Sign in

Jan Lammerding - Lab

@lammerdinglab.bsky.social
1.6K followers 1.2K following 77 posts

We study lamins and nuclear mechanobiology. Meinig School of Biomedical Engineering. Weill Institute for Cell and Molecular Biology. Cornell University. lammerding.wicmb.cornell.edu

PostsRepliesMedia
Jan Lammerding - Lab @lammerdinglab.bsky.social · 21/09/2026
Looking for a faculty position combining research in fundamental cell and molecular biology with therapeutic discovery? Join our amazing faculty at the @weillinstitute.bsky.social at Cornell University in Ithaca, New York. academicjobsonline.org/ajo/jobs/32657 Apply by Nov. 15! Please share!
03127
Reposted by Jan Lammerding - Lab
Taylor & Francis Research @tandfresearch.bsky.social · 16/09/2026
Nucleus is delighted to present a new Collection, guest edited by @lammerdinglab.bsky.social (@cornelluniversity.bsky.social) @weillinstitute.bsky.social. Featuring nine articles. This collection offers expert views and top tier analysis of key historical work. spr.ly/63325BGut9D
spr.ly
Nuclear Mechanobiology
Explore the article collection: Nuclear Mechanobiology. Published in Nucleus.
045
Jan Lammerding - Lab @lammerdinglab.bsky.social · 28/08/2026
Thanks so much!
000
Jan Lammerding - Lab @lammerdinglab.bsky.social · 26/08/2026
Interested in nuclear mechanobiology and want to know what some of the big open questions are in the field? Read our recent editorial with input from >15 leading experts in the field, along with a list of review articles on nuclear mechanobiology: www.tandfonline.com/doi/full/10....
tandfonline.com
Nuclear mechanobiology: a brief history and five unresolved questions
Published in Nucleus (Vol. 17, No. 1, 2026)
13120
Jan Lammerding - Lab @lammerdinglab.bsky.social · 30/06/2026
Interested in a faculty career in biomedical engineering #BME? Apply for the Rising Stars in Engineering in Health workshop for postdocs and PhD students interested in engineering, medicine & health: be.engineering.upenn.edu/home/rising-... Applications are open until July 31, 2026. Please share!
Image depicting stars rising from the bottom with comet trails and the words "Rising Starts in Engineering in Health"
2522
Jan Lammerding - Lab @lammerdinglab.bsky.social · 12/06/2026
I added them in the comments now, using my cell phone, and that seemed to have worked. Thanks again for pointing out the issue.
010
Jan Lammerding - Lab @lammerdinglab.bsky.social · 12/06/2026
Another attempt to include some figures from the two papers, which were somehow reduced to black boxes in the original post.
020
Jan Lammerding - Lab @lammerdinglab.bsky.social · 12/06/2026
I am not sure if it’s me or if BlueSky has some issue. Or it’s censoring lamins. ;)
100
Jan Lammerding - Lab @lammerdinglab.bsky.social · 12/06/2026
I noticed that as well but thought it was just an issue with my browser/app. I deleted the original post and reposted it again, after checking that the images were correct, but the same issue happened again. Not sure what causes the issue since even the article preview pulled from the web is black.
100
Jan Lammerding - Lab @lammerdinglab.bsky.social · 12/06/2026
This increase in nuclear stiffness was due to compaction of chromatin associated with polarization into M1-like macrophages and affected the ability of the M1-like macrophages to migrate through confined spaces. Stay tuned for further updates and insights!
010
Jan Lammerding - Lab @lammerdinglab.bsky.social · 12/06/2026
In the second story, led by Maggie and published in npj Biological Physics and Mechanics (rdcu.be/fl0V8), we found that polarization of bone marrow derived macrophages results in increased nuclear stiffness, despite a decrease in lamin A/C levels.
rdcu.be
Polarization increases nuclear stiffness in macrophages despite reduction in lamin A/C levels
npj Biological Physics and Mechanics - Polarization increases nuclear stiffness in macrophages despite reduction in lamin A/C levels
131
Jan Lammerding - Lab @lammerdinglab.bsky.social · 12/06/2026
Given the important function of LBR in chromatin organization, these findings point to a competitive model between A-type lamins, B-type lamins, and LBR at the nuclear envelope that could play key roles during development and disease.
