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Katherine Aird

@airdlab.bsky.social
2.6K followers 1.4K following 94 posts

My lab studies the interplay between cancer metabolism and cell cycle dysregulation. Professor at The Wistar Institute airdlab.com

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Katherine Aird @airdlab.bsky.social · 30/07/2026
Huge congratulations to first author Aidan Cole. He is brilliant, an awesome person, and currently looking for an industry position. Reach out if you have any leads- he’ll be the best colleague!
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Katherine Aird @airdlab.bsky.social · 30/07/2026
We are so grateful for our coauthors and colleagues @raquelbuj.bsky.social @mzspectrum.bsky.social @nadinehempel.bsky.social and many others as well as funding support from the NCI, CDMRP, @wistar.org, @upmchillmancc.bsky.social
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Katherine Aird @airdlab.bsky.social · 30/07/2026
Thrilled to see our work on senescence & metastasis out! We found that chemotherapy increases ovarian cancer metastasis in a paracrine manner via fructose. Dietary fructose is sufficient to increase metastatis. This work has multiple implications related to both chemo and diet.
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Katherine Aird @airdlab.bsky.social · 28/05/2026
Excited to see it out! Thank you!
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Reposted by Katherine Aird
Barbara Marte @barbmarte.bsky.social · 28/05/2026
new out in Nature www.nature.com/articles/s41...
nature.com
αKG-mediated carnitine synthesis drives DNA repair via histone acetylation - Nature
The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...
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Reposted by Katherine Aird
Andrea Andress Huacachino, PhD @chemistandrea.bsky.social · 27/05/2026
Amazing work from @airdlab.bsky.social and @mzspectrum.bsky.social Labs led by insanely talented Apporva Uboveja! Very grateful to play a small part in this impactful work.
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Katherine Aird @airdlab.bsky.social · 27/05/2026
Thank you for your contributions!
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Katherine Aird @airdlab.bsky.social · 27/05/2026
Thank you Joel!!
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Katherine Aird @airdlab.bsky.social · 27/05/2026
See the press release here: www.wistar.org/press-releas...
wistar.org
Wistar Institute and Temple Scientists Identify Metabolic Target to Overcome Chemotherapy Resistance in Ovarian Cancer
Wistar Institute and Temple Scientists Identify Metabolic Target to Overcome Chemotherapy Resistance in Ovarian Cancer Press Releases
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Katherine Aird @airdlab.bsky.social · 27/05/2026
It's time to rewrite reviews-aKG doesn't just regulate demethylation. Work from my lab and @mzspectrum.bsky.social demonstrates a new role for aKG in promoting histone acetylation and DNA repair through regulating carnitine synthesis. Congrats Apoorva Uboveja! www.nature.com/articles/s41...
nature.com
αKG-mediated carnitine synthesis drives DNA repair via histone acetylation - Nature
The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...
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Katherine Aird @airdlab.bsky.social · 02/05/2026
We strongly support both the scientific & professional development of all trainees. There are opportunities to expand into new areas for those looking to transition to independence.
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Katherine Aird @airdlab.bsky.social · 02/05/2026
We are well-funded and have a strong track record of publications (including a recently accepted paper in Nature), trainee funding, and supporting the career goals of all lab members. There are also opportunities for co-mentorship!
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Katherine Aird @airdlab.bsky.social · 02/05/2026
The lab is expanding and hiring both a postdoc and staff scientist! See more on our website: airdlab.com. We study how metabolism and cell cycle states drive tumor progression, therapy response, and immune interactions. Candidates interested in mechanistic cancer biology are encouraged to apply.
airdlab.com
Aird Lab
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Katherine Aird @airdlab.bsky.social · 11/04/2026
Looking for a postdoc position and attending AACR in San Diego? I'll be there, too, and the lab is actively recruiting! Send me an email with your CV and cover letter, and I’ll follow up if there is a mutual fit. See more about our research at airdlab.com.
