Reposted by Sigurbjörn MarkússonOxford Biochemistry @oxfordbiochemistry.bsky.social · 22/08/2025Read the full story here: 📣Breakthrough discovery reveals new gene linked to chronic pain ➡️ bit.ly/202508_newst... 0123
Reposted by Sigurbjörn MarkússonSteve Middleton @middletonsj.bsky.social · 21/08/2025We've found a new gene linked to chronic pain in humans! The gene SLC45A4 encodes (the long-awaited) neuronal polyamine transporter, which is important for pain signalling in nerves. We hope this discovery might lead to new chronic pain treatments in the future! www.nature.com/articles/s41...nature.comSLC45A4 is a pain gene encoding a neuronal polyamine transporter - NatureThe SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice. 48025
Sigurbjörn Markússon @sigurbjornm.bsky.social · 21/08/2025Our paper on SLC45A4 is out now in @nature.com! The orphan SLC45A4 transporter is a polyamine transporter involved in chronic pain signalling!nature.comSLC45A4 is a pain gene encoding a neuronal polyamine transporter - NatureThe SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice. 1187
Reposted by Sigurbjörn MarkússonPetri Kursula @petrikursula.bsky.social · 10/12/2024...and there we have it - the first paper for 2025 😀 onlinelibrary.wiley.com/doi/10.1111/...onlinelibrary.wiley.comNanobodies against the myelin enzyme CNPase as tools for structural and functional studiesThe enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) is abundant in non-compact myelin. While its in vitro catalytic activity is well understood, the in vivo function of CNPase remains un... 1113