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Liz Worthey

@lizworthey.bsky.social
3.2K followers 492 following 735 posts

#AssociateProf #CompBio #Omics #WomenInScience #LGBTQ+Ally #Scottish #PrecisionMedicine #HealthCare #MDx #ME/CFS #RareDisease #Informatics #SciFiNerd #LongCovidAffected sites.uab.edu/cgds/ she/her

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Reposted by Liz Worthey
Matt Novak @paleofuture.bsky.social · 20/08/2026
Darth Vader praises Flock cameras: "This is what the Emperor needs. This technology will help us find the rebel scum and their hidden base on Hoth."
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Kate Wong @katewong.bsky.social · 23/06/2026
Today is my last day at Scientific American, which has been sold to LabX media group. For three decades I've led the magazine's coverage of human origins, archaeology, paleontology, animal behavior, ecology, BIRDS. End of an era. Anyway this feels weird to say, but I'm now available for assignments!
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Carl T. Bergstrom @carlbergstrom.com · 23/06/2026
ADA leaders were forcibly removed from their own meeting for sharing copies of an ADA OpEd critical of Jay Bhattacharya. Thanks to you it's now got >125,000 views. As CDC interim director, Jay also blocked publication of this paper because it showed that COVID vaccines work. You know what to do.
jamanetwork.com
Interim Estimated Effectiveness of 2025-2026 COVID-19 Vaccines in Adults
This case-control study estimates vaccine effectiveness of 2025-2026 COVID-19 vaccines among adults with COVID-19–associated emergency department or urgent care encounters and COVID-19–associated hosp...
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Liz Worthey @lizworthey.bsky.social · 13/06/2026
Who all is at #ESHG2026?
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valebodi.bsky.social @valebodi.bsky.social · 15/05/2026
After the great news from the UK about #SequenceME (a continuation and deeper dive of the first GWAS study @decodemestudy.bsky.social into the genetic factors involved in #ME/CFS). This recent paper by Prof. @lizworthey.bsky.social et al. is a must read Uncovering the genetic architecture of ME
link.springer.com
Uncovering the genetic architecture of ME/CFS: a precision approach reveals impact of rare monogenic variation - Journal of Translational Medicine
Journal of Translational Medicine - Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling and heterogeneous disorder lacking validated biomarkers or targeted therapies....
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Chenxin Li, PhD @chenxinli2.bsky.social · 09/05/2026
It’s really astonishing that we take so much resources, land, and water for ourselves but not leave enough for other creatures of this planet.
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TheBossRoss 🧶 @thebossross.bsky.social · 05/04/2026
A different perspective. Always helpful.
Christopher Penn wrote:

Just remember that given the abundance of neurodivergent people in science, it's far more likely that autism causes vaccines.
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George Conway ⚖️🇺🇸 @gtconway.bsky.social · 05/04/2026
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Tom Kindlon @tomkindlon.bsky.social · 31/03/2026
ME Research UK: A recent study found differences in the extent of immune changes in ME/CFS following SARS-CoV-2 infection vs. idiopathic ME/CFS. Do different viral triggers produce variations in underlying pathophysiology? Read more: tinyurl.com/543kcekm #mecfs #pwme #cfs 1/

Could identifying the viral trigger of ME/CFS inform future therapeutics? A recent study analysed immune cells from 10 individuals with long COVID (LC)-ME/CFS (meeting Canadian Consensus Criteria) and 10 controls (recovered from infection) Findings were compared with existing datasets from idiopathic ME/CFS patients. 
Whilst there were similarities, LC-ME/CFS showed both extensive immune cell depletion AND hyperactivation, whereas idiopathic ME/CFS showed immune cell activation without the same level of immune cell loss. 
Signs of T cell exhaustion (T cells overworked to point of malfunction) present in LC, not in idiopathic ME/CFS. 
As this is a snapshot, it cannot rule out that idiopathic ME/CFS might start out with similar immune changes. Though, these results suggest that understanding viral triggers like SARS-CoV-2 could guide future therapeutics. 
