The kidney proximal tubule undergoes dramatic cell-state transformations during recovery from injury, serving as a unique model to study the dynamic t…

Abstract. Male infertility is increasing in prevalence due to cancer treatment, environmental exposures, and patient-specific syndromes. Traditional two-di

The Reproductive and Developmental Biology Laboratory (RDBL) within the Division of Intramural Research of the National Institute of Environmental Health Sciences (NIEHS), part of the National Institu...

Misregulation of chromosome cohesion during female meiosis serves as a reproductive isolating barrier in mice.

YouTube video by Stowers Institute for Medical Research

Blastoids are stem cell-derived structures that mimic natural blastocysts by incorporating all three lineages: trophectoderm, epiblast, and primitive endoderm. However, current methods often yield inc...

The autophagy-related protein ATG9A is integral to cellular autophagy and lipid mobilization, yet its importance in mammalian physiology remains underexplored. Using a liver-specific conditional At...

Learn about the history and importance of the gender gap currently impacting women's health sciences - Join us on 28 August

Ovarian multinucleated giant cells are a unique macrophage population that arise within the aging mammalian ovary. This study characterizes their transcriptome in mice, uncovering a potential role in ...

See why the ovary − often reduced to its reproductive role − menopause, age and estrogen affect a woman’s health throughout her body and lifetime.

Biochemistry; Molecular biology; Molecular interaction

Aging | doi:10.18632/aging.206253. Emma S. Gargus, Rhea Sharma, Rebecca Gu, Camille Mulcahy, Brian W. Johnson, Jing Song, Jungwha Lee, Mary Zelinski, Francesca E. Duncan

Abstract. Pioneer transcription factors (PTFs) bind to inaccessible chromatin and recruit collaborating transcription factors to promote chromatin accessib

The field of developmental metabolism seeks to understand how nutrient availability and the regulation of metabolic pathways support and influence critical biological processes such as tissue patterni...

The annual NIEHS Biomedical Career Symposium, now in its 27th year, is one of the largest assemblies of biomedical organizations and young scientists in Research Triangle Park, North Carolina.

In general, the kinetochore position and the sister-chromatid cohesion site are spatially linked. Here, the authors find a meiosis-specific distal cohesion site decoupled from the kinetochore in Perom...

Female reproductive aging is accompanied by a dramatic rise in the incidence of egg aneuploidy. Premature loss of chromosome cohesion proteins and untimely separation of chromosomes is thought to unde...

Transcription initiation limits histone acetylation and H2AZ incorporation at promoters.

Position Summary Dr. Amargant-Riera’s research laboratory focuses on understanding the mechanisms that define oocyte quality. The lab uses mouse models and human samples to investigate the mechanical ...