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Michael D. Wilson

@wilson-md.bsky.social
371 followers 484 following 35 posts

Senior Scientist, Program in Genetics and Genome Biology, Hospital for Sick Children; Associate Professor Dept. of Molecular Genetics, University of Toronto. Visiting Professor, University of Western Australia.

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Michael D. Wilson @wilson-md.bsky.social · 03/02/2026
This is an amazing rescue story. After spending a year in Australia with my family it was clear how much emphasis was put in teaching all kids to swim and how important it is. What a brave boy. Hero. www.cbc.ca/news/world/a...
cbc.ca
Australian boy, 13, swims for 4 hours to save family swept out to sea | CBC News
A 13-year-old boy is credited with saving the lives of his mother and two younger siblings with an hourslong swim after the family was swept out to sea off the Australian coast.
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Michael D. Wilson @wilson-md.bsky.social · 15/01/2026
Happiness is a kid waking up to find out its a snow day.
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Wyeth Wasserman @wywywa.bsky.social · 18/12/2025
UBC and BC Cancer are recruiting a cancer stem cell faculty member at the Associate Professor or Professor rank for the new Connie Eaves Chair in Cancer Stem Cell Research. A great position recognizing a giant in the field. Please share. #Vancouver ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
ubc.wd10.myworkdayjobs.com
Associate Professor (tenure) or Professor (tenure) Dr. Connie Eaves Chair in Cancer Stem Cell Research
Academic Job Category Faculty Bargaining Job Title Associate Professor (tenure) or Professor (tenure) Dr. Connie Eaves Chair in Cancer Stem Cell Research Department School of Biomedical Engineering | ...
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Jüri Reimand @reimand.bsky.social · 30/11/2025
⚠️New study: we mapped DNA-binding of topoisomerase TOP2B in cancer, uncovering surprising hotspots of DNA damage. TOP2B, normally essential for DNA stress relief, can act as a double-edged sword. co-led by @LiisUuskula @ChristianLee, out now @natcomms.nature.com www.nature.com/articles/s41... [1/7]
nature.com
Topoisomerase IIb binding delineates localized mutational processes and driver mutations in cancer genomes - Nature Communications
Topoisomerases resolve topological DNA stress via double-strand breaks and are established targets of cancer chemotherapies. Here, the authors link genomic binding of TOP2B with localized mutational p...
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Biodiversity Genomics Europe plus (BGE+) @biogeneurope.bsky.social · 30/09/2025
♨️Live @ #BGEconnects: Finished “EBP – How genomics is transforming understanding of biodiversity through reference genome production” by Harris Lewin, chair of @ebpgenome.bsky.social. “Reference-quality genomes can now be produced at scale”, he says. “We need to work together to scale up.” #BGE
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Brian Wilde @bwildemtl.bsky.social · 21/04/2025
Canada is ranked 1 in education, 3 in safety, 4 in justice, 4 in overall best country. We are not a broken country. We have not suffered a lost decade. Our existence is in the balance. Vote.
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Michael D. Wilson @wilson-md.bsky.social · 16/04/2025
Keep on Rockin in the free world!
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Michael D. Wilson @wilson-md.bsky.social · 04/04/2025
Michael got me over here too :)
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Stephen Turner @stephenturner.us · 27/03/2025
PatchWorkPlot: simultaneous visualization of local alignments across multiple sequences arxiv.org/abs/2503.20766 🧬🖥️🧪 github.com/yana-safonov...
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Michael D. Wilson @wilson-md.bsky.social · 24/03/2025
I couldn't agree more!
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Michael D. Wilson @wilson-md.bsky.social · 23/03/2025
This quote comes at 7:48 (not in article). Smith does a good job explaining the Cdn perspective of tariffs and the diffs between Cdn and US political systems. Noting common ground gives me more confidence that Smith's articulate opinion on Poliviere is accurate. m.soundcloud.com/breitbart/pr...
m.soundcloud.com
Premiere Danielle Smith (Alberta, CA) - March 8, 2025
Play Premiere Danielle Smith (Alberta, CA) - March 8, 2025 by Breitbart on desktop and mobile. Play over 320 million tracks for free on SoundCloud.
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Tuuli Lappalainen @tuuliel.bsky.social · 19/03/2025
4) Their definition of epigenetics is also somewhat awkward (see e.g. www.nature.com/articles/nrm...). This is a very cool paper, but the science would shine brighter without the somewhat forced attempt to dress established knowledge as a new concept via awkward terminology.
nature.com
A user's guide to the ambiguous word 'epigenetics' - Nature Reviews Molecular Cell Biology
The term 'epigenetics' has multiple interpretations, so we need to be clear which definition we are using, argues John Greally.
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Prospect Magazine @prospectmagazine.co.uk · 16/03/2025
Canada has existential choices to make in the Trump era. It had become complacent about its many virtues, and has had a sharp awakening, writes Michael Ignatieff. www.prospectmagazine...
prospectmagazine.co.uk
As America retreats, Europe must step up
An unstable world order, divided between competing superpowers, will force all other nations to make tough choices
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Michael D. Wilson @wilson-md.bsky.social · 01/03/2025
Thank you for sharing this! Many of the best meetings are in the US but it seems irresponsible to go. Sending an international student to the US at this time could even be dangerous. I have told my lab that I am not eager to support US travel, but also realize for career reasons it may be necessary.
