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Sigurbjörn Markússon

@sigurbjornm.bsky.social
45 followers 77 following 4 posts

Postdoc Drew lab - Stockholm Uni, previously PhD in Newstead lab, Oxford. Interested in structural biology and all things membrane protein related

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Reposted by Sigurbjörn Markússon
Oxford Biochemistry @oxfordbiochemistry.bsky.social · 22/08/2025
Read the full story here: 📣Breakthrough discovery reveals new gene linked to chronic pain ➡️ bit.ly/202508_newst...
Cryo-Em structure of the SLC45A4 polyamine transporter depicted by a substantial yellow and green area, a purple mid-section, punctuated with turquoise and with the top third of the whole surrounded by a transparent 'membrane'-like structure
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Reposted by Sigurbjörn Markússon
Steve Middleton @middletonsj.bsky.social · 21/08/2025
We've found a new gene linked to chronic pain in humans! The gene SLC45A4 encodes (the long-awaited) neuronal polyamine transporter, which is important for pain signalling in nerves. We hope this discovery might lead to new chronic pain treatments in the future! www.nature.com/articles/s41...
nature.com
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
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Sigurbjörn Markússon @sigurbjornm.bsky.social · 21/08/2025
Our paper on SLC45A4 is out now in @nature.com! The orphan SLC45A4 transporter is a polyamine transporter involved in chronic pain signalling!
nature.com
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
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Reposted by Sigurbjörn Markússon
Petri Kursula @petrikursula.bsky.social · 10/12/2024
...and there we have it - the first paper for 2025 😀 onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Nanobodies against the myelin enzyme CNPase as tools for structural and functional studies
The enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) is abundant in non-compact myelin. While its in vitro catalytic activity is well understood, the in vivo function of CNPase remains un...
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