iiinova — where your digital self keeps evolving

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Dr Anna Clark @drannaclark.bsky.social · 04/10/2026

Sublime dreams: Giovanni Battista Piranesi, Italian artist, architect & archaeologist, whose views of Rome & imaginary prisons influenced Neoclassicism & Romanticism; born #OTD 1720. Colosseum, Vedute di Roma, etching 1757 | Plate III Carceri d’Invenzione,etching 1761 Princeton University Art Museum

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Kevin Hall @kevinh-phd.bsky.social · 03/10/2026

It was a pleasure to present on the topic of ultra-processed foods at the Trottier Public Science Symposium alongside Ashley Gearhardt this week McGill University in Montreal. www.youtube.com/watch?v=y31u...

youtube.com

"Ultra-Processed Foods: Processing the Facts" with Dr. Ashley Gearhardt and Dr. Kevin Hall

YouTube video by McGill Office for Science and Society

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Jan Broder Engler @jbengler.de · 03/10/2026

This is how you can visualize gene expression data in #tidyheatmaps 🤩 jbengler.github.io/tidyheatmaps #rstats #dataviz #phd

library(tidyheatmaps)

tidyheatmap(df = data_exprs,
rows = external_gene_name,
columns = sample,
values = expression,
scale = "row",
annotation_col = c(sample_type, condition, group),
annotation_row = c(is_immune_gene, direction),
gaps_row = direction,
gaps_col = group
)

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Josh Grubbs @joshuagrubbsphd.com · 28/08/2026

30/43 Back to the critiques. We also name some names—calling out dominant paradigms that are conducive to bad science (looking at you, components model of addiction).

Given the above context, in attempting to define what constitutes a behavioral addiction, researchers in this domain must often wrestle with the amorphous nature of addiction itself. Unfortunately, in many cases, this conceptual struggle has resulted in the arbitrary application of substance use disorder criteria and models to behavioral addictions, a practice that we contend is both shortsighted and misguided (Borgogna et al. 2025b; Grubbs & Boness 2025). Evidence of this pitfall can be found, for example, in the uncritical and widespread use of the Components Model of addiction that is applied liberally within behavioral addiction research (Griffiths, 2005). This model, in its simplest form, argues that addictive disorders share six core components (Salience, Mood Modification, Tolerance, Withdrawal Symptoms, Conflict, and Relapse). This framework is highly influential within the behavioral addiction literature and frequently invoked as a rationale for conceptualizing diverse behaviors as addictions based on their apparent resemblance to substance use disorders and other behavioral addictions. Yet, the validity of the model is contentiously debated (Fournier et al. 2023); and modern conceptions of addiction clearly refute the notion that either tolerance or withdrawal are necessary or sufficient conditions in diagnosing addictive disorders (Hasin et al. 2013). Similarly, the mood modification aspects of excessive sexual behaviors were explicitly excluded from the ICD-11 criteria for CSBD (Kraus et al. 2018), and evaluations of their value in diagnosing CSBD have largely rejected them (Grubbs et al. 2023b). Collectively, even these simple examples demonstrate how influential frameworks can become reified within a literature, leading researchers to prioritize demonstrating similarities to substance use disorders over establishing whether a proposed condition represents a distinct and clinically meaningful disorder.

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Josh Grubbs @joshuagrubbsphd.com · 28/08/2026

27/43 Gambling, gaming & sex are rewarding and engage the same dopamine circuitry as drugs. Cleanest proof? Parkinson's patients on dopamine agonists can suddenly develop gambling disorder or hypersexuality—the dopamine agonists can trigger behavioral addictions...

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Josh Grubbs @joshuagrubbsphd.com · 28/08/2026

25/43 I can't count how many papers I've seen on "tolerance" or "withdrawal" in behavioral addictions that ignore a basic fact: those are physiological processes—neither necessary nor sufficient for addiction.

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Josh Grubbs @joshuagrubbsphd.com · 28/08/2026

18/43 The International Sex Survey is a great example (40+ countries and 26 languages!), but far from the only one. Global collaborations are basically the norm here, which lets us do amazing cross-cultural work all the time.

