iiinova — where your digital self keeps evolving

Reposted by Steven Marygold

FlyBase @flybase.bsky.social · 21/09/2026

FlyBase has added 11 new #MetabolicPathways reports in FB2026_03 covering AMINO ACID DERIVATIVE METABOLISM flybase.org/reports/FBgg... (1 new report), LIPID METABOLISM flybase.org/reports/FBgg... (6 new reports), and...

flybase.org

Pathway: AMINO ACID DERIVATIVE METABOLISM

FlyBase: a database for drosophila genetics and molecular biology

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Reposted by Steven Marygold

FlyBase @flybase.bsky.social · 18/09/2026

FlyBase release FB2026_03 is live!

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Reposted by Steven Marygold

Alliance of Genome Resources @alliancegenome.bsky.social · 02/09/2026

Alliancegenome.org version 9.1.0 is live, with fresh data and improved features.

alliancegenome.org

Alliance of Genome Resources

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FlyBase @flybase.bsky.social · 02/09/2026

As you may know, NIH abruptly terminated funding to FlyBase curators based in the United Kingdom. Please help us retain these curators and thereby enable ongoing curation of bibliographic, genetic and phenotypic data by contributing annually (tinyurl.com/4jw65mbb). Thank you. #FlyBase

tinyurl.com

FlyBase:Contribute to FlyBase - FlyBase Wiki

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Reposted by Steven Marygold

FlyBase @flybase.bsky.social · 20/08/2026

Treat biological databases as infrastructure, not projects www.nature.com/articles/d41...

nature.com

Treat biological databases as infrastructure, not projects

Letter to the Editor

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FlyBase @flybase.bsky.social · 19/06/2026

FlyBase release FB2026_02 is live! As of this release we now have 2000 gene group reports🎉, including 1453 ‘classical’ gene group reports flybase.org/lists/FBgg, 399 protein complex reports flybase.org/lists/FBgg/c..., 96 metabolic pathway reports flybase.org/lists/FBgg/m... (continued)

flybase.org

FlyBase - Gene Group List

FlyBase: a database for drosophila genetics and molecular biology

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Reposted by Steven Marygold

FlyBase @flybase.bsky.social · 19/06/2026

New metabolic pathway reports in this release cover AMINO ACID DERIVATIVE METABOLISM (7 reports) flybase.org/reports/FBgg..., NEUROTRANSMITTER METABOLISM (8 reports) flybase.org/reports/FBgg..., PIGMENT BIOSYNTHESIS (4 reports) flybase.org/reports/FBgg..., (more)

flybase.org

Pathway: AMINO ACID DERIVATIVE METABOLISM

FlyBase: a database for drosophila genetics and molecular biology

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Bloomington Drosophila Stock Center @bdsc.bsky.social · 23/06/2026

We are pleased to announce a major donation to support the work of the Bloomington Drosophila Stock Center. Lawerence Washington, husband of former BDSC director Kathy Matthews, has established an endowment in her honor. bdsc.indiana.edu/news-events/...

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Reposted by Steven Marygold

FlyBase @flybase.bsky.social · 17/03/2026

The 2026 Drosophila Community Service Award was presented earlier this month at #DROS26. This year's recipients were the REDFly Database Team and the FlyBase Developer Team, for their roles in the development of online repositories for the dissemination of Drosophila data.

The committee for the 2026 Drosophila Community Service Award for outstanding community service included Michelle Arbeitman (Co-chair), Cale Whitworth (Co-chair), Elizabeth Chen, Lydia Grmai, Amy Kiger, and Steven Marygold.

The Community Service Award recipients for 2026 were the REDFly Database Team and the FlyBase Developer team, for their roles in development of online repositories for the dissemination and analysis of Drosophila data.

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Reposted by Steven Marygold

FlyBase @flybase.bsky.social · 12/03/2026

FlyBase release FB2026_01 is live! There is news about FlyBase funding. Go to the FlyBase homepage flybase.org for details.

FlyBase Funding Update – March 2026

The NHGRI funding for FlyBase has been restored for US-based FlyBase teams but the foreign subaward that supported the essential curation team at the University of Cambridge UK has been terminated. Therefore, the Cambridge UK team now requests annual contributions from fly labs to support curation of new data into FlyBase and the Alliance of Genome Resources. Without these annual contributions, FlyBase will become frozen in its current state and become progressively less useful.

