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Kellianne

@kelliannealexa1.bsky.social
780 followers 1K following 7 posts

Postdoctoral Researcher working in the Young-Pearse lab @ Brigham and Women’s Hospital & Harvard Medical School. Neuroscientist and stem cell biologist studying the blood brain barrier in Alzheimer’s Disease.

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Reposted by Kellianne
Young-Pearse Lab @typlab.bsky.social · 13/05/2026
TYP lab takes Chicago! Grateful for the organizers putting together another great ROSMAP meeting and for the opportunity to share our work! Tracy, our amazing postdoc @garrettfogo.bsky.social and PhD student Olivia Pembridge all gave great talks! #RUSH #ROSMAP
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Young-Pearse Lab @typlab.bsky.social · 01/05/2026
Shout out to our fabulous postdoc @heuerwego.bsky.social who gave a great talk on her work leveraging iPSC models to uncover how genetic risk factors influence dysfunction in microglia in AD at the ACT Research Symposium hosted by the Kaiser Permanente Washington Health Research Institute! #ACT2026
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Young-Pearse Lab @typlab.bsky.social · 02/05/2026
Tracy and our fabulous postdoc @kelliannealexa1.bsky.social both gave fantastic talks on their work using IPSC models to study vascular dysfunction in AD at the @jax.org Vascular Contributions to Cognitive Impairment workshop! Thank you to the organizers for such an amazing meeting!
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Kellianne @kelliannealexa1.bsky.social · 01/05/2026
Grateful for the opportunity to present at the VCID workshop. Thank you to the organizers for such a thoughtful and impactful meeting. It was a pleasure connecting with so many great people and energizing to see the breadth of important work happening in this space!
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Chaitra Sathyaprakash @drchaitras.bsky.social · 14/01/2026
33rd episode of The Brain Podcast: Models matter: human-specific roles of POU3F2 and Wnt Signalling in neurodevelopment” @typlab.bsky.social I loved being a cohost on this one! Lovely guests and such a great discussion! open.spotify.com/episode/1sfN...
open.spotify.com
Models matter: human-specific roles of POU3F2 and Wnt Signalling in neurodevelopment
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Young-Pearse Lab @typlab.bsky.social · 18/10/2025
Congratulations to Dr. Zach Augur, who successfully defended his PhD thesis on Friday!! Zach had an amazing defense which highlighted his incredible productivity in the lab, culminating in 3 first-author publications throughout his thesis work!
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Young-Pearse Lab @typlab.bsky.social · 15/10/2025
Our study “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" was published in Acta Neuropathologica this week! Congratulations to lead author Zach Augur, who will be defending his thesis later this week!! link.springer.com/epdf/10.1007...
link.springer.com
Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis
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Young-Pearse Lab @typlab.bsky.social · 08/09/2025
New TYP lab publication from co-authors Zach Augur and @garrettfogo.bsky.social on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...
link.springer.com
Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons - Acta Neuropathologica Communications
Optineurin (OPTN) is an autophagy adaptor protein involved in selective autophagy, including aggrephagy and mitophagy. Pathogenic mutations in OPTN have also been linked to amyotrophic lateral scleros...
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Young-Pearse Lab @typlab.bsky.social · 10/07/2025
Huge congrats to @zacharyrmurphy.bsky.social selected as a 2025 Fujifilm Fellow at @harvard.edu 🎉 The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
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Young-Pearse Lab @typlab.bsky.social · 05/06/2025
New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...
cell.com
Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures
Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes, and neurons to investigate intercellular communication across different environmental and genetic contexts. Transcr...
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Young-Pearse Lab @typlab.bsky.social · 30/05/2025
Huge congrats to our Master’s student Emma Karp for receiving the GBM Master Prize from the Society for Biochemistry and Molecular Biology! 🏆🧬 Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠 🔗 gbm-online.de/de/studium-k...
gbm-online.de
GBM-Masterpreis - Homepage der Gesellschaft für Biochemie und Molekularbiologie e.V.
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Young-Pearse Lab @typlab.bsky.social · 04/06/2025
We are proud to celebrate Tracy as the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award! 🎉 Her guidance, encouragement, and dedication mean so much to all of us. Congratulations on this well-deserved honor!
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Kellianne @kelliannealexa1.bsky.social · 14/05/2025
Excited to be back @umasschan.bsky.social for the Boston interactive glial group meeting! So many great talks!
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Young-Pearse Lab @typlab.bsky.social · 30/04/2025
New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read! www.cell.com/neuron/abstr...
cell.com
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