Taking CSBD as an example, over the course of 2021-2023, a 42-country, 26-language research collaboration titled the International Sex Survey was conducted (Bőthe et al. 2021). This survey was led by a diverse team of international researchers and resulted in a final sample of over 82,000 participants. The results of this initiative were staggering, with over 30 publications arising from this study to date. Importantly, a key goal of this collaboration was the establishment of uniform, internationally validated assessment protocols across languages and cultural contexts (Bőthe et al. 2023), resulting in 19 papers alone dealing with the cross-cultural validity of various measures relevant to CSBD. Moreover, even among scales not included in these large-scale cross-country efforts, cross-cultural validation is common (Grubbs et al. 2023b).

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Josh Grubbs @joshuagrubbsphd.com · 28/08/2026

11/43 For our review, we focused on three diagnoses: Gaming Disorder, Gambling Disorder, and Compulsive Sexual Behavior Disorder—all in the ICD-11, all with large and rapidly growing literatures.

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Josh Grubbs @joshuagrubbsphd.com · 28/08/2026

10/43 Behavioral addictions aren't new. We trace discussions of behavioral addictions back at least a few millennia... and, arguably, they've been recognized for as long as psychiatry has existed

Humans are prone to excess. Stories of excessive substance use exist in historical records in virtually all cultures dating back thousands of years. Yet, there is also evidence throughout human history that behaviors themselves, not just substances, can become excessive or out-of-control. From ancient philosophers to modern smartphone applications, there is a millennia-long tradition of people attempting to change, reduce, or eliminate behaviors that they deem inappropriate, immoral, or excessive. For example, excessive gambling was first written about as a mental health concern as early as 1561 in the French philosopher Pascasius Justus Turq’s treatise On Gambling, or the Remedy to the Desire of Gambling for Money, which described excessive gambling as a disease (Nadeau & Valleur 2023). Furthermore, the struggles of the person vexed by excessive gambling were immortalized in Dostoevsky’s 1866 novel, The Gambler (Dostoevsky 1866). Despite this history, psychopathology-related fields have been slow to recognize such behavioral patterns as discrete mental health disorders. In the case of gambling, official recognition as a psychiatric disorder only came in 1977 with the inclusion of Pathological Gambling in the ICD-9 (Fauth-Bühler et al. 2017).

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Josh Grubbs @joshuagrubbsphd.com · 28/08/2026

9/43 Well, a LOT has shifted in a decade. The ICD-11 now officially recognizes three disorders commonly called behavioral addictions, and research has exponentially expanded.

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Josh Grubbs @joshuagrubbsphd.com · 28/08/2026

1/43 Ok folks, after much teasing and anticipation, I'm THRILLED to share our new paper in Annual Review of Clinical Psychology. Not gonna lie: I'm proud of this one, and I hope it makes an impact on the field (so please share!). A thread 🧵👇

To Be a Mental Disorder: Revisiting Behavioral Addictions
Joshua B. Grubbs, * Nicholas C. Borgogna, Beáta Bőthe, Hyoun S. Kim, Rory A. Pfund, Shane W. Kraus

Manuscript to appear in the 2027 edition of Annual Review of Clinical Psychology, this preprint may not
exactly represent the final printed copy.

Grubbs, J.B., Borgogna, N.C., Bőthe, Beáta, Kim, H.S., Pfund, R.A., & Kraus, S.W. (2027) To Be a Mental Disorder: Revisiting Behavioral Addictions. Annual Review of Clinical Psychology. 10.1146/annurev-clinpsy-061225-045608

Behavioral addictions have been recognized in various forms for centuries, yet only three—Gambling Disorder, Gaming Disorder, and Compulsive Sexual Behavior Disorder—are currently included in formal diagnostic systems. In the past decade, research on these conditions has expanded dramatically in both volume and methodological rigor, drawing on longitudinal, neurobiological, and cross-cultural designs and evolving into a truly global science. Even so, the field remains beset by unresolved controversies. Chief among these is a persistent tendency to import substance use disorder concepts—tolerance, withdrawal, and dependence—that lack conceptual and empirical support when applied to behavior. Related challenges concern the over-pathologizing of normal engagement and a reliance on confirmatory, self-report measurement of uncertain validity. We argue that advancing the field requires sustained funding, theory grounded in the disorders themselves, objective and intensive-longitudinal methods, greater diversity, and public health and regulatory attention to increasingly technological environments.

