Congratulations to the Walczak lab for this amazing piece of work just pulisbed on @natcellbio.nature.com
A must read!!!
This work adds a new letter of the ubiquitin code to immune signaling regulations!
www.nature.com/articles/s41...
nature.com
Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS–STING and Toll-like receptors 3 and 4 - Nature Cell Biology
Betrancourt, Cinko et al. identify ANKIB1-mediated K11 ubiquitination and OPTN recruitment as a shared mechanism for driving immune signalling by cGAS, TLR3 and TLR4, with functional relevance in inte...