Please visit the ‘Contribute to FlyBase’ wiki page for details of how to contribute.

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Reposted by Steven Marygold

Alliance of Genome Resources @alliancegenome.bsky.social · 12/03/2026

The March Alliance webinar is next week, March 19 at noon EDT. Tim Schedl (WormBase) & Steven Marygold (FlyBase) will speak on 'Nomenclature in Wormbase & FlyBase. Register for a Zoom link tinyurl.com/4f9ycybt by 11pm EDT on 3/18.

tinyurl.com

Alliance Of Genome Resources Event Registration

Webinar recordings are posted at https://www.youtube.com/@AllianceOfGenomeResources A schedule of future events is on the Alliance Events Calendar https://www.alliancegenome.org/event-calendar

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Reposted by Steven Marygold

FlyBase @flybase.bsky.social · 03/03/2026

#DROS26 starts tomorrow! Sadly, most of FlyBase will not be there this year. Brian Calvi, our Indiana University PI, will be speaking on "FlyBase: Past, Present, and Future" during the Techniques and Technology workshop (Sat. 3/7 7:70-7:45, Room Sheraton/Chicago 4-7). @briancalvi.bsky.social

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Reposted by Steven Marygold

Genetics Society of America @genetics-gsa.bsky.social · 03/03/2026

New tools are transforming Drosophila research—from FlyBase updates and genome annotations to CRISPR and imaging innovations. Our latest blog post highlights key advances and why citation matters. Can’t attend #Dros26? Read more: buff.ly/OuYRtkV 1/2🧵

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Genetics Society of America @genetics-gsa.bsky.social · 26/01/2026

📢 Important updates on @flybase.bsky.social @steven-flybase.bsky.social and the team updated #Drosophila enzymes database by adding absent gene ontology annotations and removing or fixing problematic ones. Learn more about these updates in #G3journal: buff.ly/dd3y2pN

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Reposted by Steven Marygold

FlyBase @flybase.bsky.social · 15/12/2025

We have recently updated FlyCyc biocyc.org/DMEL/organis..., the pathway-genome database representing Drosophila metabolism, to include enzymatic complexes as well as further improvements to enzyme annotations. #FlyCyc is now classed as a ‘Tier 1 Highly Curated Organism Database’.

Screenshot of the FlyCyc page at https://biocyc.org.

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Reposted by Steven Marygold

FlyBase @flybase.bsky.social · 12/12/2025

Release FB2025_05 of FlyBase.org is live! 'New this release' information is here flybase.org/static/new-t...

flybase.org

FlyBase: New In This Release

FlyBase: a database for drosophila genetics and molecular biology

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Reposted by Steven Marygold

Katy @katyboots.bsky.social · 04/12/2025

So excited to finally be able to share my first paper and the culmination of my PhD work with @felipekteixeira.bsky.social 🪰🔬 www.pnas.org/doi/10.1073/...

Systematic analysis of noncanonical ribosomal protein paralogs does not provide evidence for specialized functions in Drosophila

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Reposted by Steven Marygold

Michelle Arbeitman @marbeitman.bsky.social · 20/11/2025

The FlyBoard is happy to announce the call for nominations for the Drosophila Community Service Award. Please submit your nomination by 01/16/2026 by email to: drosophilaserviceaward@gmail.com. Please repost.

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Reposted by Steven Marygold

eric lai @lucksmith.bsky.social · 29/10/2025

🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off. Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2 tinyurl.com/FlyBase

tinyurl.com

FlyBase secures funding for year, but future still uncertain

The FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.

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Reposted by Steven Marygold

FlyBase @flybase.bsky.social · 03/10/2025

There's an update on the state of FlyBase on the FlyBase.org front page. You can contribute to FlyBase at this link wiki.flybase.org/wiki/FlyBase... We express enormous gratitude to the people, labs, groups, and foundations who have already helped us. #FlyBase #Drosophila