Lish et al. reveal that AD-protective CLU alleles enhance CLU upregulation in response to accumulated neuropathology, thereby dampening inflammatory signaling between microglia and astrocytes. Using s...
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Young-Pearse Lab @typlab.bsky.social · 12/04/2025
Congratulations our newly-minted PhD candidate Olivia Pembridge on passing her PQE with flying colors today! Olivia will be using a wide array of iPSC and organoid models to study mechanisms of neurodevelopment!
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Kellianne @kelliannealexa1.bsky.social · 10/04/2025
Truly grateful for the opportunity to share my work at the CSHL Brain Barriers meeting! It’s been amazing to hear about all the exciting and innovative research happening across the community 🧠🚪🩸 #cshlbbb
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Young-Pearse Lab @typlab.bsky.social · 10/04/2025
Congratulations to TYP lab Postdoctoral Research Fellow @heuerwego.bsky.social on being awarded a @brightfocus.bsky.social Alzheimer's Disease Research Fellowship! Sarah is using iPSCs to determine the cellular impacts of ABCA7 mutations in Alzheimer's disease!
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Young-Pearse Lab @typlab.bsky.social · 06/03/2025
Proud of our amazing postdoc @kelliannealexa1.bsky.social who gave a fantastic talk today on her work with neuronal hyperexcitability and modeling blood-brain-barrier dysfunction in Alzheimer's disease today as part of the BWH Neuroscience Seminar Series!
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Kellianne @kelliannealexa1.bsky.social · 28/02/2025
Congrats @alexlish.bsky.social! You should be super proud of the work you’ve accomplished! Can’t wait to see what you do next!
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Kellianne @kelliannealexa1.bsky.social · 21/02/2025
Congrats @zacharyrmurphy.bsky.social!!!
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Young-Pearse Lab @typlab.bsky.social · 04/02/2025
New TYP lab publication out today in Glia, led by talented previous PhD student Hyo Lee! Our first big analysis of induced Astrocytes from 44 individuals in the ROSMAP cohort. You can find it here: onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease
Generation and characterization of induced pluripotent stem cell (iPSC)-derived astrocytes from 44 aged humans reveals congruence of gene expression profiles between astrocyte cultures and brain and ...
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Young-Pearse Lab @typlab.bsky.social · 10/01/2025
Happy #FluorescenceFriday and inaugural bluesky post- some beautiful microglia-neuron-astrocyte co-cultures from TYP lab postdoc @heuerwego.bsky.social!
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Kellianne @kelliannealexa1.bsky.social · 13/12/2024
The elf has arrived at the TYP lab in style—complete with a sleigh and hippo-reindeer! 🎅🛷 #ElfInTheLab #LabLife #ElvesBehavingBadly
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Zachary Murphy @zacharyrmurphy.bsky.social · 23/11/2024
Back in Houston pt. 2!! This time, I had the pleasure to present a poster on Ultra-Rapid ddPCR with my co-first author Emilia Bianchini at SNO 2024. A very fun weekend! #ddPCR #SNO2024
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Jon Lim, FRCP PhD @drjonlim.bsky.social · 23/11/2024
🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov
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Lerit Lab @lablerit.bsky.social · 12/11/2024
Now that half of SciTwitter is here… Come be my colleague! The Dept of Cell Biology @EmoryUniversity is recruiting a developmental cell biologist. 🔬Do you study mechanisms of development using cell biological (and other) approaches? Join us!🔬 TY for RT! jobs.sciencecareers.org/job/664684/t...
jobs.sciencecareers.org
Tenure-track Faculty position in Cell and Developmental Biology - Atlanta, Georgia job with Emory University | 664684
This search is open to investigators conducting mechanistic studies of developmental cell biology using genetically tractable model organisms.
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The Jackson Laboratory @jax.org · 30/05/2024
📔 New review in Neuropharmacology, "Strategies to dissect microglia-synaptic interactions during aging and in #Alzheimer's disease" by Sarah Heuer, Erik Bloss & Gareth Howell: 🧪🤝🖥️ 🧬 ⑂ #jaxresearch #ScientificResearchPublishing #alzsky #Neuroscience doi.org/10.1016/j.ne...
scientific illustration
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The Jackson Laboratory @jax.org · 10/01/2024
What happens in our brains to bring about such decline and why does it vary so much between individuals? JAX's Erik Bloss, Gareth Howell & Sarah Heuer examined the effects of aging in mouse neurons & synapses, with findings in a new Aging Cell paper #Neuroscience 🧪🤝🖥️ 🧬: www.jax.org/news-and-ins...
jax.org
Sharp as a tack or vague and forgetful?
Erik Bloss, Gareth Howell and predoctoral associate Sarah Heuer are examining the effects of aging in mouse neurons and synapses.
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Oded Rechavi @odedrechavi.bsky.social · 13/11/2024
PhD student: "please don't be excited yet, these are just preliminary results, I still need to repeat the experiment multiple times" PI:
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Kellianne @kelliannealexa1.bsky.social · 15/11/2024
Fluorescence Friday! Ipsc derived endothelial cells (green/ red- tight junction proteins, blue-nucleus) #Bloodbrainbarrier #ipsc #stem #neuroscience
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