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Luca @lucagalletti.bsky.social · 03/10/2026

Composed of gold leaves and other adornments, this magnificent headdress belonged to Queen Puabi, one of the most powerful women known from ancient Mesopotamia. Discovered in the Royal Cemetery of Ur in present-day Iraq, the burial dates to approximately 2600-2500 BC. IG: @svitlana_skomsvold

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Martin Clemens Winter @martincwinter.bsky.social · 26/09/2026

Noch einmal #Stolpersteine #Heidenau: Das Bestreben, das Gedenken an Opfer d. Nationalsozialismus zu zentralisieren (und auf den Friedhof zu beschränken) hat eine lange Tradition und eine entlastende Funktion. In meiner Diss habe ich das am Beispiel der #Todesmärsche untersucht. Wen das interessert:

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Institute for Replication @i4replication.bsky.social · 25/09/2026

Over the past two years, I4R partnered with Psychological Science (@psychscience.bsky.social) on a large reproducibility project. 67 independent teams reproduced 64 articles published in 2024–2025, about 44% of eligible papers. Paper: www.econstor.eu/bitstream/10... Here's what we learned 🧵

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Nature Metabolism @natmetabolism.nature.com · 22/05/2026

RESEARCH | E Manduchi, KH Kaestner, D Avrahami et al (UPenn, US; HUJ, IL) Mapping of genome-wide DNA methylation patterns in human islet alpha and beta cells highlights age and type 2 diabetes dependent adaptations🧪

dlvr.it

Epigenetic adaptation of beta cells across lifespan and disease - Nature Metabolism

Mapping of genome-wide DNA methylation patterns in human islet alpha and beta cells highlights age and type 2 diabetes dependent adaptations and compensatory responses to altered metabolic demands.

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𝕊𝕦𝕟𝕕𝕒𝕖 𝔾𝕦𝕣𝕝 @sundaedivine.lol · 21/05/2026

Imagine being a Russian troll assigned to Bluesky: “Comrade, today you will destabilize Western democracy by arguing with poets, policy nerds, and a raccoon avatar with tenure.”

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Kevin Bird @stairwaytokevin.bsky.social · 18/05/2026

First real post on the new blog! If you follow human genetics, you've likely of "missing heritability". If you look at twins to estimate heritability, you get values much larger than what molecular genomic methods produce. IQ, for example, goes from 50-80% heritability to 10-15%. Which is right?

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Dr Anna Clark @drannaclark.bsky.social · 20/05/2026

“My love is as a fever, longing still...” Sonnet 147, Shakespeare’s Sonnets, first published #OTD 1609. Young man among roses: rare Elizabethan full-length portrait miniature, 1585-95, probably of 2nd Earl of Essex, favourite of Elizabeth I; by Nicholas Hilliard, died 1619. Victoria & Albert Museum

Young man among roses: rare Elizabethan full-length portrait miniature, 1585-95, probably of Robert Devereux, 2nd Earl of Essex, favourite of Elizabeth I; watercolour on vellum by Nicholas Hilliard, Limner to Elizabeth I and James I, died 1619.
Victoria & Albert Museum London

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Julia Carrie Wong @joolia.bsky.social · 19/05/2026

"The author of a nonfiction book about the effects of artificial intelligence on truth acknowledged on Monday that he had included numerous made-up or misattributed quotes concocted by A.I." 🫠🫠🫠

nytimes.com

Book on Truth in the Age of A.I. Contains Quotes Made Up by A.I.

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Dr. Tom Frieden @drtomfrieden.bsky.social · 20/05/2026

The early trajectory of the Ebola outbreak in DRC is alarming. Spread of the disease likely went undetected for months. Fast detection and response are crucial to stop outbreaks.