FlyBase Update – October 2025
The termination of the NIH/NHGRI FlyBase grant has placed the long-term sustainability of FlyBase at risk. However, thanks to the generous support of several key individuals and institutions, we are pleased to announce that FlyBase will remain operational through the coming year. We extend our deepest gratitude to Yukiko Yamashita, Cassandra Extavour, Hugo Bellen, Thom Kaufman, the Genetics Society of America / Drosophila Board, the Bloomington Drosophila Stock Center, an anonymous donor and the Wellcome Trust. We are especially thankful for a generous gift from Seemay Chou, Jed McCaleb, and The Navigation Fund. We also greatly appreciate the continued support from the broader Drosophila community – your donations and service fees have been vital in helping us stay afloat. Special thanks also go to Jessica Manning for her tireless administrative work at Harvard, to Ruth Lehmann, Hugo Bellen, and Paul Sternberg for advice and efforts, and to the Board of the European Drosophila Society for all their efforts. Sadly, we must also share that several long-standing FlyBase team members have recently moved on. We are immensely grateful to Susan Russo-Gelbart, Lynn Crosby, Gil dos Santos, Kris Broll, Victoria Jenkins, and TyAnna Lovato for their many years of dedicated service and contributions to FlyBase. Looking ahead, ensuring FlyBase’s sustainability beyond the next year – and successfully integrating with the Alliance – will require new funding sources. We kindly ask for your continued support:
• European labs: Please consider contributing to the Cambridge, U.K. FlyBase group
• U.S. and other non-European labs: Please consider contributing to the U.S. FlyBase groups
• Both U.K. and U.S. FlyBase are working diligently to establish an invoicing system. We appreciate your continued patience.
For more information on how to support us, please visit: Contribute to FlyBase wiki page https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase

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Reposted by Steven Marygold

FlyBase @flybase.bsky.social · 03/10/2025

New metabolic pathway reports too: the GLUCOSYLCERAMIDE BIOSYNTHESIS flybase.org/reports/FBgg..., the GPI-ANCHOR PROTEIN BIOSYNTHESIS flybase.org/reports/FBgg... and the DOLICHYL PHOSPHATE BIOSYNTHESIS flybase.org/reports/FBgg... pathways. #MetabolicPathways

flybase.org

Pathway: GLUCOSYLCERAMIDE BIOSYNTHESIS

FlyBase: a database for drosophila genetics and molecular biology

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Reposted by Steven Marygold

European Drosophila Society @fly-eds.bsky.social · 27/09/2025

Now the #EDB @flybase.bsky.social representative Katja Röper @katjaroeper.bsky.social is presenting #Flybase future plans

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Reposted by Steven Marygold

FlyBase @flybase.bsky.social · 27/09/2025

FlyBase will present posters 333 'Modeling the Mitochondrion: Building an Integrated Causal Model for Mitochondrial Processes using the Gene Ontology' and 335 'Building high-quality Genome-Scale Metabolic Models for Drosophila using the Gene Ontology' today at #EDRC2025

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Steven Marygold @steven-flybase.bsky.social · 25/09/2025

Just in time for the #EDRC2025: the #Drosophila metabolic network 'FlyCyc' has been updated at biocyc.org/organism-sum... Come and see poster P-335 on Saturday for more metabolic pathway models at #FlyBase.

biocyc.org

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Reposted by Steven Marygold

Mark Peifer (He, him) @peiferlabunc.bsky.social · 23/08/2025

The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share

Dear Fly Community,

In May 2025, the NIH terminated all grant funding to Harvard University, including the NHGRI grant that supported FlyBase. This grant also funded FlyBase teams at Indiana University (IU) and the University of Cambridge (UK), and as a result, their subawards were also canceled.

The Cambridge team has secured support for one to two years through generous donations from the European fly community, emergency funding from the Wellcome Trust, and support from the University of Cambridge. At IU, funding has been secured for one year thanks to reserve funds from Thom Kaufman and a supplement from ORIP/NIH to the Bloomington Drosophila Stock Center (BDSC).

Unfortunately, the situation at Harvard is far more critical. Harvard University had supported FlyBase staff since May but recently denied a request for extended bridge funding. As a result, all eight employees (four full-time and four part-time) were abruptly laid off, with termination dates ranging from August to mid-October depending on their positions. In addition, our curator at the University of New Mexico will leave her position at the end of August. This decision came as a shock, and we are urgently pursuing all possible funding options.

To put the need into perspective: although FlyBase is free to use, it is not free to make. It takes large teams of people and millions of dollars a year to create FlyBase to support fly research (the last NHGRI grant supported us with more than 2 million USD per annum).

