iiinova — where your digital self keeps evolving

Institute of Genetics and Cancer @uoe-igc.bsky.social · 15/10/2026

Are you a cell biologist looking for a job as a postdoctoral researcher? Join Andrew Jackson's lab to address fundamental mechanisms controlling tissue cellularity that result in epigenetic ageing and determine size in mammals. Apply by 29 October 👉🏽 edin.ac/4hXj54l

010 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 15/10/2026

Join us at IGC, working with the fantastic Shipra Bhatia!

020 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 14/10/2026

This summer, Max Franks spent 8 weeks at IGC in the Frame lab, working with Alex Loftus. His project, funded by @royalmicrosoc.bsky.social, combined cell biology and advanced microscopy to investigate glioblastoma migration. Read more👇🏽 edin.ac/3VyE7xr Interested in work experience?👉🏽 edin.ac/4jcBb2Z

010 0

Reposted by Institute of Genetics and Cancer

Michael Nicholson @mdnicholson1.bsky.social · 13/10/2026

New paper: doi.org/10.1371/jour... Why do hypermutant cancers have atypical 'weaker' driver mutations? Modelling clonal dynamics, shows that accelerated mutation rates and biases explain this enrichment in MMRd/POLEd colorectal cancers, shifting expected genotypes.

doi.org

Hyper-mutational processes provide a head-start for weak cancer drivers: Explaining atypical KRAS variants

Author summary Considerable variability exists in the effectiveness of cancer driving mutations to promote cancer. Mutations which are thought to be less effective, ‘weak’ driver mutations, are common...

2133 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 13/10/2026

To celebrate #AdaLovelaceDay, which highlights the contributions of women to STEM fields in memory of mathematician & computer science pioneer Ada Lovelace, we spent a day with PhD student Rashi Krishna who is trying to find biomarkers for a rare but aggressive cancer called leiomyosarcoma.

021 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 12/10/2026

Today is #WorldArthritisDay At IGC, the Rheumatology Research Group is carrying out research to enable the development of targeted therapies to promote joint repair after injury and to slow, halt, or potentially reverse joint destruction for patients with arthritis. Read more here 👉🏽 edin.ac/4dtveeE

edin.ac

Rheumatology Research Group | Institute of Genetics and Cancer | Institute of Genetics and Cancer

Arthritis: An Unmet Medical Need

010 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 09/10/2026

IGC is looking for a Research Assistant to work in the @sproullab.bsky.social lab. This role has a particular emphasis on the use of synthetic vector libraries combined with cellular landing pads high throughput sequencing data of variant libraries from mammalian cells. 👇🏽 edin.ac/3VrC4Lw

011 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 08/10/2026

Great to see this piece with @jmarshlab.bsky.social talking about developing a resource cataloguing computational models for predicting variant effects, what makes non-coding predictors so different from their coding counterparts, and whether VEPs will ever replace deep mutational scanning 👇🏽

030 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 07/10/2026

“These findings changed our perception of the possibilities hiding in the non-coding space,” says @alextremophile.bsky.social about two papers that revealed that variants in the non-coding RNA RNU4-2 are involved in up to 0.4% of all neurodevelopmental disorders 👇 www.nature.com/articles/d42...

nature.com

AI tools fast-track non-coding variant interpretation

Deep-learning-based AI tools are helping researchers probe challenging regions of the genome and accelerating the pace of genetic discoveries, particularly in rare disease research.

011 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 05/10/2026

October is #LiverCancerAwarenessMonth. Luke Boulter's lab studies cholangiocarcinoma, a cancer of the bile duct in the liver. Only 1 in 20 patients survive more than five years following diagnosis. Learn more about the research in this video 👉🏽 edin.ac/4vnQOb3 @cmvm-edinburghuni.bsky.social

010 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 02/10/2026

We welcomed more than 130 people to the Institute last weekend as part of #DoorsOpenDay2026. Thank you to everyone who took part, including our fantastic volunteers. Here are some images from the day including lab tours, hands-on activities and a history talk. @cmvm-edinburghuni.bsky.social

020 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 30/09/2026

We were delighted to welcome Czech Ambassador Václav Bartuška, Consul General from Manchester David Frous & Honorary Consul from Edinburgh Veronika Macleod to IGC last week to learn about our research with @jorisveltman.bsky.social, Jana Travnickova, @anetamikulasova.bsky.social & Cameron Wyatt 🔬🐟

021 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 29/09/2026

Are you a self-motivated enthusiastic postdoctoral research associate? We looking for someone to join @sproullab.bsky.social's lab at IGC to understand the role of DNA methylation in gene regulation. edin.ac/46RVkEg @cmvm-edinburghuni.bsky.social

011 0

Reposted by Institute of Genetics and Cancer

Action for ME @actionforme.bsky.social · 29/09/2026

Day 2 of the PRIME International Symposium! Today's programme focuses on current ME research and collaboration with people with lived experience. Sessions include the Research Involvement Hub, Big Survey findings and emerging research. actionforme.org.uk/prime #PRIMESymposium #MECFS #MyalgicE

PRIME International Symposium promotional graphic highlighting Day 2, focused on current ME research, patient and public involvement, and impact, taking place 28-29 September 2026.

