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Yassi Aghazadeh

@yassiag.bsky.social
585 followers 1K following 30 posts

Assistant Professor at IRCM, University of Montreal; Adjunct at McGill University. Stem cells, islets, vessels & regenerative medicine for T1D. AghazadehLab.com She/her. Tiohtiá:ke/Montreal. Opinions are my own.

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Yassi Aghazadeh @yassiag.bsky.social · 14/09/2026
Congratulations are in order for Usama for finishing his M.Sc. at @mcgill.ca Experimental Medicine!
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Zebrafish Rock! @zebrafishrock.bsky.social · 03/05/2026
First 22 hours of zebrafish development. Credit to @zebrafish007.bsky.social at #WeinsteinLab. #ZebrafishZunday 🧪
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Yassi Aghazadeh @yassiag.bsky.social · 15/04/2026
Inspiring #DesignDay @mcgilluniversity.bsky.social! Proud of Giselle for her capstone presentation on improving islet-on-a-chip platforms to better model development & obtaining a BSc in Bioeng. The fabrication/3D printing wouldn’t be possible w/o collaboration w Juncker lab & @hoeslilab.bsky.social
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Yassi Aghazadeh @yassiag.bsky.social · 25/03/2026
Great work by @tigerhzjian.bsky.social
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Yassi Aghazadeh @yassiag.bsky.social · 25/02/2026
Congratulations to all the awardees of IRCM foundation scholarship, including our own Théa Milland & Noah Verreault. I appreciate the donors who made this possible. These awards are competitive & externally reviewed - I highly appreciate the reviewers for their time, effort and support of students!
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Yassi Aghazadeh @yassiag.bsky.social · 10/02/2026
Junior PI position in cancer research open at the IRCM. Apply below 👇🏽 #PIposition #assistantprofessor #cancer #openposition #ircm
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Robert Screaton @roblab.bsky.social · 21/01/2026
Today in the 🇨🇦 National Grad course in #Islet Biology and #Diabetes we welcome superstars Cristina Nostro and @yassiag.bsky.social to discuss the latest on using #stemcell derived islet cells as a strategy to treat (cure?) #T1D!
media.tenor.com
a woman wearing sunglasses and a blue shirt is making a funny face and saying `` no autographs please '' .
ALT: a woman wearing sunglasses and a blue shirt is making a funny face and saying `` no autographs please '' .
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Yassi Aghazadeh @yassiag.bsky.social · 16/12/2025
Wrapping up a great year for the lab. We in 2025 we expanded and reached some important milestones as a growing team. Grateful for the collective effort and momentum. Wishing friends and colleagues a restful holiday season and a happy start to the new year.
EXKAPAZ scape room experience, Montreal Jardin des Panos, Montréal
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Islet Biology Lab - UMH @isletbiologylab.bsky.social · 12/12/2025
Lietzke et al. demonstrate that pluripotent stem cell-derived β cells exhibit reduced oxidative and mitochondrial fatty acid metabolism compared to primary human islets, which is related to limitations in key mitochondrial transcriptional networks. 🧪 #PancSky www.nature.com/articles/s41...
nature.com
Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells - Nature Communications
Here they show that PPARα-dependent mitochondrial programming promotes the differentiation of pluripotent stem cell-derived β cells. Targeting mitochondria has the potential to improve β cell replacem...
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Stem Cell Network @stemcellnetwork.ca · 14/11/2025
(3/3) SCN has supported this work every step of the way. From 2016–2028, SCN has committed over $11.5 million in funding for innovative diabetes research and clinical trials. ✨ Meet the SCN-funded researchers are helping pave the way.
World Diabetes Day
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Stem Cell Network @stemcellnetwork.ca · 14/11/2025
(3/3) Le RCS a soutenu chaque étape de ces travaux, s’engageant à fournir plus de 11,5 M$ de 2016 à 2028 pour des recherches innovantes et des essais cliniques sur le diabète. ✨ Faites connaissance avec les chercheurs soutenus par le RCS qui contribuent à tracer le chemin dans ce domaine.