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Linsey Marr @linseymarr.bsky.social · 14/05/2026

It's widely accepted that hantavirus transmits from rodent excreta to humans via inhalation of aerosolized virus, so I don't understand why we're so reluctant to acknowledge the inhalation route for human-to-human transmission. www.nytimes.com/2026/05/14/h...

nytimes.com

Hantavirus Doesn’t Spread Easily, but Officials May Be Downplaying Risks

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Simon Kuestenmacher @simongerman600.bsky.social · 15/05/2026

Statistical fallacies that you will want to avoid. Source: buff.ly/2YCJBHK

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Codfather #FBPE 🇫🇷🇪🇺 @codfather.bsky.social · 14/05/2026

France is mandating solar panels on every large commercial car park in the country — turning millions of square metres of idle asphalt into one of Europe's most productive clean energy assets. I have been mentioning this for months - they are shooting up on all the supermarket car parks.

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Ewan Birney @ewanbirney.bsky.social · 26/04/2026

Grant writing tips from a grumpy reviewer ploughing through grants. 1. Often your reviewers are going to come from a broad range disciplines adjacent but *not actually in* in your field. Help us get orientated in the summary with an analogy/sketch and go back to analogy / sketch throughout.

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Jan Rosenow @janrosenow.bsky.social · 25/04/2026

Denmark's coal-to-wind transition is one of the most dramatic energy transformations of the past three decades. In 1990, coal provided 90% of Danish electricity. Today it is under 3%. Wind now covers roughly 60% of electricity generation. The last coal plant is scheduled to close by 2028.

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Justin Lehmiller @justinlehmiller.bsky.social · 30/03/2026

For the very first time, the full network of nerves within the clitoris has been mapped--something that was done decades ago for the penis. www.theguardian.com/society/2026...

theguardian.com

Full network of clitoral nerves mapped out for first time

Anatomy of one of least studied human organs could improve outcomes for women who have pelvic surgery

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Carausius @carausius286.bsky.social · 30/03/2026

This gloriously rich & elaborate helmet looks Persian, Lycian or Syrian. But it isn’t. It’s Celtic. The Agris Helmet was ceremonial rather than used in war & dates from c.350 BC. It is a masterpiece of Celtic art, but experts detect Etruscan & Greek influences. Incredible 🏛️📷 Musée d'Angoulême

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Alison Fisk @alisonfisk.bsky.social · 29/03/2026

A 3,400 year old Ancient Egyptian ‘Senet’ game board with gaming pieces. Senet is one of the earliest known board games. Popular in ancient Egypt, it was associated with the soul’s journey through the underworld and was often placed in tombs. Brooklyn Museum 📷 by me #Archaeology

My photo shows an ancient Egyptian Senet gaming board. It is a small rectangular box made of glossy bright blue faience with a separate sliding drawer at one end (shown at left) for storing the blue faience gaming pieces. Six gaming pieces are shown on the game board on top of the box. Three are reel-shaped and three are semi-conical. There are four reel-shaped pieces and one semi-conical piece on the display case surface beside the game board. The long side of the gaming board is decorated with alternating ‘Isis Knot’ and ‘djed pillar’ symbols. The gaming board dimensions are 5.5 x 7.7 x 21 cm. On display at Brooklyn Museum. Dated New Kingdom, Dynasty 18, reign of Amenhotep III c. 1390-1353 BC

Here’s the Brooklyn Museum Catalogue description:

“Top of board divided into thirty compartments with dividing lines glazed black. Four squares inscribed with numerals and a nefer sign. Long sides decorated with painted design of seven panels, each with alternating ankh and djed signs. Solid end bears painted Horus name (Amenhotep III?) ‘beloved of Amon.’ Open end pierced twice on one side. Base glazed black. Ends of drawer glazed dark and light blue in checkerboard pattern. Base and interior of drawer glazed dark purple-blue. Front of drawer pierced with four small holes (for handle?); sides pierced three times and two times - purpose not evident. Condition: Object has been assembled from fragments. Extensive scattered areas of plaster restoration. The drawer was probably originally much longer. Glaze worn in spots. Numerous firing cracks”.