100
Jan Lammerding - Lab @lammerdinglab.bsky.social · 12/06/2026
In the first story, published in Nucleus (www.tandfonline.com/doi/10.1080/...), we demonstrate that lamin A can result in displacement of LBR from the nuclear envelope to the endoplasmic reticulum (ER).
tandfonline.com
Antagonistic contributions of A-type and B-type lamins to LBR localization and dynamics
Lamin B receptor (LBR) is an inner nuclear membrane protein that organizes peripheral heterochromatin and cooperates with lamins to tether chromatin at the nuclear periphery. However, how individua...
110
Jan Lammerding - Lab @lammerdinglab.bsky.social · 12/06/2026
Two recent new publications from our laboratory, led by the amazing Jacob Odell and Maggie Elpers, respectively, shed new insights into the role of nuclear #lamins and nuclear #mechanobiology in two different contexts.
Fluorescence images showing that expression of lamin A in triple-lamin-knockout (TKO) cells results in the displacement of LBR from the nuclear envelope to the endoplasmic reticulum. The figure also includes quantification of the nuclear-to-cytoplasmic ratio of LBR under the different experimental conditions.Schematic representation, representative images, and quantification of experiments on mouse bone marrow derived macrophages showing that polarization of macrophages into pro-inflammatory M1-like cells results in increased nuclear stiffness within 24 hours.
4144
Reposted by Jan Lammerding - Lab
Nature Cell Biology @natcellbio.nature.com · 09/06/2026
Attending #EESMechanobiology ? If so, be sure to find and chat with @djdavid.bsky.social (Daryl), one of our senior scientific editors. He'll be on site on Tuesday and Wednesday.
0124
Jan Lammerding - Lab @lammerdinglab.bsky.social · 28/05/2026
Great start to the Cornell Mechanobiology Hub Symposium hosted by the @weillinstitute.bsky.social, with keynote speaker Amy Shyer and over 180 participants from more than 15 institutions. #Mechanobiology thrives in Ithaca and the region, including Syracuse, Rochester, Buffalo, and Binghamton.
0111
Reposted by Jan Lammerding - Lab
fort-lab-uta.bsky.social @fort-lab-uta.bsky.social · 23/04/2026
First long term confocal imaging #Zeiss from the lab. Adipose-derived stem cells expressing LifeAct.
092
Jan Lammerding - Lab @lammerdinglab.bsky.social · 09/04/2026
Interested in #Mechanobiology? Join us for the Mechanobiology Symposium, hosted by the new Cornell Mechanobiology Hub @weillinstitute.bsky.social in Ithaca, NY, this summer. More information at mechanobiology.wicmb.cornell.edu/events-progr... Deadline for abstract submission is April 15, 2026
01911
Reposted by Jan Lammerding - Lab
luskinglab.bsky.social @luskinglab.bsky.social · 25/03/2026
Interested in the nuclear envelope? Do you reside in the US northeast (or are willing to pay a visit)? Don't miss this year's NENE (northeast nuclear envelope) - a trainee-led regional meeting that brings together scientists at all levels for a day of exciting talks and discussions. June 5th @ Yale
11512
Jan Lammerding - Lab @lammerdinglab.bsky.social · 26/03/2026
Thanks so much for inviting me. I look forward to this exciting meeting and to interacting with all the other participants!
010
Reposted by Jan Lammerding - Lab
Journal of Cell Biology @jcb.org · 19/03/2026
Deb Roy, Inoue et al. @jhu.edu introduce an #optogenetics tool to rapidly induce #microtubule acetylation in living cells and show that this triggers release of the RhoGEF GEF-H1 from #microtubules, thereby driving persistent directional cell migration. rupress.org/jcb/article/... #Cytoskeleton
14416
Reposted by Jan Lammerding - Lab
Leone Rossetti @leonerossetti.bsky.social · 26/02/2026
Interested in a PhD in collective cell migration & mechanobiology? I'm looking to support a candidate applying for a fully funded UK/Home PhD. The project studies the biophysics of migrating cells, using force measurements & optogenetics, with collaborators in Japan. #mechanobiology #PhD eb4bm.org
eb4bm.org
Home - Engineering Biology For Biomedicine
Engineering Biology for Biomedicine A UKRI:BBSRC Centre for doctoral training Why EB4BM “ Our graduates bridge fundamental biological design principles with biomedical bottlenecks, delivering engineer...
