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Gizem Terzioglu @gizemterzioglu.bsky.social · 17/11/2025

Thank you Alzforum for highlighting our preprint! It's incredibly helpful to get the experts' feedback this early on in the publishing stage! www.alzforum.org/news/researc...

alzforum.org

Does AD Risk Gene INPP5D Leave Lysosomes With a Leak? | ALZFORUM

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Reposted by Gizem Terzioglu

Young-Pearse Lab @typlab.bsky.social · 04/11/2025

We're excited to share our new pre-print, where @gizemterzioglu.bsky.social et al. identify SHIP1, the protein encoded by the Alzheimer's disease risk gene INPP5D, as a regulator of endo-lysosome function and selective phagocytosis in human iPSC-derived microglia! www.biorxiv.org/content/10.1...

biorxiv.org

INPP5D/SHIP1 is a dual regulator of endo-lysosome function and selective phagocytosis in human microglia

INPP5D, the gene encoding SHIP1, is genetically associated with Alzheimer’s disease (AD) risk and plays a central role in regulating immune function. Here, we aimed to elucidate the mechanism by which...

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Reposted by Gizem Terzioglu

Young-Pearse Lab @typlab.bsky.social · 13/06/2025

Huge shoutout to our brilliant graduate student @gizemterzioglu.bsky.social for delivering a fantastic talk at the HMS Neurobiology Pizza Talk series! 🍕🧠 She highlighted exciting insights into how SHIP1 shapes microglial function at the intersection of intracellular trafficking and immune response.

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Reposted by Gizem Terzioglu

Young-Pearse Lab @typlab.bsky.social · 21/05/2025

Big shoutout to our lab at the annual ROSMAP meeting in Chicago! 🎉 @heuerwego.bsky.social gave a great talk & won the Martha Ondrey Jr. Investigator Award 🏆 🧠 @gizemterzioglu.bsky.social crushed it with her presentation on SHIP1 & the inflammasome in microglia!

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Reposted by Gizem Terzioglu

Young-Pearse Lab @typlab.bsky.social · 14/05/2025

Some TYP members attended the BIGG meeting at UMass on Monday, and had a great time presenting talks and posters! PhD student @gizemterzioglu.bsky.social & postdoc @kelliannealexa1.bsky.social gave amazing short talks, Master's student Emma & postdoc @heuerwego.bsky.social got great poster traffic!

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Reposted by Gizem Terzioglu

Young-Pearse Lab @typlab.bsky.social · 28/03/2025

@gizemterzioglu.bsky.social will be presenting at the Microglia Symposium on the afternoon of April 4th! Her talk is titled "INPP5D/SHIP1 REGULATES MICROGLIA FUNCTION AND INFLAMMATORY RESPONSE IN ALZHEIMER'S DISEASE"

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Reposted by Gizem Terzioglu

Young-Pearse Lab @typlab.bsky.social · 28/03/2025

If you're headed to #ADPD next week, be sure to stop by the TYP lab presentations by @gizemterzioglu.bsky.social and Zach Augur to learn about some of the amazing work the lab is doing!

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