iiinova — where your digital self keeps evolving

Reposted by Adrian Cazares

Daniel Cazares @danielcazares.bsky.social · 11/05/2026

Happy to share that our latest research on the eco-evolutionary dynamics of MDR plasmids and PDPs is now out (open access vAuthor) in The ISME Journal doi.org/10.1093/isme... Here, we explored how plasmid-dependent phages (PDPs) act as a selective pressure against the spread of multidrug resistance

doi.org

Eco-evolutionary responses to plasmid-dependent phage constrain the spread of multidrug resistance plasmids

Abstract. Phage therapy offers a promising alternative to antibiotics for treating multidrug-resistant infections. Plasmid-dependent phages (PDPs) are part

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Reposted by Adrian Cazares

Wendy Figueroa @wfigueroac3.bsky.social · 06/04/2026

Out in @natcomms.nature.com! We show that while most MGEs are blocked by RM systems🛡️, the chromosome is still mobile! 🧬And that cells with defective systems act as "gateways" for HGT. Can you find the hidden Easter egg🐇🥚? Hint: There's a nod to my 🇲🇽 heritage in one of the figures! rdcu.be/fbUC8

rdcu.be

Immune-deficient bacteria serve as gateways to genetic exchange and microbial evolution

Nature Communications - The efficiency of horizontal gene transfer between different bacterial lineages is often unclear. Here, Figueroa et al. show that lateral transduction is the primary driver...

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Reposted by Adrian Cazares

Zamin Iqbal @zaminiqbal.bsky.social · 17/10/2025

Podcast with me and @turiking.bsky.social for the @milnerevolution.bsky.social series, on plasmid evolution over the last 100 years, talking about our ( @cazares-adr.bsky.social , Nick Thomson, @sarah1alexander.bsky.social & co) recent paper www.science.org/doi/10.1126/... youtu.be/Mzr3TD4ijs0?...

youtu.be

How the Vectors of Antibiotic Resistance Have Evolved - Professor Zamin Iqbal

YouTube video by Milner Centre for Evolution

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Reposted by Adrian Cazares

Michael Brockhurst @brockhurstlab.bsky.social · 06/10/2025

New preprint! Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠 Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare! An epic effort by Rosanna Wright www.biorxiv.org/content/10.1...

biorxiv.org

Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages

Only a fraction of bacterial genomes encode CRISPR-Cas systems but the selective causes of this variation are unexplained. How naturally virulent bacteriophages (phages) select for CRISPR immunity has...

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Adrian Cazares @cazares-adr.bsky.social · 06/10/2025

Imagine we could travel back in time ⏪⌛️to explore the world of bacterial pathogens before humans discovered and industrialised antibiotics We just did that to study the history of #AMR spread @science.org doi.org/10.1126/scie... If you like time travel & biology, this 🧵is for you👇

doi.org

Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance

Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data predati...

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