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Guichard-Lab

@guichard-lab.bsky.social
406 followers 421 following 10 posts

Biomolecular and Foldamer Chemistry, #Peptide Engineering, Chemical Biology, Molecular and Structural Studies. Research group at CBMN in #Bordeaux, @iecb.bsky.social @cnrs.bsky.social @univbordeaux.bsky.social Our website : www.guichard-iecb.fr

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Guichard-Lab @guichard-lab.bsky.social · 19/08/2026
Great collaboration and great outcome! Thank you all for this fantastic team effort 🥳👏 @univbordeaux.bsky.social @cnrs.fr @iecb.bsky.social @foldnetuk.bsky.social
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Julie Ledoux @jldx.bsky.social · 24/04/2026
So it is out! 🎉 I am so excited to share our preprint with Fabio Sterpne and @baam93.bsky.social on the development of a force field for oligourea foldamers, new self-assembling polymers of unnatural amino acids, designed for water desalination membranes. www.biorxiv.org/content/10.6...
biorxiv.org
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Guichard-Lab @guichard-lab.bsky.social · 17/09/2025
Congrats @radha-tomar.bsky.social for winning the poster prize at the International Symposium on #foldamers 2025 🎉👏 Huge thanks to @andrecobb.bsky.social for organizing such an inspiring meeting at King’s College London! Great science & good vibes! @foldnetuk.bsky.social @iecb.bsky.social
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FoldNetUK @foldnetuk.bsky.social · 03/09/2025
That’s a wrap! Huge thanks to our speakers, poster presenters, attendees, sponsors, organisers, @andrecobb.bsky.social, @anbismillah.bsky.social, @kingsnmes.bsky.social, EPSRC @ukri.org See you at the next #Foldamers meeting in 2027 in Budapest at HUN-REN Research Centre for Natural Sciences
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Guichard-Lab @guichard-lab.bsky.social · 20/05/2025
Definitely planning to attend - Looking forward to reconnecting with the foldamer community in London !
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Tom Grossmann @tomngrossmann.bsky.social · 28/04/2025
Great to see our paper on helicity-dependent peptide cyclizations online at the Journal of Peptide Science doi.org/10.1002/psc.... (open access) Congrats to all authors!! #peptidomimetics
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Guichard-Lab @guichard-lab.bsky.social · 25/04/2025
Really enjoyed the Korean BBQ with colleagues and friends Prof. Hee-Seung Lee from KAIST and Prof. Sung Hyun Yoo from Chonnam National University yesterday after a full day at the KCS meeting. Great food and great company!
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Guichard-Lab @guichard-lab.bsky.social · 24/04/2025
Excited to join 2025 Korean Chemical Society 135th General Meeting &Exhibition this week! Always a pleasure to catch up with colleagues and reconnect with lab alumni. Thank you, Sung Hyun @yoo-bios-lab.bsky.social for the fantastic welcome in Korea — truly appreciated! @iecb.bsky.social #ChemSky
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IECB Bordeaux @iecb.bsky.social · 14/04/2025
We are recruiting 🤩🤩🤩!!! If you are looking to establish ylur lab in a multidisciplinary institute with state-of-the-art facilities, horizontal structure and diverse faculty, apply!!!
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IECB Bordeaux @iecb.bsky.social · 31/03/2025
Join us this Friday, April 4th, for an afternoon minisymposium on protein structure and dynamics in disease! The place is as usual our IECB amphitheater!
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Boris Vauzeilles @borisvauzeilles.bsky.social · 28/03/2025
What a superb and inspiring day, discussing highly diverse aspects of #Bioinspiration - A big thank to all the speakers, chairpersons, and the attendance. As well as the people involved in the organization... Advances in Bioinspirations @inserm.fr - @cea.fr - @cnrs.fr #BMSV
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Guichard-Lab @guichard-lab.bsky.social · 24/03/2025
See our latest work on stapled peptide-foldamer hybrids targeting hDM2, using cis-4-mercaptoproline for an optimal macrocyclization. 🚀 @iecb.bsky.social @cnrsaquitaine.bsky.social @univbordeaux.bsky.social @departementsts.bsky.social #ChemBio #ChemSky Read more: doi.org/10.1002/chem...
Co-crystal structure of a macrocyclic foldamer-peptide hybrid (8a) bound to hDM2 (PDB ID 9GFK)
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Emmanuelle Thinon @thinonlab.bsky.social · 14/03/2025
Congratulations to Chloé Freyermuth on successfully defending her PhD! 🎉 I'm really proud to have her as the first PhD student in the lab @iecb.bsky.social @CBMN A huge thank you to the members of the jury: Laurence Abrami, Agnès Rötig, Ed Tate, @ffriscourt.bsky.social, @guichard-lab.bsky.social
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James Nowick @jsnowick.bsky.social · 05/03/2025
Congratulations to Jason Zhu on the publication of his manuscript "A β-Hairpin Peptide Derived from Aβ Forms Different Oligomers in the Crystal State and in Aqueous Solution" in Organic and Biomolecular Chemistry: pubs.rsc.org/en/content/a.... This
pubs.rsc.org
A β-Hairpin Peptide Derived from Aβ Forms Different Oligomers in the Crystal State and in Aqueous Solution
The supramolecular assembly of amyloid β into soluble oligomers is critical Alzheimer’s disease (AD) progression. Soluble Aβ oligomers have emerged as neurotoxic species involved in AD progression and...
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Communications Chemistry @commschem.nature.com · 12/03/2025
Just out: Stabilization of a miniprotein fold by an unpuckered proline surrogate
bit.ly