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Dr Tom Horne @hornesupremacy.bsky.social · 28/03/2026

The Gundestrup Cauldron was likely made between 150 BC and 0 BC/AD. Crafted in embossed silver, it may have originated in an area of Thracian and Celtic interaction, but came to be deposited as a probable offering in a Danish bog, perhaps taken there as a gift or booty. My 📼 Nationalmuseet

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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 21/03/2026

🧬How genetically similar are fear & GAD? A new preprint by ter Kuile et al. addresses this via their GWAS of fear-based disorders as a group (panic, agoraphobia, specific phobia, social anxiety) & a separate GWAS of GAD.

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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 01/03/2026

🧵 New publication from the PGC Anxiety Working Group. Our GWAS meta-analysis of anxiety disorders is now published in @natgenet.nature.com! 🔗: doi.org/10.1038/s415...

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Alison Fisk @alisonfisk.bsky.social · 02/03/2026

The Trier Gold Hoard! The largest #Roman gold coin hoard ever found! More than 2,650 Roman aurei, weighing 18.5 kg, were discovered inside a bronze vessel wrapped in leather bags, during construction work in 1993. The coins date from 63 AD to 196 AD. Rheinisches Landesmuseum Trier 📷 by me

My photo shows the so-called ‘Trier Gold Treasure’ in a museum display case. It is a Roman coin hoard made up of some 2,650 gold aurei. The small round gold coins are spread randomly in a dense pile across a light-coloured display case surface. To the upper right of the coin mound is the broken bowl-shaped bottom of the original copper alloy vessel that held the hoard. The metal is coloured green with corrosion. Several gold coins are scattered inside the bowl. In the lower left corner of the display case is another large, irregular fragment of the original container.

Museum information label:

In 1993, a bronze vessel with 2650 Roman gold coins (aurei) is discovered in Trier. It is the largest Roman gold coin treasure ever found. The Aureus was in the 1st and 2nd Century the standard coin of the Roman gold minting with an average weight of 7.27 g, with a very high fineness of approx. 980/1000. The coins depict 29 different emperors, empresses or relatives of the imperial house. The oldest coins were minted between 63 and 64 AD, the youngest between 193 and 196 AD. The coins were inside the vessel, which was accidentally discovered by an excavator, rolled up in leather bags. The bags were decorated with leather straps and closed enamel seal capsules.

The treasure revealed numerous secrets in its scientific processing: it probably did not represent private assets, but a state treasury that was carefully managed and over a longer period of time and enlarged. During a civil war, the gold coins were finally buried in a cellar in 196 AD and then fell into oblivion. Presumably the former administrator of the treasury took his knowledge of the hiding place with him to the grave.

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Margarete Stokowski @margaowski.bsky.social · 02/03/2026

hits different wenn man me/cfs hat

buchseite aus altem buch.

Man müßte wenigstens täglich ein gutes Gedicht lesen, ein schönes Gemälde sehen, ein sanftes Lied hören - oder ein herzliches Wort mit einem Freunde reden, um auch den schöneren, ich möchte sagen, den menschlicheren Teil unseres Wesens zu bilden.
KLEIST

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Hetan Shah @hetanshah.bsky.social · 02/03/2026

Small things to hang onto: they’ve rediscovered a painting by Rembrandt which depicts the Biblical scene when priest Zacharias is told by the Archangel Gabriel that he and his wife will have a son, John the Baptist www.bbc.co.uk/news/article...

bbc.co.uk

Rembrandt's Vision of Zacharias in the Temple rediscovered after 65 years

The painting, created by the Dutch master in 1633, had disappeared after being sold in 1961.

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Michael Friendly @datavisfriendly.bsky.social · 01/03/2026

#TodayinHistory #dataviz #Onthisday #OTD 📊 📅Feb 27, 1874 Francis Galton demonstrated the quincunx at a meeting of the Royal Institution-- showing how normal distributions arise as sum of small random effects [Stigler:1986, p.276] -- Great example of data physicalization

3D drawing of a quincunx. It shows piles of little balls separated by vertical dividers and the shape of the distribution approximates a Gausian

Portrait of Francis Galton by Charles Wellington Furse

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Simon Kuestenmacher @simongerman600.bsky.social · 01/03/2026