085 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 28/09/2026

Huge congratulations to Álvaro Lorente Macías who won the Contribution to Scientific Advancement category in the @cmvm-edinburghuni.bsky.social Postdoc Appreciation Awards for his role in drug discovery projects, including the mTOR inhibitor project. Read more about Alvaro 👉🏽 edin.ac/3TaxT65

010 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 28/09/2026

Exciting to see the official launch of the Genetic Epidemiology of ME/CFS (GEM) International Consortium at this two-day symposium. At IGC, important research into ME/CFS is being conducted by @cgatist.bsky.social, @aryback.bsky.social and Joshua Dibble who are all involved in this meeting.

0129 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 25/09/2026

Congratulations to Álvaro Lorente Macías who won the Contribution to Scientific Advancement category in the @cmvm-edinburghuni.bsky.social Postdoc Appreciation Awards and Carolina Uggenti who came second in the Contribution to Citizenship category. 🥳 Catch up on some of our profile pieces below 👇

110 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 25/09/2026

As IGC prepares for #DoorsOpenDay, Deputy Lead for Engagement Shipra Bhatia talks about the value of taking part in public engagement activities 👉🏽 edin.ac/4yjUqwo Find out more about the activities on offer at the Institute tomorrow 👉🏽 edin.ac/4x6wiMv @cmvm-edinburghuni.bsky.social

010 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 24/09/2026

The reduced risk of heart disease seen in overweight or obese people taking the weight loss drug semaglutide may not be due to a drop in weight alone, a study led by Prof Helen Colhoun shows. This suggests the drug may also be working to reduce heart disease in some other way. 👉 edin.ac/4dXqCNR

edin.ac

Obesity drug heart benefits not just due to weight loss | Institute of Genetics and Cancer | Institute of Genetics and Cancer

The reduced risk of heart disease seen in people who are overweight or have obesity taking the weight loss drug semaglutide may not be due to a drop in weight alone, a study shows.

000 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 24/09/2026

It was a fascinating day learning about the varied careers of the MRC Human Genetics Unit alumni - which only served to highlight the value of this programme.

020 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 24/09/2026

Adelaide Young is chair of the POstDoctoral Society (PODS) at IGC, which helps postdoctoral & early-career researchers in career development, networking & developing collaborations, as well as providing opportunities to socialise. Read more about her role 👉 edin.ac/4xDPotD #NPAW2026 #LovePostdocs

000 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 23/09/2026

Before lunch, there were three more talks by alumni Kerry Marie from @mcf-uom.bsky.social, Darren Logan from the Mars Advanced Research Institute and Pia Lundegaard from the University of Copenhagen, as well as three flash talks by current PhD students Rowland Lao, Lucia Puchades & James Hayes.

010 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 23/09/2026

It's fascinating to see where our former MRC HGU students have ended up with the next three talks given by Joe Rainger from @roslininstitute.bsky.social, Sue Gilchrist from @innovateuk.bsky.social - and Jane Alfred @catalysteditorial.bsky.social.

010 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 23/09/2026

"I am grateful for the launch pad the HGU has given me to carry on my career." A great start to the MRC HGU PhD Student Alumni day with a keynote talk by Girish Mali @dyneinassembly.bsky.social. @dunnschool.bsky.social @wbickmor.bsky.social

120 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 23/09/2026

For our next profile to celebrate #NPAW2026, we speak to Jana Travnickova, who studies melanoma. "I work with both zebrafish and cells and it is usually them which decide the schedule of my day." Read more here 👉 edin.ac/4hHhrn1 @cmvm-edinburghuni.bsky.social #LovePostdocs

000 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 22/09/2026

This week, we welcome our 2026 intake of PhD students to IGC, including our last cohort to the MRC Human Genetics Unit. They will join current students and alumni at an HGU PhD Alumni Day to celebrate their achievements. Find out more about the work of the MRC HGU here 👉🏽 edin.ac/4iHx0w7

040 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 22/09/2026

"There really isn’t a typical day, which is one of the things I like about the job." Today, as part of #NPAW2026, we speak to Carolina Uggenti who studies rare genetic conditions in which the immune system becomes active when it shouldn’t. Read more here 👉 edin.ac/4y3uqFm #LovePostdocs

010 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 21/09/2026

During Postdoc Appreciation Week #PAW, we are celebrating the valuable and varied roles postdoctoral researchers play at IGC. First up is Innovation Fellow and IGC Innovation Champion Dahlia Doughty Shenton. Read more here 👉 lnkd.in/enRgfgAX @edinuni-irr.bsky.social @cmvm-edinburghuni.bsky.social

000 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 21/09/2026

This year's theme for #WorldAlzheimersDay is The Earlier You Know, The More You Can Do: A Dementia Diagnosis Matters. Riccardo Marioni's lab uses computational models to understand the molecular mechanisms underlying the disease and enhance prediction of Alzheimer's. edin.ac/4rGXBfj edin.ac/4hmbWcc

edin.ac

IGC Research in a Nutshell Professor Riccardo Marioni

Professor Riccardo Marioni Institute of Genetics and Cancer.