Note: authors do not define idiopathic ME/CFS Shahbaz, S. et al (2026). Single-cell analysis reveals immune remodeling of monocytes, NK cells, T cell exhaustion, and Galectin-9—associated depletion of gamma delta and mucosal-associated invariant T cells in Long COVID with ME/CFS. Frontiers in Immunology, [online]. INFORM. INFLUENCE. INVEST. 
Ihea RESEARCH UK SCO36942
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Liz Worthey @lizworthey.bsky.social · 30/03/2026
Anyone know where one can search all of the NIH #LongCOVID #Recover funded projects? I can find bits & pieces here and there, but not a full list with details; it's hard to be sure on NIH Reporter too. Maybe you might know @michaelpelusomd.bsky.social @mvgutierrezmd.bsky.social @zalaly.bsky.social?
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Lauren Atlas @laurenatlas.bsky.social · 28/01/2026
HEAL Initiative, BRAIN initiative, Blueprint for Neuroscience Research, all now leaderless with Walter Koroshetz gone...
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doom boy @doomboy.bsky.social · 09/03/2026
love how we killed the old, frail anti-nuke ayatollah just to have him replaced with his young, healthy son who wants nukes and who just had his father, mother, wife, and child murdered on the same day by his mortal enemy. surely this will bring peace to the region
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Michael Li (李之樸) @mcpli.bsky.social · 07/03/2026
61 years ago today at the foot of the Edmund Pettus Bridge, Selma, Alabama.
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Tom Kindlon @tomkindlon.bsky.social · 07/03/2026
The Diagnostic Challenge of Chronic Fatigue Syndrome www.latimes.com/doctors-scie... Screenshot from AMMES March 2026 Newsletter #MEcfs #CFS #PwME #MyalgicEncephalomyelitis #ChronicFatigueSyndrome
Image of a doctor with a stethoscope
The Diagnostic Challenge of Chronic Fatigue Syndrome
The diagnostic process often involves clinical evaluation, testing, and specialist referrals to identify the correct condition. The risk of misdiagnosis is high. Frequently, the somatic symptoms are dismissed as psychiatric in origin. This is a dangerous error that delays appropriate care. To meet the criteria for ME/CFS, symptoms must be present for at least six months, but treatment can begin before this point.
Read more here>>
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Carl Quintanilla @carlquintanilla.bsky.social · 27/02/2026
This is amazing. www.getyourfuckingmoneyback.com
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Liz Worthey @lizworthey.bsky.social · 25/02/2026
Does anyone (maybe @longcovidadvoc.com @longcovidsupport.bsky.social @longhaulerspodcast.bsky.social @mecfsskeptic.bsky.social) know if genomic data is being generated for the #LongCOVID #Recover study? I thought it was, but have been told a few times that it is not currently being generated. Ta!
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Liz Worthey @lizworthey.bsky.social · 23/02/2026
It will be awful.
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Reposted by Liz Worthey
Error Coram Nah, B @errorcoramnobis.bsky.social · 21/02/2026
Read this thread and article. RFK Jr. is a eugenicist pushing experiments on vulnerable black populations.
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Liz Worthey @lizworthey.bsky.social · 21/02/2026
The fact that is it quakers-town is not lost on me. A central tenet of Quakerism is the commitment to peace, which has in the past compelled Quakers to protest against war, militarism, and violence.
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Liz Worthey @lizworthey.bsky.social · 19/02/2026
Let's hope that Prince Andrew - sorry Andrew Mountbatten -Windsor - is a big enough fish that they can't murder him in custody like the others..
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Corey O'Neill @coreyoneill.bsky.social · 18/02/2026
👀 👀 Here's a visual representation of how many times Trump's name appears in the Epstein files... so far. www.instagram.com/p/DUgiBD_EiSP
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sarah boothby @swastrosarah.bsky.social · 15/02/2026
51% Long Covid is ME. Research the Canadian Consensus Criteria for best diagnostic tools available for #ME @sabrinapoirier.bsky.social is also a great resource 🙏🏻 as is @sunsopeningband.bsky.social 🙏🏻🙏🏻 particularly on understanding how #PEM Trump's everything in symptom management.
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Acyn @acyn.bsky.social · 13/02/2026
Sanders: The American people do not want this country to be an authoritarian society or an oligarchy. We have our differences, that’s what democracy is about—we argue it out. We don’t throw people who disagree in jail. We don’t intimidate the media. We don’t send ICE agents to shoot people.