UN projections suggest that global deaths will exceed global births by 2084. This means: that's when the UN expects global population to decline (most other demographic institutes of course put this date a decade or two earlier). Source: buff.ly/PoGvNwq

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Michael Friendly @datavisfriendly.bsky.social · 25/02/2026

#stats Here's a nifty interactive demo of confidence intervals by Kristoffer Magnusson rpsychologist.com/d3/ci/

rpsychologist.com

Interpreting Confidence Intervals

Interactive visualization of confidence intervals

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Joachim Schork @joachimschork.bsky.social · 25/02/2026

In an upcoming module of the Statistics Globe Hub, I will show how to create informative visualizations with ggstatsplot in R, how to include statistical results automatically, and how to use this workflow in real projects. More info: statisticsglobe.com/hub #Statistics #DataScience #RStats

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Baptiste Couvy-Duchesne @baptistecd.bsky.social · 25/02/2026

Happy to share our latest paper, the work of @clarajiang.bsky.social who trained brain-based predictors of depression on the UK Biobank (N=7,500 curated cases and matched controls) using AI/deeplearning as well as efficient statistical learning (BLUP). See thread below for a summary of findings

nature.com

Applying machine-learning and deep-learning to predict depression from brain MRI and identify depression-related brain biology - Translational Psychiatry

Translational Psychiatry - Applying machine-learning and deep-learning to predict depression from brain MRI and identify depression-related brain biology

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Marc Veldhoen @marcveld.bsky.social · 24/02/2026

Are obesity drugs causing a severe complication? What the science says The United Kingdom and Brazil have issued warnings about a possible link between GLP-1 weight-loss drugs and pancreatic inflammation, but the connection is murky. www.nature.com/artic... 1/4

nature.com

Are obesity drugs causing a severe complication? What the science says

Nature - The United Kingdom and Brazil have issued warnings about a possible link between GLP-1 weight-loss drugs and pancreatic inflammation, but the connection is murky.

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New Scientist @newscientist.com · 24/02/2026

Fathers may get postpartum depression at a similar rate to mothers, but it’s often overlooked. At last, the way we diagnose and treat it is improving, for the good of the whole family

newscientist.com

Postpartum depression in dads is common – we can now spot and treat it

Fathers may get postpartum depression at a similar rate to mothers, but it’s often overlooked. At last, the way we diagnose and treat it is improving, for the good of the whole family

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Ben Goldacre @bengoldacre.bsky.social · 23/02/2026

OpenSAFELY is open from today! Huge thanks to all who supported this vast collaboration: whole population GP data; in a productive platform; innovative privacy protections; unprecedented support from professions, privacy campaigners; &c Now it's over to users! www.bennett.ox.ac.uk/blog/2026/02...

bennett.ox.ac.uk

OpenSAFELY news: you can apply to do non-COVID research, from today! | Bennett Institute for Applied Data Science

We are delighted to announce that - from today - you can submit applications to the OpenSAFELY service for non-COVID-19 studies.

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Daniel Lakens @lakens.bsky.social · 23/02/2026

198 effect sizes in ego depletion resesrch showed an effect size of d=0.62. Preregistered large replications (including some by original authors) yielded an effect size of 0. No one has been able to offer any other explanation for this huge research waste than massive p-hacking.

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Joachim Schork @joachimschork.bsky.social · 24/02/2026

The Statistics Globe Hub starts in just one week, on March 2, and new modules will be released every week. Here are the topics of the first ten weeks. Interested in joining? You can find more information here: statisticsglobe.com/hub #statistics #datascience #ai #rstats #python

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Jay Van Bavel, PhD @jayvanbavel.bsky.social · 23/02/2026

Humans are social animals. Our relationships give life meaning and joy. I think we need to bring back parties, dating, and visiting friends.

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The Mental Elf @thementalelf.bsky.social · 24/02/2026

💔 Suicide risk after involuntary psychiatric care remains elevated for years, not just weeks. Swedish study: risk nearly 200x higher in first month post-discharge, still 50x elevated at five years. Personality disorder patients faced greatest vulnerability. buff.ly/ruJXTOE #SuicidePrevention

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