The serotonin transporter (SERT) is a key antidepressant target. Here, authors present a cryo-EM structure where the antidepressant vilazodone spans the main SERT binding site toward a secondary ...

Epitope tags are short amino acid sequences fused to a protein’s N- or C-terminus. When paired with an antibody that specifically recognizes this sequence, epit

The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

The astrocytic γ-aminobutyric acid (GABA) transporter, GAT3, is essential for terminating GABAergic signalling in the central nervous system. Selective inhibition of GAT3 offers a potential strategy f...