0105
Jan Lammerding - Lab @lammerdinglab.bsky.social · 22/02/2026
Considering a graduate degree in biomedical engineering and wondering if a Master of Engineering degree is worth it? Join this virtual information session hosted by the Meinig School of Biomedical Engineering at Cornell University: www.duffield.cornell.edu/bme/meng/ MEng applications are still open!
020
Jan Lammerding - Lab @lammerdinglab.bsky.social · 17/02/2026
Great summer research opportunity for undergraduate students interested in cardiovascular research at Cornell BME. Projects range from tissue engineering and cardiac device to disease models and spatial & single cell transcriptomics. Apply at: www.cnf.cornell.edu/education/re.... Please share.
012
Jan Lammerding - Lab @lammerdinglab.bsky.social · 01/02/2026
New undergraduate summer research opportunities in cardiac research and biomedical engineering at the Cornell Meinig School of Biomedical Engineering, sponsored by the American Heart Association. Apply by Feb. 28 at www.cnf.cornell.edu/education/re.... Please share.
cnf.cornell.edu
Cornell Cardiac Undergraduate Research Experience (CURE) Program | CNF
053
Jan Lammerding - Lab @lammerdinglab.bsky.social · 24/01/2026
Inserting the novel lamin A/C emerin-binding domain into lamin B, which normally does not bind emerin, is sufficient to anchor emerin to the nuclear envelope. The novel emerin-binding domains acts in addition to the well established emerin-binding domain in the lamin A/C tail.
000
Jan Lammerding - Lab @lammerdinglab.bsky.social · 24/01/2026
Preventing lamin A/C polymerization, or using lamin A/C truncations that bind to the nuclear membrane but are unable to form filaments, is sufficient to ensure nuclear emerin localization, but insufficient to keep it firmly in place.
100
Jan Lammerding - Lab @lammerdinglab.bsky.social · 24/01/2026
This work, led by fantastic Cornell BMCB PhD graduate Jacob Odell, and with support of Kristen Nedza, we show that lamin A/C has not one, but two independent emerin-binding domains, and that lamin filaments are required to ensure emerin localization to the nuclear envelope and anchor it in place.
100
Jan Lammerding - Lab @lammerdinglab.bsky.social · 24/01/2026
Lamins A and C is required to anchor emerin at the nuclear envelope, and mutations in these proteins cause devastating diseases such as Emery-Dreifuss muscular dystrophy (EDMD). In work now available in #JBiolChem at www.jbc.org/article/S002..., we identify a novel lamin A/C-emerin binding site.
1121
Jan Lammerding - Lab @lammerdinglab.bsky.social · 24/01/2026
Very exciting work from @maggieutgaard.bsky.social in the Beach & Oakes labs pointing to a novel mechanoresponsive roles of septins in protecting the nucleus from mechanical stress. Enjoy the science, and the beautiful movies!
050
Jan Lammerding - Lab @lammerdinglab.bsky.social · 22/01/2026
Negin Majedi delivering a fantastic kick-off presentation on the #mechanobiology of cancer immune engineering as part of the new #MechanobiologyHub seminar series hosted by the @weillinstitute.bsky.social at Cornell University.
071
Jan Lammerding - Lab @lammerdinglab.bsky.social · 07/12/2025
Attending the ASCB/EMBO Cell Bio #cellbio2025 in Philadelphia? Check out the posters from our lab on nuclear mechanobiology, lamins, and mechanotransduction today and on Tuesday. I will be there too and look forward to catching up!
0153
Jan Lammerding - Lab @lammerdinglab.bsky.social · 25/11/2025
Good eye! Yes, it’s 2um wide and 5um tall, very similar to some of the smaller interstitial spaces in vivo.