Stabilization of a miniprotein fold by an unpuckered proline surrogate
Communications Chemistry, Published online: 12 March 2025; doi:10.1038/s42004-025-01474-6Proline plays an important role in mediating protein folding and stability, however, the impact of noncanonical proline analogues on protein folding and stability is…
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Ivan Huc Group @akhuc.bsky.social · 27/02/2025
Please check out our Angew. communication on DNA mimic foldamers that can outcompete DNA itself in the binding of proteins! 🧬 onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
DNA Mimic Foldamer Recognition of a Chromosomal Protein
Biomolecular mimics are intended to outperform their natural counterparts. However, B-DNA surface mimicry to target DNA-binding proteins has long remained underdeveloped. We have introduced helical a...
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Frederic Friscourt @ffriscourt.bsky.social · 07/02/2025
It was such a pleasure and privilege to have Prof Sabine Flitsch from Manchester university presenting today at our IECB seminar series @iecb.bsky.social @univbordeaux.bsky.social @departementsts.bsky.social
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IECB Bordeaux @iecb.bsky.social · 28/01/2025
Join us next week on Friday the 7th, at 11 am, in our IECB amphitheater to learn a whole lot on the design and applications of enzyme cascades for organic synthesis 🤓🧪👩‍🔬⚗️! Guest speaker Prof. Sabine Flitsch from the University of Manchester 🤩!!! www.iecb.u-bordeaux.fr/evenements/i...
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Guichard-Lab @guichard-lab.bsky.social · 03/01/2025
Happy to share our work on guanidinium-stapled peptides, now published in @angewandtechemie.bsky.social! A versatile method to stabilize peptide helices for precise protein surface recognition. Congrats to the team and special thanks to Morgane Pasco! 👏 🔗 doi.org/10.1002/anie... @iecb.bsky.social
Guanidinium‐Stapled Helical Peptides for Targeting Protein‐Protein Interactions
Peptide stapling has emerged as a versatile approach in drug discovery to reinforce secondary structure elements especially α-helices and improve properties of linear…
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Nature Reviews Drug Discovery @natrevdrugdiscov.nature.com · 02/01/2025
2024 FDA approvals nature.com/articles/d41... The FDA approved 50 new therapeutics in 2024, with green lights for a novel schizophrenia drug, a first MASH medicine and much more - find out about them in our annual round-up
Graph of annual FDA approvals
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Christophe Biot @cbiot.bsky.social · 01/01/2025
Happy New Year, ChemBio community! 🎉 In 2025, let’s advance chemical biology together: mobility grants to foster collaborations, training & mentoring for young scientists, and join us in Nantes (June 6-8) for our annual meeting. Free to join, spread the word! #GDRChemBio #ChemBio
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C&EN (Chemical & Engineering News) @cenmag.bsky.social · 01/01/2025
Sir J. Fraser Stoddart, Chair Professor in Chemistry at the University of Hong Kong, died Dec. 30, 2024, at the age of 82. He was on holiday in Australia with his family. cen.acs.org/people/obitu... #chemsky
Sir J. Fraser Stoddart
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Ivan Huc Group @akhuc.bsky.social · 18/12/2024
Check out our article in @angewandtechemie.bsky.social about the design of foldamers that aggregate into abiotic quaternary structures 🧩 Congrats to Shuhe! onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
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Tom Grossmann @tomngrossmann.bsky.social · 11/12/2024
Great to see so many familiar & new faces here! Read on our biomimetic design strategies: www.thieme-connect.com/products/ejo... 👉 #proteomimetics for challenging targets 👉 #INCYPRO chemical #proteinengineering 👉 covalent #peptidomimetics inhibitors Big thanks to all former & present group members!
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Rémi Fronzes @fronzeslab.bsky.social · 28/11/2024
Congratulations to our @iecb.bsky.social and MFP colleague Nicolas Reyes for his medal from the French académie des sciences (médaille de la section de Biologie moléculaire et cellulaire, génomique). @univbordeaux.bsky.social @cnrs.bsky.social
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Emmanuelle Thinon @thinonlab.bsky.social · 26/11/2024
Great to meet the #chembio community from Bordeaux (France) for the Chemistry Biology Interface Day (CBID 2024) today! Congratulations to Cléo Chidaine (ARNA) and Melissa Kosovari (CBMN) on winning the poster prizes! Thanks to @univbordeaux.bsky.social and @iecb.bsky.social for sponsoring/hosting
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IECB Bordeaux @iecb.bsky.social · 13/11/2024
Join us next Thursday (Nov 21) for our 'Membrane-Interacting Peptides & Multiscale Biophysics' symposium organized in honor of Dr. Frances Separovic from the University of Melbourne and her award of the title Doctor Honoris Causa from the University of Bordeaux 👏👏👏!
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IECB Bordeaux @iecb.bsky.social · 07/11/2024
Join us next Wednesday at our IECB amphitheater for a fantastic line-up of speakers aspiring to join our IECB faculty 👏👏👏!
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IECB Bordeaux @iecb.bsky.social · 07/11/2024
If you are in our corner next week, come and join us for the first Ambassador's Tour Seminar in Chemical Sciences by Professor Ayyalusamy Ramamoorthy from Florida State University 🧪⚗️!!! Where 🤩? At our IECB amphitheater When 🤓? Tuesday, Nov 12th, 11 AM
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