Tom Yates @tomayates.bsky.social · 27/09/2026youtu.beLittle Yellow RosesYouTube video by Fay Hield - Topic 010
Tom Yates @tomayates.bsky.social · 07/09/2026Are there good data on bone penetration for MDR TB drugs, incl the new ones? Particularly interested in penetration into bones with poor blood supply. Presumably quinolones and LZD get in okay. What about the other drugs? #TBsky 111
Tom Yates @tomayates.bsky.social · 05/09/2026Rare good newsshare.googleThere’s a quick way to slow climate change. Why isn’t everyone doing it? – podcastTurkmenistan, who in 2023 the Guardian revealed as the worst country for methane mega-leaks, has begun to plug them. Environment editor Damian Carrington tells Madeleine Finlay why some experts call s... 010
Tom Yates @tomayates.bsky.social · 03/09/2026youtube.comGoing undercover to expose Reform's secret donations plotYouTube video by Channel 4 News 010
Tom Yates @tomayates.bsky.social · 27/08/2026Did you see this nice critique from @pwgtennant.bsky.social? DAN ZOSTER trial has completed enrollment, so we should have a definitive answer soon! 260
Reposted by Tom YatesMalcolm 朝精 Barrett @malcolmbarrett.malco.io · 27/08/2026Further evidence that being rich is one of the best things you can do for your health 1114
Tom Yates @tomayates.bsky.social · 27/08/2026Thanks - the RCT has completed enrollement already, so we'll have the answer soon enough! I'd like to see some methods work looking at how reassured we should be by negative control outcomes 0110
Tom Yates @tomayates.bsky.social · 27/08/2026I think the DAN ZOSTER study has already completed recruitment 120
Tom Yates @tomayates.bsky.social · 27/08/2026Already very wealthy people agreeing to participate in lucrative sportswashing projects for vile dictatorships says an awful lot about about their character 000
Tom Yates @tomayates.bsky.social · 25/08/2026youtu.beDeportee (Plane Wreck at Los Gatos)YouTube video by Dolly Parton - Topic 030
Reposted by Tom YatesMinnie Rahman @minnierahman.bsky.social · 24/08/2026Well, there we have it. No ending rough sleeping in the UK then that's for sure. 13720
Reposted by Tom YatesJulia M. Rohrer @dingdingpeng.the100.ci · 25/08/2026“Aiding and abetting foodborne illness may be lettuce’s biggest offense. But it doesn’t have much else going for it, either, and there’s a reasonably strong case that we would be better off without it.”washingtonpost.comColumn | Why we should stop eating lettuce, cyclospora or notLettuce makes us sick, wastes resources and has minimal nutritional value. Why are we still consuming it? 8406
Tom Yates @tomayates.bsky.social · 25/08/2026I don't understand this. We need a right sided winger and better full back and defensive midfield options. Why not make offers for Camavinga and Mbaye? 000
Tom Yates @tomayates.bsky.social · 15/08/2026I find the argument made here problematic. Either it is ethical to randomise to a placebo or it isn't. I'd do response adaptive randomisation.nature.comProtecting those who protect us: the ethics of Ebola post-exposure trialsA landmark prophylaxis trial offers an opportunity to rethink how research protects the people risking their lives to halt outbreaks. 021
Reposted by Tom YatesSam Freedman @samfr.bsky.social · 15/08/2026I wish media outlets would describe Nathan Cofnas as a racist rather than a "self-defined race realist" which doesn't mean anything to most people. His writing meets any definition of racism however narrowly and cautiously drawn. 672598570
Tom Yates @tomayates.bsky.social · 15/08/2026Academia is full of over promoted white people, many of whom have exagerated their achievements. Unbelievably sad. 060
Reposted by Tom YatesADVANcing Clinical Evidence in Infectious Diseases (ADVANCE-ID) @advance-id.bsky.social · 14/08/2026Demystify clinical trial design & enhance your research toolkit!📊✨ Join our statistical seminars supported by @advance-id.bsky.social & @who.int Explore clinical trial theory & real-life examples with global experts. Master the numbers in the mission against disease here: ad-id.co/stats 1129
Reposted by Tom YatesMichael Marks @drmichaelmarks.bsky.social · 13/08/2026Excited to now able to say funded @nihr.bsky.social for Streptococcal Adaptive Platform Trial (STRAP!) Evaluating 1) Optimal backbone anitibiotics 2) Benefit adjunctive anti-toxin antibiotics 3) Benefit IVIG Collab with Australia (hope also NZ & Canada) building off SNAP. Aim open in UK in 2027 3173
Reposted by Tom YatesSimon Hattenstone @shattenstone.bsky.social · 10/08/2026We all know the long banned imprisonment for public protection sentence is inhumane. Another review will just kick the can down the road yet again. All Andy Burnham need to do is introduce a bill to re-sentence prisoners still serving IPPs. By me. www.theguardian.com/commentisfre...dashboard.ophan.co.ukSign in - Google Accounts 032
