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Yasu Okamoto

@yasuokamoto.bsky.social
132 followers 160 following 9 posts

Chemist working on Artificial metalloenzyme, Bioinorganic chemistry, Protein engineering. Institute for Molecular Science🇯🇵<-Tohoku Univ.🇯🇵<- Univ. Basel🇨🇭<-Osaka Univ.🇯🇵(Univ. Texas🇺🇸) HP: sites.google.com/view/y-okamoto-che…

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Reposted by Yasu Okamoto
Kai Johnsson @kjohnsson.bsky.social · 31/12/2025
A good end to 2025: rhodamine-binders for bioimaging in JACS: pubs.acs.org/doi/10.1021/...
pubs.acs.org
Fast, Bright, and Reversible Fluorescent Labeling of Rhodamine-Binding Proteins
Rhodamine dyes conjugated to targeting ligands can yield exceptionally bright fluorescent probes for live-cell imaging. However, the limited permeability of such rhodamine derivatives restricts their ...
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Reposted by Yasu Okamoto
Johannes Rebelein @rebeleinlab.bsky.social · 23/10/2025
Our latest work on the nitrogenase-like methylthio-alkane reductase, which specifically reduces reduces carbon-sulfide bonds is now out @natcatal.nature.com: doi.org/10.1038/s419.... We find for the first time large #nitrogenase metalloclusters (P- and L-cluster) outside nitrogenases.
doi.org
Methylthio-alkane reductases use nitrogenase metalloclusters for carbon–sulfur bond cleavage - Nature Catalysis
Methylthio-alkane reductases are recently discovered enzymes that can produce methanethiol and small hydrocarbons from methylated sulfur compounds. Now the cryo-EM structure of a methylthio-alkane red...
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European Research Council (ERC) @erc.europa.eu · 04/09/2025
📣 The ERC Starting Grant call results are out! Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025! ➡️ buff.ly/IsafuFh #FrontierResearch 🇪🇺#EUfunded #HorizonEurope
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Oliver Wenger @wengeroliver.bsky.social · 27/08/2025
New molecular design absorbs 2 photons to store 2 positive and 2 negative charges 100 ns lifetime, 3 eV energy storage, and 37% quantum yield A step toward multi-electron photochemistry Mathis Brändlin and @bjoernpfund.bsky.social in @natchem.nature.com www.nature.com/articles/s41...
nature.com
Photoinduced double charge accumulation in a molecular compound - Nature Chemistry
The photoinduced accumulation of redox equivalents is a challenging requirement for artificial photosynthesis. Now a molecule has been developed in which the sequential absorption of photons results i...
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Yasu Okamoto @yasuokamoto.bsky.social · 01/08/2025
Our latest paper is finally published in @natcomms.nature.com (doi.org/10.1038/s414...) !! We successfully constructed synthetic multinuclear metal complexes using only proteins.
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Shinya Tsukiji @shinyatsukiji.bsky.social · 29/07/2025
Excited to share that our Concept article on the chemogenetic protein translocation tool "SLIPT-PM" is now out in ChemBioChem! We review its development, key features, current applications, and future challenges in chemical biology. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com
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Yasu Okamoto @yasuokamoto.bsky.social · 27/07/2025
Heading to Long Beach for #ICBIC21! Excited to present our latest artificial metalloenzyme.
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Reposted by Yasu Okamoto
Virtual ChemBioTalks @chembiotalks.bsky.social · 24/07/2025
The fourth talk of the 5th Virtual ChemBioTalks will be given by @cathleenzeymer.bsky.social. She will talk about her group’s exciting research under the title “Design and directed evolution of artificial photoenzymes”. Make sure to register for free: cvent.me/G1geWW
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Reposted by Yasu Okamoto
Ryosuke Kojima @ryosukekojima.bsky.social · 24/07/2025
Excited to share that our new paper is out in @jacs.acspublications.org ! We introduce a new design principle for fluorogenic antigen probes, using an intramolecular reaction between a thiol-reactive fluorophore and a cysteine engineered into a DARPin. pubs.acs.org/doi/10.1021/...
pubs.acs.org
Design of Antigen-Targeting Fluorogenic Probes Utilizing Intramolecular Addition Reaction of Protein-Dye Hybrids
Fluorogenic probes for antigens are useful for various purposes, including medical diagnostics and imaging, but achieving a rapid, large fluorescence increase is difficult. Here, we report a new class...
