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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 19h

Our next Variant Effects Seminar is tomorrow – October 6, when @marianomartin.bsky.social and Seulki Kwon will present their research. Discover this month's speakers and get joining instructions: www.varianteffect.org/seminar-seri... #DeepMutationalScanning #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 29/09/2026

Learn more about our next two Variant Effects Seminar speakers and their research. Mariano Martín Gomez and Seulki Kwon will present on October 6 (16.00-1700, UTC). Learn more about the seminar series and how to join their talks at www.varianteffect.org/seminar-seri...

The composite image shows headshots of the next two speakers of our Variant Effects Seminar Series (VESS) - Mariano Martín Gomez (left) and Seulki Kwon (right).

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 24/09/2026

Are you an AVE member? Membership is open to anyone invested in creating comprehensive variant effect maps. Joining gives you access to: ☑️ Newsletters ☑️ Community Slack channels ☑️ Literature, resources & technical expertise ☑️ Collaboration & career opportunities Join today: tinyurl.com/3smfcaks

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 22/09/2026

Join us on October 6 for another edition of our early career seminar series. The seminar will feature @marianomartin.bsky.social (Institute for Bioengineering of Catalonia) and Seulki Kwon (Broad Institute). More information and joining instructions: www.varianteffect.org/seminar-seri...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 17/09/2026

We're delighted that Nobel Laureate David Baker, Director of the Institute for Protein Design at the University of Washington, will deliver a keynote address at the Mutational Scanning Symposium, next June. Event registration opens soon. Learn more: tinyurl.com/3x8d5rev Image: Christopher P. Michel

The image shows MSS keynote speaker, Dr David Baker. He is holding a multicoloured protein model towards the camera. Image credit: Christopher P. Michel

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 16/09/2026

Our YouTube channel is a great resource that incudes: ✅ Deep mutational scanning principles ✅ Functional evidence workshops ✅ Mutational Scanning Symposia ✅ Early career seminars ✅ Virology Interest Group talks and more. Search by presenter, topic or series: tinyurl.com/2e4rbcm3

The image is a screenshot of the Atlas of Variant Effects YouTube homepage.

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 09/09/2026

If you missed last week's Variant Effects Seminar, you can now find the presentations on the VESS playlist on our YouTube channel. Catch up with the excellent talks from Sergio Garcia Busto and Kortni Kindree whenever it works for you. See the VESS playlist: youtu.be/24n8i78STPQ?...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 27/08/2026

If you're interpreting functional assays for clinical use, check out this resource from members of our ClinGen/AVE Functional Data Working Group. Get more information and download the presentation: www.varianteffect.org/clinical-app... Read the preprint: www.medrxiv.org/content/10.6...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 26/08/2026

Join us next week for the Variant Effects Seminar! Our September speakers are Sergio Garcia Busto (@sangerinstitute.bsky.social, @cam.ac.uk) and Kortni Kindree (University of Toronto) Learn more about our speakers, their work and how to join the seminar: www.varianteffect.org/seminar-seri...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 24/08/2026

Have you listened to the Variants and Us (VUS) podcast yet? Now into its second season, the podcast focuses on the basic and translational science necessary to map the effect of variants in disease and rare disease. Listen to all episodes here: www.varianteffect.org/podcast/

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 17/08/2026

Our next Variant Effects Seminar is on September 1. Join Sergio Garcia Busto (@sangerinstitute.bsky.social, @cam.ac.uk) and Kortni Kindree (University of Toronto) and explore their research. Learn more about our speakers' work and how to join the seminar: www.varianteffect.org/seminar-seri...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 04/08/2026

Don't forget, we'll be live later for our Variant Effects Seminar. Today's talk is with @sarahgurev.bsky.social. Find your time zone and join us at 4.00 pm (UTC): www.varianteffect.org/seminar-seri...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 29/07/2026

Our Variant Effects Seminar Series returns next Tuesday, August 4! Join @sarahgurev.bsky.social for her presentation, 'Towards reliable viral mutation effect prediction for pandemic preparedness'. Discover Sarah's work and get the event joining info: www.varianteffect.org/seminar-seri...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 28/07/2026