World Diabetes Day
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Yassi Aghazadeh @yassiag.bsky.social · 23/10/2025
Proud PI moment at @RéseauThéCell: 🏅 Ying Deng – Best Poster PhD 🏅 Thea Milland – Best Poster MSc 🏅 Giselle de Leon – Best Poster BSc Representing @ircm.bsky.social , Ying and Thea @umontreal.ca , Giselle @mcgill.ca Grateful to organizers Kim Santerre and Dr Corinne Hoesli for this meeting!
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Yassi Aghazadeh @yassiag.bsky.social · 23/10/2025
It was great honor to attend and present at @navbo.bsky.social Vascular 2025 meeting. Huge thanks to the organizers for putting this tremendous meeting together. And what a special session focusing on vascularization of organoids and disease on a chip models.
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Stem Cell Network @stemcellnetwork.ca · 29/09/2025
📢 McGill University is hiring! The Department of Pharmacology and Therapeutics, with the Meakins-Christie Labs at the RI-MUHC, invites applications for a tenure-track Assistant Professor in Pluripotent Stem Cells in Regenerative Medicine. Learn more and apply. ➡️ stemcellnetwork.ca/wp-content/u...
Tenure-Track Assistant Professor
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Yassi Aghazadeh @yassiag.bsky.social · 27/09/2025
Interesting and impactful new work by Estall lab: “Here, we identify a novel biological pathway downstream of glucagon that promotes the hepatic lipid accumulation associated with fasting” 👇🏽👇🏽👇🏽 #Glucagon #MASLD #Fasting
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Institut de recherches cliniques de Montréal (IRCM) @ircm.bsky.social · 21/08/2025
Congratulations to Dr. Côté on his appointment to the Canadian Academy of Health Sciences! This prestigious distinction recognizes his scientific leadership, the excellence of his health research as well as his commitment to collaboration and innovation in health. 🔗 bit.ly/3HGWhX3
🎉 Congratulations to Dr. Jean-François Côté on his appointment to the Canadian Academy of Health Sciences! This prestigious distinction recognizes his scientific leadership, the excellence of his health research—particularly on cell migration and metastasis—as well as his commitment to collaboration and innovation in health.
A well-deserved recognition! 👏
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Ondine Cleaver @ondinecleaver.bsky.social · 13/08/2025
I’m one of the mentors for this year long internship :) Apply if you have interest in writing and Science Communication. There’s opportunity to get some of your pieces in DB @devbiol.bsky.social! Apply today!!
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Yassi Aghazadeh @yassiag.bsky.social · 04/08/2025
Very proud to share the first review from the lab with contributions of all lab members. Writing this gave our new lab opportunity to read and discuss many papers and grow as a team. www.frontiersin.org/journals/imm...
frontiersin.org
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Yassi Aghazadeh @yassiag.bsky.social · 27/06/2025
Very excited about our project aiming at advancing cell therapies for type 1 diabetes. and very thankful for receiving funding from @stemcellnetwork.ca
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Islet Biology Lab - UMH @isletbiologylab.bsky.social · 22/04/2025
Preza et al. show that a circadian transcription factor specific to maturing stem cell-derived-β cells, DEC1, regulates insulin responsiveness to glucose. 🧪 #PancSky #StemCells www.biorxiv.org/content/10.1...
biorxiv.org
DEC1 Regulates Human β Cell Functional Maturation and Circadian Rhythm
Stem cell-derived islet (SC-islet) organoids offer hope for cell replacement therapy in diabetes, but their immature function remains a challenge. Mature islet function requires the β-cell circadian c...
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Development @dev-journal.bsky.social · 22/04/2025
Stem cell-based models of early human development Read this Development at a Glance Article by Lizhong Liu @liliulab.bsky.social and Jun Wu @jun-wu-lab.bsky.social: journals.biologists.com/dev/article/...
Poster titled Stem cell-based models of early human development
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Islet Biology Lab - UMH @isletbiologylab.bsky.social · 09/04/2025
Bonifacio and Ziegler summarize current evidence and guidance while emphasizing the need for continued research alongside broader screening application in #type1diabetes. 🧪 #PancSky dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...
dom-pubs.onlinelibrary.wiley.com
Type 1 diabetes risk factors, risk prediction and presymptomatic detection: Evidence and guidance for screening
Type 1 diabetes is recognized as a chronic disease with a presymptomatic phase that does not require insulin therapy and a clinical phase where insulin treatment becomes necessary. The presymptomati...
