Psychopharmacology - As cannabis legalization and decriminalization have expanded, it is increasingly perceived as a low-risk substance. Concurrently, the potency of cannabis products and the...

Pouget et al. identified distinct CA1 neuron ensembles active during specific moments of fear learning and uncovered the core engram essential for memory formation.

Neural mechanisms underlying local striatal serotonin release are not fully understood. Here authors show that striatal cholinergic interneurons drive local serotonin release by activating nicotinic r...

The authors mapped spontaneous and choice activity across mouse prefrontal cortex. The activity maps aligned with intrinsic connectivity rather than anatomical subregions, suggesting that connectivity...

Recent evidence suggests that astrocytes, through coordinated activation in sparse ensembles, contribute to memory traces — termed ‘astro-neuronal engrams’. In this Perspective, Sánchez Romero and Nav...

Ogg et al. use in vivo imaging techniques to record activity in the locus coeruleus (LC) and the orbitofrontal cortex (OFC) during a reversal learning task in freely moving rodents. They show that man...

Flexibility and stability of neuronal ensembles are crucial features of brain function. Little is known about how these properties of local circuits are influenced by long-range inputs. We show, in mi...

Bracco et al. show that pre-movement beta oscillations emerge in a cerebello-cortical network as the environment becomes predictable and outcomes stabilize. The evolution of these oscillations predict...

Luo et al. identify distinct supramammillary-dentate gyrus subcircuits that differentially regulate memory and emotion. In Alzheimer’s disease (AD) models, these pathways show aberrant activity, but targeted optogenetic activation selectively restores cognitive or affective functions, revealing circuit-level mechanisms underlying diverse AD symptoms and highlighting potential therapeutic targets.

The serotonin (5-HT)2A receptor is the primary target of numerous psychoactive drugs including serotonergic psychedelics, and mediates psychedelics-induced neuroplasticity, but the signaling mechanism...

The acquisition of temporally proximate information can impair the brain’s ability to consolidate earlier experiences, resulting in retroactive interference (RI). Recognition-based behavioral paradigm...

Scientific Reports - Absence of sex differences in serotonergic control of orbitofrontal cortex neuronal activity

The serotonin-2A receptor (5-HT2AR) is an interesting target for drug design in the context of antidepressants that might have a rapid onset of action and/or be effective in treatment-resistant cases....

This comprehensive review of amygdala intercalated cells (ITCs) proposes a revised model of ITCs as a highly coordinated system that integrates diverse inputs to orchestrate brain-wide networks and sh...

Memory engrams are formed through experience-dependent plasticity of neural circuits, but their detailed architectures remain unresolved. Using three-dimensional electron microscopy, we performed nano...

Forgetting is a ubiquitous phenomenon that is actively promoted in many species. The act of remembering some experiences can cause the forgetting of others in both humans and rats. We previously found...