As our Variant Effect Seminar Series (VESS) returns, we caught up with two of our earliest speakers, Mafalda Dias & Jonathan Frazer. Now group leaders at the Centre for Genomic Regulation (CRG) in Barcelona, we explore the role of VESS in their journey. Read their interview: tinyurl.com/m4ncw2nf

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 23/07/2026

Mark your calendars for the next instalment of our Variant Effects Seminar Series. 🗓️ On August 4, Sarah Gurev will be our sole speaker, with her extended presentation, 'Toward reliable viral mutation effect prediction for pandemic preparedness'. More info: tinyurl.com/4ms3mmzy

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 13/07/2026

Our Variant Effects Seminar Series (VESS) is taking a break this month, but will be back on August 4 with an extended presentation from @sarahgurev.bsky.social, 'Towards reliable viral mutation effect prediction for pandemic preparedness'. Discover VESS and all speakers: tinyurl.com/4atzepeb

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 07/07/2026

Our Variant Effects Seminar Series (VESS) is organized and led by a committee of early career scientists. We asked Priyanka Bajaj and @ohannab.bsky.social about their experiences on the VESS committee, as they depart for new adventures in variant science. Read now: tinyurl.com/lifeaftervess

Composite image of Priyanka Bajaj (left) and Ohanna C. L. Bezerra (right)

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 29/06/2026

Did you know you can find all the Variant Effects Seminars on the AVE YouTube channel? Established in 2021, the seminar series reached its 100 speaker milestone last month. So, there are plenty of great talks to choose from. Find your next watch: tinyurl.com/AVE-VESS #AtlasOfVariantEffects

Screen grab of the Variant Effects Seminar Series (VESS) playlist on the Atlas of Variant Effects (AVE) YouTube Channel.

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 25/06/2026

Why should you attend MSS 2027? We asked PhD student Rebeca Olvera-León about her experiences at the last four MSS events, and found out what she was most looking forward to for MSS 2027: bit.ly/4eHgiJz Tell us, what do you hope is on the program for MSS 2027?

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 24/06/2026

We are delighted that Jay Shendure will be a keynote speaker at MSS 2027. He says, "It's phenomenal to see the community that AVE has grown in to, and the impact that it's having. I'm excited to have the opportunity to share some perspective and our latest work." www.varianteffect.org/mss2027/

Dr Jay Shendure stands, arms folded and smiling, with his back to the bench, in his laboratory. Photo courtesy of Ron Wurzer.

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 24/06/2026

It's exactly 1 year until the 10th anniversary MSS 2027 in Seattle! MSS unites the functional genomics community, fostering field-defining discussions and collaborations. Co-organizer, Doug Fowler, PhD, discusses the event: bit.ly/4wbDzKV #VariantEffect27 #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 17/06/2026

Don't miss Abbye McEwen's deep dive into interpretation of variants of unknown significance (VUS) - happening today (12.00 pm ET / 9.00 am PT / 5.00 pm BST). Join here: bit.ly/3Seq0LL #DeepMutationalScanning #VariantScientistNetwork #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 15/06/2026

This Wednesday, are you ready to go beyond the VUS and learn more about using multiplexed assays of variant effects (MAVEs) to inform clinical variant classification? It's free to sign up: bit.ly/3Seq0LL #DeepMutationalScanning #VariantScientistNetwork #VUS #MAVE #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 11/06/2026

Last week our Variant Effects Seminar Series (VESS), reached its 100th speaker. Are you in our gallery? Let us know! VESS is led by and exists for early career scientists, enabling them share their work on interpreting human genetic variation. Learn more: www.varianteffect.org/seminar-seri...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 09/06/2026

MAVEs are transforming how labs evaluate genetic variants, providing functional evidence at scale. Join Dr Abbye McEwen for an introduction to MAVEs and to learn how these datasets may help resolve variants of uncertain significance. Register free: bit.ly/3Seq0LL #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 01/06/2026

Join us tomorrow for a special VESS seminar, as we mark our 100th speaker milestone with a talk from postdoctoral researcher, Ezequiel Galpern. We also have some special guests, as we look to the next 100 speakers! Joining info: www.varianteffect.org/seminar-seri... #AtlasOfVariantEffects

Milestone at the mic: Celebrating 100 VESS speakers. The image shows celebratory green fireworks, the name and title of presenter (Ezequiel A Galpern) and a joining link and QR code.