110
Jan Lammerding - Lab @lammerdinglab.bsky.social · 25/11/2025
Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute.bsky.social
14412
Reposted by Jan Lammerding - Lab
Renkawitz Lab @renkawitzteam.bsky.social · 13/11/2025
Thanks to @katemiro.bsky.social , Megan King, Verena Ruprecht & @lammerdinglab.bsky.social for organising the very first meeting on the “Mechanobiology of the Nucleus” #MBNSRC @faseborg.bsky.social and for the invitation to present our discoveries. The conference was fantastic!
1103
Jan Lammerding - Lab @lammerdinglab.bsky.social · 13/11/2025
Thanks so much! We were delighted to have you as a speaker! Looking forward to the next one in two years!
000
Jan Lammerding - Lab @lammerdinglab.bsky.social · 07/11/2025
Congratulations!!
110
Jan Lammerding - Lab @lammerdinglab.bsky.social · 06/11/2025
It’s been a pleasure working with @apdaria.bsky.social, Julie Heffler, and the Prosser Lab on this study, supported by the Leducq Foundation and the National Institutes of Health (NIH). This research is one step to get us closer to an effective treatment for cardiac #laminopathies and #LMNA-DCM.
160
Jan Lammerding - Lab @lammerdinglab.bsky.social · 24/09/2025
Registration is still open, and abstracts for posters are still accepted (email me for info or questions)!
000
Jan Lammerding - Lab @lammerdinglab.bsky.social · 24/09/2025
Congratulations!!
110
Jan Lammerding - Lab @lammerdinglab.bsky.social · 18/09/2025
A big thank you for the GENEROUS support, although general support is good too! :)
000
Jan Lammerding - Lab @lammerdinglab.bsky.social · 18/09/2025
A big Thank You to the general support from the NIH-NHLBI, the Leducq Foundation, the American Heart Association @ahascience.bsky.social, a Fleming Research Fellowship, and the Mills family.
110
Jan Lammerding - Lab @lammerdinglab.bsky.social · 18/09/2025
Expression of a dominant negative nesprin domain, DN KASH, which disrupts the LINC complex, reduces forces on the nucleus, reduces nuclear envelope rupture, and restores expression of many dysregulated genes. DN KASH expression also rescues cardiac function and extends survival by >1 year.
100
Jan Lammerding - Lab @lammerdinglab.bsky.social · 18/09/2025
Detailed transcriptomic analyses indicate that a subset of cardiomyocytes drives disease progression by expression of genes associated with sterile inflammation, likely downstream of nuclear envelope rupture and activation of cytosolic DNA sensors, independent of cGAS/STING.
101
Jan Lammerding - Lab @lammerdinglab.bsky.social · 18/09/2025
How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint (doi.org/10.1101/2024...), led by the amazing Noam Zuela-Sopilniak and Julien Morival, we show that cardiomyocyte-specific lamin A/C depletion causes severe DCM, consistent with other studies.
2125
Reposted by Jan Lammerding - Lab
Martin Humphries @martinhumphries.bsky.social · 03/09/2025
Odell, J et al. (@lammerdinglab.bsky.social lab) A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites. bioRxiv posted 2 September 2025 doi:10.1101/2025.09.01.673543. www.biorxiv.org/content/10.1...
biorxiv.org
A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites
Lamins form a dense meshwork at the inner surface of the inner nuclear membrane (INM), where they interact with other nuclear envelope proteins such as emerin. Emerin is an integral membrane protein t...
292
Jan Lammerding - Lab @lammerdinglab.bsky.social · 04/09/2025
Thanks so much for highlighting our work!
010
Jan Lammerding - Lab @lammerdinglab.bsky.social · 30/08/2025
I should point out that the conference is held in Melbourne, Florida, not Australia!
120
Jan Lammerding - Lab @lammerdinglab.bsky.social · 29/08/2025
Speakers include: @luskinglab.bsky.social @renkawitzteam.bsky.social @pcusachs.bsky.social @gabrielneurohr.bsky.social @simonereber.bsky.social @zierlab.bsky.social @katemiro.bsky.social @sarawickstrom.bsky.social @rashmi-priya.bsky.social @stroudlab.bsky.social @becklab.bsky.social & many more!
174
Jan Lammerding - Lab @lammerdinglab.bsky.social · 29/08/2025
Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...
22714