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wellerchen.bsky.social

@wellerchen.bsky.social

Reposted by @wellerchen.bsky.social

Chris McGinnis @cmcginnis.bsky.social · 27/03/2025

Thrilled to see our paper out today in @cp-cancercell.bsky.social — in collaboration with @yardenasamuels.bsky.social @wellerchen.bsky.social and many others, we show how perturbing translation fidelity causes aberrant peptide generation in tumors and anti-tumor immune responses in vivo — 🧵here

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Reposted by @wellerchen.bsky.social

Parker Institute for Cancer Immunotherapy (PICI) @parkerici.bsky.social · 27/03/2025

What if a “mistake” made tumors easier to find? New PICI-funded study from co-first author @cmcginnis92 at @stanfordmedicine shows that removing TYW2 scrambles protein translation—producing signals that help the immune system detect and attack cancer. 🔗 www.cell.com/cancer-cell/...

cell.com

Translation dysregulation in cancer as a source for targetable antigens

Weller et al. substantiate the role of translation dysregulation in mediating anti-tumor immunity by demonstrating that TYW2 loss in melanoma cells induces aberrant peptide MHC presentation, increasin...

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wellerchen.bsky.social @wellerchen.bsky.social · 02/04/2025

Thanks a lot @acir-org.bsky.social for highlighting our work and generating this great illustration!!

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wellerchen.bsky.social @wellerchen.bsky.social · 12/03/2025

Brilliant meeting at the #MICC2025 in Athens! I was fortunate to get a picture with my mentor @yardenasamuels.bsky.social next to my poster.

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