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 26/05/2026

Join us, next Tuesday as we mark 100 speakers in VESS! After Ezequiel Galpern's presentation we will celebrate our first 100 speakers and a look to the future of this fantastic early-career seminar series. See you there ➡️ www.varianteffect.org/seminar-seri... #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 20/05/2026

Our Variant Effect Seminar Series is marking a milestone! Join us on Tuesday, June 2, for our 100th speaker, Ezequiel Galpern. Plus, special VESS guests, as we celebrate and look forward to the next 100 speakers! Join here: www.varianteffect.org/seminar-seri... #AtlasOfVariantEffects

The image shows celebratory fireworks in shades of green and has the text "Milestone at the mic: 100 VESS speakers. June 2, 2026. It also details the presenter (Ezequiel Galpern) with a photo and title of his talk.

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 18/05/2026

Both talks from the May episode of the Variant Effects Seminar Series (VESS) are now available to watch on our YouTube channel ⏯️ bit.ly/4ud02Xa. Catch up with Thea Klarsø Schulze and Jerome Freudenberg's presentations anytime! #Genomics #VariantInterpretation #AtlasOfVariantEffects

May VESS flier with images of both speakers and their presentation titles.

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 14/05/2026

Catch up on all 3 days' talks from the Mutational Scanning Symposium (MSS) 2026 on our YouTube channel ⏯️ bit.ly/4diP7FD Whether you're watching for the first time or revisiting a favorite talk, there's something insightful to enjoy! #VariantEffect26 #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 13/05/2026

You can now find the Day 2 presentations from the MSS 2026 over on our YouTube channel. ⏯️ bit.ly/4tzo9hQ The final day's talks will be live soon, so watch this space! #VariantEffect26 #Genomics #DeepMutationalScanning #FunctionalGenomics #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 05/05/2026

Tomorrow, our Variant Effect Seminar speakers will be covering various aspects of the modeling of variant effects. They hope you can join them! Details here: www.varianteffect.org/seminar-seri... #Genomics #VariantInterpretation #DeepMutationalScanning #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 27/04/2026

Next week's Variant Effect Seminar: Thea Klarsø Schulze will discuss predictive models of variant effects on protein abundance. Jerome Freudenberg will cover modeling of variant effects in FACS-based deep mutational scans with Lilace. www.varianteffect.org/seminar-seri... #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 21/04/2026

May's Variant Effect Seminar features Thea Klarsø Schulze of the MRC Laboratory of Molecular Biology, Cambridge, UK and Jerome Freudenberg from the Pimentel lab at UCLA, USA. Bookmark the event in your calendar: www.varianteffect.org/seminar-seri... #AtlasOfVariantEffects

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 15/04/2026

MSS 2026 brought together the global MAVE community for 3 days of superb scientific presentations, posters and interactions. Many thanks to our sponsors: Ambry Genetics, Illumina, AFGN, BBI, Twist Bioscience, the Collaborative Centre for Genomic Cancer Medicine, WEHI, SVI & ACMD. #VariantEffect26

The image says thank you to the sponsors of the Mutational Scanning Symposium (MSS) 2026 and shows the sponsors' logos. These are as follows:
Gold sponsors: Ambry Genetics and Illumina.
Silver sponsors: Australian Functional Genomics Network (AFGN), Brotman Baty Institute (BBI), the Collaborative Centre for Genomic Cancer Medicine and Twist Bioscience.
Bronze sponsors: WEHI (the Walter and Eliza Hall Institute of Medical Research).
Venue sponsors: St Vincent's Institute of Medical Research (SVI) and The Aikenhead Centre for Medical Discovery (ACMD).