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Michael D. Wilson @wilson-md.bsky.social · 28/02/2025
Congratulations Federico!
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Alexandra Gallant-Lee @alexandragallant.com · 26/02/2025
This is incredible
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ian bremmer @ianbremmer.com · 25/02/2025
the united states no longer condemns russia’s invasion of ukraine. aligning the us with belarus, sudan, north korea and other failed states. a reflection of changing policy and a wake up call for us allies.
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Michael D. Wilson @wilson-md.bsky.social · 18/02/2025
I like tweet. It pays tribute to the happy premuskian days sci-twitter. Also avoids adding another silly verb to the vocabulary:)
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Liz Worthey @lizworthey.bsky.social · 17/02/2025
MW: Highlighting the importance of collaborative research to his own work - pointed out that a very fruitful project in his lab was spearheaded as a collaboration by a student who rotated in both labs and brought them together, the PIs now work together successfully on join projects #LorneGenome25
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Lewis Kamb @lewiskamb.bsky.social · 14/02/2025
CDC source: “We just had word that all our fellows and post doc staff are laid off effective immediately. The famous Epidemic Intelligence Service, aka the Disease Detectives, is no more. That’s 1260 staff. They are calling this ‘Phase 1’.”
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Michael D. Wilson @wilson-md.bsky.social · 13/02/2025
And gives a clear example that turned out to be quite true: "For example: the spread of cancer is alarming—what are we to do about it? At the moment, no one can answer the question for lack of knowledge; and the knowledge is not likely to emerge except through endowed research."
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Michael D. Wilson @wilson-md.bsky.social · 13/02/2025
He clearly links the good life to funding research: "The knowledge required can only exist where governments or millionaires devote themselves to its discovery and diffusion."
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Michael D. Wilson @wilson-md.bsky.social · 13/02/2025
"What I Believe" by Bertrand Russell is 100 yrs old and still relevant (www.gutenberg.org/ebooks/73782). "The good life, as we conceive it, demands a multitude of social conditions, and cannot be realized without them. The good life, we said, is a life inspired by love and guided by knowledge."
gutenberg.org
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Heba Gowayed هبة جويد @hebagowayed.bsky.social · 10/02/2025
You heard it here first folks, borders aren’t real, they’re just an artificial line someone drew. This quote will 100% start one of my book chapters.
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Charlie Angus @charlieangus104.bsky.social · 09/02/2025
You are making a big difference in standing up to tyranny. Your decision to cancel the family trip to the United States is freaking them out. As Donald insults our nation, businesses are watching our tourism dollars dry up. Boycott all trips to the United States. www.thetravel.com/us-travel-as...
thetravel.com
U.S. Travel Association Warns of Economic Tourism Disaster After Thousands of Canadian Tourists Cancel Trips in Protest
While Proposed Tariffs Against Canada Are Now Paused, Canadian Travel Agencies Already Witnessing Retaliation in Form of Canceled Trips
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Mark Cuban @mcuban.bsky.social · 09/02/2025
This is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !” globalnews.ca/news/9793403...
globalnews.ca
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
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Michael D. Wilson @wilson-md.bsky.social · 04/02/2025
Sound advice!
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Joshua J. Friedman @joshuajfriedman.com · 02/02/2025
There's such a tone of sadness to the CBC reporting right now. Adrienne Arsenault says, “I feel like the whole country, all of us, are getting both a history lesson and a politics lesson and an economics lesson and a lesson in heartache.”
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c0nc0rdance @c0nc0rdance.bsky.social · 27/01/2025
PubMed launched in 1996, but took time to take off as an Internet-enabled replacement. Now it's easy to forget how miserable the alternative was. Thank you, National Library of Medicine, for keeping grad students where they belong: listening to true crime podcasts while pipetting.
A grad student at a bench, pipette in hand, and headset on listening to something.  It's a cartoon-type of illustration I stole from a site called "The Pathologist" used as the icon for the podcast list they recommend.
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Michael D. Wilson @wilson-md.bsky.social · 22/01/2025
Congratulations!
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Michael D. Wilson @wilson-md.bsky.social · 21/01/2025
Dr. Derry have you found a new job? Nevertheless great to see you take matters into your own hands!
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Michael D. Wilson @wilson-md.bsky.social · 17/01/2025
Looking forward to it!
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Miguel Ramalho-Santos @mrsantos.bsky.social · 02/01/2025
We found that copies of the LINE1 transposon are key “architects” of the nucleolar genome in human embryonic stem cells. This work brings together two facets of Barbara McClintock’s pioneering research: nucleolar organizer regions and transposable elements. www.genesdev.org/cgi/doi/10.1...
genesdev.org
LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
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Michael D. Wilson @wilson-md.bsky.social · 12/12/2024
This looks great. I am looking forward to trying this out. Thank you for sharing!