To help sustain FlyBase operations, we have been reaching out to you to ask for your support. We have set up a donation site in Cambridge, UK, to which European labs have and can continue to contribute, and a new donation site at IU to which labs in the US and the rest of the world can contribute. We urge researchers to work with their grant administrators to contribute to FlyBase via these sites if at all possible, as more of the money will go to FlyBase. However, we appreciate that some fu…

https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase

Our immediate goals are:

1. To maintain core curation activities and keep the FlyBase website online

2. To complete integration with the Alliance of Genome Resources (The Alliance).

Integration with the Alliance is essential for FlyBase’s long-term sustainability. For nearly a decade, NHGRI/NIH has supported the unification of Model Organism Databases (MODs) into the Alliance, which we aim to achieve by 2028. Therefore, securing bridge funding to sustain FlyBase over the next three years is crucial for successful integration and the long-term access to FlyBase data.

At present, our remaining funds will allow us to keep the FlyBase website online for approximately one more year. Beyond that, its future is uncertain unless new funding is secured. We will, of course, continue pursuing additional grant opportunities as they arise.

Given the uncertainty of future NIH or alternative funding sources, we are relying on the Fly community for support. Your contributions will directly help us retain the staff needed to complete this transition and to secure ongoing fly data curation into the Alliance beyond 2028.

We at FlyBase are incredibly grateful for the outpouring of support from the community during this challenging time. Your encouragement has strengthened our resolve and underscores how vital this resource remains to Drosophila research worldwide.

Sincerely,
The FlyBase Team

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Katja Röper @katjaroeper.bsky.social · 15/08/2025

If you run a fly lab and have not yet contributed to save FlyBase, please look at our wiki page for the latest information!

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Reposted by Steven Marygold

Cahir O'Kane @cahirokane.bsky.social · 15/08/2025

UK taxpayers who donate to @flybase.bsky.social privately can use Gift Aid if they donate through the University of Cambridge philanthropy site (link below). This increases the value of your donation at no cost to yourself.

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Reposted by Steven Marygold

Brian Calvi @briancalvi.bsky.social · 15/08/2025

Flybase is free to use but not free to make. It takes large teams of people and millions of dollars a year to create the knowledgebas and tools for fly research. Please donate generously.

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Reposted by Steven Marygold

The Company of Biologists @biologists.bsky.social · 22/07/2025

Our next extraordinary biologist is Norbert Perrimon, a @dmmjournal.bsky.social Editorial Advisory Board member and author of one of @dev-journal.bsky.social's most cited papers. #100biologists @perrimonlab.bsky.social

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Reposted by Steven Marygold

FlyBase @flybase.bsky.social · 25/07/2025

Also a lot of new #MetabolicPathway reports: NUCLEOTIDE-SUGAR BIOSYNTHESIS flybase.org/reports/FBgg..., HEME BIOSYNTHESIS flybase.org/reports/FBgg..., IRON-SULFUR CLUSTER ASSEMBLY flybase.org/reports/FBgg..., Mo-MOLYBDOPTERIN COFACTOR BIOSYNTHESIS flybase.org/reports/FBgg...,

flybase.org

Pathway: NUCLEOTIDE-SUGAR BIOSYNTHESIS

FlyBase: a database for drosophila genetics and molecular biology

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Reposted by Steven Marygold

Katy Ong @ongkaty.bsky.social · 10/07/2025

All proceeds from my #sciart Etsy shop will now be donated to @flybase.bsky.social . Due to fed cuts, this beloved resource that I use daily has lost it's funding, and I'm helping in my small way. Now's a good time stock up on #STEM & #drosophila gifts & swag! www.etsy.com/shop/Picosti...

drosophila embroidered patches and enamel pins

IgM antibody enamel pins in purple and cyan

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Reposted by Steven Marygold

Royal Society Publishing @royalsocietypublishing.org · 17/06/2025

Michael Ashburner FRS was an influential figure in the fields of Drosophila genomics and early sequencing database initiatives such as @ebi.embl.org. Read about their contributions across genetics and bioinformatics in the new biographical memoir: buff.ly/f01zNat @geneticscam.bsky.social‬

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Max Kozlov @maxkozlov.bsky.social · 17/06/2025

After ruling the NIH grant cuts were illegal yesterday, Judge Young, a Reagan appointee on the bench since 1985, ended the hearing with a blistering 15-minute speech. I've cleaned up my notes — here are his remarks in full. 🧵

nature.com

Judge rules against NIH grant cuts — and calls them discriminatory

The decision means that the US biomedical agency has to restore funding to hundreds of research projects, but the government will likely appeal.