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Pookleblinky @pookleblinky.bsky.social · 13/02/2026
We are all kind of waiting for RFK to actually, finally pick up an easily preventable disease and then die in agony of it while he tries to use it as justification for an array of snake oils. Everyone like "it's tuberculosis, just take antibiotics!" and he's like "no, urine inhalation therapy"
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valebodi.bsky.social @valebodi.bsky.social · 11/02/2026
Dr. Jarred Younger explains E. A. Worthey’s lab latest eye opening research paper: A precision approach to understanding #ME/CFS Uncovering the genetic architecture of ME/CFS: a precision approach reveals impact of rare monogenic variation link.springer.com/article/10.1... @lizworthey.bsky.social
youtube.com
083 - A precision approach to understanding ME/CFS
YouTube video by Jarred Younger, PhD
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ME/CFS Science @mecfsscience.org · 26/12/2025
6) Link to the study: Birch et al. Uncovering the genetic architecture of ME/ CFS: a precision approach reveals impact of rare monogenic variation. link.springer.com/ar... Discussion on S4ME: www.s4me.info/thread...
link.springer.com
Uncovering the genetic architecture of ME/CFS: a precision approach reveals impact of rare monogenic variation
Journal of Translational Medicine - Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling and heterogeneous disorder lacking validated biomarkers or targeted therapies....
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Liz Worthey @lizworthey.bsky.social · 10/02/2026
This is a bit of a rant, I know; I’m just genuinely frustrated by the lack of pathways to obtain access to omics data from #LongCovid data from the #NIH #RECOVER project.
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Aaron Rupar @atrupar.com · 24/01/2026
"They say they're coming to save us from some evil? They're talking about our neighbors who take care of us ... Alex was murdered while he was helping. Mr Rogers said look for the helpers, & right now the helpers have a target on our forehead ... Mr Rogers would be here right now too, so I'm here."
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Kyle Griffin @kylegriffin1.bsky.social · 24/01/2026
Minnesota Bureau of Criminal Apprehension Superintendent Drew Evans says his team arrived on the scene of the shooting to conduct an independent investigation and "were blocked by federal agents with the Department of Homeland Security."
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Jeana Berry @berry-jam.bsky.social · 24/01/2026
Ron, you have a HUGE following and am hoping you can get this out to people: The Military Police Brigade in NC is being deployed to Minnesota by Trump to begin Martial Law in the State. I cannot tell you how I know this but please believe me that it is happening!
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Claes de Vreese @claesdevreese.bsky.social · 17/01/2026
Copenhagen town hall square, Denmark right now. Massive solidarity with Greenland demonstrations. Source: dr.dk
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C.H. Romatowski @chromatowski.bsky.social · 17/01/2026
A real “tell your parents” paper (since everyone on Bsky is canonically 38). Review of 21 studies of ppl over 50: • Shingles vax associated w/47% lower risk of Alzheimer’s, 24% lower risk of any dementia • Pneumonia vax had 36% lower risk of Alzheimer's • Tdap had 33% lower risk of any dementia
academic.oup.com
Association between vaccinations and risk of dementia: a systematic review and meta-analysis
AbstractImportance. Dementia is a highly prevalent issue in older people. Whilst the prevention of dementia is a public health priority, the role of vaccin
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C.H. Romatowski @chromatowski.bsky.social · 17/01/2026
Yeah, it’s not an easy decision for those of us with wonky immune systems. I def don’t presume to know what you should do but Alzheimer’s is on my mind because of this—
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Mitchell R. Vollger @mrvollger.bsky.social · 12/01/2026
I am hiring a staff bioinformatician for my new lab at the University of Utah! Please consider applying if you are on the hunt: employment.utah.edu/salt-lake-ci...
employment.utah.edu
Jobs | University of Utah
Founded in 1850, The University of Utah is the flagship institution of higher learning in Utah, and offers over 100 undergraduate and more than 90 graduate degree programs to over 30,000 students. Uni...