airdlab.com
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Rich Possemato @richpossemato.bsky.social · 09/01/2026
Join us for the 2026 NYAS Cancer Metabolism conference on March 24th at NYU Langone! The poster deadline is rapidly approaching. Speakers include @airdlab.bsky.social @bensahralab.bsky.social Javier Garcia-Bermudez, Marcus Goncalves, @naama-kanarek.bsky.social @bdmanning.bsky.social Erika Pearce,
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Ronny Drapkin @rdrapkin8-penn.bsky.social · 22/09/2025
Excited to share the Ovarian Cancer Research Syndicate line-up of speakers for the fall. Please share. We have amazing trainees presenting and the latest from leaders in the field. @powelldrescher.bsky.social @srocf.bsky.social @pennmedcso.bsky.social @penncancer.bsky.social
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Katherine Aird @airdlab.bsky.social · 18/09/2025
We are also actively recruiting postdocs. If you are getting ready to graduate- consider Philly! It is a great place to live and to do impactful science. Check out our website for more information on our work on the intersection of metabolism and the cell cycle in cancer: airdlab.com
airdlab.com
Aird Lab
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Katherine Aird @airdlab.bsky.social · 18/09/2025
My lab at The Wistar Institute is recruiting on multiple levels! We are looking for a research technician and/or senior lab manager to help support all lab projects. Cell culture, molecular biology, and animal handling expertise and 3+ years of experience needed. Apply here: lnkd.in/ecvdTwkf
lnkd.in
Job Details | Dayforce Jobs
Find your next adventure
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Katherine Aird @airdlab.bsky.social · 03/09/2025
Big day for multiple lab members who celebrated a promotion! Congrats to Apoorva Uboveja for promotion to Staff Scientist and Aidan Cole for starting as a postdoc! I am now a full professor too 🤓 Want to learn more about our science or join the lab? Visit Airdlab.com
airdlab.com
Aird Lab
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Katherine Aird @airdlab.bsky.social · 14/08/2025
In the second, we discovered that cisplatin drives ovarian cancer metastasis through a metabolic cross-talk between senescent cancer cells with non-senescent cancer cells. We identified fructose as the upstream driver of this phenotype. First author Dr. Cole just defended!
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Katherine Aird @airdlab.bsky.social · 14/08/2025
In the first, @raquelbuj.bsky.social discovered that tumors can respond to anti-PD1 without T cells! Mechanistically, this is through a zinc-dependent increase in macrophage phagocytosis, and this is driven through cancer cell CDKN2A-mediated zinc compartmentalization.
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Katherine Aird @airdlab.bsky.social · 14/08/2025
The summer has been busy! Along with the move and a PhD defense, we have updated two preprints: www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...
biorxiv.org
The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming
Cellular senescence, characterized by a stable cell cycle arrest, is a well-documented consequence of several widely used chemotherapeutics that has context-dependent roles in cancer. Although senesce...
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Katherine Aird @airdlab.bsky.social · 01/08/2025
Thanks! There are so many great scientists (including you!) I am looking forward to interacting with!
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Katherine Aird @airdlab.bsky.social · 22/07/2025
Our excellent technicians are staying on at Pitts. We are actively recruiting to fill those positions. If you or someone you know is located in Philly and looking for a position, please share: jobs.dayforcehcm.com/en-US/wistar...
jobs.dayforcehcm.com
Job Details | Dayforce Jobs
Find your next adventure
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Katherine Aird @airdlab.bsky.social · 22/07/2025
I could not be more excited to finally announce that my lab will be moving to The Wistar Institute in Philadelphia in early September! While this is somewhat of a homecoming for me, it is a new adventure for the 6 lab members moving with me! More details to come about new roles and opportunities!
jobs.dayforcehcm.com
Job Details | Dayforce Jobs
Find your next adventure
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Katherine Aird @airdlab.bsky.social · 06/05/2025
Thank you for organizing this! I’ve enjoyed it every year!
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Katherine Aird @airdlab.bsky.social · 23/04/2025
Our preprint by @raquelbuj.bsky.social was highlighted! What a cool idea to give early career scientists the opportunity to practice peer review skills! See the updated preprint: www.biorxiv.org/content/10.1....
biorxiv.org
CDKN2ALow cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance
Approximately 50% of cancers exhibit decreased CDKN2A expression ( CDKN2A Low), which is linked to immune checkpoint blockade (ICB) resistance. While CDKN2A is traditionally recognized as a tumor supp...
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Katherine Aird @airdlab.bsky.social · 23/04/2025
Thank you for highlighting our preprint!
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Katherine Aird @airdlab.bsky.social · 15/03/2025
I look forward to voting against you in the primary.
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Katherine Aird @airdlab.bsky.social · 14/03/2025
Finally got through! Keep calling! 202 224 4254
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Katherine Aird @airdlab.bsky.social · 14/03/2025
Anyone else having trouble contacting Fetterman? I’ve tried both his DC and Pittsburgh office numbers, and it keeps disconnecting
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Katherine Aird @airdlab.bsky.social · 14/03/2025
The fact that he doesn’t have an aide to brief him on these topics tells you all you need to know. I’ve called and emailed many times.
