The endosomal Na+ /H+ exchanger HsNHE6 regulates organellar pH and is implicated in neurological disease. Here the authors determine its cryo-EM structure and show a kinetic preference for K+ over Na+ transport.

The endosomal Na+ /H+ exchanger HsNHE6 regulates organellar pH and is implicated in neurological disease. Here the authors determine its cryo-EM structure and show a kinetic preference for K+ over Na+...

Nature Communications - Carnitine uptake by OCTN2 supports fatty acid metabolism. Here, authors report cryo-EM structures of human OCTN2, revealing the mechanism of sodium ion-dependent carnitine...

MAASTY, a methacrylic acid–styrene copolymer, enables high-resolution structural determination of human membrane proteins in native nanodiscs, efficiently solubilizing diverse membrane proteins and pr...

Chronic neuropathic pain, caused by nerve damage or disease, affects 10% of the population with rising incidence. The burden is exacerbated by ineffective treatments and overreliance on opioids. Neuro...