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Tom Kindlon @tomkindlon.bsky.social · 05/01/2026
"Re-analysis: 200 treatments by 4000 Long Covid/ME patients" by Siebe Rozendal (January 4, 2026) viralpersistence.substack.com/p/re-analyzi... #LongCovid #MEcfs #CFS #PwME #MyalgicEncephalomyelitis #ChronicFatigueSyndrome
Re-analysis: 200 treatments by 4000 Long Covid/ME patients
I ranked 200+ treatments by effect scores and got a new Top 5
Siebe Rozendal
Jan 04, 2026

In 2023, a survey was run among 3,925 ME/CFS and Long Covid patients called TREATME. It asked patients which treatments they have tried and how they responded to it. It is by far the biggest survey of its kind. I am really grateful to Martha Eckey, a PharmD and patient herself, for collecting the data and to the Open Medicine Foundation for having helped her to analyze and publish it.
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Liz Worthey @lizworthey.bsky.social · 09/01/2026
Wow. Not surprising, but still shocking.
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Liz Worthey @lizworthey.bsky.social · 09/01/2026
New paper from our team: we used an n-of-1 #PrecisionMedicine framework in a small #ME/CFS cohort and found rare, large-effect pathogenic/likely pathogenic variants in ~1/3 of participants #Genomics link.springer.com/article/10.1...
link.springer.com
Client Challenge
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Liz Worthey @lizworthey.bsky.social · 06/01/2026
Very cool
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Liz Worthey @lizworthey.bsky.social · 05/01/2026
Here’s hoping for a better 2026!! I’ve been quiet recently: sadly on a big #longcovid #me/cfs crash most of this year…., but working from home and taking the holidays off has helped a little. So hoping to be on more..
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David Corn @davidcorn.bsky.social · 23/09/2025
This ought to be engraved somewhere.
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Raider @iwillnotbesilenced.bsky.social · 15/08/2025
An unarmed veteran was attacked from behind, sustaining injuries and being dragged into a Portland ice building.
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Greg Jenner (Historian) @gregjenner.bsky.social · 15/08/2025
Very funny cartoon from @stephencollins.bsky.social www.theguardian.com/lifeandstyle...
theguardian.com
It’s all Greek to me – Plato and Socrates tackle a Captcha test: the Stephen Collins cartoon
Tick all the images with chariots …
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Liz Worthey @lizworthey.bsky.social · 15/08/2025
We have some bandwidth and so I’m interested in expanding the nbr of ME/CFS patients whose genomes we analyze. If you have data and would be interested in signing up to our protocol (we have found interesting findings in some, but not all people) please reach out and I can explain. #ME/CFS #Genomics
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Liz Worthey @lizworthey.bsky.social · 27/05/2025
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Studying the Effect of Long COVID-19 Infection on Sleep Quality Using Wearable Health Devices: Observational Study
Patients with COVID-19 have increased sleep disturbances and decreased sleep quality during and after the infection. The current published literature focuses mainly on qualitative analyses based on su...
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Agnes Caruso @agnescaruso.bsky.social · 25/05/2025
What types of variants are most commonly missed? #eshg2025
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Xosé M Fernández @xosegb.bsky.social · 24/05/2025
Choose Europe for Science: EU comes together to attract top research talent research-and-innovation.ec.europa.eu/news/all-res...
research-and-innovation.ec.europa.eu
Choose Europe for Science: EU comes together to attract top research talent
Research and innovation news alert: The European Union is stepping up to become the world’s most attractive destination for researchers and innovators.
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Liz Worthey @lizworthey.bsky.social · 25/05/2025
AM: 1,715 combinations with nominally significant impacts were identified in UK Biobank study. Two clinically relevant examples of effect heterogeneity were seen: 1) BMA -T2D attenuates with age, 2) LDL cholesterol exacerbates with increased urate. Study just published #ESHG2025
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Liz Worthey @lizworthey.bsky.social · 25/05/2025
AM: Resid-Strat, DR by G, DR by X, and Raw-Strat methods were all tested in term of impact on Type 1 error. Each method was found to be differentially affected by collider biases #ESHG2025
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Liz Worthey @lizworthey.bsky.social · 25/05/2025
AM: discussing sources of collider bias - biases that occur when an exposure and outcome (or factors causing these) each influence a common third variable #ESHG2025
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