Tom Yates @tomayates.bsky.social · 08/08/2026I wouldn't fund a stand alone RCT but I could perhaps support a Vit D randomisation in a TB prevention platform trial 000
Tom Yates @tomayates.bsky.social · 08/08/2026I can see where you are coming from, but the Vit D - TB trials were small compared with other prevention trials Big savings can be made elsewhere, e.g. trial regulation, affordable placebos, trials embedded in routine care, platform designs, fewer observational cohorts on questions amenable to RCT 100
Tom Yates @tomayates.bsky.social · 08/08/2026At NNT 1000, you could prevent 60,000 cases of TB per year in South Africa ~ 720,000 DALYs South Africa is willing to pay USD 3200 per DALY, so USD 2.3bn approx threshold for this intervention I suspect you could fortify commonly eaten foods in South Africa for much less than that? 100
Tom Yates @tomayates.bsky.social · 08/08/2026The Mongolian trial was wildly underpowered for disease outcomes What happens if you use the results of the Tanzanian trial as your prior?trial.ad 100
Tom Yates @tomayates.bsky.social · 08/08/2026For individual patient treatment, I would offer something low risk with NNT of 100, perhaps 200, to prevent a case of TB For mass supplementation, I would be interested in smaller effects 100
Tom Yates @tomayates.bsky.social · 08/08/2026The 1.1 is for an infection endpoint, and the negative South African trial also had an infection endpoint There is no good reason to think Vit D would reduce Mtb exposure Primary disease endpoints were 0.87 (0.49-1.55) in Mongolia and 0·78 (0·54-1·13) in Tanzania 110
Tom Yates @tomayates.bsky.social · 08/08/2026I'm not convinced that the TB trial is negative, I think they chose the wrong primary outcome I think the big scandal here is how much it costs to run RCTs of low risk interventionsshare.googleEfficacy of vitamin D supplementation for the prevention of pulmonary tuberculosis and mortality in HIV: a randomised, double-blind, placebo-controlled trialObservational data suggests that low vitamin D status is associated with an increased incidence of pulmonary tuberculosis (TB) and mortality among people living with HIV. The primary aims of this stud... 100
Reposted by Tom YatesDan Lewer @danlewer.bsky.social · 07/08/2026Can we get a UX engineer involved in the clinical trial governance process please 001
Tom Yates @tomayates.bsky.social · 06/08/2026If reviewers and editors are happy, publish the submitted pdfs. No awful copy editing. Use the money saved to lower the APC and to pay a statistical reviewer. 110
Tom Yates @tomayates.bsky.social · 04/08/2026I understand Suhail Doi dislikes this implementation, which I can understand as IVhet is not a RE model and outputs different estimates to the HC model 110
Tom Yates @tomayates.bsky.social · 04/08/2026Do we need some stewardship data too. E.g. presumably vanc will select for VRE more than fidaxomicin? 120
Tom Yates @tomayates.bsky.social · 04/08/2026Are there packages to run IVhet meta-analyses in R or Python? I have implemented in Stata but my Gen Z colleague is not impressed by that ... #StatSkystatic.klipy.comDinosaurs Are Awesome: Nat Geo ExploresALT: Dinosaurs Are Awesome: Nat Geo Explores 100
Reposted by Tom YatesStella Creasy MP @stellacreasy.bsky.social · 03/08/2026Walthamstow please share - the big pre loved school uniform sale will be from Wednesday 12th August at the Salvation Army on Forest Road. Every item - including blazers - 50p and most local schools covered. Save money and save carbon by reusing well kept uniform! #loveWalthamstow 11414
Tom Yates @tomayates.bsky.social · 31/07/2026Yep, its never been based on contribution. Why should a newly arrived migrant entering the workforce be treated any differently to e.g. an 18 year old entering the workforce? Make a decision at the border, then treat everybody in the country with dignity and compassion. 030
Tom Yates @tomayates.bsky.social · 31/07/2026Sounds like a similar scenario. People on Health and Care Visas have access to NHS but are not able to access lots of community services, support with housing, social security For example, I've had patients I was unable to discharge from hospital because they were not eligible for community rehab 110
Tom Yates @tomayates.bsky.social · 30/07/2026At the moment, people on Health & Care Worker Visa have no recourse to public funds. Why deny social security if they e.g. injure themselves at work? Treating carers with respect should include looking after them if they fall on hard times. Current rules deeply exploitative @stellacreasy.bsky.social 142
