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Ulrike Endesfelder

@uendesfelder.bsky.social
1.7K followers 1.2K following 35 posts

Single-Molecule Microbiology and Biophysics @unibonn.bsky.social posting a mix of science & personal opinions just science can be found on www.ifmb.uni-bonn.de/en/research/rg-endesfelder & github.com/Endesfelder-Lab

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Ulrike Endesfelder @uendesfelder.bsky.social · 22/10/2025
Last call for Les Houches! Apply now or never! ;) (ok, in 2 years again then) and share with your friends.
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Markus Deserno @markusdeserno.bsky.social · 26/09/2025
I am super excited to announce that we have a tenure-track faculty position in biophysics open in the Department of Physics at Carnegie Mellon! 🧪 Interfolio link: apply.interfolio.com/174360 PLEASE, share widely across the blue skies! Let me briefly explain what we're looking for: 1/10
Tenure-track Position in Biophysics at Carnegie Mellon University, Department of Physics

Location: Pittsburgh, PA
Open Date: Sep 19, 2025

Description
The Department of Physics at Carnegie Mellon University invites applications for a tenure-track faculty position in biophysics. The appointment is intended to be at the Assistant Professor level, but exceptional candidates at a higher level may also be considered. We seek outstanding candidates with a strong record in cellular and subcellular biophysics. Topics of particular interest include, but are not limited to, uncovering how key characteristics of living systems arise from the interplay between supramolecular cellular structures, how the emergent cellular circuitry defines goals and enables robust decision making, and how metabolic resources are allocated. This encompasses understanding of how information is learned, stored, transduced, and processed across subcellular structures. Applicants with theoretical, data science, or experimental backgrounds within biological physics are encouraged to apply. The ideal candidate will strengthen and extend research programs of current biophysics faculty in the Department of Physics and collaborate with broader life science activities across many departments at CMU and the wider Pittsburgh area.