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Yassi Aghazadeh @yassiag.bsky.social · 31/03/2025
A protective INS SNP causes accelerated IRE1α-dependent decay of insulin mRNA, alleviates ER stress and reduces beta-cell immunogenicity www.cell.com/cell/fulltex...
cell.com
Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay
Insulin gene variation predisposes individuals to type 1 diabetes (T1D). We report a new mechanism of genetic protection from T1D in which insulin mRNA with a protective SNP is broken down by IRE1α, t...
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Diabetologia @diabetologiajnl.bsky.social · 28/03/2025
Enterovirus infections may occur throughout the natural history of type 1 #diabetes and may be associated to islet cell HLA-I hyperexpression. @teresarc.bsky.social @sarahibex.bsky.social #T1D #DiabetesResearch link.springer.com/article/10.1... 🔓
link.springer.com
Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes - Diabetologia
Aims/hypothesis Earlier studies of pancreases from donors with type 1 diabetes demonstrated enteroviral capsid protein VP1 in beta cells. In the context of a multidisciplinary approach undertaken by t...
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Yassi Aghazadeh @yassiag.bsky.social · 26/03/2025
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Alex Rubinsteyn @alexr.bsky.social · 25/03/2025
I've been really hoping someone would do a study like this! www.mcponline.org/article/S153...
mcponline.org
Deleterious knock-outs in the HLA class I antigen processing and presentation machinery induce distinct changes in the immunopeptidome
The human leukocyte antigen (HLA) processing and presentation machinery (APPM) is altered in various diseases and in response to drug treatments. Defects in the machinery may change presentation level...
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Christos Karampelias @ckarampelias.bsky.social · 26/03/2025
Nice discussion on the usefulness of genetic and autoantibody screening in children for T1D
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Yassi Aghazadeh @yassiag.bsky.social · 23/03/2025
Happy Persian new year, Norouz, and the beginning of spring! 🌸🪻☀️
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Robert Screaton @roblab.bsky.social · 19/02/2025
Today, rising stars @drprentice.bsky.social and @yassiag.bsky.social swing through the 🇨🇦 National #Islet and #Diabetes Course to discuss the latest on vascularizing stem cell-derived islet cells, adipose-islet communication, beta cell proliferation, and more @cirtn.bsky.social
media.tenor.com
a man holding two cell phones with the words kind of a big deal
ALT: a man holding two cell phones with the words kind of a big deal
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Yassi Aghazadeh @yassiag.bsky.social · 19/02/2025
Honored to have recieved this together with Dr Hoesli and @martinsauvageau.bsky.social
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Yassi Aghazadeh @yassiag.bsky.social · 12/02/2025
More cause to celebrate in this anti science climate! Happy international day of women and gender minorities in science 🧬
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The Histochemical Society (HCS) and Journal (JHC) @histochemicalsoc.bsky.social · 27/01/2025
Read the latest Special Topic on Endothelial Cell and Pericyte Homeostasis and Pathogenesis in JHC: "Role of the Pancreatic Islet Microvasculature in Health and Disease." Click to read for FREE: bit.ly/4fihNMw #capillary #diabetes #endothelialcell
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Jorge Ferrer @jorge-ferrer.bsky.social · 02/02/2025
Still time to apply! Applications from US welcome – four years can feel longer or shorter depending on where you are 😉
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Institut de recherches cliniques de Montréal (IRCM) @ircm.bsky.social · 19/12/2024
#RECRUITMENT | Shape Your Future in Biomedical Research At the IRCM, you can choose the program that best suits you and start your journey towards a rewarding career in research. The recruitment period runs from December 15, 2024, to January 31, 2025. www.ircm.qc.ca/en/studies #DrivenByLife
#RECRUITMENT | Shape Your Future in Biomedical Research
At the IRCM, you can choose the program that best suits you and start your journey towards a rewarding career in research.
