since patterns of tau as captured by PET scans vary markedly across individuals and the role of inter-individual variability in shaping these patterns remains underexplored. e.g. see: rdcu.be/eJKD5

rdcu.be

Four distinct trajectories of tau deposition identified in Alzheimer’s disease

Nature Medicine - Systematic characterization of longitudinal tau variability in human Alzheimer’s disease using an unbiased subtyping algorithm reveals four trajectories of tau deposition...

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harry h behjat @aitchbi.bsky.social · 07/10/2025

[🧵3] most evidence from human studies on this hypothesis, however, is based on group-level models of brain networks. to truly validate the hypothesis, we need to go beyond group means, and work at the individual level.

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harry h behjat @aitchbi.bsky.social · 07/10/2025

[🧵1] there is a protein that helps neurons in the brain keep their shape & function: tau. but misfolded forms of tau appear in Alzheimer’s disease (AD) and correlate strongly with cognitive decline.

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harry h behjat @aitchbi.bsky.social · 07/10/2025

does brain connectivity drive spread of pathological proteins in Alzheimer’s disease? ✨ preprint: www.biorxiv.org/content/10.1... if the question intrigues you, please read on 🧵⤵️

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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 04/10/2025

Patient-specific functional brain architecture explains cortical patterns of tau PET in Alzheimer's disease www.biorxiv.org/content/10.1101/202…

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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 04/10/2025

Quantum-like dynamics in the human brain www.biorxiv.org/content/10.1101/202…

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Boris Bernhardt @borismontreal.bsky.social · 02/10/2025

🚨 New paper in Nature Methods: HippoMaps: multiscale cartography of the human hippocampus Open-source tools & data to explore structure and function of the 🍤🧠 (histology, in/ex vivo MRI, iEEG) Led by @jordandekraker.bsky.social docs: hippomaps.readthedocs.io paper: doi.org/10.1038/s415...

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Alex Fornito @alexfornito.bsky.social · 19/09/2025

Interested in the mechanisms shaping the extraordinary complexity of the connectome? Then check out our new preprint, lead by Francis Normand with a stellar team, showing how geometry constrains connectome architecture: biorxiv.org/content/10.1... Full thread here: tinyurl.com/sfv3yf73

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Golia Shafiei @goliashf.bsky.social · 22/09/2025

Excited to share that our work introducing the Reproducible Brain Charts (RBC) data resource is now published in Neuron!! 🎉 📚 Read the paper: authors.elsevier.com/c/1lpaF3BtfH... 🧠 Explore the RBC dataset: reprobrainchart.github.io

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DrBreaky @drbreaky.bsky.social · 14/09/2025

Interested in hippocampal dynamics and their interactions with cortical rhythms? Our physically constrained model of cortico-hippocampal interactions - complete with fast geometrically informed numerical simulation (available at embedded github repo) www.biorxiv.org/content/10.1...

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Andrea Santoro @andreasantoro.bsky.social · 09/09/2025

Latest work at #EUSIPCO25!🚀 We bring Topological Signal Processing to the brain 🧠 — showing that edge-based approaches outperform classical GSP in task decoding. Great collab with M.Nurisso & @lordgrilo.bsky.social 🙌 Paper 👉 eusipco2025.org/wp-content/u... #Neuroimaging #SignalProcessing #TSP

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Sylvain Baillet @sylvainbaillet.bsky.social · 29/09/2025

This is a major milestone for @sylviavilleneuve.bsky.social & PREVENT-AD. Their vision & dedication have led to a series of impactful studies & high-profile publications, and the future promises insights as this unique dataset continues to grow. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

alz-journals.onlinelibrary.wiley.com

The PREVENT‐AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond

The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) is an investigator-driven study that was created in 2011 and enrolled cognitively normal older ...

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Bratislav Misic @misicbata.bsky.social · 16/09/2025

Network spreading and local biological vulnerability in amyotrophic lateral sclerosis | doi.org/10.1038/s420... How do brain network structure and local biological features shape the spatial patterning of atrophy in ALS? @asafarahani.bsky.social investigates ⤵️

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Bratislav Misic @misicbata.bsky.social · 10/09/2025

The effect of spherical projections on spin tests for brain maps | doi.org/10.1162/IMAG... Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️

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biofinder.bsky.social @biofinder.bsky.social · 05/09/2025

🚨New paper alert! Our study led by @teanijarv.bsky.social investigated why some individuals with Alzheimer’s disease (AD) develop hemispheric asymmetry in tau pathology and what drives this phenomenon. Out now in Nature Communications! 🔗Full article: doi.org/10.1038/s414... A thread🧵👇

doi.org

Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer’s Disease - Nature Communications

Asymmetrical distribution of tau pathology in Alzheimer’s disease is linked to asymmetrical amyloid-beta deposition, not reduced brain connectivity, suggesting regional vulnerability plays a key role ...

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Jake Vogel @jwvogel.bsky.social · 22/07/2025

‼️NEW PREPRINT‼️ What if you could take a normal 3T T1w MRI and make it look like it was acquired from a 7T scanner? That's exactly what we do using AI in our new preprint! Link: arxiv.org/abs/2507.13782 #neuroskyence #neurosky #compneuro #AI #datascience #neurology #mrisky #neuroimaging

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