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 06/04/2026

🧬 Join the VESS Organizing Committee! We are looking for early-career scientists to help shape our global, community-driven seminar program. 📅 Deadline to apply: April 30, 2026 ℹ️ Learn more and apply👇 forms.gle/vdLh3mu9Fuid... #VESS #VariantEffects #Seminar #Genomics #EarlyCareer

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 27/03/2026

The final speaker of the 2026 Mutational Scanning Symposium is Melissa Call from WEHI (Walter and Eliza Hall Institute of Medical Research). Her talk is covering how mutational profiling of SARS-CoV-2 PLpro exposes inhibitor escape routes. #VariantEffect26 #AtlasOfVariantEffectsAlliance

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 27/03/2026

Many thanks to all our MSS 2026 sponsors. It's great to have you here! At the podium now is Joel Geoghegan from Illumina. #VariantEffect26

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 27/03/2026

Our last speaker in this session is Linda Wijaya of The Kids Research Institute Australia and The University of Western Australia, whose talk is about unraveling the RASopathy Syndromes using iPSC-derived neural disease modeling. #VariantEffect26 #DiseaseModeling #AtlasOfVariantEffectsAlliance

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 27/03/2026

Up next on the final day of MSS 2026 is Yu-Jen Lin of the University of California, Berkeley. She's giving a talk on CAGI 7 ARSA missense prediction assessment. #VariantEffect26 #MissenseVariants #CAGI7 #AtlasOfVariantEffectsAlliance

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 27/03/2026

On stage now is Alistair Dunham of the Wellcome Sanger Institute with a talk about the standardization and joint analysis of 2041 MAVEs. #VariantEffect26 #MAVEs #AtlasOfVariantEffectsAlliance

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 27/03/2026

We're back with Christopher Hahn from SA Pathology and the University of South Australia, on the topic of deep mutational scanning to measure the transactivational effect of GATA2 and ERG variants to benefit clinical interpretation. #VariantEffect26 #AtlasOfVariantEffectsAlliance

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 27/03/2026

Our final speaker before morning coffee is Doug Fowler from the University of Washington. His talk details pathway-scale variant effect mapping in human cells with LABEL-seq. #VariantEffect26 #LABELseq ##DeepMutationalScanning #AtlasOfVariantEffectsAlliance

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 26/03/2026

Next to the stage is Jun Yang of St. Jude Children's Research Hospital - ALSAC. His presentation details MAVE-informed protein language models for predicting pharmacokinetics variant function at scale. #VariantEffect26 #MAVEs #ProteinLanguageModels #AtlasOfVariantEffectsAlliance

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 26/03/2026

We're now joined by Max Stammnitz from the Centre for Genomic Regulation (CRG) in Barcelona. His presentation is about the genetic architecture of allosteric plant hormone receptors. #VariantEffect26 #DeepMutationalScanning #AtlasOfVariantEffectsAlliance

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 26/03/2026

Taking the stage now is Mark Dawson of the Peter MacCallum Cancer Centre. His talk is about understanding human pathology with base editing at single-cell resolution. #VariantEffect26 #BaseEditing #AtlasOfVariantEffectsAlliance

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 26/03/2026

Yesterday evening, we enjoyed a fantastic poster session at MSS 2026. There was a real buzz with lots of great conversations! #VariantEffect26

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 26/03/2026

Opening the final day of MSS 2026 is Maitreya Dunham from the University of Washington. Her keynote is entitled, 'From ARS1 to ZWF1: some adventures in deep mutational scanning'. #VariantEffect26 #DeepMutationalScanning #AtlasOfVariantEffectsAlliance

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 26/03/2026

Today's final speaker is Polina Polunina from the University of Freiburg. Her presentation today is entitled, 'Modeling viral evolution as sequence transitions: a transformer approach using time-resolved SARS-CoV-2 spike data'. #VariantEffect26 #AtlasOfVariantEffectsAlliance

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 26/03/2026

Next to speak is Xinyu Wu from WEHI (the Walter and Eliza Hall Institute of Medical Research). His talk discusses the elucidation of distinct conformations in thrombopoietin receptor activation. #VariantEffect26 #DeepMutationalScanning #AtlasOfVariantEffectsAlliance

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