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Chenxin Li, PhD @chenxinli2.bsky.social · 12/12/2024
My Tidyverse local synteny visualizer is up on GitHub: github.com/cxli233/Tidy... GitHub page contains 2 example datasets, as well as step-by-step instruction & explanations on how it works. Details on required input data are discussed in the GitHub page. Let me know if you run into issues.
Local synteny visualization with 3 species highlighting 3 homologous groups of genes.  Local synteny visualization of 5 bean varieties, highlighting numerous TIR-NBS-LRR family disease resistant genes.
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Michael D. Wilson @wilson-md.bsky.social · 02/12/2024
Congratulation Maik et al. what a fantastic system and exciting results.
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Michael D. Wilson @wilson-md.bsky.social · 02/12/2024
:) Its weird how acronyms become old friends in the lab but don't resonate so much out in the wild!
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Michael D. Wilson @wilson-md.bsky.social · 02/12/2024
Thank you Julien! It has been a long time coming. We have done some more digging into the TEs but there is a lot more to do! We are excited to make use of this and see others do the same!
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Michael D. Wilson @wilson-md.bsky.social · 30/11/2024
Looking forward to seeing them. I just did this myself. The only issue compared to twitter was that not enough coauthors are on here to tag. When I joined it was great to see you here bringing sci-bluesky to life!
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Michael D. Wilson @wilson-md.bsky.social · 29/11/2024
Thanks to all co-authors and colleagues who made this possible. Special thanks to Dustin Sokolowski (who is now a @CANSSIOntario Fellow in @jaredsimpson.bsky.social's lab who has driven this project and just presented the results today at #BIOMORA24 in Berlin! Feedback is welcome! 10/9.
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Michael D. Wilson @wilson-md.bsky.social · 29/11/2024
Naked mole rats have even lost the rapidly evolving sperm-specific zonadhesin gene which I spent years knocking out and studying in graduate school :) (jbc.org/article/S002... 9/9
jbc.org
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Michael D. Wilson @wilson-md.bsky.social · 29/11/2024
Key findings? One that stands out is that naked mole rats have lost several genes that cause male fertility or sperm abnormalities when lost in mice. NMRs have deranged and atypical sperm compared to other mammals and this may be due to their eusocial lifestyle. 8/9
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Michael D. Wilson @wilson-md.bsky.social · 29/11/2024
We joined forces not only to analyse and share this chromosomal-level NMR genome, but also generate its successor, a telomere-to-telomere assembly that will resolve complex regions and the darkest secrets of the NMR genome. 7/9
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Michael D. Wilson @wilson-md.bsky.social · 29/11/2024
This also led to a collaboration with Gabriel Balmus (whose team, like ours, they needed a better genome) Evan Eichler, Rémy Bruggmann, @psalmotoxin.bsky.social, Alexander_Nater, Mihai Miclăuș and several others. 6/9
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Michael D. Wilson @wilson-md.bsky.social · 29/11/2024
A wonderful outcome of getting the genome online early includes several collaborations with NMR and genomics experts worldwide. For example, Diana Laird and her team provided NMR karyotypes from their new NMR cell lines and Jingtao Lilue did some wonderful conserved synteny analyses. 5/10
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Michael D. Wilson @wilson-md.bsky.social · 29/11/2024
We were fortunate to work with @DThybert, Leanne Haggerty and others at @ebi.embl.org and @ensembl.bsky.social to incorporate to annotate, align and share this data with the research community. 4/9
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Michael D. Wilson @wilson-md.bsky.social · 29/11/2024
Together with @jaredsimpson.bsky.social @pughlab.bsky.social Dustin Sokolowski fearlessly embarked on this project with support from @NSERC_CRSNG, Dr. Faykoo-Martinez, Dr. Holmes and several members of my lab (@rathnakumar25, Sana Akhtar Alvi, Simon Monis, and Huayun Hou). 3/9
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Michael D. Wilson @wilson-md.bsky.social · 29/11/2024
This naked mole-rat (NMR) genome project started as @CIHRIGH-funded collaboration with Melissa Holmes, Dustin Sokolowski, and Mariela Faykoo-Martinez. While studying the genetics behind the extreme pubertal suppression that occurs NMRs, it became clear we needed a more complete NMR genome. 2/9
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Michael D. Wilson @wilson-md.bsky.social · 29/11/2024
Excited to share our preprint describing a new naked mole rat reference genome! www.biorxiv.org/content/10.1... 1/9
biorxiv.org
An updated reference genome sequence and annotation reveals gene losses and gains underlying naked mole-rat biology
The naked mole-rat (NMR; Heterocephalus glaber ) is a eusocial subterranean rodent with a highly unusual set of physiological traits that has attracted great interest amongst the scientific community....
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Ewan St. John Smith @psalmotoxin.bsky.social · 28/11/2024
BIOMORA24 is go!!! Going to be an amazing few days of science, meeting old friends & meeting people in the flesh who I’ve only seen online/read papers of/emailed!
Opening slides of meeting in lecture theatreOpening slides of meeting in lecture theatreOpening slides of meeting in lecture theatreOpening slides of meeting in lecture theatre
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