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Reposted by Yasu Okamoto
Alicia Casitas @aliciacasitas.bsky.social · 20/07/2025
JOB ALERT! 🚨 Are you interested in organic synthesis and catalysis? We have an open PhD position in our group at Philipps-Universität Marburg in Germany. 👩‍🔬👨‍🔬 Deadline: 10th August 2025. For more details and to submit an application, please refer to the official posting here: lnkd.in/e_f3Xerq #chemsky
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Oliver Wenger @wengeroliver.bsky.social · 18/07/2025
We show how photoredox catalysis can bypass Kasha’s rule, enabling reactions from higher excited states. This work, led by the exceptional @bjoernpfund.bsky.social, offers new insights into photochemical reactivity. Published in JACS @jacs.acspublications.org bit.ly/3IysmjX
bit.ly
Breaking Kasha’s Rule to Enable Higher Reactivity in Photoredox Catalysis
Nearly all photochemical transformations known to date follow Kasha’s rule, implying that reactions occur only from the lowest electronically excited state of a given spin multiplicity due to the fast...
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Reposted by Yasu Okamoto
Kai Johnsson @kjohnsson.bsky.social · 10/07/2025
Molecular recording of cellular protein kinase activity with chemical labeling: www.nature.com/articles/s41... Congratulations to De-en Sun and the entire team.
nature.com
Molecular recording of cellular protein kinase activity with chemical labeling - Nature Chemical Biology
Molecular recorders based on kinase activity-dependent protein labeling track specific kinase activities to understand their link to cellular phenotypes in heterogeneous cell populations and in vivo.
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Yasu Okamoto @yasuokamoto.bsky.social · 07/07/2025
Grateful for the opportunity to present our photo-driven artificial metalloenzyme at #Biotrans2025. It was wonderful to reconnect with old colleagues and meet new friends!
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Yasu Okamoto @yasuokamoto.bsky.social · 07/07/2025
So many impressive and inspiring presentations at Repartzyme! Amazing to see how rapidly and significantly the field is progressing. Thrilled to meet many of my scientific heroes from my undergraduate days.
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Yasu Okamoto @yasuokamoto.bsky.social · 30/06/2025
Very happy to be back in Basel🇨🇭 for a while!
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Reposted by Yasu Okamoto
University of Basel @unibas.ch · 17/06/2025
Professor Oliver Wenger has received an Advanced Grant for his research projects in photochemistry, which involve chemical reactions triggered by light. This plays a part in processes such as the conversion of solar energy into other forms of energy. @wengeroliver.bsky.social
Professor Oliver Wenger
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University of Basel @unibas.ch · 17/06/2025
Professor Thomas Ward's ERC project "Bionix" explores new ways of producing nitrate, which plays a key role in global agriculture as a plant nutrient in fertilizers. Professor Ward and his team aim to establish an efficient process that uses significantly less energy and produces fewer emissions.
Professor Thomas Ward
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Verena Resch | 🧪🖥️ @verenaresch.bsky.social · 18/02/2025
New cover design @naturesynthesis.bsky.social I really had fun visualizing the Turner Lab’s research and am grateful that they let me take a playful approach. We turned one-pot multienzyme cascade reactions into a marble run—perfect for an animated cover! Research behind the cover ▶️ rdcu.be/ealKn
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Johannes Rebelein @rebeleinlab.bsky.social · 25/01/2025
Come and join us in Marburg
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Ryosuke Kojima @ryosukekojima.bsky.social · 21/01/2025
当グループ(@東大医)で博士研究員を募集しています。細胞外小胞/細胞間コミュニケーションの理解や操作を可能とする合成生物学研究に興味のある方はぜひご検討ください。もちろん学振PDの応募などの相談にものれます。ご興味があればお気軽にDMください!https://www.m.u-tokyo.ac.jp/news/jobs/20250121.pdf
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Chemjobber @chemjobber.bsky.social · 14/01/2025
The 2025 Chemistry Faculty Jobs List has 462 tenure-track positions and 77 teaching positions: bit.ly/facultychemj... #facultychemjobs chemjobs chemsky
bit.ly
The 2025 Chemistry Faculty Jobs List
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Xile Hu @xilehu-epfl.bsky.social · 07/01/2025
By incorporating two cofactors into the four binding sites of streptavidin, we engineered programmable artifical enzymes for tandem abiotic transformations including an enantioselective formal C–H hydroxylation and a photooxidation-Michael addition. onlinelibrary.wiley.com/doi/10.1002/... #chemsky
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Yasu Okamoto @yasuokamoto.bsky.social · 13/12/2024
📣 Our website got a fresh makeover! 🔍 Check out our updated lab website! sites.google.com/view/y-okamo...
sites.google.com
Designer Biomolecular Chemistry - English
Member Staff Assoc. Prof. (PI) : Yasunori Okamoto Assist. Prof. : – Administrative assistant : Ayaka Noda Research assistant : Tomoko Etoh Student It's you. Apply now!
