MOSAIC is a versatile multimodal microscope that allows seamless transition between various light-sheet, two-photon, label-free and super-resolution modalities. It is demonstrated in various systems r...

Brightness demixing is a method for simultaneously detecting different fluorophores in single-molecule localization microscopy based on their brightness rather than their spectral properties. As this ...

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Standard algorithms fail to fully exploit the spatial information in DNA-PAINT. Here, the authors present G5M, an algorithm providing molecular maps by accurately inferring biomolecule positions at di...

Dynamic Binder Exchange (DyBE) leverages transient binder–target interactions to enhance labeling efficiency by up to 15-fold in super-resolution microscopy. DyBE maps nanoscale receptor tyrosine kin...

Cell junction remodeling is central to epithelial morphogenesis and tissue rheology, and depends on the interplay between adhesion molecules and the actomyosin cortex. E-cadherin constitutes the molec...

Stimulated emission depletion (STED) microscopy enables super-resolution imaging of complex biological samples in 3D, in large volumes, and live. However, molecular quantification with STED has remain...

Super-resolution microscopy identifies nano-sized tau aggregates (nano-aggregates) and reveals distinct transitions in their morphology and phosphorylation profiles across control, Primary Age-Relate...

Neurotransmitter release and membrane retrieval at active zones require precise spatial and temporal coordination relying on an intricate molecular machinery. However, the exact nano-structural organi...

Massive-Photonics offers ready-to-use labelling kits for DNA-PAINT based super-resolution imaging.

By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...