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Yan Shao

@yanshao.bsky.social
24 followers 23 following 10 posts
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Reposted by Yan Shao
Gerry Tonkin-Hill @gerrythill.bsky.social · 02/09/2026
Glad to share StrainSpy, a new method developed by Sudaraka and co which identifies strain-level associations in metagenomics using ANI estimates from tools like Sylph. www.biorxiv.org/content/10.6...
biorxiv.org
Accurate detection of metagenomic strain-level associations using average nucleotide identity with StrainSpy
Genetic variation among microbial strains of the same species can profoundly influence their phenotypes, ecological functions, and impacts on human health. Traditionally, the relative abundance of a s...
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Reposted by Yan Shao
Gerry Tonkin-Hill @gerrythill.bsky.social · 30/06/2026
Happy to share the latest work from Zunair Khurram, a PhD student in our lab! Zunair has developed a new method, MxSure, to infer within-host substitution rates and transmission thresholds from longitudinal isolate and metagenomic sequencing data. www.biorxiv.org/content/10.6...
biorxiv.org
MxSure: a mixture model for inferring within-host substitution rates and transmission SNP thresholds
Quantifying short-term evolutionary rates of microbial genomes is essential for understanding the processes that shape within-host evolution and for establishing thresholds needed to track transmissio...
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Yan Shao @yanshao.bsky.social · 28/04/2026
Great to see TRACS out in press - a new metagenomic strain transmission tool, led by @gerrythill.bsky.social. With improved precision and sensitivity, and unique support for custom reference and minor-strain detection, TRACS enables more rigorous and comprehensive strain-level metagenomics analysis.
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Reposted by Yan Shao
Wellcome Sanger Institute @sangerinstitute.bsky.social · 24/04/2026
Read ‘Enhanced metagenomics-enabled transmission inference with TRACS’ from @sangerinstitute.bsky.social, @petermaccc.bsky.social , University of Oslo, @gerrythill.bsky.social and others, in @natmicrobiol.nature.com , here ⤵️ www.nature.com/articles/s41...
nature.com
Strain-level transmission inference across multi-kingdom metagenomic data using TRACS - Nature Microbiology
The TRACS algorithm tracks bacteria, viruses and parasites in metagenomic or population sequencing data, detecting microbial transmission even when multiple strains coexist within a host.
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Reposted by Yan Shao
Jim Shaw @jimshaw.bsky.social · 27/03/2026
Myloasm, our long-read metagenome assembler, is now published! w/ @mgmarin.bsky.social and @lh3lh3.bsky.social Very rewarding after > a year of development and countless hours thinking about assembly. Thanks to beta testers, Li lab, and reviewers who gave very helpful feedback. rdcu.be/famFj
rdcu.be
High-resolution metagenome assembly for modern long reads with myloasm
Nature Biotechnology - A long-read metagenome assembly method recovers circular and complete genomes better than existing tools.
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Reposted by Yan Shao
Nature Microbiology @natmicrobiol.nature.com · 16/03/2026
Out Now! Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids #MicroSky
go.nature.com
Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids
Nature Microbiology, Published online: 16 March 2026; doi:10.1038/s41564-026-02297-4Clostridium perfringens lacking perfringolysin O toxin isolated from preterm infants metabolizes human milk oligosaccharide disialyllacto-N-tetraose to produce metabolites that promote the growth of commensal bifidobacteria, inhibit pathogens and suppress inflammation in an organoid model.
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Yan Shao @yanshao.bsky.social · 20/02/2026
Excited to share our latest work on early-life Bifidobacteria. We built a global genomic atlas of 4,000+ genomes from 48 countries for B. infantis and B. longum, expanding previous resources by 15-fold. Read the press release @sangerinstitute.bsky.social: www.sanger.ac.uk/news_item/mi...
sanger.ac.uk
Missing microbes in UK infant gut and probiotics highlighted by global microbiome atlas
Experts have created a global atlas of over 4,000 bacterial genomes from two key bacteria found in the infant gut. It highlights one that is often used in infant probiotics is rare in Western babies a...
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Reposted by Yan Shao
Wellcome Sanger Institute @sangerinstitute.bsky.social · 19/02/2026
A global atlas of two key babybiome bacteria has found one of these is missing in UK babies, despite being common in children from other countries. This atlas is 15x larger than other studies and lays the foundation for more effective, tailored infant probiotics. www.sanger.ac.uk/news_item/mi...
sanger.ac.uk
Missing microbes in UK infant gut and probiotics highlighted by global microbiome atlas
Experts have created a global atlas of over 4,000 bacterial genomes from two key bacteria found in the infant gut. It highlights one that is often used in infant probiotics is rare in Western babies a...
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Reposted by Yan Shao
Jim Shaw @jimshaw.bsky.social · 28/05/2025
Announcing myloasm, a new long-read (ONT R10/PacBio) metagenome assembler that I've been working on during my postdoc in the Heng Li lab (@lh3lh3.bsky.social). myloasm-docs.github.io
myloasm-docs.github.io
myloasm - metagenomic assembly with (noisy) long reads
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Yan Shao @yanshao.bsky.social · 21/03/2025
🚨 We’re #hiring a Staff Scientist to drive innovative computational workflows for large-scale, multi-omics data in human microbiome research @sangerinstitute.bsky.social 📅 Closing date: 27th April 2025 📢 Please share & apply! sanger.wd103.myworkdayjobs.com/en-US/Wellco...
sanger.wd103.myworkdayjobs.com
Staff Scientist - Computational
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
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Reposted by Yan Shao
Josie Bryant @josiebryant.bsky.social · 12/03/2025
If you have experience in sc/spatial transcriptomics with an interest in microbes....come and join our team as a computational postdoc: sanger.wd103.myworkdayjobs.com/WellcomeSang... Incredibly exciting datasets on host-microbe interactions in the lung. Pls RT and reach out if you are interested.
sanger.wd103.myworkdayjobs.com
Postdoctoral Fellow - Computational
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
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Reposted by Yan Shao
Gavin Boothroyd @boothroydgav.bsky.social · 12/03/2025
Really looking forward to attending @microbiologysociety.org annual meeting in Liverpool. As well as a great @pacbio.bsky.social symposium with talks from @jewilki.bsky.social and @yanshao.bsky.social we will have the #Vega system on booth so please stop past for a demo #MicroBio25
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Reposted by Yan Shao
Tommi Mäklin @themaklin.bsky.social · 05/12/2024
New paper: We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers. www.sciencedirect.com/science/arti...
sciencedirect.com
Geographical variation in the incidence of colorectal cancer and urinary tract cancer is associated with population exposure to colibactin-producing Escherichia coli
Biomedical research has implicated the bacterial metabolite colibactin as a causal risk factor for several cancer types, in particular, colorectal can…
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