More details on Interfolio: https://apply.interfolio.com/174360
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Ulrike Endesfelder @uendesfelder.bsky.social · 12/09/2025
Please share: The application for Les Houches is open (until Oct 31) fluorescenceleshouches.wordpress.com *This is for you, if you ever wanted to learn all about fluorescence markers & how to apply them for your biological research!* PS: no fees this year, you just need to get there, that's all!
fluorescenceleshouches.wordpress.com
French-German WE-Heraeus-Seminar "Fluorescence markers for advanced microscopy : From photophysics to biology - 2026"
March 15-20 2026, Les Houches, France
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Maja Klevanski @majaklevanski.bsky.social · 30/08/2025
It was an amazing meeting! Thank you Ulrike (@uendesfelder.bsky.social), Mike (@heilemannlab.bsky.social), Ulrich and all! I’m still under the spell of the scientific insights and the warm, encouraging spirit of this community.💖
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Heilemann Lab @heilemannlab.bsky.social · 27/08/2025
We are heading on with Laura Jaekel from the Endesfelder Lab @uendesfelder.bsky.social reporting EVE, a 'cool tool' to analyze event-based localization data #SMLMS2025 👏
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Heilemann Lab @heilemannlab.bsky.social · 27/08/2025
Xavier Darzacq is our keynote speaker of today and takes us on an amazing journey through the cell nucleus with amazing single-molecule biology #SMLMS2025 www.tjian-darzacq.mcb.berkeley.edu
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Heilemann Lab @heilemannlab.bsky.social · 28/08/2025
Day #2 of #SMLMS2025 is taking off right now and introduced by Uli Kubitscheck👇🏻
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Heilemann Lab @heilemannlab.bsky.social · 28/08/2025
First on stage is Maja Klevanski @majaklevanski.bsky.social from Heidelberg University presenting her great work on multiplexed super-resolution imaging of proteins and glycans in tissue #SMLMS2025
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Heilemann Lab @heilemannlab.bsky.social · 28/08/2025
Jarno Mäkelä @jmakela.bsky.social from Aalto University shares his great work on single-molecule dynamics of heat shock proteins in E. coli #SMLMS2025 (unpublished work, so no images here)
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Heilemann Lab @heilemannlab.bsky.social · 28/08/2025
Johannes Hohlbein @hohlbeinlab.bsky.social from Wageningen presenting his great work on the dynamics of the E. coli replication initiator DnaA #SMLMS2025
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Heilemann Lab @heilemannlab.bsky.social · 28/08/2025
👉🏻 check out his recent paper that came out right on time for #SMLMS2025 👍 doi.org/10.1038/s414...
doi.org
The Escherichia coli replication initiator DnaA is titrated on the chromosome - Nature Communications
A DNA-binding protein, DnaA, regulates the initiation of chromosomal replication in bacteria. Here, Olivi et al. show that the bacterial chromosome sequesters DnaA in a growth rate-dependent manner, s...
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Heilemann Lab @heilemannlab.bsky.social · 28/08/2025
The next presentation is by Qingru Li from TU Delft reporting really 'cool work' on cryo-4Pi single-molecule localization microscopy #SMLMS2025
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Heilemann Lab @heilemannlab.bsky.social · 28/08/2025
Johannes Stein @jmstein.bsky.social from Harvard/Wyss reports impressive work on imaging the nuclear ultrastructure of cells using cryosections and DNA-PAINT #SMLMS2025
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Massive Photonics @massivephotonics.bsky.social · 28/08/2025
📢 Don’t forget to stop by our booth at #SMLMS2025! We’re excited to share how our #DNAPAINT solutions and labeling kits can help you unlock nanoscale insights 🔬🧬 📍WP Building Foyer, near the windows
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Marina Weisband @afelia.bsky.social · 09/08/2025
Wollt ihr als aula-Botschafter*innen Demokratie an Schulen bringen? Ihr könnt euch im September kostenlos ausbilden lassen! Von überall, nicht nur aus Rheinland-Pfalz! Link forms.cloud.microsoft/e/Y0rdhWJtjgl (Ich weiß, Forms, wird gerade geändert)
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SMLMS 2025 @smlm-symposium.bsky.social · 28/07/2025
Made a starter package of people that are joining ySMLMS and SMLMS 2025 - just tell us (e.g. reply to this post) if you want to get on the package list! go.bsky.app/BZzDS3F
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Ulrike Endesfelder @uendesfelder.bsky.social · 23/07/2025
Danke @jmwiarda.bsky.social für diese Einordnung! Und an alle anderen: 👉unbedingt lesenswert!
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SMLMS 2025 @smlm-symposium.bsky.social · 02/07/2025
Thanks to the Fonds der Chemischen Industrie we can cover the accommodation costs of all participants giving a talk at youngSMLMS! And thanks to the Bonner Graduiertenzentrum youngSMLMS participation will also be free! 👉 Don’t miss the abstract submission deadline - it's this *Friday 4th of July*.
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Ulrike Endesfelder @uendesfelder.bsky.social · 30/06/2025
If you would like to be selected as a speaker from the abstracts, please use your chance until the end of the week to submit! 👇
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SMLMS 2025 @smlm-symposium.bsky.social · 30/06/2025
We are happy to announce Christopher Grossert from Midel Photonics as one of the speakers in our youngSMLMS panel discussion! After finishing his PhD in Physics, he first worked in IT consulting and has co-founded the startup Midel Photonics four years ago where he now works in production and IT.
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SMLMS 2025 @smlm-symposium.bsky.social · 27/06/2025
