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Nico Dantuma

@ubiquitinneuro.bsky.social
253 followers 293 following 11 posts

Professor of Molecular Cell Biology. The Dantuma lab at the Karolinska Institute studies protein degradation in Alzheimer's, Parkinson's and other neurodegenerative diseases as well as cancer. Interests: triathlon, kayaking, scuba diving, climbing, etc.

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Nico Dantuma @ubiquitinneuro.bsky.social · 24/07/2026
Our latest review @febsj.bsky.social deals with how to stimulate proteasomal degradation and its potential as a therapeutic target. febs.onlinelibrary.wiley.com/doi/full/10....
febs.onlinelibrary.wiley.com
FEBS Press
The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome...
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Reposted by Nico Dantuma
Craig A. Goodman @craigagoodman1.bsky.social · 07/07/2026
Stimulating proteasomal degradation in human proteinopathies febs.onlinelibrary.wiley.com/doi/10.1111/...
febs.onlinelibrary.wiley.com
FEBS Press
The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome....
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Reposted by Nico Dantuma
RyanLab_TCD @ryanlab.bsky.social · 16/05/2026
#Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient degradation www.nature.com/articles/s41...
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Nico Dantuma @ubiquitinneuro.bsky.social · 21/05/2026
How mitochondria hinder destruction of mutant proteins that cause Parkinson's and Huntington's disease. Our latest study published in Nature Communications. www.nature.com/articles/s41...
nature.com
Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient degradation - Nature Communications
Accumulation of aggregation-prone proteins is linked to neurodegenerative diseases. Here, the authors show that mitochondrial association hinders cells to efficiently clear these toxic proteins. Preve...
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Nico Dantuma @ubiquitinneuro.bsky.social · 08/09/2025
We are looking for a postdoc! Interested in protein degradation in cancer and neurodegeneration? Interested in the ubiquitin-proteasome system and autophagy? Application deadline Sept 26. #karolinskainstitutet #stockholm #postdocposition ki.varbi.com/en/what:job/...
ki.varbi.com
Postdoctoral Researcher in Intracellular Protein Degradation in Cancer
Do you want to contribute to top quality medical research? The Dantuma lab at the Department of Cell and Molecular Biology has a long-standing interest in understanding the role of intracellular prote
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Nico Dantuma @ubiquitinneuro.bsky.social · 27/06/2025
The Karolinska Institute announces 20 positions for Assistant Professors for outstanding early-career researchers. Positions include a startup package. Application deadline September 2nd. ki.varbi.com/en/what:job/...
ki.varbi.com
Assistant Professor in Cell and Molecular Biology
Join a global community of excellence Karolinska Institutet, Department of Cell and Molecular Biology Are you a bold, creative researcher ready to shape the future of medical science? Karolinska Insti
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Nico Dantuma @ubiquitinneuro.bsky.social · 27/06/2025
The Karolinska Institute announces 20 positions for Assistant Professors in Biomedical Science for outstanding early-career researchers. Positions include a startup package. Application deadline September 2nd. ki.varbi.com/en/what:job/....
ki.varbi.com
Assistant Professor in Biomedical Science
Join a global community of excellence Are you a bold, creative researcher ready to shape the future of medical science? Karolinska Institutet (KI), one of the world’s foremost medical universities,
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ProteoCure @proteocure.bsky.social · 24/05/2025
Congrats to Corentin Bouvier, awardee of the FEBS Journal prize at the annual COST ProteoCure meeting. @costprogramme.bsky.social @febsj.bsky.social #ProteoCure2025
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Reposted by Nico Dantuma
ProteoCure @proteocure.bsky.social · 24/05/2025
Congrats to Mónica Pozo Rodriguez, awardee of the FEBS Open Bio Poster prize at the annual COST ProteoCure meeting. @costprogramme.bsky.social @febspress.bsky.social #ProteoCure2025
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ProteoCure @proteocure.bsky.social · 24/05/2025
Congrats to Simon Tack, awardee of the FEBS Journal Oral Presentation prize at the annual COST ProteoCure meeting. @costprogramme.bsky.social @febsj.bsky.social #ProteoCure2025
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Reposted by Nico Dantuma
ProteoCure @proteocure.bsky.social · 21/05/2025
An introduction into the role of mitochondrial dynamics in dealing with misfolded mitochondrial proteins by Luca Scorrano at the #ProteoCure2025 annual meeting. #COST
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Nico Dantuma @ubiquitinneuro.bsky.social · 21/05/2025
Michael Glickman presented his latest data on one of our favorite proteins UBB+1 and its role in Alzheimer's disease at the annual meeting of COST ProteoCure in Heraklion.
