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Jan Lammerding - Lab @lammerdinglab.bsky.social · 21/09/2026

Looking for a faculty position combining research in fundamental cell and molecular biology with therapeutic discovery? Join our amazing faculty at the @weillinstitute.bsky.social at Cornell University in Ithaca, New York. academicjobsonline.org/ajo/jobs/32657 Apply by Nov. 15! Please share!

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 30/06/2026

Interested in a faculty career in biomedical engineering #BME? Apply for the Rising Stars in Engineering in Health workshop for postdocs and PhD students interested in engineering, medicine & health: be.engineering.upenn.edu/home/rising-... Applications are open until July 31, 2026. Please share!

Image depicting stars rising from the bottom with comet trails and the words "Rising Starts in Engineering in Health"

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 12/06/2026

Another attempt to include some figures from the two papers, which were somehow reduced to black boxes in the original post.

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 12/06/2026

Two recent new publications from our laboratory, led by the amazing Jacob Odell and Maggie Elpers, respectively, shed new insights into the role of nuclear #lamins and nuclear #mechanobiology in two different contexts.

Fluorescence images showing that expression of lamin A in triple-lamin-knockout (TKO) cells results in the displacement of LBR from the nuclear envelope to the endoplasmic reticulum. The figure also includes quantification of the nuclear-to-cytoplasmic ratio of LBR under the different experimental conditions.

Schematic representation, representative images, and quantification of experiments on mouse bone marrow derived macrophages showing that polarization of macrophages into pro-inflammatory M1-like cells results in increased nuclear stiffness within 24 hours.

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 28/05/2026

Great start to the Cornell Mechanobiology Hub Symposium hosted by the @weillinstitute.bsky.social, with keynote speaker Amy Shyer and over 180 participants from more than 15 institutions. #Mechanobiology thrives in Ithaca and the region, including Syracuse, Rochester, Buffalo, and Binghamton.

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 09/04/2026

Interested in #Mechanobiology? Join us for the Mechanobiology Symposium, hosted by the new Cornell Mechanobiology Hub @weillinstitute.bsky.social in Ithaca, NY, this summer. More information at mechanobiology.wicmb.cornell.edu/events-progr... Deadline for abstract submission is April 15, 2026

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 22/02/2026

Considering a graduate degree in biomedical engineering and wondering if a Master of Engineering degree is worth it? Join this virtual information session hosted by the Meinig School of Biomedical Engineering at Cornell University: www.duffield.cornell.edu/bme/meng/ MEng applications are still open!

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 17/02/2026

Great summer research opportunity for undergraduate students interested in cardiovascular research at Cornell BME. Projects range from tissue engineering and cardiac device to disease models and spatial & single cell transcriptomics. Apply at: www.cnf.cornell.edu/education/re.... Please share.

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 24/01/2026

Lamins A and C is required to anchor emerin at the nuclear envelope, and mutations in these proteins cause devastating diseases such as Emery-Dreifuss muscular dystrophy (EDMD). In work now available in #JBiolChem at www.jbc.org/article/S002..., we identify a novel lamin A/C-emerin binding site.

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 22/01/2026

Negin Majedi delivering a fantastic kick-off presentation on the #mechanobiology of cancer immune engineering as part of the new #MechanobiologyHub seminar series hosted by the @weillinstitute.bsky.social at Cornell University.

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 07/12/2025

Attending the ASCB/EMBO Cell Bio #cellbio2025 in Philadelphia? Check out the posters from our lab on nuclear mechanobiology, lamins, and mechanotransduction today and on Tuesday. I will be there too and look forward to catching up!

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 25/11/2025

Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute.bsky.social

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 18/09/2025

Expression of a dominant negative nesprin domain, DN KASH, which disrupts the LINC complex, reduces forces on the nucleus, reduces nuclear envelope rupture, and restores expression of many dysregulated genes. DN KASH expression also rescues cardiac function and extends survival by >1 year.

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 18/09/2025

Detailed transcriptomic analyses indicate that a subset of cardiomyocytes drives disease progression by expression of genes associated with sterile inflammation, likely downstream of nuclear envelope rupture and activation of cytosolic DNA sensors, independent of cGAS/STING.

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 18/09/2025

How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint (doi.org/10.1101/2024...), led by the amazing Noam Zuela-Sopilniak and Julien Morival, we show that cardiomyocyte-specific lamin A/C depletion causes severe DCM, consistent with other studies.

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 29/08/2025

Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 19/08/2025

Interested in #mechanobiology of the cell nucleus? The submission deadline for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus is August 31, 2025. Submit your abstract to be considered for a platform presentation. #MBNSRC events.faseb.org/event/Mechan...

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 26/07/2025

What allows lamins A and C to confer much stronger mechanical stability to the nuclei than lamin B? We show that even though all lamins can protect the nucleus from small cell intrinsic forces, only lamin A/C protect the nucleus from large deformations: www.biorxiv.org/content/10.1... 1/n

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 16/07/2025

Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC. Find more information and register at: events.faseb.org/event/Mechan... Submit abstracts by August 31, 2025. Please share and see you in October!

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 21/03/2025

Celebrating 140 Years of Women in Engineering at Cornell @cornellengineering.bsky.social and their amazing achievements. Hosted by @mchvdm.bsky.social and Lara Estroff, trailblazers in their own right.

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 22/11/2024

For #FluorescenceFriday, a found an old video of MDA-MB-231 cells in a dense collagen matrix dividing, acquired on a lattice lightsheet microscope at the @aicjanelia.bsky.social. Mitotic chromosomes are fun to watch! This was just a quick test video, hence the limited but still impressive quality.

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 21/11/2024

Meet the amazing people behind our research, a fantastic team of scientists and engineers from various disciplines and countries, united in their interest in #mechanobiology and its application to basic science and disease. Plus a huge passion for working together and enriching the community.

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 16/11/2024

A late entry for #FluorescenceFriday or an early post for #MicroscopyMonday, reposting a movie of a breast cancer cell migrating through a small microfluidic constriction by contracting its rear cortex. You can find the full story at journals.biologists.com/jcs/article-...

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 15/11/2024

Sharing this on behalf of the Connecting Intermediate Filaments community: Tune in next Wednesday November 20, for our first #ConnectingIFs seminar of the season 2024-2025, with Prof. Carsten Grashoff, University of Munster (www.uni-muenster.de/Biologie.IMZ...) @ 10.00 AM EST, 16:00 CET

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 26/11/2023

Interested in nuclear mechanobiology and attending the ASCBiology/EMBO Cellbio2023 meeting in Boston next week? Make sure to visit the "Nuclear Mechanobiology" subgroup session on Saturday, Dec. 2, from 1:00 to 3:30pm with an excellent lineup of speakers. plan.core-apps.com/ascbembo2023...

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