We are happy to announce Koen J.A. Martens @kjamartens.bsky.social from the ImPhys in Delft, Netherlands, as one of our workshop leaders! He has a background in single-molecule localization microscopy & single-particle tracking and is working on smart SR-imaging using e.g. event-based sensors.
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Ulrike Endesfelder @uendesfelder.bsky.social · 26/06/2025
I am at the end of my tether to be able to comment on this in any proper way...
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SMLMS 2025 @smlm-symposium.bsky.social · 26/06/2025
We are happy to announce Estibaliz Gómez de Mariscal @gomez-mariscal.bsky.social from the Gulbenkian Institute in Oeiras, Portugal as one of our workshop leaders at the youngSMLMS! She investigates HIV viral transmission & focuses on AI in SR Microscopy. She also strongly supports open science.
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SMLMS 2025 @smlm-symposium.bsky.social · 25/06/2025
We are happy to announce Daniel Sage (bigwww.epfl.ch/sage/) from the EPFL in Lausanne, Switzerland as one of our workshop leaders at the youngSMLMS 2025! His work is centered on computational bioimaging & he is interested in open science & has contributed to many open source tools for the community.
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SMLMS 2025 @smlm-symposium.bsky.social · 23/06/2025
We are happy to announce Siân Culley from the King’s college in London, UK as one of our workshop leaders at the youngSMLMS 2025! Her research focuses on image restoration of super-resolution imaging data and image fidelity using deep learning approaches.
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Ulrike Endesfelder @uendesfelder.bsky.social · 17/06/2025
👇high recommendation! The team is currently preparing an amazing program for you guys! Don't miss! 👇 👉 smlms.org/young-smlms
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Ulrike Endesfelder @uendesfelder.bsky.social · 12/06/2025
👇 Reminder on deadlines for i) early bird, ii) free child care option and iii) abstract talk selection! 👇
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Emmanuel Margeat @emmanuelmargeat.bsky.social · 26/05/2025
Applications are now open for the 4th edition of the “Ecole de Physique des Houches” on Fluorescence Markers for Advanced Microscopies, a WE-Heraeus seminar. March 15th-20th 2026 Join us to learn everything you wanted to know about Fluorescent Markers for advanced microscopies.
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Ulrike Endesfelder @uendesfelder.bsky.social · 15/05/2025
Margot Friedländer verlor ihre Familie im Holocaust. Wie kann es sein, dass gewisse Politiker „Familie und Freunden“ ihr Mitgefühl aussprechen? Gerade dass sie *keine* Familie mehr hatte, ist keine private Tragödie, sondern Teil unserer Geschichte. Danke für Ihr Zeugnis und Ihr Erinnern!
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Ulrike Endesfelder @uendesfelder.bsky.social · 11/04/2025
Sehr lesenswerte 3.5 Seiten! Und übrigens eine sehr gute Frage: wie resilient & wehrhaft sind eigentlich unsere Gremien und Verordnungen? @unibonn.bsky.social
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Ulrike Endesfelder @uendesfelder.bsky.social · 07/04/2025
Please share with all your colleagues and friends! The more the merrier! 👇👇👇 more info on smlms.org!
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Ulrike Endesfelder @uendesfelder.bsky.social · 03/04/2025
Nothing to add... Poor world... Let's all try to contribute our tiny bit to make the world a bit more "healthy" again, there are enough major global "construction sites" to choose from..
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Ulrike Endesfelder @uendesfelder.bsky.social · 24/03/2025
Congrats Siegfried and lab! Amazing data!
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Ulrike Endesfelder @uendesfelder.bsky.social · 28/02/2025
👇🏼👇🏼👇🏼
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Ulrike Endesfelder @uendesfelder.bsky.social · 21/02/2025
what they say!
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Adam Bonica @adambonica.bsky.social · 20/02/2025
The DOGE firings have nothing to do with “efficiency” or “cutting waste.” They’re a direct push to weaken federal agencies perceived as liberal. This was evident from the start, and now the data confirms it: targeted agencies overwhelmingly those seen as more left-leaning. 🧵⬇️
Scatterplot titled “Empirical Evidence of Ideological Targeting in Federal Layoffs: Agencies seen as liberal are significantly more likely to face DOGE layoffs.”
	•	The x-axis represents Perceived Ideological Leaning of federal agencies, ranging from -2 (Most Liberal) to +2 (Most Conservative), based on survey responses from over 1,500 federal executives.
	•	The y-axis shows Agency Size (Number of Staff) on a logarithmic scale from 1,000 to 1,000,000.

Each point represents a federal agency:
	•	Red dots indicate agencies that experienced DOGE layoffs.
	•	Gray dots indicate agencies with no layoffs.

Key Observations:
	•	Liberal-leaning agencies (left side of the plot) are disproportionately represented among red dots, indicating higher layoff rates.
	•	Notable targeted agencies include:
	•	HHS (Health & Human Services)
	•	EPA (Environmental Protection Agency)
	•	NIH (National Institutes of Health)
	•	CFPB (Consumer Financial Protection Bureau)
	•	Dept. of Education
	•	USAID (U.S. Agency for International Development)
	•	The National Nuclear Security Administration (DOE), despite its conservative leaning (+1 on the scale), is an exception among targeted agencies.
	•	A notable outlier: the Department of Veterans Affairs (moderately conservative) also faced layoffs despite its size.

Takeaway:

The figure visually demonstrates that DOGE layoffs disproportionately targeted liberal-leaning agencies, supporting claims of ideological bias. The pattern reveals that layoffs were not driven by agency size or budget alone but were strongly associated with perceived ideology.

Source: Richardson, Clinton, & Lewis (2018). Elite Perceptions of Agency Ideology and Workforce Skill. The Journal of Politics, 80(1).
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