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Saccharomyces Genome Database @yeastgenome.bsky.social · 09/06/2025

FlyBase needs your help! Because of recent changes to government funding, the NIH grant that supported FlyBase has been "terminated." flybase.org

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Cahir O'Kane @cahirokane.bsky.social · 05/06/2025

This vital resource @flybase.bsky.social is in acute peril: its funding blocked by the vindictiveness of Trump. Emergency funds needed *now*, pending longer term solutions. Personal donations from Europe can be made here (UK taxpayers can gift-aid); other routes also possible. US appeal to follow.

philanthropy.cam.ac.uk

Drosophila Genetic Database

The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

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Reposted by Steven Marygold

European Drosophila Society @fly-eds.bsky.social · 04/06/2025

#Drosophila @flybase.bsky.social requires emergency funding: "As it stands, by the end of July, 2025, there will be no future updates to #FlyBase, and in the worst case scenario access to the website will also be lost". Please help if you can!

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Katja Röper @katjaroeper.bsky.social · 04/06/2025

European Fly PIs: please respond to the email we sent out yesterday and help save FlyBase!

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Mark A. Hanson @hansonmark.bsky.social · 03/06/2025

The #Drosophila community can donate to the European side to save FlyBase @flybase.bsky.social at the following link: www.philanthropy.cam.ac.uk/give-to-camb...

We are writing to ask your help in saving FlyBase. We have lost the majority of funding for FlyBase from the US National Institute of Health (NIH), due to the turmoil of current US politics. We had successfully renewed FlyBase grant funding for another 5 years, however the main FlyBase Grant from NIH to Harvard, with its subawards to Indiana University and Cambridge UK, has been terminated at short notice. Furthermore, the user fees that have been so generously provided by Drosophila researchers are tied to the FlyBase grant so we are not permitted to use those either. As it stands, by the end of July, 2025, there will be no future updates to FlyBase, and in the worst case scenario access to the website will also be lost.

We are therefore reaching out to the community to request emergency funding to maintain the FlyBase team until we can source alternative and sustainable grant support. We have assembled and trained an expert group of curators in Cambridge, and if they are lost, it is unlikely we would be able to restart FlyBase should funds became available later. If FlyBase is essential for your research, please do make a contribution, as you would pay for other essential reagents. We appreciate that research funds are tight for many of you, but ask you to take a moment to consider how your group would be able to pursue your research without FlyBase.

We have divided our new fundraising efforts into a USA component to support Harvard and Indiana FlyBase teams, and this component within Europe to support the Cambridge UK team. Please note, in our fundraising we are not using the term FlyBase to ensure that there is no risk that NIH could freeze these funds too, but instead have used the name Drosophila Genetic Database. Please work with your administration to make your payments as soon as possible. ...

If we get a rapid positive response from the community, we will be able to reassure our Cambridge curators that they still have a job ahead and retain them, rather than losing them to other jobs.

There are two ways you can contribute:

Method 1. If you are able to pay with lab funds, we have attached two requests for payments, aimed at smaller and larger labs, which we hope will be acceptable for your finance administrators. If you require a different kind of form, please reply with the details that you need. Similarly, if you wish to pay a different amount we can also adjust it for you.
Please use the reference ‘Drosophila Genetic Database’ and add your name and institution to the requests.

Method 2. If you want to make a personal donation or if it is easier to pay with a credit card, we have set up the following crowdfunding website:
https://www.philanthropy.cam.ac.uk/give-to-cambridge/physiology-development-and-neuroscience/drosophila-genetic-database

Thank you in advance for your help in saving our essential Drosophila Database.

We will keep you updated.

With best wishes,

Nick Brown and Katja Röper

Cambridge UK PIs of the Drosophila genetic curation team

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Max Kozlov @maxkozlov.bsky.social · 21/05/2025

Who's calling the shots at NIH? Sworn testimonies and internal e-mails reveal for the first time the breadth of DOGE's control over the world's largest public biomedical funder. DOGE has provided lists of hundreds of grants to cut, and DOGE is now reviewing ALL NIH awards before they're released

nature.com

NIH killed grants on orders from Elon Musk’s DOGE

Court documents and internal correspondence show the cost-cutting force has broad control over the world’s largest public biomedical funder.

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Max Kozlov @maxkozlov.bsky.social · 21/05/2025

This story was possible thanks to NIH employees who reached out; I'm always looking for more sources, so please DM me or find me on Signal (mkozlov.01). PS: If you hit a paywall trying to read the story, making a free account will open up the full story.

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