Tom Yates @tomayates.bsky.social · 29/07/2026Has anyone got this paper in pdf? #TBSkypubmed.ncbi.nlm.nih.govEstimating tuberculosis case mortality in England and Wales, 2001-2002 - PubMedMortality among TB cases is underestimated by national TB surveillance. Real-time data linkage between case reports and death registrations would allow a more accurate and timely estimate of TB mortal... 000
Tom Yates @tomayates.bsky.social · 29/07/2026I think no unmeasured confounding is always going to be tricky in observational data on treatment initiation in acute settings - e.g. 'patient looks awful' is often not fully captured by a set of numbers 000
Tom Yates @tomayates.bsky.social · 29/07/2026Cloning, censoring and weighting is often used to estimate impact of treatment duration on outcomes Presumably, it can also be used to estimate the impact of delays in starting treatment? #episky 120
Tom Yates @tomayates.bsky.social · 26/07/2026Leeds just got Harry Wilson on a free, and he was class last season - more goals and assists than Salah over the same period, and available for more games 100
Reposted by Tom YatesDave Clark @daveclarkreports.eurosky.social · 22/07/2026And here's AFP picture taken by one of the photographers in the PA picture, Justin Tallis 18768190
Tom Yates @tomayates.bsky.social · 21/07/2026Raising the personal allowance is very poorly targeted Loads of the money will go to people who are already comfortably off, and households where one or more workers earn less than the current threshold get little or nothing Much better to raise universal credit, I would have thought? 000
Tom Yates @tomayates.bsky.social · 21/07/2026Do you think these more principled methods can be easily adopted? Widespread use of D-L RE models is problematic, particularly in scenario described in blog: small trials motivate a large null replication study, with meta-analysis still suggesting benefit due to small studies carrying undue weight 010
Tom Yates @tomayates.bsky.social · 21/07/2026In the Stata package metan, there is a model(IVhet) option If you prefer to stick with RE, there are alternatives to DL which offer more conservative coverage and, in this example, might appropriately have resulted in a confidence interval that did not exclude the possibility of no effect 010
Tom Yates @tomayates.bsky.social · 21/07/2026I don't understand why Suhail Doi's IVhet model isn't more widely used Avoids the point estimate being unduly pulled around by small studies - the problem in this example - whilst providing a confidence interval with coverage that properly reflects variability due to between-study heterogeneitypubmed.ncbi.nlm.nih.govAdvances in the meta-analysis of heterogeneous clinical trials I: The inverse variance heterogeneity model - PubMedThis article examines an improved alternative to the random effects (RE) model for meta-analysis of heterogeneous studies. It is shown that the known issues of underestimation of the statistical error... 362
Reposted by Tom YatesThe Lancet Infectious Diseases @thelancetinfdis.bsky.social · 21/07/2026New Comment Reconsidering the rVSVΔG-ZEBOV-GP vaccine during the 2026 Bundibugyo virus outbreak www.thelancet.com/journals/lan...thelancet.comReconsidering the rVSVΔG-ZEBOV-GP vaccine during the 2026 Bundibugyo virus outbreakThe ongoing 2026 Bundibugyo virus disease (BVD) public health emergency of international concern in DR Congo and Uganda has exposed gaps in preparedness for non-zairense orthoebolaviruses. With BVD va... 011
Reposted by Tom YatesStella Creasy MP @stellacreasy.bsky.social · 19/07/2026I consistently voice concerns about the idea drilling rosebank would be good for either the climate or the cost of living crisis - in the coming days as this debate returns I will continue to be a voice for prioritising the transition to clean energy for the sake of our pockets and our planet. 1314023
Reposted by Tom YatesMichael Marks @drmichaelmarks.bsky.social · 18/07/2026Academic clinical jobs @lshtm.bsky.social for people in UK clinical training Clinical Lecturers 1) Infectious Diseases (ST3-6) tinyurl.com/4vbjwrkr 2) Paediatrics (ST4-7) tinyurl.com/2hajhbs3 3) Public Health (ST3-5) tinyurl.com/yzd5cmxa Clinical Fellow in Primary Care (ST1) tinyurl.com/mpsmk7zk 0410
Tom Yates @tomayates.bsky.social · 16/07/2026Me and George Osbourne can take joint responsibility 010
Tom Yates @tomayates.bsky.social · 16/07/2026I've just had an analysis accepted for publication that I began working on 14 years ago - some drinks will be had tonight!static.klipy.comEngland Crowd Cheering with SmokeALT: England Crowd Cheering with Smoke 2130
Reposted by Tom YatesMarie Le Conte @youngvulgarian.marieleconte.com · 15/07/2026[boldly] I just don't think the British government needs to have Shabana Mahmood in it, I think we managed fine without her and we can just keep going without her, it's fine, Andy Burnham doesn't need to find a space for her in cabinet, there are other MPs 461136182