010 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 18/09/2026

In the summer, 4th year Edinburgh Medical School student Tamanna Bostani spent eight weeks in Nick Gilbert's lab at IGC, after being awarded a @cmvm-edinburghuni.bsky.social Summer Studentship. Read more about Tamanna's experience here 👉 edin.ac/4xYBK5b Find more opportunities 👉 edin.ac/4jcBb2Z

000 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 17/09/2026

#ThrowbackThursday What do the following images have in common? To mark 300 years of @edinburghmedschool.bsky.social, join us on 26 September to learn about the history of the Western General Hospital site - home to scientific discoveries, medical breakthroughs & community care. 👉 edin.ac/4zPSj4A

020 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 16/09/2026

Jennifer Schickhofer is part of an international trial for a personalised cancer vaccine using cells taken from her tumour, led by consultant medical oncologist and senior clinical research fellow Mike Stares at the Edinburgh Cancer Centre. Watch here on @stv.news 👉 www.youtube.com/watch?v=Jq0-...

youtube.com

Personalised cancer vaccine trialled in Scotland

YouTube video by STV News

000 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 15/09/2026

Research @uoe-igc.bsky.social sits at the frontier of some of the most data-intensive science being done today. The next EIDF drop-in is a chance to explore how the right infrastructure can make your data-intensive, AI-driven, and sensitive-data workflows faster, more secure, and more efficient.

010 0

Reposted by Institute of Genetics and Cancer

Duncan Sproul @sproullab.bsky.social · 14/09/2026

🚨 #Postdoc position open. Want to understand non-canonical #epigenetic regulation of mammalian transcription? Come work @uoe-igc.bsky.social in Edinburgh! We’re looking for a motivated & collaborative colleague with a strong track record. 📅 14 October 2026 📢 Please share Apply here 👇

elxw.fa.em3.oraclecloud.com

Post-Doctoral Research Associate

An exciting postdoctoral position is available to research the role of epigenetic marks in gene regulation.

02021 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 10/09/2026

Join us at IGC for Doors Open Day on 26 September to take part in lab & building tours, drop-in activities and talks about our research as well as a History of the Western General Hospital site to mark 300 years of the Edinburgh Medical School. Sign up here 👉 edin.ac/4x6wiMv

000 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 10/09/2026

Technicians got together for a well deserved coffee morning at IGC as part of #TechnicianWeekScotland, celebrating the vital role technicians play across the country. @uoetechnicians.bsky.social @cmvm-edinburghuni.bsky.social

010 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 09/09/2026

We're proud that @andrewwood.bsky.social is leading one of the projects announced by ARIA today.

020 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 08/09/2026

@onehealthgenomics.bsky.social & @edinburgh-uni.bsky.social hosted the #ClinicalGenomesScotland meeting yesterday. Sophie Dow, founder of @salvesenresearch.bsky.social, spoke about waiting 13 years for a diagnosis for her daughter Annie, who is missing 25 genes. @geneticallianceuk.bsky.social

021 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 07/09/2026

Sir Munir Pirmohamed from @liverpooluni.bsky.social gave a keynote talk about pharmacogenomics - the study of how genetic variation affects response to drugs. With 99.9% of us having at least one variant, there is increasing evidence of the value of pharmacogenomic testing. #ClinicalGenomesScotland

011 0

Reposted by Institute of Genetics and Cancer

Element Biosciences @elembio.bsky.social · 04/09/2026

We're at Clinical Genomes Scotland 2026! 🧬 Come see how our platforms support demanding clinical research workflows with throughput, accuracy, and flexibility included. Catch our talk Mon 9/7, 2:50pm! 🎤 See you there: bit.ly/4ykcMgj. #ClinicalResearch #NextGenSequencing

021 0

Institute of Genetics and Cancer @uoe-igc.bsky.social · 03/09/2026

Read this blog in Inside Precision Medicine following up on research by Andrew Wood and his lab, involving Evelina Gudauskaitė, Brianda Areli Hernández Morán and Gillian Taylor 👇 edin.ac/4yjTfN3

edin.ac

How Cancer-Causing Proteins Accumulate May Shape Response to PROTACs

How oncogenes increase protein levels may shape PROTAC response and help identify tumors most likely to benefit from targeted protein degradation.

001 0