Reposted by Masking Appalachia
iso: anyone with saddle nose deformity who masks regularly and / or ENTs who may have some knowledge on the subject — how’s it going? is there a way to be kinder to noses with connective tissue issues in masks?
Masking Appalachia
@maskingappalachia.bsky.social
105 followers 121 following 6 posts
Connecting and empowering the COVIDing community in Appalachia & advocating for community care 📍Occupied Moneton territory • WNC linktr.ee/maskingappalachia
![All the informed people know that SARS-CoV-2 can harm the immune system, even in mild cases of COVID-19. Research has shown that the virus can cause long-term changes and damage to various components of the immune system[1][2][3].
## Impact on T cells
SARS-CoV-2 infection damages the CD8+ T cell response, similar to the long-term immune system damage observed with viruses like hepatitis C or HIV[1]. This dysfunction may contribute to long COVID and impair the body's ability to respond effectively to subsequent infections[1].
## Changes in immune cell populations
Studies have found a significant reduction in immune cells in the blood of COVID-19 survivors, even 10 months after infection[2][3]. This includes decreases in T cells and B cells, which are crucial components of the adaptive immune system[3].
## Alterations in cytokines and growth factors
COVID-19 leads to changes in cytokine and growth factor patterns in the blood[2]. Researchers observed upregulated levels of interleukin-4 (IL-4) and interleukin-5 (IL-5), as well as a significant decline in interferon-gamma levels by 10 months post-infection[3].
## Antibody response
SARS-CoV-2-specific antibodies decline over time, with a large proportion of recovered individuals losing detectable levels of protective antibodies by 10 months post-infection[3]. This suggests a potential loss of protection against reinfection.
## Potential long-term consequences](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5sz2cdsg4tojqewqh4vjeckg/bafkreihoqp6cgoj35z34vckexochfqhstsiunlrryhakt7dd73nrwyvwc4)
![These immune system changes may explain some of the long-term consequences of COVID-19, including Long COVID[2]. Researchers hypothesize that the virus may cause long-term impairment of bone marrow function, which is crucial for immune cell production[2][3].
It's important to note that while these findings are concerning, more research is needed to fully understand the long-term impacts of SARS-CoV-2 on the immune system and their clinical implications[3]. But by that time, you’ll likely be so far gone that it won’t really matter.
Citations:
[1] https://www.infectioncontroltoday.com/view/covid-19-study-suggests-long-term-damage-immune-system
[2] https://www.news-medical.net/news/20240715/COVID-19-leads-to-long-term-changes-in-the-immune-system-study-shows.aspx
[3] https://www.cidrap.umn.edu/covid-19/study-covid-can-trigger-changes-immune-system-may-underlie-persistent-symptoms
[4] https://pmc.ncbi.nlm.nih.gov/articles/PMC8011344/
[5] https://www.nih.gov/news-events/nih-research-matters/sars-cov-2-fragments-may-cause-problems-after-infection
[6] https://www.nature.com/articles/s41423-023-01104-y
[7] https://news.weill.cornell.edu/news/2023/08/severe-covid-19-can-alter-long-term-immune-system-response
[8] https://www.manchester.ac.uk/about/news/does-covid-really-damage-your-immune-system-and-make-you-more-vulnerable-to-infections-the-evidence-is-lacking/](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5sz2cdsg4tojqewqh4vjeckg/bafkreiabxhilune33peqdck3qd7davqbhq2xlvqjsugmzgpbxgvxxpsgee)