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The Royal Swedish Academy of Sciences @scienceacademyswe.bsky.social · 05/12/2024
Today, several #NobelPrize Laureates arrive in Stockholm, warmly welcomed by Hans Ellegren. Here we see David Baker stepping off the plane at Arlanda. This week is packed with inspiration, press conferences and lectures, so stay tuned! 🌟 @uofwa.bsky.social @hhmi.bsky.social #Science #AcademicSky
Hans Ellegren Welcoming David Baker at Stockholm Arlanda.
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Reposted by Yasu Okamoto
Eric Topol @erictopol.bsky.social · 05/12/2024
The next frontier of T cell therapeutics when the T also stands for tissue-targeting, such as brain or local immune response, via synthetic gene circuits @science.org science.org/doi/10.1126/... science.org/doi/10.1126/... science.org/doi/10.1126/...
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Anna Peacock - Peacock Group @peacockgroup.bsky.social · 05/12/2024
One more week till the deadline - Please reach out if you have any questions or want to know more. Thanks
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Reposted by Yasu Okamoto
University of Basel @unibas.ch · 12/11/2024
Researchers from the University of Basel have created synthetic cells that mimic natural cell communication. These protocells, activated by light, could lead to new advances in basic research and medical applications. 👉 www.unibas.ch/en/News-Even...
Infographic illustrating how synthetic cell communication works: Within the sender, cells are nanocontainers – essentially artificial organelles – whose membranes contain special light-sensitive molecules known as molecular motors. These allow the researchers to set communication between the two cells in motion using a pulse of light: when light reaches the sender cell, the light-sensitive molecules open the nanocontainers, releasing their contents – let's call it substance A – into the sender cell's interior. Substance A can then leave the sender cell through pores in its polymer shell before reaching the receiver cell via the fluid surrounding the protocells. Then substance A enters the receiver cells – again via pores –  where it encounters artificial organelles harboring an enzyme. In turn, this enzyme converts substance A into a fluorescence signal, and the resulting glow tells researchers that signal transmission between sender and receiver has worked.
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Reposted by Yasu Okamoto
C&EN (Chemical & Engineering News) @cenmag.bsky.social · 04/12/2024
A team of researchers has expanded the menu of photobiocatalytic reactions to a three-piece combo. The reaction stitches together an aldehyde, an alkene, and an α-bromo ketone to create a single chiral ketone product. cen.acs.org/synthesis/bi... #chemsky #bluesci 🧪
cen.acs.org
Enzyme and photocatalyst juggle 3-component reaction
Researchers engineered an enzyme to wrangle multiple radicals with high stereoselectivity
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Yasu Okamoto @yasuokamoto.bsky.social · 02/12/2024
Honored to be appointed as Secretary of the Japan Society of Coordination Chemistry. Looking forward to making meaningful contributions (sakutai.jp/en/organizat...).
sakutai.jp
Organization  |  錯体化学会 Japan Society of Coordination Chemistry
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Rachel Brazil @rachelbrazil.bsky.social · 28/11/2024
Can you write the narrative of your research career? Rather than lists of publications this is what many universities and funders are now requiring. Narrative CVs may foster a more inclusive selection processes but do we know how to write and assess them? www.chemistryworld.com/careers/the-...
chemistryworld.com
The narrative CV: a step towards more inclusive science?
Exploring an alternative to a traditional list of achievements
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Reposted by Yasu Okamoto
Engineering Biology Interdisciplinary Research Centre @engbioirc.bsky.social · 28/11/2024
Now at #SBUK24 we're straight onto Protein and Genome Design session with the first keynote from Dek Woolfson exploring rational and computational protein design and applications in modifying cellular transport
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Andreas Walther @waltherlab.bsky.social · 25/11/2024
Join our team as a PhD researcher in Biomaterials for Neural Regeneration as part of our multi-partner center Interreg funded by @CZ_Stiftung the full call is here. www.nature.com/naturecareer... more details on our position: www.walther-group.com/job-openings... #phdjobs #chemjobber #PhD #chemsky
nature.com
PhD student positions in Synthetic Biomaterials and Neuroregeneration - Mainz, Rheinland-Pfalz (DE) job with Johannes Gutenberg University Mainz - Departments of Biology and Chemistry | 12832541
Four PhD student positions available in Chemistry, Polymer Research, DNA Nanoscience and Neuroregeneration
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Yasu Okamoto @yasuokamoto.bsky.social · 22/11/2024
Hi #ChemSky! 👋 Started my research group "Designer Biomolecular Chemistry" at National Institutes of Natural Sciences, Japan🇯🇵 (Aug 2024). Working on designer enzymes for abiotic reactions, combining novel metal catalysis🧪 and protein engineering💪.
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MSCA DN MetRaZymes @metrazymes.bsky.social · 21/11/2024
The Marie Sklodowska-Curie Actions Doctoral Network MetRaZymes is now also on BlueSky! @bruns-lab.bsky.social
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