Single-nucleus RNA sequencing and spatial validation across human and mouse striatum define principles of neuronal specialization across cell types, subregions, and species. These findings lay the fou...

In 2025, the words we use to describe emotions matter, but their definitions are controversial. Here, I unpack the different positions in this space and the rationales behind them—and I invite 13…

https://neuro-agent-models.github.io/

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Axons of dopamine (DA) neurons express nicotinic receptors (nAChRs) that have been shown to both facilitate and suppress striatal DA release, but the mechanisms underlying these opposing actions are u...

I believe we should talk about the mistakes we make.

Nature Neuroscience - Liu and colleagues show that the vigor (that is, speed and amplitude) of dexterous movements is not controlled by ongoing fluctuations in extracellular dopamine within the...

The cerebral cortex, cerebellum, and basal ganglia are essential for flexible learning in mammals. Although traditionally thought to operate under different learning rules, recent evidence suggests th...

Individual dopaminergic neurons encode future rewards over distinct temporal horizons.

Individual dopaminergic neurons encode future rewards over distinct temporal horizons.