The recruitment period runs from December 15, 2024, to January 31, 2025.
If you are selected by our researchers, you will be invited, at the IRCM's expense, to participate in a short stay at our facilities in May 2025.
#DrivenByLife
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Heiko Lickert @heikolickert.bsky.social · 21/01/2025
Application deadline is get closer - make sure you do not miss this exciting EMBO workshop on liver and pancreatic biology and disease 😉 meetings.embo.org/event/25-liv...
meetings.embo.org
Liver and pancreas in metabolic disease: from pathways to therapies
The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…
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Sara Nunes Vasconcelos, PhD she/her/hers🇨🇦🇧🇷 @saravasconcelos.bsky.social · 29/01/2025
Amidst the craziness in the world right now I feel there is even more reason to celebrate: Xuetao's paper is now online! Check it out : www.cell.com/stem-cell-re... 1/3
cell.com
Microvessel co-transplantation improves poor remuscularization by hiPSC-cardiomyocytes in a complex disease model of myocardial infarction and type 2 diabetes
In this article, Nunes Vasconcelos and colleagues show that co-delivery of adipose-derived microvessels and hiPSC-cardiomyocytes improves cardiomyocyte survival, graft size, and cardiac function in a ...
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Eric Topol @erictopol.bsky.social · 27/01/2025
Spatial multi-omics has just gone to the next level! www.nature.com/articles/s41... www.nature.com/articles/s41... —Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm —"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"
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Institut de recherches cliniques de Montréal (IRCM) @ircm.bsky.social · 06/01/2025
This CityNews report highlights the expertise of Dr. Jane Yardley of the IRCM whose research focuses on physical activity in postmenopausal women living with type 1 diabetes. bit.ly/4fHOvXL
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Yassi Aghazadeh @yassiag.bsky.social · 14/12/2024
Celebrating the end of a fun, collaborative & productive year! Wishing everyone a happy holiday season ⛄️
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Ondine Cleaver @ondinecleaver.bsky.social · 06/12/2024
Important discussion in @devbiol.bsky.social by Scott Gilbert. As scientists, and as developmental biologists, we really need to share the facts we know with the public. #DevBio
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Institut de recherches cliniques de Montréal (IRCM) @ircm.bsky.social · 29/11/2024
#SciencePOP | Discover the 2024 winners in pictures Before a delighted audience, finalists of 12 institutions from all across Quebec gathered and competed in three high-level challenges. www.ircm.qc.ca/en/news-deta...
ircm.qc.ca
Provincial Grand Finale of the Science POP Competition: Science Comes Out on Top
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Vuk Stambolic @vukstambolic.bsky.social · 12/11/2024
We are recruiting! Princess Margaret Cancer Centre in Toronto is recruiting an early career cancer research scientist at Assistant Professor level. Apply! Spread the word! www.nature.com/naturecareer...
nature.com
Scientist I - Cancer Biology - Toronto (City), Ontario (CA) job with Princess Margaret Cancer Centre | 12831982
Princess Margaret seeks early-career faculty scientists to establish research programs in Cancer Biology - broadly defined.
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Yassi Aghazadeh @yassiag.bsky.social · 27/11/2024
Check out our review led by the amazing @rlhull-meichle.bsky.social on the role of pancreatic microvascualture in health and disease and beta cell replacement therapies: journals.sagepub.com/doi/full/10....
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Aida Martinez-Sanchez @aidamartinezs.bsky.social · 27/11/2024
We are recruiting a postdoctoral research associate! Have a look at the flyer and/or the links below and get in touch if you have any questions! And please, share widely!! www.imperial.ac.uk/jobs/search-...
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Heiko Lickert @heikolickert.bsky.social · 25/11/2024
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”. doi.org/10.1038/s422... A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
doi.org
Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism
The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.
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Yassi Aghazadeh @yassiag.bsky.social · 14/11/2023
On this #WorldDiabetesDay we took the opportunity to bring special attention to type ONE diabetes by #BlueBalloonChallenge, & to highlight the need for new therapies + exercise. Sneak peak below with @JaneYardley2 @Herve_VR @Olilideng @ircm_mtl @DiabetesCanada (full video tmrw)
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