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Katherine Aird @airdlab.bsky.social · 14/03/2025
This is a terrible take. I voted for a progressive democrat yet you are now seemingly a republican puppet. Your constituents want you to vote no!
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Katherine Aird @airdlab.bsky.social · 21/02/2025
I never imagined needing to care about the federal registry. This is the worst timeline
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Katherine Aird @airdlab.bsky.social · 18/02/2025
I need to write my PO, but I just feel so bad bothering her. 😥
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Katherine Aird @airdlab.bsky.social · 13/02/2025
That sucks. I’m so sorry
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Katherine Aird @airdlab.bsky.social · 13/02/2025
Thank you. So many labs and trainees are in worse positions. It’s devastating
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Katherine Aird @airdlab.bsky.social · 13/02/2025
Yep I had a 1% that was supposed to be in council today. Great times we live in
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Katherine Aird @airdlab.bsky.social · 13/02/2025
The problem is that they are not able to hold meetings to decide which grants to fund now. It’s very good news that NIH took a stand, but what about the future of scientific discovery?
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Jeremy Berg @jeremymberg.bsky.social · 13/02/2025
Bluetorial: The rationale for the “NIH” indirect cost “plan” is based on misunderstood (unintentional or intentional) accounting and math The value of real government transparency
media.tenor.com
a cartoon of homer simpson holding a card
ALT: a cartoon of homer simpson holding a card
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Katherine Aird @airdlab.bsky.social · 12/02/2025
If you live in PA District 12: contact Summer Lee Summer Lee: 202 225 2135 (summerlee.house.gov/contact)
summerlee.house.gov
Contact - Summer Lee
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Katherine Aird @airdlab.bsky.social · 12/02/2025
If you are worried about the constitutional crisis, NIH/NSF funding, diversity issues, or anything else: CONTACT YOUR REPRESENTATIVES. For those in PA: Dave McCormick: 202 224 6324 (www.mccormick.senate.gov/share-your-o...) John Fetterman: 202 224 4254 (www.fetterman.senate.gov/contact/)
summerlee.house.gov
Contact - Summer Lee
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Josh Gerstein @joshgerstein.bsky.social · 11/02/2025
BREAKING: Federal judge in Boston broadens block on Trump's NIH grant 15% overhead limit (indirect cost rates) to all recipients nationwide. Doc: www.documentcloud.org/documents/25... #TROpalooza ain't done
documentcloud.org
AAMCOrd021025
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Jeremy Berg @jeremymberg.bsky.social · 10/02/2025
A useful tool and a great thing to do... 5calls.org/issue/nih-ns...
5calls.org
Save NIH and NSF Research Funding ⭑ 5 Calls
On February 7, the Trump administration moved to cut billions of dollars in funding from the National Institutes of Health (NIH) and National Science …
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Reposted by Katherine Aird
Stephen Floor @snf.bsky.social · 09/02/2025
not paying indirect costs for research is like only paying the players in the Super Bowl. can't have a Super Bowl without coaches, referees, security, janitors, announcers, stadium staff, and a stadium - and you can't have research without supporting people and facilities
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Katherine Aird @airdlab.bsky.social · 09/02/2025
Find more info about the NIH here: www.nih.gov/about-nih/wh...
nih.gov
Direct Economic Contributions
NIH directly supports the economy through investments in research institutions and job formation.
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Katherine Aird @airdlab.bsky.social · 09/02/2025
Governmental support for research is a requirement for the health of our economy and citizens. If these cuts are not immediately reversed, there will be dire consequences for our country.
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Katherine Aird @airdlab.bsky.social · 09/02/2025
#3: The NIH funds research to understand diseases such as cancer, diabetes, cardiovascular disease, among others. Cutting NIH funds will delay treatments and cures for these diseases, which will impact Americans for generations.
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Katherine Aird @airdlab.bsky.social · 09/02/2025
#2: The biomedical research endeavor employs >300,000 workers, including janitorial and maintenance staff, admins and IT staff.. These cuts will cause many people to lose their jobs. This isn’t just in coastal elite cites. Big universities are often the major employer in many US cities.
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Katherine Aird @airdlab.bsky.social · 09/02/2025
Cutting NIH funds hurts all Americans. Why? Three main reasons: #1: These funds support a huge industry in all states. For every $1 of NIH funding generated, there is a short-term return of ~$2.46 in economic activity. $4B in cuts will take away $10B from the economy.
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