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Nico Dantuma @ubiquitinneuro.bsky.social · 06/03/2025
Mitochondria a safe haven for aggregation-prone proteins? #neurodegeneration. #Parkinson. Find our latest manuscript in @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Mitochondria serve as a Holdout Compartment for Aggregation-Prone Proteins hindering Efficient Ubiquitin-Dependent Degradation
The accumulation of protein aggregates has been causatively linked to the pathogenesis of neurodegenerative diseases. In this study, we have conducted a genome-wide CRISPR-Cas9 screen to identify cell...
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Reposted by Nico Dantuma
Lisa Heinke @lisaheinke.bsky.social · 06/03/2025
Fantastic new paper out @nature.com! @merbllab.bsky.social discovers proteasome-derived peptides that function as a defence against bacterial infections. I'm not an immunologist but even I can tell that this finding has huge implications for new therapeutic interventions! 👉 go.nature.com/43k1a0H
nature.com
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
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Nico Dantuma @ubiquitinneuro.bsky.social · 05/02/2025
Today at 13:15 I will give a seminar at Uppsala Biomedical Centre entitled "Stimulating proteasomal degradation of neurodegeneration-associated proteins".
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Nature Chemical Biology @natchembio.nature.com · 28/01/2025
A Perspective from Xiaoyu Zhang, Gabriel Simon, and Benjamin Cravatt discusses recent strategies to expand the E3 ligase landscape and the scope of targeted protein degradation www.nature.com/articles/s41...
nature.com
Implications of frequent hitter E3 ligases in targeted protein degradation screens - Nature Chemical Biology
This Perspective discusses recent strategies to expand the scope of targeted protein degradation (TPD) and the implications of unexpected convergence of diverse screening efforts on a small subset of ...
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Reposted by Nico Dantuma
SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 27/01/2025
Join us in Vienna 8-9 May for the #Ubiquitin & Friends Symposium 2025! Excellent line-up of guest speakers👇And many slots for talks from abstracts, plus flash-talks & posters! Lots of opportunities to network with peers & experts in a friendly atmosphere! ➡️ www.protein-degradation.org/symposium/
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Reposted by Nico Dantuma
Silvia Ramundo @sramundo.bsky.social · 28/01/2025
Looking forward to this year’s EMBO meeting about ESCRT proteins at the scenic Caux Palace, Montreux (CH) / To receive a notification when the website goes live, sign up here: coming-soon.embo.org/w25-75
coming-soon.embo.org
ESCRT function, evolutionary diversity and mechanism of action
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Reposted by Nico Dantuma
Max-Planck-Gesellschaft @maxplanck.de · 23/01/2025
More than 40 percent of #postdocs leave academia. Those who landed a coveted faculty position were more likely to have had a highly cited paper, changed their research topic between their #PhD and postdoc, or moved abroad after receiving their doctorate. www.pnas.org/doi/10.1073/... @pnas.org
nature.com
More than 40% of postdocs leave academia, study reveals
Publishing highly cited papers helps postdoctoral researchers to land a faculty job.
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Reposted by Nico Dantuma
Castañeda Lab at SU @castanedalab.bsky.social · 06/01/2025
Inspired by recent discoveries on ubiquitin-mediated condensates under physiological and stress conditions, we wrote this review on the intersection of protein quality control, phase separation, and function! #PQC #UPS #autophagy #ubiquitin #condensates
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Rune Busk Damgaard @rbdamgaard.bsky.social · 15/11/2024
Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn
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Nico Dantuma @ubiquitinneuro.bsky.social · 22/01/2025
In our latest study, we report on how the SARS-CoV-2 protease PLpro manipulates autophagy. Paper in the Journal #Autophagy. #Covid, #Ubiquitin, #Proteasome. bit.ly/3E7cByg
bit.ly
Regulation of N-degron recognin-mediated autophagy by the SARS-CoV-2 PLpro ubiquitin deconjugase
Viral proteases play critical roles in the host cell and immune remodeling that allows virus production. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) papain-like protease (PLpro...
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Nico Dantuma @ubiquitinneuro.bsky.social · 22/01/2025
I’ve just done my #eXit! the X exodus is massive. Don't lose any of your followers. Thanks to #HelloQuitX I've registered 1631 new passengers for a journey to #BlueSky & #Mastodon. Join us on app.helloquitx.com and automatically find your communities on #January20!
app.helloquitx.com
HelloQuitteX
Libérez vos espaces numériques
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